CY1108568T1 - Αναστολεας για διαγνωση και θεραπεια ασθενων με αιμορροφιλια α - Google Patents

Αναστολεας για διαγνωση και θεραπεια ασθενων με αιμορροφιλια α

Info

Publication number
CY1108568T1
CY1108568T1 CY20081101315T CY081101315T CY1108568T1 CY 1108568 T1 CY1108568 T1 CY 1108568T1 CY 20081101315 T CY20081101315 T CY 20081101315T CY 081101315 T CY081101315 T CY 081101315T CY 1108568 T1 CY1108568 T1 CY 1108568T1
Authority
CY
Cyprus
Prior art keywords
factor viii
human antibody
antibody
specificity
nucleotide sequence
Prior art date
Application number
CY20081101315T
Other languages
English (en)
Inventor
Johannes Jacobus Voorberg
Den Brink Edward Norbert Van
Ellen Anne Maria Turenhout
Original Assignee
Stichting Sanquin Bloedvoorziening
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Sanquin Bloedvoorziening filed Critical Stichting Sanquin Bloedvoorziening
Publication of CY1108568T1 publication Critical patent/CY1108568T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Temperature Or Quantity Of Heat (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

Ένα πολυνουκλεοτίδιο, το οποίον περιλαμβάνει μία συνεχόμενη νουκλεοτιδική αλληλουχία για ένα ανθρώπινο αντίσωμα με ειδικότητα παράγοντα VIII, ή συμπληρωματική σε μία νουκλεοτιδική αλληλουχία που κωδικεύει ένα ανθρώπινο αντίσωμα με ειδικότητα παράγοντα VIII, ή είναι ικανή να υβριδίζεται επιλεκτικά κάτω από αυστηρές συνθήκες με μία τέτοια νουκλεοτιδική αλληλουχία. Αυτό το πολυνουκλεοτίδιο μπορεί να χρησιμοποιηθεί σαν ιχνηθέτης ή εκκινητής για ανίχνευση αναστολέων παράγοντα VII, ή να χρησιμοποιηθεί για παραγωγή ανασυνδυασμένου πολυπεπτιδίου. Ένα πολυπεπτίδιο το οποίον περιλαμβάνει μία συνεχόμενη αμινοξική αλληλουχία που αντιστοιχεί σε ή μιμείται ένα θραύσμα ή παράγωγο ενός ανθρώπινου αντισώματος με ειδικότητα παράγοντα VIII ή ένα αντι-ιδιοτυπικό αντίσωμα που κατευθύνεται εναντίον ενός ανθρώπινου αντισώματος με ειδικότητα παράγοντα VIII. Φαρμακευτικές συνθέσεις οι οποίες περιέχουν τέτοιο πολυπεπτίδιο ή αντίσωμα.
CY20081101315T 1998-05-08 2008-11-17 Αναστολεας για διαγνωση και θεραπεια ασθενων με αιμορροφιλια α CY1108568T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201543 1998-05-08
EP99921292A EP1095143B1 (en) 1998-05-08 1999-05-07 Inhibitor for diagnosis and treatment of haemophilia a patients

Publications (1)

Publication Number Publication Date
CY1108568T1 true CY1108568T1 (el) 2014-04-09

Family

ID=8233706

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101315T CY1108568T1 (el) 1998-05-08 2008-11-17 Αναστολεας για διαγνωση και θεραπεια ασθενων με αιμορροφιλια α

Country Status (12)

Country Link
US (1) US7364735B1 (el)
EP (1) EP1095143B1 (el)
JP (1) JP2002514422A (el)
AT (1) ATE405649T1 (el)
AU (1) AU760678B2 (el)
CA (1) CA2327587C (el)
CY (1) CY1108568T1 (el)
DE (1) DE69939379D1 (el)
DK (1) DK1095143T3 (el)
ES (1) ES2313783T3 (el)
PT (1) PT1095143E (el)
WO (1) WO1999058680A2 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
US7829085B2 (en) 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
EP1325342A2 (en) * 2000-10-13 2003-07-09 Baxter Aktiengesellschaft Xenogeneic antibody containing plasma reagents and associated methods
AU2003227687B2 (en) * 2002-04-29 2009-10-15 Stichting Sanquin Bloedvoorziening Antagonists of factor VIII interaction with low-density lipoprotein receptor-related protein
EP1388544A1 (en) 2002-07-31 2004-02-11 D. Collen Research Foundation vzw Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof
EP1706079B1 (en) 2003-08-14 2013-02-20 ThromboGenics N.V. Antibodies against factor viii with modified glycosylation in the variable region
FR2889534B1 (fr) * 2005-08-04 2012-11-02 Lab Francais Du Fractionnement Anticorps anti-idiotypique neutralisant l'activite inhibitrice d'un anticorps inhibiteur du facteur viii
US11155635B2 (en) * 2016-12-14 2021-10-26 Pangen Biotech Inc. Anti-coagulation factor VIII antibody and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731245A (en) * 1983-12-29 1988-03-15 Kitasato Kenkyusho Vaccine, antigen and antibody for treating microorganisms of the MCLS-type streptococcus sanguis
JPH0764879B2 (ja) * 1984-01-12 1995-07-12 チロン コ−ポレイシヨン フアクタ−ｖ▲ｉｉｉ▼ｃに対するモノクロ−ナル抗体
US5543145A (en) 1984-09-17 1996-08-06 Baxter International, Inc. Pharmaceutical composition and method for the suppression of factor VIII inhibitor production
US5149637A (en) * 1987-04-06 1992-09-22 Scripps Clinic & Research Foundation Recombinant Factor VIIIC fragments
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
WO1993003151A1 (en) 1991-08-10 1993-02-18 Medical Research Council Treatment of cell populations
CA2125396A1 (en) 1991-12-10 1993-06-24 Wayne A. Marasco Reactive neutralizing human anti-gp 120 recombinant antibody, dna coding the same and use thereof
AU7732894A (en) * 1993-09-22 1995-04-10 Nichols Institute Diagnostics Graves' ophthalmopathy associated antibodies, graves' ophthalmopathy orbital antigen, and methods of use thereof
EP0659766A1 (en) 1993-11-23 1995-06-28 Schering-Plough Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
AU3161695A (en) 1994-08-19 1996-03-14 Novo Nordisk A/S A method of treating a patient with a biologically active compound
US6258529B1 (en) 1994-12-01 2001-07-10 Oravax, Inc. PCR amplification of rearranged genomic variable regions of immunoglobulin genes
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
US5916771A (en) * 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method

Also Published As

Publication number Publication date
CA2327587C (en) 2011-09-13
AU760678B2 (en) 2003-05-22
JP2002514422A (ja) 2002-05-21
CA2327587A1 (en) 1999-11-18
EP1095143B1 (en) 2008-08-20
US7364735B1 (en) 2008-04-29
WO1999058680A2 (en) 1999-11-18
ES2313783T3 (es) 2009-03-01
EP1095143A2 (en) 2001-05-02
ATE405649T1 (de) 2008-09-15
AU3853899A (en) 1999-11-29
PT1095143E (pt) 2008-11-28
WO1999058680A3 (en) 2001-02-22
DK1095143T3 (da) 2009-01-05
DE69939379D1 (de) 2008-10-02

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