ATE327985T1 - Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen - Google Patents

Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen

Info

Publication number
ATE327985T1
ATE327985T1 AT01979066T AT01979066T ATE327985T1 AT E327985 T1 ATE327985 T1 AT E327985T1 AT 01979066 T AT01979066 T AT 01979066T AT 01979066 T AT01979066 T AT 01979066T AT E327985 T1 ATE327985 T1 AT E327985T1
Authority
AT
Austria
Prior art keywords
amino
group
tetrahydrobenzothiazoles
alkyl
producing
Prior art date
Application number
AT01979066T
Other languages
English (en)
Inventor
Karel Pospisilik
Hans Jan Hoorn
Theodorus Hendricus Ant Peters
Jacobus Maria Lemmens
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Application granted granted Critical
Publication of ATE327985T1 publication Critical patent/ATE327985T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
AT01979066T 2000-09-18 2001-09-14 Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen ATE327985T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002262A ES2187249B1 (es) 2000-09-18 2000-09-18 Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles.

Publications (1)

Publication Number Publication Date
ATE327985T1 true ATE327985T1 (de) 2006-06-15

Family

ID=8494959

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01979066T ATE327985T1 (de) 2000-09-18 2001-09-14 Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen
AT01981155T ATE301646T1 (de) 2000-09-18 2001-09-18 Verfahren zur racematspaltung von 2-amino-6- propylamino-4,5,6,7-tetrahydrobenzothiazol sowie verbindungen dafür

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01981155T ATE301646T1 (de) 2000-09-18 2001-09-18 Verfahren zur racematspaltung von 2-amino-6- propylamino-4,5,6,7-tetrahydrobenzothiazol sowie verbindungen dafür

Country Status (10)

Country Link
US (3) US6770761B2 (de)
EP (2) EP1318986B1 (de)
AT (2) ATE327985T1 (de)
AU (2) AU2002211055A1 (de)
DE (1) DE60120197T2 (de)
DK (2) DK1318986T3 (de)
ES (3) ES2187249B1 (de)
PT (2) PT1318986E (de)
SI (1) SI1318986T1 (de)
WO (2) WO2002022590A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2241118A (en) * 1990-02-15 1991-08-21 Ibm Electrical apparatus with forced air cooling
US20060281797A1 (en) * 2001-12-11 2006-12-14 University Of Virginia Patent Foundation Neurorestoration with R(+) Pramipexole
US7157480B2 (en) * 2001-12-11 2007-01-02 University Of Virginia Patent Foundation Use of pramipexole to treat amyotrophic lateral sclerosis
PE20040134A1 (es) 2002-07-25 2004-03-06 Pharmacia Corp Forma de dosificacion de una vez al dia de pramipexol
US20050226926A1 (en) 2002-07-25 2005-10-13 Pfizer Inc Sustained-release tablet composition of pramipexole
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
GB2394951A (en) * 2002-11-04 2004-05-12 Cipla Ltd One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
EP1730129B1 (de) 2004-03-19 2011-01-19 Dipharma Francis S.r.l. Zwischenprodukte für die herstellung von pramipexol
US20080096939A1 (en) * 2004-07-03 2008-04-24 Andreas Keil Process For Preparation Of Pramipexole By Chiral Chromatography
NZ589267A (en) * 2004-08-13 2012-06-29 Boehringer Ingelheim Int Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
NZ553645A (en) * 2004-08-13 2010-09-30 Boehringer Ingelheim Int Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
US20060069263A1 (en) * 2004-09-30 2006-03-30 Irina Gribun Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole
US20060148866A1 (en) * 2004-12-30 2006-07-06 Chemagis Ltd. Novel process for preparing pramipexole and its optical isomeric mixture by reduction with sodium triacetoxyborohydride
CN1834092B (zh) * 2005-03-15 2010-04-28 姜能桥 盐酸普拉克索的制备方法
US20090062549A1 (en) * 2005-05-03 2009-03-05 Seema Kanwar Process for the preparation of pramipexole and new anhydrous forms of its dihydrochloride
ES2264378B1 (es) 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
JP2009504748A (ja) * 2005-08-15 2009-02-05 ユニバーシティ オブ バージニア パテント ファウンデーション Ｒ（＋）プラミペキソールを用いた神経回復
EP1926486A4 (de) * 2005-09-21 2009-06-10 Chemagis Ltd Neue polymorphen von (s)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazolmonotartrat und herstellungs- und anwendungsverfahren dafür
WO2007054970A2 (en) * 2005-10-25 2007-05-18 Alembic Limited Novel polymorphic forms of (s)-(-)-2-amino-6-(n- propylamino) 4,5,6,7- tetrahydrobenzothiazole
PL378587A1 (pl) * 2005-12-29 2007-07-09 Instytut Farmaceutyczny Sposób wytwarzania (S)-(-)-2-amino-6-n-propyloamino-4,5,6,7-tetrahydrobenzotiazolu i/lub jego soli
ITMI20060044A1 (it) * 2006-01-13 2007-07-14 Dipharma Spa Sintesi di intermedi pr la preparazione di pramipexolo
CA2641665A1 (en) * 2006-02-10 2007-08-16 Boehringer Ingelheim International Gmbh Modified release formulation
US20090098202A1 (en) * 2006-02-10 2009-04-16 Boehringer Ingelheim International Gmbh Extended Release Formulation
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
US20070259930A1 (en) * 2006-04-10 2007-11-08 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
DK2026803T3 (da) * 2006-05-16 2012-04-16 Knopp Neurosciences Inc Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf
ATE405554T1 (de) * 2006-06-26 2008-09-15 Helm Ag Verfahren zur herstellung von pramipexole
WO2008001204A2 (en) * 2006-06-29 2008-01-03 Antares Pharma Ipl Ag Transdermal compositions of pramipexole having enhanced permeation properties
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
AU2008224844B2 (en) * 2007-03-14 2012-08-09 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
JP2012500283A (ja) 2008-08-19 2012-01-05 ノップ ニューロサイエンシーズ、インク． （ｒ）−プラミペキソールを使用した組成物並びにその方法
EP2442655A4 (de) * 2009-06-19 2013-04-03 Knopp Neurosciences Inc Zusammensetzungen und verfahren zur behandlung von amyotropher lateralsklerose (als)
ITMI20101998A1 (it) * 2010-10-27 2012-04-28 Dipharma Francis Srl Procedimento per la racemizzazione di acidi carbossilici
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
CN104072442B (zh) * 2013-03-28 2016-09-28 成都弘达药业有限公司 一种化合物及其制备方法
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
SI3838271T1 (sl) 2013-07-12 2025-12-31 Areteia Therapeutics, Inc. Zdravljenje povišanih ravni eozinofilcev in/ali bazofilcev
PT3033081T (pt) 2013-08-13 2021-06-01 Knopp Biosciences Llc Composições e métodos para o tratamento da urticária crónica
AU2014306683B2 (en) 2013-08-13 2017-10-12 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
CN108084115B (zh) * 2017-12-28 2020-03-17 上海博志研新药物技术有限公司 盐酸普拉克索及其中间体的制备方法
CN110669024A (zh) * 2019-10-30 2020-01-10 福建福瑞明德药业有限公司 一种(s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑*l-酒石酸盐的碱析方法
CN116178304B (zh) * 2023-03-10 2024-10-25 中国药科大学 一种盐酸普拉克索的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186087B1 (de) * 1984-12-22 1989-08-23 Dr. Karl Thomae GmbH Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel
EP0207696A1 (de) 1985-06-24 1987-01-07 Eli Lilly And Company Dialkylaminotetrahydrobenzothiazole und -oxazole
DE3620813A1 (de) * 1986-06-21 1987-12-23 Boehringer Ingelheim Kg Neue tetrahydro-benzothiazole, ihre herstellung und verwendung

Also Published As

Publication number Publication date
AU2002212815A1 (en) 2002-03-26
ATE301646T1 (de) 2005-08-15
ES2260296T3 (es) 2006-11-01
ES2187249B1 (es) 2004-09-16
WO2002022591A1 (en) 2002-03-21
EP1318987B1 (de) 2005-08-10
US6770761B2 (en) 2004-08-03
DE60120197T2 (de) 2007-03-15
EP1318986A1 (de) 2003-06-18
ES2242778T3 (es) 2005-11-16
DK1318986T3 (da) 2006-10-02
WO2002022590A1 (en) 2002-03-21
SI1318986T1 (sl) 2006-10-31
PT1318986E (pt) 2006-10-31
US20040068119A1 (en) 2004-04-08
DK1318987T3 (da) 2005-12-12
EP1318987A1 (de) 2003-06-18
US6727367B2 (en) 2004-04-27
ES2187249A1 (es) 2003-05-16
US20040029936A1 (en) 2004-02-12
AU2002211055A1 (en) 2002-03-26
EP1318986B1 (de) 2006-05-31
DE60120197D1 (de) 2006-07-06
US20020103240A1 (en) 2002-08-01
PT1318987E (pt) 2005-10-31

Similar Documents

Publication Publication Date Title
ATE327985T1 (de) Verfahren zur herstellung von 2-amino-6- (alkyl)amino-4,5,6,7-tetrahydrobenzothiazolen
ATE285391T1 (de) Verfahren zur herstellung von arylalkylethern
ID21547A (id) Kristal-kristal dari turunan benzimidazol dan produksinya
CL2008000584A1 (es) Procedimiento de preparacion de esteres dialquilicos de acidos alquil-amido-tiofosforicos que comprende la reaccion de un ditiofosfato con agente de oxidacion en solucion de caracter acido y reaccion del producto obtenido con una amina (divisional de
HRP990167B1 (en) Sulphinic acid derivatives, method for producing them, and their use
ATE346062T1 (de) Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten
BG105457A (en) Method for the preparation of citalopram
ATE194365T1 (de) Verfahren zur herstellung von polyorganosiloxanen durch hydrolyse von organohalosilanen
DE69907656D1 (de) Polyethoxylierte retinamid-derivate und verfahren zu ihrer herstellung
DE69911430D1 (de) Verfahren zur herstellung von 1-(1h)-benzoquinolizin-3-on derivaten
ATE38673T1 (de) Verfahren zur herstellung von alkylsilicaten aus siliciummetall.
DE3767564D1 (de) 7-(phenylacetamido)-4-alkylcumarine, verfahren zu ihrer herstellung sowie ihre verwendung in verfahren zur fluorometrischen bestimmung der aktivitaet von hydrolasen, insbesondere von penicillin-g-acylase.
EP1334968A4 (de) Verfahren zur herstellung substituierter anilinverbindungen
ATE309187T1 (de) Verfahren zur reinigung von abgasströmen
DE60104704D1 (de) Verfahren zur herstellung einer substituierten imidazopyridinverbindung
DE60015177D1 (de) Verfahren zur herstellung von 2-[4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxyessigsäure und zwischenprodukte dafür
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
DE59908429D1 (de) Verfahren zur herstellung von (1r,4s)-2-azabicyclo 2.2.1 hept-5-en-3-on-derivaten
ATE234288T1 (de) Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür
DE69518252D1 (de) Verfahren zur herstellung von 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalin-derivaten
DE59803194D1 (de) Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
ATE170565T1 (de) Verfahren zur biotechnologischen herstellung von alkoholen, aldehyden und carbonsäuren
ATE104959T1 (de) Verfahren zur herstellung von vitamin a aldehyd.
ATE253553T1 (de) Verfahren zur herstellung von 2- alkylthiobenzonitril-derivaten
ATE217611T1 (de) Verfahren zur herstellung von phosphodiesterase iv inhibitoren

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1318986

Country of ref document: EP

REN Ceased due to non-payment of the annual fee