ATE325341T1 - Zusammenhang zwischen konformation und biologischer aktivität von apoptose-induzierenden phosphodiesteroligonukleotiden - Google Patents
Zusammenhang zwischen konformation und biologischer aktivität von apoptose-induzierenden phosphodiesteroligonukleotidenInfo
- Publication number
- ATE325341T1 ATE325341T1 AT02760451T AT02760451T ATE325341T1 AT E325341 T1 ATE325341 T1 AT E325341T1 AT 02760451 T AT02760451 T AT 02760451T AT 02760451 T AT02760451 T AT 02760451T AT E325341 T1 ATE325341 T1 AT E325341T1
- Authority
- AT
- Austria
- Prior art keywords
- bases
- phosphodiesteroligonucleotides
- apoptosis
- conformation
- inducing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B99/00—Subject matter not provided for in other groups of this subclass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/335—Modified T or U
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Evolutionary Biology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Theoretical Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31329001P | 2001-08-17 | 2001-08-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE325341T1 true ATE325341T1 (de) | 2006-06-15 |
Family
ID=23215136
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02760451T ATE325341T1 (de) | 2001-08-17 | 2002-08-19 | Zusammenhang zwischen konformation und biologischer aktivität von apoptose-induzierenden phosphodiesteroligonukleotiden |
AT02767738T ATE428781T1 (de) | 2001-08-17 | 2002-08-19 | Oligonukleotid-zusammansetzungen und deren verwendung zur induzierung von apoptose |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02767738T ATE428781T1 (de) | 2001-08-17 | 2002-08-19 | Oligonukleotid-zusammansetzungen und deren verwendung zur induzierung von apoptose |
Country Status (14)
Country | Link |
---|---|
US (5) | US7199228B2 (de) |
EP (2) | EP1448986B1 (de) |
JP (2) | JP4504015B2 (de) |
KR (2) | KR100943567B1 (de) |
AT (2) | ATE325341T1 (de) |
AU (2) | AU2002330663B2 (de) |
CA (2) | CA2457783A1 (de) |
DE (2) | DE60211206T2 (de) |
DK (1) | DK1417307T3 (de) |
ES (1) | ES2325247T3 (de) |
HK (1) | HK1069205A1 (de) |
IL (4) | IL160407A0 (de) |
MX (2) | MXPA04001480A (de) |
WO (2) | WO2003016528A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030032610A1 (en) * | 1996-06-03 | 2003-02-13 | Gilchrest Barbara A. | Method to inhibit cell growth using oligonucleotides |
EP2363133A1 (de) * | 2000-03-31 | 2011-09-07 | Trustees of Boston University | Zusammensetzung enhalted DNA-Fragmente und ihre medizinischen und kosmetischen Verwendungen |
US7087586B2 (en) * | 2001-04-24 | 2006-08-08 | Bioniche Life Sciences, Inc. | Oligonucleotide compositions and their use to induce differentiation of cells |
KR100943567B1 (ko) * | 2001-08-17 | 2010-02-22 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 세포사멸-유도성 포스포디에스테르올리고뉴클레오타이드의 입체구조-활성 관계성 |
WO2004014312A2 (en) * | 2002-08-08 | 2004-02-19 | Sirna Therapeutics, Inc. | Small-mer compositions and methods of use |
US20060269924A1 (en) * | 2003-04-11 | 2006-11-30 | Trustees Of Boston University | Modulation of telomere-initiated cell signaling |
WO2007028985A2 (en) * | 2005-09-07 | 2007-03-15 | The Secretary Of State For Defence | Adjuvanted vaccine |
GB0906234D0 (en) | 2009-04-14 | 2009-05-20 | Secr Defence | Vaccine |
KR100998365B1 (ko) | 2009-06-29 | 2010-12-06 | 압타바이오 주식회사 | 치료 효능이 있는 변형핵산 및 구아노신을 함유하는 올리고뉴클레오티드 변형체 |
JP2013510189A (ja) * | 2009-11-10 | 2013-03-21 | バイオニケ ライフ サイエンシーズ インコーポレイテッド | 非dna塩基含有ポリヌクレオチド組成物、および免疫応答の調節のためのそれらの使用 |
CN106709925A (zh) * | 2016-12-30 | 2017-05-24 | 上海联影医疗科技有限公司 | 医学图像中椎块的定位方法及其装置 |
CN107704697B (zh) * | 2017-10-18 | 2019-08-20 | 西南交通大学 | 一种型材三维拉弯成形性预测评价优化方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106727A (en) * | 1989-04-27 | 1992-04-21 | Life Technologies, Inc. | Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers |
WO1993018187A1 (en) * | 1992-03-13 | 1993-09-16 | California Institute Of Technology | Triple helix recognition of dna |
US5962426A (en) * | 1993-06-25 | 1999-10-05 | Yale University | Triple-helix forming oligonucleotides for targeted mutagenesis |
DK0805876T3 (da) * | 1995-01-19 | 2000-11-06 | Gen Probe Inc | Nukleinsyreamplifikationsoligonukleotider og prober til Lyme-sygdom-associeret Borrelia |
US5643890A (en) | 1995-01-31 | 1997-07-01 | The Board Of Regents Of The University Of Nebraska | Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases |
JP2003517283A (ja) * | 1999-04-08 | 2003-05-27 | オアシス バイオサイエンシーズ インコーポレイティッド | プライマーペアの増幅及び配列決定並びにそれらの使用 |
EP1238070B1 (de) * | 1999-12-13 | 2007-08-15 | Bioniche Life Sciences Inc. | Synthetische oligonukleotide die therapeutisch nützlich sind |
KR100943567B1 (ko) * | 2001-08-17 | 2010-02-22 | 바이오니취 라이프 사이언시즈 인코포레이티드 | 세포사멸-유도성 포스포디에스테르올리고뉴클레오타이드의 입체구조-활성 관계성 |
EP1465910A4 (de) * | 2002-02-20 | 2005-03-16 | Sirna Therapeutics Inc | Durch rna-interferenz vermittelte inhibierung der genexpression von checkpointkinase-1 (chk-1) unter verwendung kurzer interferierender nukleinsäuren |
-
2002
- 2002-08-19 KR KR1020047002322A patent/KR100943567B1/ko not_active IP Right Cessation
- 2002-08-19 DK DK02767738T patent/DK1417307T3/da active
- 2002-08-19 ES ES02767738T patent/ES2325247T3/es not_active Expired - Lifetime
- 2002-08-19 JP JP2003521837A patent/JP4504015B2/ja not_active Expired - Fee Related
- 2002-08-19 WO PCT/IB2002/003323 patent/WO2003016528A2/en active Application Filing
- 2002-08-19 KR KR1020047002321A patent/KR101017483B1/ko not_active IP Right Cessation
- 2002-08-19 CA CA002457783A patent/CA2457783A1/en not_active Abandoned
- 2002-08-19 IL IL16040702A patent/IL160407A0/xx unknown
- 2002-08-19 DE DE60211206T patent/DE60211206T2/de not_active Expired - Lifetime
- 2002-08-19 WO PCT/IB2002/003324 patent/WO2003016567A2/en active IP Right Grant
- 2002-08-19 US US10/223,672 patent/US7199228B2/en not_active Expired - Fee Related
- 2002-08-19 CA CA002457789A patent/CA2457789A1/en not_active Abandoned
- 2002-08-19 JP JP2003521874A patent/JP4469603B2/ja not_active Expired - Fee Related
- 2002-08-19 EP EP02760451A patent/EP1448986B1/de not_active Expired - Lifetime
- 2002-08-19 MX MXPA04001480A patent/MXPA04001480A/es active IP Right Grant
- 2002-08-19 AU AU2002330663A patent/AU2002330663B2/en not_active Ceased
- 2002-08-19 AT AT02760451T patent/ATE325341T1/de not_active IP Right Cessation
- 2002-08-19 AU AU2002326067A patent/AU2002326067B2/en not_active Ceased
- 2002-08-19 US US10/223,234 patent/US7200531B2/en not_active Expired - Fee Related
- 2002-08-19 MX MXPA04001315A patent/MXPA04001315A/es active IP Right Grant
- 2002-08-19 EP EP02767738A patent/EP1417307B1/de not_active Expired - Lifetime
- 2002-08-19 IL IL16040802A patent/IL160408A0/xx unknown
- 2002-08-19 AT AT02767738T patent/ATE428781T1/de active
- 2002-08-19 DE DE60231986T patent/DE60231986D1/de not_active Expired - Lifetime
-
2004
- 2004-02-15 IL IL160408A patent/IL160408A/en not_active IP Right Cessation
- 2004-02-15 IL IL160407A patent/IL160407A/en not_active IP Right Cessation
-
2005
- 2005-02-25 HK HK05101599A patent/HK1069205A1/xx not_active IP Right Cessation
-
2007
- 2007-01-24 US US11/626,614 patent/US7893242B2/en not_active Expired - Fee Related
- 2007-02-09 US US11/705,044 patent/US20080077372A1/en not_active Abandoned
-
2011
- 2011-02-07 US US13/021,983 patent/US8350016B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |