ATE339426T1 - Arylborsäuren für die behandlung von fettsucht - Google Patents

Arylborsäuren für die behandlung von fettsucht

Info

Publication number
ATE339426T1
ATE339426T1 AT02746808T AT02746808T ATE339426T1 AT E339426 T1 ATE339426 T1 AT E339426T1 AT 02746808 T AT02746808 T AT 02746808T AT 02746808 T AT02746808 T AT 02746808T AT E339426 T1 ATE339426 T1 AT E339426T1
Authority
AT
Austria
Prior art keywords
sub
substituted
sup
group
optionally
Prior art date
Application number
AT02746808T
Other languages
German (de)
English (en)
Inventor
Stephen Randall Holmes-Farley
W Harry Mandeville Iii
Chad Cori Huval
Xinhua Li
Pradeep K Dhal
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of ATE339426T1 publication Critical patent/ATE339426T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02746808T 2001-06-29 2002-07-01 Arylborsäuren für die behandlung von fettsucht ATE339426T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30208101P 2001-06-29 2001-06-29
US35946702P 2002-02-22 2002-02-22

Publications (1)

Publication Number Publication Date
ATE339426T1 true ATE339426T1 (de) 2006-10-15

Family

ID=26972758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02746808T ATE339426T1 (de) 2001-06-29 2002-07-01 Arylborsäuren für die behandlung von fettsucht

Country Status (12)

Country Link
US (3) US6858592B2 (enExample)
EP (1) EP1404685B1 (enExample)
JP (1) JP2004535452A (enExample)
AT (1) ATE339426T1 (enExample)
AU (2) AU2002316499B2 (enExample)
CA (1) CA2489681A1 (enExample)
CY (1) CY1105829T1 (enExample)
DE (1) DE60214713T2 (enExample)
DK (1) DK1404685T3 (enExample)
ES (1) ES2275888T3 (enExample)
PT (1) PT1404685E (enExample)
WO (1) WO2003002570A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
WO2003105860A1 (en) * 2002-06-14 2003-12-24 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
AU2003291567A1 (en) * 2002-11-19 2004-06-15 Genzyme Corporation Polymeric boronic acid derivatives as lipase inhibitors
JP2008519853A (ja) * 2004-11-12 2008-06-12 トラスティーズ オブ タフツ カレッジ リパーゼ阻害物質
WO2006098270A1 (ja) * 2005-03-14 2006-09-21 Eisai R & D Management Co., Ltd. オキシメチルホウ素化合物
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
US10157355B2 (en) 2005-11-15 2018-12-18 General Electric Company Method to view schedule interdependencies and provide proactive clinical process decision support in day view form
US7801058B2 (en) * 2006-07-27 2010-09-21 Mobitrum Corporation Method and system for dynamic information exchange on mesh network devices
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
CA2731645C (en) * 2007-07-24 2017-05-23 The University Of British Columbia Substituted aryl-fluoroborates as imaging agents
EP2282742A1 (en) * 2008-04-09 2011-02-16 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118155A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
JP2012523425A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
US8709489B2 (en) 2009-09-30 2014-04-29 Surmodics, Inc. Emulsions containing arylboronic acids and medical articles made therefrom
BR112012019120A2 (pt) * 2010-02-03 2016-06-28 Infinity Pharmaceuticais Inc forma sólida, composição farmacêutica, método de preparação do composto 1, método de tratamento de uma condição mediada por faah
US8546617B1 (en) 2012-03-23 2013-10-01 Empire Technology Development Llc Dioxaborinanes and uses thereof
US9120938B2 (en) 2012-07-31 2015-09-01 Empire Technology Development Llc Polymerizable organoboron alkyd resin anti fouling coatings
WO2014021845A1 (en) * 2012-07-31 2014-02-06 Empire Technology Development Llc Polymerizable organoboron alkyd resin anti fouling coatings
ES2618374T3 (es) * 2012-10-17 2017-06-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Composiciones y métodos para mejorar la absorción de glucosa
EP2964658B1 (en) 2013-03-08 2024-08-07 The University Of British Columbia Positron-emitting substituted organofluoroborates as imaging agents
US11078528B2 (en) 2015-10-12 2021-08-03 Advanced Cell Diagnostics, Inc. In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto
CN106243343B (zh) * 2016-08-11 2018-04-03 江苏大学 一种苯硼酸功能化嵌段聚合物的合成及应用
US12427209B2 (en) 2018-12-18 2025-09-30 Provincial Health Services Authority Dual mode 18F-labelled theranostic compounds and uses thereof
AU2022245308A1 (en) * 2021-03-24 2023-09-21 Trustees Of Tufts College Boronic acid compounds, compositions and methods

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496722A (en) * 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
GB8819224D0 (en) 1988-08-12 1988-09-14 Merck Patent Gmbh Process for preparation of rod-like compounds
DE3930663C1 (en) 1989-09-14 1990-11-15 Merck Patent Gmbh, 6100 Darmstadt, De Cross-coupling metal organic cpds. and e.g. halogen cpds. - includes using transition metal-palladium catalyst and opt. metal alcoholate
EP0478050A1 (en) 1990-09-24 1992-04-01 Unilever N.V. Detergent composition
GB9024775D0 (en) 1990-11-14 1991-01-02 Axis Research Chemical compounds
IE914573A1 (en) 1991-01-17 1992-07-29 Ici Plc Boron compounds
HUT65823A (en) * 1991-04-30 1994-07-28 Procter & Gamble Liquid detergents with an aryl boronic acid and process for using thereof
GB9119920D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
CH683522A5 (de) 1992-03-13 1994-03-31 Hoffmann La Roche Verfahren zur Herstellung von Diarylen.
JP3257029B2 (ja) 1992-04-22 2002-02-18 日本油脂株式会社 フェニルボロン酸誘導体及び製造方法
CA2096496A1 (en) 1992-05-29 1993-11-30 Bradley C. Pearce Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
US5290817A (en) * 1992-06-09 1994-03-01 The Du Pont Merck Pharmaceutical Co. Substituted 1-benzylindanes and their use as inhibitors of phospholipase A2
WO1994014803A1 (en) 1992-12-21 1994-07-07 Zeneca Limited Quinuclidine derivatives as squalene synthase inhibitors
GB2276162A (en) 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benazilide derivatives
US5776951A (en) 1993-06-30 1998-07-07 Glaxo Wellcome Inc. Anti-atherosclerotic diaryl compounds
AU7121394A (en) * 1993-07-09 1995-02-06 Borax Consolidated Ltd Boronic acid or borinic acid derivatives as enzyme stabilizers
JP3412198B2 (ja) * 1993-08-31 2003-06-03 日本油脂株式会社 変性マレイン酸共重合体および用途
JPH09503773A (ja) 1993-10-19 1997-04-15 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ−１ｄレセプター拮抗剤用のベンズアニリド誘導体
EP0741693B1 (en) 1994-01-27 1999-03-24 Novartis AG Process for the preparation of arylacetic ester derivatives via palladium-catalyzed cross coupling reaction
US5631364A (en) * 1994-03-31 1997-05-20 Axis Biochemicals Asa Labelled boronic acid derivatives
SI9400289A (en) 1994-07-13 1996-02-29 Ponikvar Jadranka Buturovic A method for preventing blood coagulation in a haemodialysis circuit or haemodialysis analogy procedure in the extra-body circuit.
WO1996017833A1 (en) 1994-12-09 1996-06-13 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
FI972896A7 (fi) 1995-01-09 1997-07-08 Novo Nordisk As Nestemäisten entsyymikoostumusten stabilointi
US6008219A (en) 1995-03-27 1999-12-28 Smithkline Beech P.L.C. Bicyclic amine derivatives and their use as anti-psychotic agents
UA58494C2 (uk) * 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
WO1996041859A1 (en) * 1995-06-13 1996-12-27 Novo Nordisk A/S 4-substituted-phenyl-boronic acids as enzyme stabilizers
US5631371A (en) * 1995-11-22 1997-05-20 Bayer Corporation Method for the preparation of substituted 3-(phenylimino)-3H-phenothiazines and phenoxazines
GB9603137D0 (en) 1996-02-15 1996-04-17 Merck Sharp & Dohme Therapeutic agents
AU5446098A (en) 1996-11-21 1998-06-10 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
JP2001526643A (ja) 1997-04-18 2001-12-18 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ１ａ、５ｈｔ１ｂおよび５ｈｔ１ｄ受容体アンタゴニスト活性を合わせ持つ化合物を含む二環式アリールまたは二環式複素環
JP2002504122A (ja) 1997-06-13 2002-02-05 ノースウエスタン ユニバーシティー ベータラクタマーゼ阻害剤及びその使用方法
US6184363B1 (en) * 1997-06-13 2001-02-06 Northwestern University Inhibitors of β-lactamases and uses therefor
JP2002510328A (ja) 1997-07-25 2002-04-02 スミスクライン・ビーチャム・コーポレイション ビトロネクチン受容体アンタゴニスト
CO5011067A1 (es) 1997-11-03 2001-02-28 Novartis Ag Derivados de bifenilo como productos farmaceuticos, su pre- paracion y composiciones farmaceuticas que los contienen
US6264937B1 (en) * 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
WO1999047474A1 (en) 1998-03-18 1999-09-23 Ciba Specialty Chemicals Holding Inc. Coupling reactions with palladium catalysts
AU5235599A (en) 1998-07-31 2000-02-21 Eli Lilly And Company N-substituted sulfonamide derivatives
EP1112262B1 (en) 1998-09-09 2004-08-04 Inflazyme Pharmaceuticals Ltd. Substituted gamma-phenyl-delta-lactones and analogs thereof and uses related thereto
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
DE19857765A1 (de) * 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
WO2000035904A1 (en) 1998-12-16 2000-06-22 Northwestern University INHIBITORS OF β-LACTAMASES AND USES THEREFOR
WO2000042213A1 (en) 1999-01-13 2000-07-20 The Research Foundation Of State University Of New York A novel method for designing protein kinase inhibitors
BRPI0011172B8 (pt) 1999-04-14 2021-05-25 Pacific Corp derivados do 4,5-diaril-3(2h)-furanona como inibidores de ciclooxigenase-2
JP4507294B2 (ja) 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
CN1285601C (zh) 2000-11-30 2006-11-22 佳能株式会社 发光器件和显示器
JP3589450B2 (ja) 2001-03-13 2004-11-17 独立行政法人 科学技術振興機構 アミド脱水縮合触媒として有用なパーフルオロアルキルフェニルホウ酸
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
WO2003106384A2 (en) 2002-06-01 2003-12-24 Johns Hopkins University Novel boronic chalcone derivatives and uses thereof
US7045652B2 (en) * 2002-07-03 2006-05-16 Pfizer Inc Processes for preparing substituted aryl boronic acids

Also Published As

Publication number Publication date
DK1404685T3 (da) 2007-01-22
US7049304B2 (en) 2006-05-23
US20030064963A1 (en) 2003-04-03
US6858592B2 (en) 2005-02-22
DE60214713D1 (de) 2006-10-26
EP1404685B1 (en) 2006-09-13
CY1105829T1 (el) 2011-02-02
DE60214713T2 (de) 2007-09-06
WO2003002570A1 (en) 2003-01-09
JP2004535452A (ja) 2004-11-25
US7456156B2 (en) 2008-11-25
US20060128664A1 (en) 2006-06-15
PT1404685E (pt) 2007-01-31
CA2489681A1 (en) 2003-01-09
HK1065046A1 (en) 2005-02-08
AU2002316499B2 (en) 2005-08-04
EP1404685A1 (en) 2004-04-07
US20050107336A1 (en) 2005-05-19
ES2275888T3 (es) 2007-06-16
AU2005220192A1 (en) 2005-12-01

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