DK0845464T3 - S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater - Google Patents

S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater

Info

Publication number
DK0845464T3
DK0845464T3 DK97308549T DK97308549T DK0845464T3 DK 0845464 T3 DK0845464 T3 DK 0845464T3 DK 97308549 T DK97308549 T DK 97308549T DK 97308549 T DK97308549 T DK 97308549T DK 0845464 T3 DK0845464 T3 DK 0845464T3
Authority
DK
Denmark
Prior art keywords
type
indolidinyl
intermediates
acid ester
butyric acid
Prior art date
Application number
DK97308549T
Other languages
Danish (da)
English (en)
Inventor
Takayuki Kawaguchi
Sumihiro Nomura
Kenji Tsujihara
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of DK0845464T3 publication Critical patent/DK0845464T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/133—Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
    • G02F1/1333—Constructional arrangements; Manufacturing methods
    • G02F1/1345—Conductors connecting electrodes to cell terminals
    • G02F1/13452—Conductors connecting driver circuitry and terminals of panels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • G—PHYSICS
    • G02—OPTICS
    • G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/1303—Apparatus specially adapted to the manufacture of LCDs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nonlinear Science (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mathematical Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Manufacturing & Machinery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
DK97308549T 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater DK0845464T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28807496 1996-10-30

Publications (1)

Publication Number Publication Date
DK0845464T3 true DK0845464T3 (da) 2003-12-01

Family

ID=17725479

Family Applications (2)

Application Number Title Priority Date Filing Date
DK02006610T DK1236728T3 (da) 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf
DK97308549T DK0845464T3 (da) 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmørsyreesterforbindelser som mellemprodukter for camptothecinderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK02006610T DK1236728T3 (da) 1996-10-30 1997-10-27 S-type 2-substituerede hydroxy-2-indolidinylsmörsyreesterforbindelser og fremgangsmåde til fremstilling deraf

Country Status (14)

Country Link
US (7) US5932732A (de)
EP (3) EP1528062A3 (de)
KR (5) KR100474496B1 (de)
CN (3) CN1077109C (de)
AT (2) ATE247120T1 (de)
CA (2) CA2533685C (de)
DE (2) DE69736308T2 (de)
DK (2) DK1236728T3 (de)
ES (2) ES2205134T3 (de)
HK (2) HK1050356B (de)
ID (1) ID18747A (de)
PT (2) PT845464E (de)
SG (4) SG88737A1 (de)
TW (1) TW464652B (de)

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MXPA03004095A (es) 2000-11-09 2004-09-10 Neopharm Inc Complejos de sn-38 con lipidos y sus metodos de uso.
US20090137816A1 (en) * 2000-12-15 2009-05-28 Kurt Baum Process for the manufacture of diaminofurazan
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
TWI245768B (en) 2001-02-21 2005-12-21 Yakult Honsha Kk Process for synthesizing camptothecin related compound(s)
CN101337900B (zh) * 2001-02-21 2013-12-18 株式会社雅库路特本社 喜树碱相关化合物的合成方法
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
WO2003101406A1 (en) * 2002-06-03 2003-12-11 California Pacific Medical Center Homo-camptothecin derivatives
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
JP4433918B2 (ja) * 2004-07-15 2010-03-17 コニカミノルタエムジー株式会社 画像形成方法
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
CN100390177C (zh) * 2004-11-25 2008-05-28 复旦大学 6-氰基-7-甲基-1,1-(2,2-二甲基-1,3-亚丙二氧基)-5-氧-1,2,3,5-四氢吲哚哩啶(i)的制备方法
WO2007015259A2 (en) * 2005-08-03 2007-02-08 Avra Laboratories Pvt. Ltd. Method of synthesizing key intermediates for the production of camptothecin derivatives
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN104341429B (zh) * 2013-07-29 2016-08-10 北大方正集团有限公司 (s)-喜树碱中间体的制备方法及(s)-喜树碱的制备方法
IL277748B1 (en) * 2018-04-06 2024-03-01 Seagen Inc Camptothecin peptide conjugates
CN113041841B (zh) * 2021-03-22 2022-07-12 万华化学集团股份有限公司 一种抗污染浓水隔网的制备方法及应用

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US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
DE3682874D1 (de) * 1985-10-21 1992-01-23 Daiichi Seiyaku Co Pyranoindolizinderivate und verfahren zu ihrer herstellung.
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
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US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
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US4943579A (en) 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
JP2524803B2 (ja) * 1988-03-29 1996-08-14 株式会社ヤクルト本社 新規なカンプトテシン誘導体およびその製造法
ATE211142T1 (de) * 1989-09-15 2002-01-15 Res Triangle Inst Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog
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SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
ATE213232T1 (de) * 1995-11-13 2002-02-15 Hoechst Ag Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren
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CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
TW464652B (en) * 1996-10-30 2001-11-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
DE19719817A1 (de) * 1997-05-13 1998-11-19 Hoechst Ag Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren

Also Published As

Publication number Publication date
CN1077109C (zh) 2002-01-02
CA2533685C (en) 2009-05-26
EP0845464A2 (de) 1998-06-03
US5932732A (en) 1999-08-03
HK1050356B (zh) 2007-01-19
PT845464E (pt) 2003-12-31
PT1236728E (pt) 2006-10-31
US20020161231A1 (en) 2002-10-31
EP1236728A2 (de) 2002-09-04
TW464652B (en) 2001-11-21
DE69736308D1 (de) 2006-08-17
EP0845464A3 (de) 1999-06-23
KR20060086818A (ko) 2006-08-01
US6277992B1 (en) 2001-08-21
DE69724081D1 (de) 2003-09-18
US20030135049A1 (en) 2003-07-17
ID18747A (id) 1998-05-07
KR100474496B1 (ko) 2005-09-30
EP1528062A2 (de) 2005-05-04
EP0845464B1 (de) 2003-08-13
KR100578779B1 (ko) 2006-05-12
ES2267879T3 (es) 2007-03-16
US6388078B1 (en) 2002-05-14
SG104284A1 (en) 2004-06-21
EP1236728B1 (de) 2006-07-05
CN1183414A (zh) 1998-06-03
EP1236728A3 (de) 2002-12-18
ATE332303T1 (de) 2006-07-15
CA2219692C (en) 2007-05-22
CN1313286A (zh) 2001-09-19
HK1011538A1 (en) 1999-07-16
US6716983B2 (en) 2004-04-06
DE69736308T2 (de) 2007-06-14
KR100567957B1 (ko) 2006-04-05
CN100473654C (zh) 2009-04-01
US7060832B2 (en) 2006-06-13
ATE247120T1 (de) 2003-08-15
KR19980033318A (ko) 1998-07-25
HK1050356A1 (en) 2003-06-20
CA2533685A1 (en) 1998-04-30
CN1915995A (zh) 2007-02-21
KR100525025B1 (ko) 2005-10-31
SG103322A1 (en) 2004-04-29
ES2205134T3 (es) 2004-05-01
DK1236728T3 (da) 2006-10-30
EP1528062A3 (de) 2007-02-07
SG116433A1 (en) 2005-11-28
MX9708343A (es) 1998-08-30
US6114529A (en) 2000-09-05
CA2219692A1 (en) 1998-04-30
US6015901A (en) 2000-01-18
SG88737A1 (en) 2002-05-21
DE69724081T2 (de) 2004-06-09
CN100528879C (zh) 2009-08-19
KR100653592B1 (ko) 2006-12-05

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