ATE321146T1 - Methoden zur modifikation von kohlenhydratanteilen - Google Patents

Methoden zur modifikation von kohlenhydratanteilen

Info

Publication number
ATE321146T1
ATE321146T1 AT96900106T AT96900106T ATE321146T1 AT E321146 T1 ATE321146 T1 AT E321146T1 AT 96900106 T AT96900106 T AT 96900106T AT 96900106 T AT96900106 T AT 96900106T AT E321146 T1 ATE321146 T1 AT E321146T1
Authority
AT
Austria
Prior art keywords
carbohydrate
proportions
modification
methods
glycoproteins
Prior art date
Application number
AT96900106T
Other languages
English (en)
Inventor
Marleen Maras
Roland Contreras
Original Assignee
Ab Enzymes Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23444573&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE321146(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ab Enzymes Gmbh filed Critical Ab Enzymes Gmbh
Application granted granted Critical
Publication of ATE321146T1 publication Critical patent/ATE321146T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96900106T 1994-12-30 1996-01-02 Methoden zur modifikation von kohlenhydratanteilen ATE321146T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/366,800 US5834251A (en) 1994-12-30 1994-12-30 Methods of modifying carbohydrate moieties

Publications (1)

Publication Number Publication Date
ATE321146T1 true ATE321146T1 (de) 2006-04-15

Family

ID=23444573

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96900106T ATE321146T1 (de) 1994-12-30 1996-01-02 Methoden zur modifikation von kohlenhydratanteilen

Country Status (9)

Country Link
US (1) US5834251A (de)
EP (2) EP0799318B2 (de)
AT (1) ATE321146T1 (de)
AU (1) AU4348696A (de)
DE (1) DE69635948T3 (de)
DK (1) DK0799318T4 (de)
ES (1) ES2260768T5 (de)
PT (1) PT799318E (de)
WO (1) WO1996021038A1 (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US6008203A (en) * 1995-07-14 1999-12-28 Glycotech Corp. Methods for treatment of EGF receptor associated cancers
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US6083725A (en) * 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US6399336B1 (en) * 1997-01-16 2002-06-04 Neose Technologies, Inc. Practical in vitro sialylation of recombinant glycoproteins
US20040191256A1 (en) * 1997-06-24 2004-09-30 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
DE19754622A1 (de) 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
US7244601B2 (en) 1997-12-15 2007-07-17 National Research Council Of Canada Fusion proteins for use in enzymatic synthesis of oligosaccharides
AU7849200A (en) * 1999-10-01 2001-05-10 University Of Victoria Innovation And Development Corporation Mannosidases and methods for using same
WO2001079520A1 (en) 2000-04-13 2001-10-25 Biotica Technology Limited Hybrid glycosylated products and their production and use
US20060034828A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
US20060024304A1 (en) * 2000-06-28 2006-02-02 Gerngross Tillman U Immunoglobulins comprising predominantly a Man5GlcNAc2 glycoform
PT1522590E (pt) * 2000-06-28 2009-10-26 Glycofi Inc Métodos para a produção de glicoproteínas modificadas
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7625756B2 (en) 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7863020B2 (en) 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US20060034830A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GalGlcNAcMan5GLcNAc2 glycoform
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
CA2411968C (en) * 2000-06-30 2009-12-15 Flanders Interuniversity Institute For Biotechnology (Vib) Protein glycosylation modification in pichia pastoris
JPWO2002068661A1 (ja) * 2001-02-26 2004-06-24 東洋紡績株式会社 β１，２−Ｎ−アセチルグルコサミニルトランスフェラーゼＩＩ活性を有する融合タンパク質及びその製造方法
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7265084B2 (en) * 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
WO2004099231A2 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7226903B2 (en) * 2001-10-10 2007-06-05 Neose Technologies, Inc. Interferon beta: remodeling and glycoconjugation of interferon beta
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
EP2292271A3 (de) * 2001-10-10 2011-09-14 BioGeneriX AG Neumodulierung und Glykokonjugation von Antikörpern
US7125843B2 (en) * 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
US7297511B2 (en) * 2001-10-10 2007-11-20 Neose Technologies, Inc. Interferon alpha: remodeling and glycoconjugation of interferon alpha
US7179617B2 (en) 2001-10-10 2007-02-20 Neose Technologies, Inc. Factor IX: remolding and glycoconjugation of Factor IX
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7439043B2 (en) * 2001-10-10 2008-10-21 Neose Technologies, Inc. Galactosyl nucleotide sugars
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7399613B2 (en) * 2001-10-10 2008-07-15 Neose Technologies, Inc. Sialic acid nucleotide sugars
US7265085B2 (en) * 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycoconjugation methods and proteins/peptides produced by the methods
EA007030B1 (ru) * 2001-10-22 2006-06-30 Апплайд Резеч Системз Арс Холдинг Н.В. Гонадотропины для фолликулогенеза
US20030232383A1 (en) * 2001-11-02 2003-12-18 Sylvia Daunert Novel reagentless sensing system for measuring carbohydrates based on the galactose/glucose binding protein
US7473680B2 (en) * 2001-11-28 2009-01-06 Neose Technologies, Inc. Remodeling and glycoconjugation of peptides
EP2359685B1 (de) * 2001-12-27 2013-12-04 GlycoFi, Inc. Verfahren für die rekombinante veränderung von kohlenhydratstrukturen des säugetiertyps
US20060034829A1 (en) * 2001-12-27 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a MAN3GLCNAC2 glycoform
AU2003210220A1 (en) * 2002-01-23 2003-09-02 Debiopharm Sa Production of epi-hne-4 comprising reduction of improperly processed form
WO2003090695A2 (en) * 2002-04-25 2003-11-06 Transkaryotic Therapies, Inc. TREATMENT OF α-GALACTOSIDASE A DEFICIENCY
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
IL165717A0 (en) * 2002-06-26 2006-01-15 Flanders Interuniversity Inst A strain of methylotrophic yeast for producing proteins
US20060105387A1 (en) * 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
NZ542094A (en) 2003-03-14 2008-12-24 Neose Technologies Inc Branched polymer conjugates comprising a peptide and water-soluble polymer chains
WO2006127896A2 (en) * 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
EP1613261A4 (de) * 2003-04-09 2011-01-26 Novo Nordisk As Intrazelluläre bildung von peptidkonjugaten
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US7507573B2 (en) 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
MXPA06005732A (es) * 2003-11-24 2006-08-17 Neose Technologies Inc Eritropoyetina glucopegilada.
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080318850A1 (en) * 2003-12-03 2008-12-25 Neose Technologies, Inc. Glycopegylated Factor Ix
US7956032B2 (en) * 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) * 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
CN101072789B (zh) 2004-01-08 2013-05-15 生物种属学股份公司 肽的o-连接的糖基化
JP4932699B2 (ja) * 2004-03-17 2012-05-16 グライコフィ， インコーポレイテッド 真菌および酵母におけるシチジンモノホスフェート−シアル酸合成経路を操作する方法
AU2005233387B2 (en) * 2004-04-15 2011-05-26 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
AU2005243427B2 (en) * 2004-05-04 2010-07-22 Novo Nordisk Health Care Ag O-linked glycoforms of polypeptides and method to manufacture them
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
EP1799249A2 (de) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegyliertes interferon alpha
JP2008514215A (ja) * 2004-09-29 2008-05-08 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 改変タンパク質
EP1814573B1 (de) 2004-10-29 2016-03-09 ratiopharm GmbH Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
CA2593682C (en) 2005-01-10 2016-03-22 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
US20060246544A1 (en) * 2005-03-30 2006-11-02 Neose Technologies,Inc. Manufacturing process for the production of peptides grown in insect cell lines
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
EP1888098A2 (de) 2005-05-25 2008-02-20 Neose Technologies, Inc. Glykopegylierte erythropoetin-formulierungen
JP2009515508A (ja) * 2005-08-19 2009-04-16 ネオス テクノロジーズ インコーポレイテッド グリコｐｅｇ化因子ｖｉｉおよび因子ｖｉｉａ
US20070105755A1 (en) * 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
JP2009507040A (ja) * 2005-09-02 2009-02-19 グライコフィ， インコーポレイテッド 主としてｇｌｃｎａｃｍａｎ３ｇｌｃｎａｃ２糖形態を含む免疫グロブリン
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
JP2009544327A (ja) 2006-07-21 2009-12-17 ノヴォ ノルディスク アー／エス Ｏ−結合型グリコシル化配列によるペプチドのグリコシル化
EP2054521A4 (de) 2006-10-03 2012-12-19 Novo Nordisk As Verfahren zur reinigung von polypeptid-konjugate
US20080207487A1 (en) * 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
US9862956B2 (en) 2006-12-10 2018-01-09 Danisco Us Inc. Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
EP2102366A4 (de) 2006-12-10 2010-01-27 Dyadic International Inc Expression und hochdurchsatz-screening komplexer exprimierter dna-bibliotheken bei fadenpilzen
JP5184786B2 (ja) * 2007-01-19 2013-04-17 サントリーホールディングス株式会社 フラボノイド類の配糖化方法
KR20150064246A (ko) 2007-04-03 2015-06-10 바이오제너릭스 게엠베하 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법
KR101812400B1 (ko) 2007-04-03 2017-12-27 옥시레인 유케이 리미티드 분자의 글리코실화
US20090053167A1 (en) * 2007-05-14 2009-02-26 Neose Technologies, Inc. C-, S- and N-glycosylation of peptides
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
CN101965200B (zh) 2008-02-27 2013-06-19 诺沃-诺迪斯克有限公司 缀合的因子ⅷ分子
US8815242B2 (en) * 2009-05-27 2014-08-26 Synageva Biopharma Corp. Avian derived antibodies
US9598682B2 (en) 2009-09-29 2017-03-21 Vib Vzw Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose
EP2494050A4 (de) * 2009-10-30 2013-10-30 Merck Sharp & Dohme In glycoengineerter pichia pastoris hergestellter granulozytenkolonienstimulierender faktor
JP2013511272A (ja) * 2009-11-19 2013-04-04 オキシレイン ユーケー リミテッド 哺乳類様複合ｎ−グリカンを生成する酵母株
RU2604811C2 (ru) 2010-05-27 2016-12-10 Мерк Шарп Энд Домэ Корп. Способ получения антител с улучшенными свойствами
WO2012042387A2 (en) 2010-09-29 2012-04-05 Oxyrane Uk Limited De-mannosylation of phosphorylated n-glycans
JP6151183B2 (ja) 2010-09-29 2017-06-21 オキシレイン ユーケー リミテッド マンノース−１−ホスホ−６−マンノース結合からキャップを外すことおよびリン酸化ｎ−グリカンを脱マンノシル化することができるマンノシダーゼならびに哺乳動物細胞による糖タンパク質の取り込みを促進する方法
EP2714732A4 (de) 2011-05-25 2014-12-10 Merck Sharp & Dohme Verfahren zur herstellung fc-haltiger polypeptide mit verbesserten eigenschaften
WO2013087992A1 (en) * 2011-12-13 2013-06-20 Glykos Finland Oy Glycoprotein
KR20190114003A (ko) 2012-03-15 2019-10-08 옥시레인 유케이 리미티드 폼페병의 치료를 위한 방법 및 물질
SG11201508347YA (en) * 2013-03-14 2015-11-27 Glycobia Inc Oligosaccharide compositions, glycoproteins and methods to produce the same in prokaryotes
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
WO2019219220A1 (de) 2018-05-18 2019-11-21 Leibniz-Institut für Plasmaforschung und Technologie e.V. Desinfektionsverfahren mit einem durch reaktion von h2o2 und no2- in situ gebildetem desinfektionswirkstoff

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4770994A (en) * 1982-07-30 1988-09-13 Abbott Laboratories Determination of carbohydrate acceptors
US5272066A (en) * 1986-03-07 1993-12-21 Massachusetts Institute Of Technology Synthetic method for enhancing glycoprotein stability
GB8610600D0 (en) * 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5324663A (en) * 1990-02-14 1994-06-28 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
WO1991016449A1 (en) * 1990-04-16 1991-10-31 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
AU8941191A (en) * 1990-11-30 1992-06-25 Hsc Research And Development Limited Partnership Cloning of udp-n-acetylglucosamine:alpha-3-d-mannoside beta -1,2-n-acetylglucosaminyltransferase i

Also Published As

Publication number Publication date
ES2260768T5 (es) 2013-03-12
AU4348696A (en) 1996-07-24
DE69635948T2 (de) 2006-12-21
EP0799318B2 (de) 2012-11-07
EP0799318A1 (de) 1997-10-08
EP1715057A2 (de) 2006-10-25
EP1715057A3 (de) 2006-12-06
EP0799318B1 (de) 2006-03-22
DE69635948D1 (de) 2006-05-11
ES2260768T3 (es) 2006-11-01
US5834251A (en) 1998-11-10
DK0799318T4 (da) 2013-02-18
PT799318E (pt) 2006-08-31
DK0799318T3 (da) 2006-07-31
DE69635948T3 (de) 2013-03-07
WO1996021038A1 (en) 1996-07-11

Similar Documents

Publication Publication Date Title
ATE321146T1 (de) Methoden zur modifikation von kohlenhydratanteilen
DE3475748D1 (en) Method of enhancing the enteric resorption of heparin and a heparin preparation so obtained
ATE465253T1 (de) Glykoformen von faktor vii
DE69428267D1 (de) Erzeugung von Kanalsidentifizierer
DE69001968T2 (de) Verfahren zur erzeugung von wasserstoffperoxyd.
DE69132562T2 (de) Verfahren zur automatischen Erzeugung von partiellen, differentialen Gleichungen zur Simulation
ES8802408A1 (es) Un panel para acristalamiento de edificios y vehiculos, soportes publicitarios, instalaciones deportivas y aplicaciones similares.
DE3853453D1 (de) Verfahren zur Erzeugung von Aufbauanweisungen für dreidimensionale Montagen.
ATE82781T1 (de) Verfahren zur zellstoffbehandlung.
DE3788797T2 (de) System zur Auslöschung von Interferenzen.
DE3789487D1 (de) Vorrichtung zur Erzeugung von Elektronenstrahlen.
BR8403005A (pt) Composicao alvejante detergente encorpada
DE69016879T2 (de) Verfahren zur Reinigung von N-Phosphonmethylglyzin.
DK142782A (da) Fremgangsmaade til fremstilling af 2-oxo-1-(substitueret phosphor)-azetidiner
DE59404861D1 (de) Gewebe zur Verstärkung bzw. Armierung von Flächengebilden
ATE120199T1 (de) Verfahren zur herstellung von n- phosphonomethylglycin.
DE69532334D1 (de) Verfahren zur Stabilisierung von einer wässerigen Alkalische-Phosphatase Lösung
DE3768599D1 (de) Verfahren zur erzeugung von phosphatueberzuegen.
DE68910881T2 (de) Verfahren zur Erzeugung von extraleichtem Natriumkarbonat.
DE69030301T2 (de) System zur Erzeugung von Referenzmustern
DE59404066D1 (de) Gewebe zur Verstärkung bzw. Armierung von Flächengebilden
DE3585843D1 (de) Verfahren zur herstellung von maskenmustern.
ATE102668T1 (de) Phosphatzusammensetzung und ihre benuetzung.
DE69030478T2 (de) Anordnung zur Erzeugung von Mosaikeffekten
DE68919459T2 (de) Schaltung zur Unterdrückung von Störsignalen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0799318

Country of ref document: EP