DK1095143T3 - Inhibitor til diagnosticering og behandling af patienter med hæmofili A - Google Patents

Inhibitor til diagnosticering og behandling af patienter med hæmofili A

Info

Publication number
DK1095143T3
DK1095143T3 DK99921292T DK99921292T DK1095143T3 DK 1095143 T3 DK1095143 T3 DK 1095143T3 DK 99921292 T DK99921292 T DK 99921292T DK 99921292 T DK99921292 T DK 99921292T DK 1095143 T3 DK1095143 T3 DK 1095143T3
Authority
DK
Denmark
Prior art keywords
factor viii
human antibody
antibody
specificity
nucleotide sequence
Prior art date
Application number
DK99921292T
Other languages
English (en)
Inventor
Johannes Jacobus Voorberg
Den Brink Edward Norbert Van
Ellen Anne Maria Turenhout
Original Assignee
Sanquin Bloedvoorziening
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanquin Bloedvoorziening filed Critical Sanquin Bloedvoorziening
Application granted granted Critical
Publication of DK1095143T3 publication Critical patent/DK1095143T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK99921292T 1998-05-08 1999-05-07 Inhibitor til diagnosticering og behandling af patienter med hæmofili A DK1095143T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201543 1998-05-08
PCT/NL1999/000285 WO1999058680A2 (en) 1998-05-08 1999-05-07 Method for diagnosis and treatment of haemophilia a patients with an inhibitor

Publications (1)

Publication Number Publication Date
DK1095143T3 true DK1095143T3 (da) 2009-01-05

Family

ID=8233706

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99921292T DK1095143T3 (da) 1998-05-08 1999-05-07 Inhibitor til diagnosticering og behandling af patienter med hæmofili A

Country Status (12)

Country Link
US (1) US7364735B1 (da)
EP (1) EP1095143B1 (da)
JP (1) JP2002514422A (da)
AT (1) ATE405649T1 (da)
AU (1) AU760678B2 (da)
CA (1) CA2327587C (da)
CY (1) CY1108568T1 (da)
DE (1) DE69939379D1 (da)
DK (1) DK1095143T3 (da)
ES (1) ES2313783T3 (da)
PT (1) PT1095143E (da)
WO (1) WO1999058680A2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
WO2005016455A2 (en) 2003-08-14 2005-02-24 D. Collen Research Foundation Vzw Antibodies against factor viii with modified glycosylation in the variable region
US7829085B2 (en) 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
AU2002210517A1 (en) * 2000-10-13 2002-04-22 Baxter Aktiengesellschaft Xenogeneic antibody containing plasma reagents and associated methods
CA2484155C (en) * 2002-04-29 2015-10-13 Baxter International Inc. Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein
EP1388544A1 (en) 2002-07-31 2004-02-11 D. Collen Research Foundation vzw Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof
FR2889534B1 (fr) * 2005-08-04 2012-11-02 Lab Francais Du Fractionnement Anticorps anti-idiotypique neutralisant l'activite inhibitrice d'un anticorps inhibiteur du facteur viii
KR101989779B1 (ko) * 2016-12-14 2019-06-17 (주) 팬젠 항-혈액응고 제viii인자 항체 및 그 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731245A (en) * 1983-12-29 1988-03-15 Kitasato Kenkyusho Vaccine, antigen and antibody for treating microorganisms of the MCLS-type streptococcus sanguis
DE152746T1 (de) * 1984-01-12 1986-04-10 Chiron Corp., Emeryville, Calif. Monoklonale antikoerper gegen faktor-viii-c.
US5543145A (en) 1984-09-17 1996-08-06 Baxter International, Inc. Pharmaceutical composition and method for the suppression of factor VIII inhibitor production
US5149637A (en) * 1987-04-06 1992-09-22 Scripps Clinic & Research Foundation Recombinant Factor VIIIC fragments
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
JPH06509473A (ja) * 1991-08-10 1994-10-27 メディカル・リサーチ・カウンシル 細胞個体群の処理
EP0618970A1 (en) 1991-12-10 1994-10-12 Dana Farber Cancer Institute Reactive neutralizing human anti-gp120 recombinant antibody, dna coding the same and use thereof
AU7732894A (en) * 1993-09-22 1995-04-10 Nichols Institute Diagnostics Graves' ophthalmopathy associated antibodies, graves' ophthalmopathy orbital antigen, and methods of use thereof
EP0659766A1 (en) * 1993-11-23 1995-06-28 Schering-Plough Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
WO1996005860A1 (en) 1994-08-19 1996-02-29 Novo Nordisk A/S A method of treating a patient with a biologically active compound
US6258529B1 (en) 1994-12-01 2001-07-10 Oravax, Inc. PCR amplification of rearranged genomic variable regions of immunoglobulin genes
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
US5916771A (en) * 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method

Also Published As

Publication number Publication date
EP1095143A2 (en) 2001-05-02
ES2313783T3 (es) 2009-03-01
PT1095143E (pt) 2008-11-28
AU760678B2 (en) 2003-05-22
CA2327587A1 (en) 1999-11-18
ATE405649T1 (de) 2008-09-15
EP1095143B1 (en) 2008-08-20
AU3853899A (en) 1999-11-29
US7364735B1 (en) 2008-04-29
WO1999058680A2 (en) 1999-11-18
WO1999058680A3 (en) 2001-02-22
JP2002514422A (ja) 2002-05-21
CA2327587C (en) 2011-09-13
CY1108568T1 (el) 2014-04-09
DE69939379D1 (de) 2008-10-02

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