DE69816467D1 - Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung - Google Patents

Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung

Info

Publication number
DE69816467D1
DE69816467D1 DE69816467T DE69816467T DE69816467D1 DE 69816467 D1 DE69816467 D1 DE 69816467D1 DE 69816467 T DE69816467 T DE 69816467T DE 69816467 T DE69816467 T DE 69816467T DE 69816467 D1 DE69816467 D1 DE 69816467D1
Authority
DE
Germany
Prior art keywords
robo
polypeptides
nucleic acids
nervous
family
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69816467T
Other languages
English (en)
Other versions
DE69816467T2 (de
Inventor
S Goodman
Thomas Kidd
J Mitchell
Guy Tear
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69816467D1 publication Critical patent/DE69816467D1/de
Application granted granted Critical
Publication of DE69816467T2 publication Critical patent/DE69816467T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69816467T 1997-10-20 1998-10-20 Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung Expired - Lifetime DE69816467T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6292197P 1997-10-20 1997-10-20
US62921P 1997-10-20
US97117297A 1997-11-14 1997-11-14
US971172 1997-11-14
PCT/US1998/022164 WO1999020764A1 (en) 1997-10-20 1998-10-20 Robo: a family of polypeptides and nucleic acids involved in nerve guidance

Publications (2)

Publication Number Publication Date
DE69816467D1 true DE69816467D1 (de) 2003-08-21
DE69816467T2 DE69816467T2 (de) 2004-04-15

Family

ID=26742861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69816467T Expired - Lifetime DE69816467T2 (de) 1997-10-20 1998-10-20 Robo: eine familie polypeptiden und nukleinesäuren wirksam in nervenzellleitung

Country Status (8)

Country Link
US (2) US20050059040A1 (de)
EP (1) EP1025231B1 (de)
JP (2) JP2003517262A (de)
AT (1) ATE245190T1 (de)
AU (1) AU729496B2 (de)
CA (1) CA2304926C (de)
DE (1) DE69816467T2 (de)
WO (1) WO1999020764A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1586660A1 (de) * 1997-04-18 2005-10-19 Millennium Pharmaceuticals, Inc. Neue Moleküle der T85-verwandten Proteinfamilie und ihre Verwendung
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
JP2005504307A (ja) * 2001-10-02 2005-02-10 メディカル リサーチ カウンシル 癌の早期検出のための方法
AU2002329438A1 (en) * 2001-10-02 2003-04-14 Medical Research Council Methods and animal models for tumor formation involving dutti
WO2003075860A2 (en) * 2002-03-08 2003-09-18 Abgent, Inc. Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof
JP4643450B2 (ja) 2003-08-08 2011-03-02 株式会社ペルセウスプロテオミクス 癌高発現遺伝子
US8940488B2 (en) 2004-03-31 2015-01-27 Hiroyuki Aburatani Cancer diagnosis and treatment of cancer using anti-robo 1 antibody
DE602005022693D1 (de) 2004-03-31 2010-09-16 Perseus Proteomics Inc Krebsdiagnose und behandlung unter verwendung eines anti-robo1-antikörpers
JP5117765B2 (ja) 2007-05-28 2013-01-16 国立大学法人 東京大学 抗ｒｏｂｏ１抗体を含むｐｅｔ用腫瘍診断剤
FR2958936A1 (fr) * 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
FR2969617A1 (fr) * 2010-12-23 2012-06-29 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs.
US20130273049A1 (en) * 2010-12-23 2013-10-17 Sanofi Robo1-fc fusion protein for use in the treatment of hepatocarcinoma
PL2800578T3 (pl) * 2012-01-05 2019-05-31 Boston Medical Center Corp Przekazywanie sygnału przez Slit-Robo do diagnostyki i leczenia choroby nerek
AU2018278809B2 (en) 2017-06-02 2022-03-31 Boston Medical Center Corporation Recombinant ROBO2 proteins, compositions, methods and uses thereof
US11406682B2 (en) 2017-08-24 2022-08-09 Bar-Ilan University Roundabout (Robo) receptor inhibitors and uses thereof
US20220348628A1 (en) * 2019-09-24 2022-11-03 The Regents Of The University Of California Novel receptors having a fibronectin repeat for ligand-dependent transcriptional regulation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565331A (en) * 1993-11-12 1996-10-15 The Regents Of The University Of California Nucleic acids encoding neural axon outgrowth modulators
EP1009856A4 (de) * 1997-04-18 2003-02-12 Millennium Pharm Inc Moleküle einer mit fthma-070 verwandten proteinfamilie und die mit t85 verwandte proteinfamilie und ihre verwendung

Also Published As

Publication number Publication date
AU1105799A (en) 1999-05-10
JP4636413B2 (ja) 2011-02-23
ATE245190T1 (de) 2003-08-15
US20100233819A1 (en) 2010-09-16
JP2003517262A (ja) 2003-05-27
US20050059040A1 (en) 2005-03-17
CA2304926A1 (en) 1999-04-29
AU729496B2 (en) 2001-02-01
CA2304926C (en) 2005-06-21
DE69816467T2 (de) 2004-04-15
EP1025231A1 (de) 2000-08-09
EP1025231B1 (de) 2003-07-16
WO1999020764A1 (en) 1999-04-29
JP2006174839A (ja) 2006-07-06

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