ZA200006613B - Mechanical stress induced genes, expression products therefrom, and uses thereof. - Google Patents

Mechanical stress induced genes, expression products therefrom, and uses thereof. Download PDF

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Publication number
ZA200006613B
ZA200006613B ZA200006613A ZA200006613A ZA200006613B ZA 200006613 B ZA200006613 B ZA 200006613B ZA 200006613 A ZA200006613 A ZA 200006613A ZA 200006613 A ZA200006613 A ZA 200006613A ZA 200006613 B ZA200006613 B ZA 200006613B
Authority
ZA
South Africa
Prior art keywords
protein
gene
mrna
cells
bone
Prior art date
Application number
ZA200006613A
Other languages
English (en)
Inventor
Paz Einat
Rami Skaliter
Alexander Faerman
Orna Mor
Elena Feinstein
Original Assignee
Quark Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quark Biotech Inc filed Critical Quark Biotech Inc
Publication of ZA200006613B publication Critical patent/ZA200006613B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
ZA200006613A 1998-05-15 2000-11-14 Mechanical stress induced genes, expression products therefrom, and uses thereof. ZA200006613B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8567398P 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
ZA200006613B true ZA200006613B (en) 2002-02-14

Family

ID=22193209

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200006613A ZA200006613B (en) 1998-05-15 2000-11-14 Mechanical stress induced genes, expression products therefrom, and uses thereof.

Country Status (9)

Country Link
EP (1) EP1082463B1 (de)
JP (1) JP2002535956A (de)
AT (1) ATE350486T1 (de)
AU (1) AU4004699A (de)
CA (1) CA2332150A1 (de)
DE (1) DE69934688T2 (de)
IL (2) IL139637A0 (de)
WO (1) WO1999060164A1 (de)
ZA (1) ZA200006613B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151514A1 (en) * 1998-05-11 2002-10-17 Paz Einat Genes associated with mechanical stress, expression products therefrom, and uses thereof
US7259253B2 (en) 1999-05-14 2007-08-21 Quark Biotech, Inc. Genes associated with mechanical stress, expression products therefrom, and uses thereof
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US6986988B2 (en) 1999-10-06 2006-01-17 Quark Biotech, Inc. Method for enrichment of natural antisense messenger RNA
WO2001025488A2 (en) * 1999-10-06 2001-04-12 Quark Biotech, Inc. Method for enrichment of natural antisense messenger rna
US6468749B1 (en) 2000-03-30 2002-10-22 Quark Biotech, Inc. Sequence-dependent gene sorting techniques
WO2002046753A1 (fr) * 2000-12-06 2002-06-13 Takara Bio Inc. Reseau d'adn fonctionnel
WO2002077019A1 (en) * 2001-03-23 2002-10-03 Dana Farber Cancer Institute,Inc. Methods and compositions for modulating tumor suppression
US20030191073A1 (en) 2001-11-07 2003-10-09 Challita-Eid Pia M. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
BE1014949A3 (fr) * 2001-08-14 2004-07-06 Probiox Procede de detection de stress oxydant et trousse pour sa mise en oeuvre.
US7226594B2 (en) 2001-11-07 2007-06-05 Agensys, Inc. Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
AU2004274861A1 (en) * 2003-06-06 2005-03-31 Wyeth Methods and materials for identifying agents which modulate bone remodeling and agents identified thereby
CN101076348A (zh) 2004-10-08 2007-11-21 克里纽沃药物有限公司 用于在受试者中诱导黑素原生成的组合物和方法
US8350009B2 (en) 2005-03-31 2013-01-08 Agensys, Inc. Antibodies and related molecules that bind to 161P2F10B proteins
EP1863848A4 (de) 2005-03-31 2009-09-23 Agensys Inc An 161p2f10b-proteine bindende antikörper und verwandte moleküle
CA2619174C (en) 2005-08-15 2016-12-20 Vaxin, Inc. Immunization of avians by administration of non-replicating vectored vaccines
FR2893328B1 (fr) * 2005-11-17 2014-01-31 Lvmh Rech Procede pour depister des marqueurs impliques dans la resistance de keratinocytes a des deformations mecaniques.
PT2056855E (pt) 2006-08-31 2014-12-12 Clinuvel Pharmaceuticals Ltd Derivados de alfa-msh para o tratamento de fotodermatoses
HUE038611T2 (hu) 2008-03-27 2018-10-29 Clinuvel Pharmaceuticals Ltd Vitiligo terápia
TWI504410B (zh) 2010-02-08 2015-10-21 Agensys Inc 結合至161p2f10b蛋白之抗體藥物結合物(adc)
EP2487185A1 (de) 2011-02-11 2012-08-15 Clinuvel Pharmaceuticals Limited Hexapeptid mit verbesserter Aktivität bei der Reparatur von zellulärer DNA von Dermiszellen
ES2645156T3 (es) 2011-03-21 2017-12-04 Altimmune Inc. Agente terapéutico inmunológico de acción rápida y prolongada
ES2626297T3 (es) 2011-08-12 2017-07-24 Merial, Inc. Preservación asistida por vacío de productos biológicos, en particular de vacunas
WO2014012090A1 (en) 2012-07-13 2014-01-16 The Broad Institute, Inc. Molecular sleds comprising a positively-charged amino acid sequence and a molecular cargo and uses thereof
JP2015527889A (ja) 2012-07-25 2015-09-24 ザ ブロード インスティテュート, インコーポレイテッド 誘導可能なdna結合タンパク質およびゲノム撹乱ツール、ならびにそれらの適用
WO2014121104A1 (en) * 2013-01-31 2014-08-07 The Regents Of The University Of California Pooled genetic perturbation effects
US11332719B2 (en) 2013-03-15 2022-05-17 The Broad Institute, Inc. Recombinant virus and preparations thereof
WO2015057671A1 (en) 2013-10-14 2015-04-23 The Broad Institute, Inc. Artificial transcription factors comprising a sliding domain and uses thereof
JP6545084B2 (ja) * 2015-11-11 2019-07-17 株式会社Adeka 潤滑油組成物及びその製造方法
WO2022198126A1 (en) * 2021-03-19 2022-09-22 Washington University Methods for generating mechanically-responsive cells and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9204303A (es) * 1991-07-23 1993-11-01 Rhone Poulenc Rorer Int Factor regulador del crecimiento de osteoclasto.
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5968770A (en) * 1995-02-10 1999-10-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
US5861249A (en) * 1996-04-23 1999-01-19 Cold Spring Harbor Laboratory Assays and reagents for identifying modulators of cdc25-mediated mitotic activation

Also Published As

Publication number Publication date
CA2332150A1 (en) 1999-11-25
IL139637A (en) 2009-09-22
IL139637A0 (en) 2002-02-10
WO1999060164A1 (en) 1999-11-25
EP1082463A4 (de) 2003-05-21
EP1082463B1 (de) 2007-01-03
ATE350486T1 (de) 2007-01-15
AU4004699A (en) 1999-12-06
DE69934688D1 (de) 2007-02-15
JP2002535956A (ja) 2002-10-29
EP1082463A1 (de) 2001-03-14
DE69934688T2 (de) 2007-10-18

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