ATE349469T1 - Kristallisierung von igf-1 - Google Patents

Kristallisierung von igf-1

Info

Publication number
ATE349469T1
ATE349469T1 AT02724908T AT02724908T ATE349469T1 AT E349469 T1 ATE349469 T1 AT E349469T1 AT 02724908 T AT02724908 T AT 02724908T AT 02724908 T AT02724908 T AT 02724908T AT E349469 T1 ATE349469 T1 AT E349469T1
Authority
AT
Austria
Prior art keywords
igf
crystalization
relates
candidate
indirect
Prior art date
Application number
AT02724908T
Other languages
German (de)
English (en)
Inventor
Michelle Schaffer
Mark Ultsch
Felix Vajdos
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE349469T1 publication Critical patent/ATE349469T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
AT02724908T 2001-02-09 2002-02-01 Kristallisierung von igf-1 ATE349469T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26797701P 2001-02-09 2001-02-09
US28707201P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
ATE349469T1 true ATE349469T1 (de) 2007-01-15

Family

ID=26952796

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02724908T ATE349469T1 (de) 2001-02-09 2002-02-01 Kristallisierung von igf-1
AT06026832T ATE439378T1 (de) 2001-02-09 2002-02-01 Verfahren zur identifizierung von indirekten igf- 1-agonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06026832T ATE439378T1 (de) 2001-02-09 2002-02-01 Verfahren zur identifizierung von indirekten igf- 1-agonisten

Country Status (19)

Country Link
US (8) US7084240B2 (https=)
EP (3) EP1358209B1 (https=)
JP (2) JP4489352B2 (https=)
KR (1) KR100872613B1 (https=)
CN (1) CN100439397C (https=)
AT (2) ATE349469T1 (https=)
AU (1) AU2002255508B2 (https=)
BR (1) BR0207422A (https=)
CA (1) CA2431033A1 (https=)
DE (3) DE60233359D1 (https=)
DK (2) DK1358209T3 (https=)
ES (2) ES2331150T3 (https=)
HU (1) HUP0500733A3 (https=)
IL (2) IL156435A0 (https=)
MX (1) MXPA03007042A (https=)
NZ (3) NZ526672A (https=)
PL (1) PL374181A1 (https=)
WO (1) WO2002064627A2 (https=)
ZA (1) ZA200304900B (https=)

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WO2002072780A2 (en) * 2001-03-14 2002-09-19 Genentech, Inc. Igf antagonist peptides
US7244703B2 (en) 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
US6914049B2 (en) 2001-09-18 2005-07-05 Bioexpertise, Llc IGF-binding protein-derived peptide or small molecule
US6861406B2 (en) * 2001-09-18 2005-03-01 Bioexpertise, Llc IGF-binding protein-derived peptide
EP1627323A4 (en) * 2003-05-06 2008-04-09 New Century Pharmaceuticals ALBUMIN FIXATION SITES FOR EVALUATING DRUG INTERACTIONS OR THE DEVELOPMENT OF MEDICAMENTS BASED ON THEIR ALBUMIN BINDING PROPERTIES
US20070043509A1 (en) * 2003-11-03 2007-02-22 Carter Daniel C Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
CN101829319A (zh) 2003-12-08 2010-09-15 Cpex药品公司 用于胰岛素治疗的药用组合物及方法
WO2006001911A2 (en) * 2004-05-06 2006-01-05 Genentech, Inc. Crystal structure of the hepatocyte growth factor beta chain and methods of use
WO2005108424A1 (en) * 2004-05-06 2005-11-17 Genentech, Inc. Crystal structure of the complex of hepatocyte growth factor bata chain with met receptor and methods of use
RU2527893C2 (ru) * 2004-07-19 2014-09-10 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
JP2008514240A (ja) * 2004-10-01 2008-05-08 インヴィトロジェン コーポレーション 生体分子のインビトロ合成用の供給バッファー、系、及び方法
US7556776B2 (en) * 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
CA2689549A1 (en) * 2007-06-08 2008-12-18 Massachusetts Institute Of Technology Igf for the treatment of rett syndrome and synaptic disorders
WO2009026172A2 (en) * 2007-08-17 2009-02-26 The Regents Of The University Of California New approach for designing diabetes drugs
CN101139391B (zh) * 2007-08-21 2012-07-25 陈志南 Cd147胞外区晶体结构及应用
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
WO2011011072A2 (en) * 2009-07-22 2011-01-27 Ipsen Pharma S.A.S. Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59
WO2011011071A2 (en) * 2009-07-22 2011-01-27 Ipsen Pharma S.A.S. Analogues of insulin-like growth factor-1 (igf-1)
WO2011047204A1 (en) * 2009-10-14 2011-04-21 Mount Sinai School Of Medicine Method of treating memory disorders and enhancing memory using igf-ii compounds
US20150119394A1 (en) * 2012-03-28 2015-04-30 Merck Sharp & Dohme Corp. Insulin-Like Growth Factor-1 Receptor Inhibitors
KR101711584B1 (ko) * 2012-12-18 2017-03-02 재단법인 의약바이오컨버젼스연구단 변형된 eprs 단백질의 결정 구조 및 이의 결정화 방법
ES2872998T3 (es) 2013-12-19 2021-11-03 Puretein Bioscience Llc Procedimientos de tratamiento de animales
US12324827B2 (en) 2019-09-09 2025-06-10 The University Of Chicago Combination therapy for the treatment of migraines
WO2021248160A1 (en) * 2020-06-01 2021-12-09 Loma Linda University Health Methods of treatment of a cytokine storm
WO2025259950A1 (en) * 2024-06-14 2025-12-18 Cz Biohub Sf, Llc Genetically encoded lysosome targeting chimeras for cell-mediated delivery

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Also Published As

Publication number Publication date
US20060293507A1 (en) 2006-12-28
IL156435A0 (en) 2004-01-04
HUP0500733A2 (hu) 2005-10-28
EP1801120A1 (en) 2007-06-27
US20020165155A1 (en) 2002-11-07
JP2009215299A (ja) 2009-09-24
US20060281905A1 (en) 2006-12-14
HK1060138A1 (en) 2004-07-30
US7354769B2 (en) 2008-04-08
JP4489352B2 (ja) 2010-06-23
IL156435A (en) 2009-09-22
US20060287235A1 (en) 2006-12-21
CN1703425A (zh) 2005-11-30
EP1772464B1 (en) 2009-08-12
WO2002064627A2 (en) 2002-08-22
CN100439397C (zh) 2008-12-03
JP2005503329A (ja) 2005-02-03
ES2278020T3 (es) 2007-08-01
KR20040064610A (ko) 2004-07-19
BR0207422A (pt) 2005-04-19
US7596455B2 (en) 2009-09-29
WO2002064627A3 (en) 2003-07-31
EP1358209A2 (en) 2003-11-05
EP1358209B1 (en) 2006-12-27
DK1358209T3 (da) 2007-05-07
CA2431033A1 (en) 2002-08-22
US20050215477A1 (en) 2005-09-29
EP1772464A3 (en) 2007-10-03
EP1772464A2 (en) 2007-04-11
US20060276397A1 (en) 2006-12-07
NZ526672A (en) 2006-10-27
DE60217066T2 (de) 2007-07-12
US20060287510A1 (en) 2006-12-21
DE60233359D1 (de) 2009-09-24
DK1772464T3 (da) 2009-12-14
AU2002255508B2 (en) 2008-04-03
US7084240B2 (en) 2006-08-01
DE60217066D1 (de) 2007-02-08
DE60217066T4 (de) 2010-07-01
US7433788B2 (en) 2008-10-07
NZ548359A (en) 2007-11-30
MXPA03007042A (es) 2004-05-24
ES2331150T3 (es) 2009-12-22
ZA200304900B (en) 2005-07-27
NZ548358A (en) 2008-04-30
US7238658B2 (en) 2007-07-03
PL374181A1 (en) 2005-10-03
HUP0500733A3 (en) 2010-01-28
KR100872613B1 (ko) 2008-12-09
US7297763B2 (en) 2007-11-20
ATE439378T1 (de) 2009-08-15
US20060270839A1 (en) 2006-11-30

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