ATE339440T1 - Entzündungshemmende verbindungen und ihre verwendung - Google Patents
Entzündungshemmende verbindungen und ihre verwendungInfo
- Publication number
- ATE339440T1 ATE339440T1 AT01931171T AT01931171T ATE339440T1 AT E339440 T1 ATE339440 T1 AT E339440T1 AT 01931171 T AT01931171 T AT 01931171T AT 01931171 T AT01931171 T AT 01931171T AT E339440 T1 ATE339440 T1 AT E339440T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory compounds
- inflammatory
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20126100P | 2000-05-02 | 2000-05-02 | |
US09/643,260 US6864355B1 (en) | 2000-05-02 | 2000-08-22 | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE339440T1 true ATE339440T1 (de) | 2006-10-15 |
Family
ID=26896561
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01931171T ATE339440T1 (de) | 2000-05-02 | 2001-05-02 | Entzündungshemmende verbindungen und ihre verwendung |
AT01935035T ATE279438T1 (de) | 2000-05-02 | 2001-05-02 | Entzündungshemmende verbindungen und ihre verwendung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01935035T ATE279438T1 (de) | 2000-05-02 | 2001-05-02 | Entzündungshemmende verbindungen und ihre verwendung |
Country Status (11)
Country | Link |
---|---|
US (6) | US6864355B1 (de) |
EP (4) | EP1829888A1 (de) |
JP (4) | JP2003531918A (de) |
AR (1) | AR031696A1 (de) |
AT (2) | ATE339440T1 (de) |
AU (3) | AU5763101A (de) |
CA (2) | CA2414296A1 (de) |
DE (2) | DE60106423T2 (de) |
ES (1) | ES2231494T3 (de) |
TW (1) | TWI316062B (de) |
WO (2) | WO2001083547A2 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8680059B2 (en) | 1998-05-20 | 2014-03-25 | Biotempt B.V. | Oligopeptide acetate and formulations thereof |
EP1138692A1 (de) | 2000-03-29 | 2001-10-04 | Erasmus Universiteit Rotterdam | Fragmente des menschlichen Choriongonadotropins als Immunoregulatoren |
US20030220258A1 (en) | 2001-12-21 | 2003-11-27 | Robbert Benner | Treatment of ischemic events |
US6844315B2 (en) | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
US6921751B1 (en) | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
US20030104622A1 (en) * | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
US6864355B1 (en) * | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
US7358330B2 (en) | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
USRE43279E1 (en) | 2000-03-29 | 2012-03-27 | Biotemp B.V. | Compositions capable of reducing elevated blood urea concentration |
US7049395B2 (en) * | 2000-05-02 | 2006-05-23 | Yale University | Anti-inflammatory compounds and uses thereof |
WO2002065990A2 (en) * | 2001-02-16 | 2002-08-29 | University Of Southern California | A COMPOSITION AND METHOD FOR RECONSTITUTING I$G(K)B KINASE IN YEAST AND METHODS OF USING SAME |
US20030171253A1 (en) * | 2001-04-19 | 2003-09-11 | Averil Ma | Methods and compositions relating to modulation of A20 |
US20030165985A1 (en) * | 2001-05-08 | 2003-09-04 | Derry Jonathan M.J. | Methods for identifying compounds that antagonize cd40 signaling |
US7033991B2 (en) * | 2001-07-16 | 2006-04-25 | Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College | Inhibiting furin with polybasic peptides |
US20030083262A1 (en) * | 2001-08-30 | 2003-05-01 | Praecis Pharmaceuticals Inc. | Methods and compositions for treating inflammatory disorders |
GB0127916D0 (en) * | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
US7786084B2 (en) | 2001-12-21 | 2010-08-31 | Biotempt B.V. | Treatment of burns |
US7501391B2 (en) | 2001-12-21 | 2009-03-10 | Biotempt B.V. | Treatment of transplant survival |
MXPA04006614A (es) | 2002-01-07 | 2004-10-04 | Eisai Co Ltd | Deazapurinas y usos de las mismas. |
DE10300222A1 (de) * | 2003-01-03 | 2004-07-15 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Viruserkrankungen |
US7390872B2 (en) * | 2003-09-24 | 2008-06-24 | Institut Pasteur | NF-κB peptides designed to disrupt NEMO oligomerization |
WO2007004869A2 (en) | 2005-07-05 | 2007-01-11 | Biotempt B.V. | Treatment of tumors |
EP1864692A1 (de) | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Verwendung von peptiden zum Schutz von Strahlenschäden |
EP2001455A2 (de) | 2006-03-15 | 2008-12-17 | Theralogics, Inc. | Verfahren zur behandlung von muskelschwunderkrankungen mithilfe von hemmern der nf-kb-aktivierung |
CA2649940C (en) | 2006-04-22 | 2012-08-07 | Hollis-Eden Pharmaceuticals, Inc. | Drugs and uses to modulate inflammation, metabolic disorders and other conditions |
US7919579B2 (en) * | 2006-10-27 | 2011-04-05 | The Board Of Regents Of The University Of Texas System | Imaging and therapeutic targeting of prostate and bladder tissues |
CA2685720C (en) * | 2007-05-01 | 2016-07-05 | Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo - Fapesp | Analgesic compounds |
US20090075902A1 (en) * | 2007-05-25 | 2009-03-19 | Robbins Paul D | Inhibiting the signs of aging by inhibiting nf-kappa b activation |
WO2010144742A2 (en) | 2009-06-10 | 2010-12-16 | Nono, Inc. | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
US8080518B2 (en) * | 2007-12-05 | 2011-12-20 | Arbor Vita Corporation | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
FR2927080A1 (fr) * | 2008-02-05 | 2009-08-07 | Servier Lab | Structure cristalline du domaine cc2-lz de nemo |
KR101122845B1 (ko) * | 2009-07-30 | 2012-03-21 | 부산대학교 산학협력단 | 경구용 염증성 장질환 치료제 |
ES2743600T3 (es) | 2010-03-12 | 2020-02-20 | Brigham & Womens Hospital Inc | Métodos de tratamiento de los trastornos inflamatorios vasculares |
WO2012154684A2 (en) * | 2011-05-06 | 2012-11-15 | University Of Rochester | Method of preventing development of psoriatic lesions |
JP2015509949A (ja) * | 2012-02-23 | 2015-04-02 | エンコード バイオ, インコーポレイテッド | Nemo結合ドメイン融合タンパク質 |
WO2014069597A1 (ja) * | 2012-11-01 | 2014-05-08 | 国立大学法人京都大学 | 線維化非ヒト動物及びその用途 |
WO2014190257A2 (en) | 2013-05-23 | 2014-11-27 | Ohio State Innovation Foundation | Chemical synthesis and screening of bicyclic peptide libraries |
KR101576904B1 (ko) * | 2014-07-31 | 2015-12-14 | (주)케어젠 | 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도 |
CN114432423A (zh) | 2014-09-26 | 2022-05-06 | 拉金德拉·萨哈伊·巴特纳格尔 | 用于治疗疾病和病症的NFkB活性的抑制剂 |
EP3515452B1 (de) | 2016-09-22 | 2023-09-13 | Mercator Medsystems, Inc. | Behandlung einer restenose mit temsirolimus |
CN117866042A (zh) | 2016-11-09 | 2024-04-12 | 俄亥俄州国家创新基金会 | 含有二硫化物的细胞穿透肽及其制备和使用方法 |
WO2018098282A2 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
WO2018098226A1 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
AU2018272061A1 (en) | 2017-05-26 | 2020-01-02 | Mercator Medsystems, Inc. | Combination therapy for treatment of restenosis |
CN111760174B (zh) | 2018-03-14 | 2023-08-25 | 墨卡托医疗系统公司 | 用于局部药物递送的医疗器械和医疗方法 |
WO2019217682A1 (en) | 2018-05-09 | 2019-11-14 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
CN113214356B (zh) * | 2021-06-03 | 2023-02-21 | 兰州大学 | 十氟联苯环化修饰的nbd多肽类似物及其制备方法和应用 |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
US5804374A (en) | 1980-12-05 | 1998-09-08 | Massachusetts Insti. Technology | Nuclear factors associates with transcriptional regulation |
US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
US4839288A (en) | 1986-01-22 | 1989-06-13 | Institut Pasteur | Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes |
US5466585A (en) | 1986-04-15 | 1995-11-14 | Ciba-Geigy Corporation | Interferon-induced human protein in pure form, monoclonal antibodies thereto, and test kits containing these antibodies |
US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
US5674980A (en) | 1989-12-21 | 1997-10-07 | Biogen Inc | Fusion protein comprising tat-derived transport moiety |
US5888762A (en) | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
US5889150A (en) | 1991-01-18 | 1999-03-30 | New York University Medical Center | Expression-cloning method for identifying target proteins for eukaryotic tyrosine kinases and novel target protiens |
US5166133A (en) * | 1991-04-17 | 1992-11-24 | Cetus Corporation | Method for inhibing adhesion of white blood cells to endothelial cells |
US5889169A (en) | 1991-05-16 | 1999-03-30 | Cold Spring Harbor Laboratory | Cell cycle regulatory protein p16 gene |
US5723719A (en) | 1991-08-08 | 1998-03-03 | Health Research Inc. | Transgenic mouse as model for diseases involving dopaminergic dysfunction |
DE4126968A1 (de) | 1991-08-14 | 1993-02-18 | Detlev Prof Dr Med Ganten | Transgene ratten, die in ihrem genom mindestens ein menschliches gen enthalten, das an der blutdruckregulation beteiligt ist |
WO1993006123A1 (en) | 1991-09-20 | 1993-04-01 | Fred Hutchinson Cancer Research Center | Human cyclin e |
US5605930A (en) | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
US5882894A (en) | 1991-11-20 | 1999-03-16 | Trustees Of Dartmouth College | Nucleic acids encoding CR8 polypeptides, vector and transformed cell thereof, and expression thereof |
WO1993014200A1 (en) | 1992-01-07 | 1993-07-22 | Tsi Corporation | Transgenic animal models for alzheimer's disease |
US5733720A (en) | 1992-06-18 | 1998-03-31 | Washington University | Genetically engineered cell lines for detecting infectious herpesvirus and methods therefor |
US5602307A (en) | 1992-08-12 | 1997-02-11 | Baylor College Of Medicine | Non-human animal having predefined allele of a cellular adhesion gene |
US5731490A (en) | 1992-09-29 | 1998-03-24 | The Ontario Cancer Institute | Mutant mouse lacking the expression of interferon regulatory factor 1 (IRF-1) |
US5489743A (en) | 1993-01-19 | 1996-02-06 | Amgen Inc. | Transgenic animal models for thrombocytopenia |
US5888981A (en) | 1993-06-14 | 1999-03-30 | Basf Aktiengesellschaft | Methods for regulating gene expression |
US5882941A (en) | 1994-05-04 | 1999-03-16 | Massachusette Institute Of Technology | Programmable genotoxic agents and uses therefor |
WO1995034573A1 (en) | 1994-06-03 | 1995-12-21 | Brigham And Women's Hospital | Identification of polycystic kidney disease gene, diagnostics and treatment |
US5667987A (en) | 1994-07-12 | 1997-09-16 | Bristol-Myers Squibb Company | P53 response genes |
US5885580A (en) | 1994-07-29 | 1999-03-23 | Ajinomoto Co., Inc. | Anti-AIDS secretory recombinant BCG vaccine |
US5888773A (en) | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
IL116026A (en) | 1994-11-22 | 2005-08-31 | Rhone Poulenc Rorer Sa | Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses |
US5846743A (en) | 1995-02-22 | 1998-12-08 | Brigham And Women's Hospital, Inc. | Polyphoshoinositide binding peptides for intracellular drug delivery |
US5728915A (en) | 1995-05-08 | 1998-03-17 | Children's Hospital, Inc. | Transgenic mice which express simian SV 40 T-antigen under control of the retinoblastoma gene promoter |
FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
US5895813A (en) | 1995-10-13 | 1999-04-20 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Diagnosis and treatment of TKA-1 related disorders |
US5891643A (en) | 1995-11-14 | 1999-04-06 | Abbott Laboratories | Use of nuclear magnetic resonance to design ligands to target biomolecules |
US5906819A (en) | 1995-11-20 | 1999-05-25 | Kirin Beer Kabushiki Kaisha | Rho target protein Rho-kinase |
US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
ZA9610721B (en) | 1995-12-21 | 1998-06-19 | Cornell Res Foundation Inc | Grapevine leafroll virus proteins and their uses. |
US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
DE19605274A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Nukleinsäurekonstrukte für die zellzyklusregulierte Expression von Genen, derartige Konstrukte enthaltende Zellen sowie deren Verwendung zur Herstellung von Heilmitteln |
US5905146A (en) | 1996-03-15 | 1999-05-18 | University Of Arkansas | DNA binding protein S1-3 |
US5961976A (en) | 1996-06-03 | 1999-10-05 | United Biomedical, Inc. | Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV |
US5648238A (en) | 1996-06-18 | 1997-07-15 | Incyte Pharmaceuticals, Inc. | Human protein kinase C inhibitor homolog |
CA2744096C (en) | 1996-07-31 | 2013-07-30 | Laboratory Corporation Of America Holdings | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
US5908756A (en) | 1996-08-30 | 1999-06-01 | Johns Hopkins University | Protein inhibitor of neuronal nitric oxide synthase |
US5876972A (en) | 1996-09-23 | 1999-03-02 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Nucleic acid molecules coding for tumor suppressor proteins and methods for their isolation |
US5874290A (en) | 1996-11-08 | 1999-02-23 | Northwest Biotherapeutics, Llc | Nucleotide and amino acid sequences of a D2-2 gene associated with brain tumors and methods based thereon |
US5968895A (en) | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
AU734827B2 (en) | 1997-05-21 | 2001-06-21 | Board Of Trustees Of The Leland Stanford Junior University | Composition and method for enhancing transport across biological membranes |
US5885803A (en) | 1997-06-19 | 1999-03-23 | Incyte Pharmaceuticals, Inc. | Disease associated protein kinases |
US6235512B1 (en) * | 1997-07-01 | 2001-05-22 | Tularik Inc. | IKK-α proteins, nucleic acids and methods |
US5851812A (en) | 1997-07-01 | 1998-12-22 | Tularik Inc. | IKK-β proteins, nucleic acids and methods |
US5891432A (en) | 1997-07-29 | 1999-04-06 | The Immune Response Corporation | Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same |
US5885779A (en) | 1997-09-09 | 1999-03-23 | University Of British Columbia | Repressed trans-activator system for characterization of protein-protein interactions |
US6015787A (en) | 1997-11-04 | 2000-01-18 | New England Medical Center Hospitals, Inc. | Cell-permeable protein inhibitors of calpain |
WO1999029721A1 (en) | 1997-12-10 | 1999-06-17 | Washington University | Anti-pathogen system and methods of use thereof |
WO1999031255A2 (en) * | 1997-12-16 | 1999-06-24 | Genencor International, Inc. | Novel egiii-like enzymes, dna encoding such enzymes and methods for producing such enzymes |
US6030834A (en) | 1997-12-30 | 2000-02-29 | Chiron Corporation | Human IKK-beta DNA constructs and cells |
GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
CA2350919A1 (en) | 1998-11-13 | 2000-05-25 | Cyclacel Limited | Antennapedia homeodomain helix 3 derived translocation vectors |
US5972655A (en) | 1998-11-19 | 1999-10-26 | The Research Foundation Of State University Of New York | Y2H61 an IKK binding protein |
US6864355B1 (en) | 2000-05-02 | 2005-03-08 | Yale University | Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain |
US7049395B2 (en) | 2000-05-02 | 2006-05-23 | Yale University | Anti-inflammatory compounds and uses thereof |
-
2000
- 2000-08-22 US US09/643,260 patent/US6864355B1/en not_active Expired - Lifetime
-
2001
- 2001-05-02 WO PCT/US2001/040654 patent/WO2001083547A2/en active IP Right Grant
- 2001-05-02 JP JP2001580978A patent/JP2003531918A/ja not_active Withdrawn
- 2001-05-02 EP EP06019053A patent/EP1829888A1/de not_active Withdrawn
- 2001-05-02 EP EP01935035A patent/EP1280820B1/de not_active Expired - Lifetime
- 2001-05-02 TW TW090110497A patent/TWI316062B/zh not_active IP Right Cessation
- 2001-05-02 ES ES01935035T patent/ES2231494T3/es not_active Expired - Lifetime
- 2001-05-02 DE DE60106423T patent/DE60106423T2/de not_active Expired - Lifetime
- 2001-05-02 AU AU5763101A patent/AU5763101A/xx active Pending
- 2001-05-02 AU AU6116401A patent/AU6116401A/xx not_active Withdrawn
- 2001-05-02 EP EP10012327A patent/EP2314601A1/de not_active Withdrawn
- 2001-05-02 EP EP01931171A patent/EP1282643B1/de not_active Expired - Lifetime
- 2001-05-02 US US09/847,940 patent/US6831065B2/en not_active Expired - Lifetime
- 2001-05-02 AR ARP010102065A patent/AR031696A1/es unknown
- 2001-05-02 AU AU2001257631A patent/AU2001257631B2/en not_active Ceased
- 2001-05-02 AT AT01931171T patent/ATE339440T1/de not_active IP Right Cessation
- 2001-05-02 DE DE60123041T patent/DE60123041T2/de not_active Expired - Lifetime
- 2001-05-02 CA CA002414296A patent/CA2414296A1/en not_active Abandoned
- 2001-05-02 WO PCT/US2001/014346 patent/WO2001083554A2/en active IP Right Grant
- 2001-05-02 AT AT01935035T patent/ATE279438T1/de not_active IP Right Cessation
- 2001-05-02 CA CA002414290A patent/CA2414290A1/en not_active Abandoned
- 2001-05-02 JP JP2001580971A patent/JP2003531636A/ja active Pending
-
2004
- 2004-11-01 US US10/979,683 patent/US7538089B2/en not_active Expired - Fee Related
-
2009
- 2009-04-15 US US12/424,334 patent/US7872094B2/en not_active Expired - Fee Related
-
2010
- 2010-12-02 US US12/958,615 patent/US8017726B2/en not_active Expired - Fee Related
-
2011
- 2011-08-08 US US13/204,919 patent/US8217138B2/en not_active Expired - Fee Related
- 2011-12-09 JP JP2011270736A patent/JP2012100663A/ja active Pending
- 2011-12-09 JP JP2011270735A patent/JP2013056876A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE339440T1 (de) | Entzündungshemmende verbindungen und ihre verwendung | |
ATE277910T1 (de) | Urazil verbindungen und deren verwendung | |
ATE370931T1 (de) | Heterozyklische verbindungen und ihre verwendungen | |
DE60139477D1 (de) | 2-cyanopyrrolidin-derivate und ihre verwendung als arzneimittel | |
ATE424202T1 (de) | Substituierte 2-thio-3,5-dicyano-4-phenyl-6- aminopyridine und ihre verwendung | |
ATE533508T1 (de) | Cripto-blockierende antikörper und ihre verwendung | |
DE50207849D1 (de) | Substituierte 2-oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre verwendung | |
EE200300071A (et) | Kinasoliini derivaadid | |
DE60103974D1 (de) | Gyrase-inhibitoren und ihre verwendung | |
DE60027479D1 (de) | Harzstruktur und ihre verwendung | |
ATE298337T1 (de) | Neue verwendung sowie neue n-azabicycloamid- verbindungen | |
DE60016326D1 (de) | Wasser-absorbierende Zusammensetzung und ihre Verwendung | |
ATE261449T1 (de) | Thienopyrimidin verbindungen, ihre herstellung und verwendung | |
ATE332294T1 (de) | Dihydro-1,3,5-triazin-diamin-derivate und ihre therapeutische verwendung | |
ATE420642T1 (de) | Neue formulierungen und ihre verwendung | |
DE60027927D1 (de) | Harzstruktur und ihre verwendung | |
DE60112635D1 (de) | Ölzusammensetzung und ihre Verwendung | |
DE60230608D1 (de) | Tyra-gene und ihre verwendung | |
DE50206094D1 (de) | Substituierte isoindole und ihre verwendung | |
DE60006970D1 (de) | Fluorogene verbindungen und ihre verwendungen | |
NO20021503D0 (no) | Kinazolinoner | |
DE59906907D1 (de) | Phosphororganische verbindungen und ihre verwendung | |
ATE268327T1 (de) | Benzazol-verbindungen und ihre verwendung | |
DE50202730D1 (de) | Substituierte isoindole und ihre verwendung | |
DE59902692D1 (de) | Phosphororganische verbindungen und ihre verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |