ATE323695T1 - Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer - Google Patents

Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer

Info

Publication number
ATE323695T1
ATE323695T1 AT03765694T AT03765694T ATE323695T1 AT E323695 T1 ATE323695 T1 AT E323695T1 AT 03765694 T AT03765694 T AT 03765694T AT 03765694 T AT03765694 T AT 03765694T AT E323695 T1 ATE323695 T1 AT E323695T1
Authority
AT
Austria
Prior art keywords
proton pump
pump inhibitor
benzimidazole derivatives
inhibitor prodrugs
prodrugs
Prior art date
Application number
AT03765694T
Other languages
German (de)
English (en)
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Original Assignee
Winston Pharmaceuticals Llc
Univ California
Us Gov Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Winston Pharmaceuticals Llc, Univ California, Us Gov Veterans Affairs filed Critical Winston Pharmaceuticals Llc
Application granted granted Critical
Publication of ATE323695T1 publication Critical patent/ATE323695T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
AT03765694T 2002-07-19 2003-07-15 Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer ATE323695T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19

Publications (1)

Publication Number Publication Date
ATE323695T1 true ATE323695T1 (de) 2006-05-15

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03765694T ATE323695T1 (de) 2002-07-19 2003-07-15 Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer

Country Status (23)

Country Link
US (3) US6897227B2 (US06897227-20050524-C00025.png)
EP (1) EP1556371B1 (US06897227-20050524-C00025.png)
JP (1) JP4463103B2 (US06897227-20050524-C00025.png)
KR (2) KR100788778B1 (US06897227-20050524-C00025.png)
AT (1) ATE323695T1 (US06897227-20050524-C00025.png)
AU (1) AU2003259154B2 (US06897227-20050524-C00025.png)
BR (1) BR0312802A (US06897227-20050524-C00025.png)
CA (1) CA2492718C (US06897227-20050524-C00025.png)
CO (1) CO5690576A2 (US06897227-20050524-C00025.png)
DE (1) DE60304726T2 (US06897227-20050524-C00025.png)
DK (1) DK1556371T3 (US06897227-20050524-C00025.png)
ES (1) ES2263028T3 (US06897227-20050524-C00025.png)
HK (1) HK1079207A1 (US06897227-20050524-C00025.png)
IL (1) IL166371A0 (US06897227-20050524-C00025.png)
MX (1) MXPA05000657A (US06897227-20050524-C00025.png)
NO (1) NO20050801L (US06897227-20050524-C00025.png)
NZ (1) NZ538221A (US06897227-20050524-C00025.png)
PL (1) PL375255A1 (US06897227-20050524-C00025.png)
PT (1) PT1556371E (US06897227-20050524-C00025.png)
RU (1) RU2292342C2 (US06897227-20050524-C00025.png)
TW (1) TW200502231A (US06897227-20050524-C00025.png)
WO (1) WO2004009583A2 (US06897227-20050524-C00025.png)
ZA (1) ZA200501116B (US06897227-20050524-C00025.png)

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US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US7211590B2 (en) * 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
KR20060041224A (ko) * 2003-07-15 2006-05-11 알러간, 인코포레이티드 양성자 펌프 억제제의 이성질체적으로 순수한 프로드러그를제조하는 방법
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
WO2005082338A2 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Prodrugs for the intravenous administration of proton pump inhibitors
BRPI0507784A (pt) * 2004-02-18 2007-07-17 Allergan Inc métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons
EP1722794A1 (en) * 2004-03-11 2006-11-22 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
PT1740571E (pt) 2004-04-28 2009-09-02 Hetero Drugs Ltd Processo para preparar compostos de piridinilmetil-1hbenzimidazol na forma enantiomericamente enriquecida ou como enantiómeros únicos
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
US20070265311A1 (en) * 2006-01-10 2007-11-15 Rubino Mark P Therapeutic Salt Compositions and Methods
BRPI0711048A2 (pt) * 2006-05-09 2011-08-23 Astrazeneca Ab formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
EP2661265B1 (en) 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
RU2589709C2 (ru) 2010-12-23 2016-07-10 Мерк Шарп Энд Домэ Корп. Хиноксалины и азахиноксалины в качестве модуляторов рецептора crth2
CA2973370A1 (en) * 2015-01-09 2016-07-14 The Regents Of The University Of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

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US430042A (en) * 1890-06-10 Valve
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4758597A (en) * 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) * 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
WO1991019712A1 (en) * 1990-06-20 1991-12-26 Aktiebolaget Astra Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
RO117792B1 (ro) * 1994-06-10 2002-07-30 Byk Gulden Lomberg Chem Fab Arilalchiltioalchil-tiopiridine substituite, utilizate pentru combaterea bacteriilor helicobacter
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
CN100396675C (zh) * 1998-08-10 2008-06-25 加利福尼亚州大学董事会 质子泵抑制剂的前药
CA2714085C (en) * 1998-08-12 2013-02-05 Emory University Method of manufacture of 1,3-oxathiolane nucleosides
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) * 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
CA2425363A1 (en) 2000-10-12 2003-04-10 Fumihiko Sato Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
BR0312802A (pt) 2005-04-19
PT1556371E (pt) 2006-09-29
WO2004009583A3 (en) 2004-03-18
NO20050801L (no) 2005-02-15
DE60304726T2 (de) 2007-08-09
HK1079207A1 (en) 2006-03-31
KR20070005029A (ko) 2007-01-09
NZ538221A (en) 2006-11-30
CA2492718C (en) 2010-12-21
ZA200501116B (en) 2006-11-29
US6897227B2 (en) 2005-05-24
US20050143423A1 (en) 2005-06-30
AU2003259154C1 (en) 2004-02-09
DE60304726D1 (de) 2006-05-24
ES2263028T3 (es) 2006-12-01
AU2003259154A1 (en) 2004-02-09
US20040102484A1 (en) 2004-05-27
DK1556371T3 (da) 2006-08-21
IL166371A0 (en) 2006-01-16
JP2005536519A (ja) 2005-12-02
JP4463103B2 (ja) 2010-05-12
KR100788778B1 (ko) 2007-12-27
KR100822981B1 (ko) 2008-04-16
EP1556371A2 (en) 2005-07-27
AU2003259154B2 (en) 2006-12-07
CA2492718A1 (en) 2004-01-29
TW200502231A (en) 2005-01-16
RU2292342C2 (ru) 2007-01-27
EP1556371B1 (en) 2006-04-19
KR20050047078A (ko) 2005-05-19
US20050182101A1 (en) 2005-08-18
RU2005105564A (ru) 2005-10-10
CO5690576A2 (es) 2006-10-31
PL375255A1 (en) 2005-11-28
WO2004009583A2 (en) 2004-01-29
MXPA05000657A (es) 2005-08-19

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