ATE332303T1 - 2-substituierte hydroxy-2- indolinylbuttersäureesterverbindungen des s-typs und verfahren zu ihrer herstellung - Google Patents

2-substituierte hydroxy-2- indolinylbuttersäureesterverbindungen des s-typs und verfahren zu ihrer herstellung

Info

Publication number
ATE332303T1
ATE332303T1 AT02006610T AT02006610T ATE332303T1 AT E332303 T1 ATE332303 T1 AT E332303T1 AT 02006610 T AT02006610 T AT 02006610T AT 02006610 T AT02006610 T AT 02006610T AT E332303 T1 ATE332303 T1 AT E332303T1
Authority
AT
Austria
Prior art keywords
type
indolinyl
production
acid ester
ester compounds
Prior art date
Application number
AT02006610T
Other languages
English (en)
Inventor
Takayuki Kawaguchi
Sumihiro Nomura
Kenji Tsujihara
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of ATE332303T1 publication Critical patent/ATE332303T1/de

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/133—Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
    • G02F1/1333—Constructional arrangements; Manufacturing methods
    • G02F1/1345—Conductors connecting electrodes to cell terminals
    • G02F1/13452—Conductors connecting driver circuitry and terminals of panels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/1303—Apparatus specially adapted to the manufacture of LCDs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nonlinear Science (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mathematical Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02006610T 1996-10-30 1997-10-27 2-substituierte hydroxy-2- indolinylbuttersäureesterverbindungen des s-typs und verfahren zu ihrer herstellung ATE332303T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28807496 1996-10-30

Publications (1)

Publication Number Publication Date
ATE332303T1 true ATE332303T1 (de) 2006-07-15

Family

ID=17725479

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02006610T ATE332303T1 (de) 1996-10-30 1997-10-27 2-substituierte hydroxy-2- indolinylbuttersäureesterverbindungen des s-typs und verfahren zu ihrer herstellung
AT97308549T ATE247120T1 (de) 1996-10-30 1997-10-27 2-substituierte hydroxy-2- indolininylbluttersäureester des s-reihe als camptothecin-zwischnprodukte

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97308549T ATE247120T1 (de) 1996-10-30 1997-10-27 2-substituierte hydroxy-2- indolininylbluttersäureester des s-reihe als camptothecin-zwischnprodukte

Country Status (14)

Country Link
US (7) US5932732A (de)
EP (3) EP1236728B1 (de)
KR (5) KR100474496B1 (de)
CN (3) CN1077109C (de)
AT (2) ATE332303T1 (de)
CA (2) CA2533685C (de)
DE (2) DE69736308T2 (de)
DK (2) DK0845464T3 (de)
ES (2) ES2205134T3 (de)
HK (2) HK1050356B (de)
ID (1) ID18747A (de)
PT (2) PT1236728E (de)
SG (4) SG116433A1 (de)
TW (1) TW464652B (de)

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CA2427467C (en) 2000-11-09 2010-01-12 Neopharm, Inc. Sn-38 lipid complexes and methods of use
US20090137816A1 (en) * 2000-12-15 2009-05-28 Kurt Baum Process for the manufacture of diaminofurazan
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
CN101337900B (zh) * 2001-02-21 2013-12-18 株式会社雅库路特本社 喜树碱相关化合物的合成方法
TWI245768B (en) 2001-02-21 2005-12-21 Yakult Honsha Kk Process for synthesizing camptothecin related compound(s)
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
US20040034050A1 (en) * 2002-06-03 2004-02-19 Yang Li-Xi Homo-camptothecin derivatives
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
JP4433918B2 (ja) * 2004-07-15 2010-03-17 コニカミノルタエムジー株式会社 画像形成方法
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
CN100390177C (zh) * 2004-11-25 2008-05-28 复旦大学 6-氰基-7-甲基-1,1-(2,2-二甲基-1,3-亚丙二氧基)-5-氧-1,2,3,5-四氢吲哚哩啶(i)的制备方法
WO2007015259A2 (en) * 2005-08-03 2007-02-08 Avra Laboratories Pvt. Ltd. Method of synthesizing key intermediates for the production of camptothecin derivatives
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN104341429B (zh) * 2013-07-29 2016-08-10 北大方正集团有限公司 (s)-喜树碱中间体的制备方法及(s)-喜树碱的制备方法
IL277748B1 (en) * 2018-04-06 2024-03-01 Seagen Inc Camptothecin peptide conjugates
CN113041841B (zh) * 2021-03-22 2022-07-12 万华化学集团股份有限公司 一种抗污染浓水隔网的制备方法及应用

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EP0220601B1 (de) * 1985-10-21 1991-12-11 Daiichi Seiyaku Co., Ltd. Pyranoindolizinderivate und Verfahren zu ihrer Herstellung
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US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
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JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
JP2524803B2 (ja) * 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体およびその製造法
ATE211142T1 (de) * 1989-09-15 2002-01-15 Res Triangle Inst Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog
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KR960029336A (ko) * 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
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SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
WO1997018194A1 (de) 1995-11-13 1997-05-22 Hoechst Aktiengesellschaft CYCLISCHE UND HETEROCYCLISCHE N-SUBSTITUIERTE α-IMINOHYDROXAM- UND CARBONSÄUREN
AU7732996A (en) 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
SG116433A1 (en) * 1996-10-30 2005-11-28 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof.
DE19719817A1 (de) * 1997-05-13 1998-11-19 Hoechst Ag Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren

Also Published As

Publication number Publication date
ES2205134T3 (es) 2004-05-01
PT845464E (pt) 2003-12-31
US6388078B1 (en) 2002-05-14
CN1077109C (zh) 2002-01-02
SG103322A1 (en) 2004-04-29
EP0845464A3 (de) 1999-06-23
US5932732A (en) 1999-08-03
EP0845464A2 (de) 1998-06-03
US6015901A (en) 2000-01-18
EP1236728A2 (de) 2002-09-04
KR100525025B1 (ko) 2005-10-31
TW464652B (en) 2001-11-21
HK1050356A1 (en) 2003-06-20
PT1236728E (pt) 2006-10-31
ES2267879T3 (es) 2007-03-16
ATE247120T1 (de) 2003-08-15
US6277992B1 (en) 2001-08-21
EP1236728B1 (de) 2006-07-05
DE69736308T2 (de) 2007-06-14
KR100653592B1 (ko) 2006-12-05
SG88737A1 (en) 2002-05-21
CA2533685A1 (en) 1998-04-30
SG116433A1 (en) 2005-11-28
KR20060086818A (ko) 2006-08-01
CA2219692C (en) 2007-05-22
US7060832B2 (en) 2006-06-13
KR19980033318A (ko) 1998-07-25
KR100578779B1 (ko) 2006-05-12
DK0845464T3 (da) 2003-12-01
US20030135049A1 (en) 2003-07-17
CN1313286A (zh) 2001-09-19
EP1236728A3 (de) 2002-12-18
EP1528062A2 (de) 2005-05-04
CA2219692A1 (en) 1998-04-30
CN1183414A (zh) 1998-06-03
DK1236728T3 (da) 2006-10-30
EP1528062A3 (de) 2007-02-07
DE69724081T2 (de) 2004-06-09
KR100474496B1 (ko) 2005-09-30
ID18747A (id) 1998-05-07
DE69736308D1 (de) 2006-08-17
US20020161231A1 (en) 2002-10-31
CN100528879C (zh) 2009-08-19
US6716983B2 (en) 2004-04-06
DE69724081D1 (de) 2003-09-18
EP0845464B1 (de) 2003-08-13
KR100567957B1 (ko) 2006-04-05
SG104284A1 (en) 2004-06-21
CN100473654C (zh) 2009-04-01
CA2533685C (en) 2009-05-26
HK1011538A1 (en) 1999-07-16
HK1050356B (zh) 2007-01-19
CN1915995A (zh) 2007-02-21
MX9708343A (es) 1998-08-30
US6114529A (en) 2000-09-05

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