|
EP0710288B1
(de)
|
1993-06-10 |
2006-04-05 |
Genetic Therapy, Inc. |
Adenovirale vektoren für die behandlung der hämophilie
|
|
US7252989B1
(en)
*
|
1994-04-04 |
2007-08-07 |
Board Of Regents, The University Of Texas System |
Adenovirus supervector system
|
|
CA2192442C
(en)
*
|
1994-06-10 |
2007-09-25 |
Imre Kovesdi |
Complementary adenoviral vector systems and cell lines
|
|
US5851806A
(en)
*
|
1994-06-10 |
1998-12-22 |
Genvec, Inc. |
Complementary adenoviral systems and cell lines
|
|
DK0787200T3
(da)
|
1994-10-28 |
2005-08-15 |
Univ Pennsylvania |
Forbedret adenovirus og fremgangsmåder til anvendelse heraf
|
|
CA2206683A1
(en)
*
|
1994-12-12 |
1996-06-20 |
Genetic Therapy, Inc. |
Improved adenoviral vectors and producer cells
|
|
IL116816A
(en)
*
|
1995-01-20 |
2003-05-29 |
Rhone Poulenc Rorer Sa |
Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof
|
|
DE69636068T2
(de)
*
|
1995-02-21 |
2006-11-30 |
Cantab Pharmaceuticals Research Ltd. |
Virale zubereitungen, vektoren, immunogene und impfstoffe
|
|
US6251957B1
(en)
|
1995-02-24 |
2001-06-26 |
Trustees Of The University Of Pennsylvania |
Method of reducing an immune response to a recombinant virus
|
|
US5872154A
(en)
*
|
1995-02-24 |
1999-02-16 |
The Trustees Of The University Of Pennsylvania |
Method of reducing an immune response to a recombinant adenovirus
|
|
US6281010B1
(en)
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
US5756283A
(en)
*
|
1995-06-05 |
1998-05-26 |
The Trustees Of The University Of Pennsylvania |
Method for improved production of recombinant adeno-associated viruses for gene therapy
|
|
US6040183A
(en)
*
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
|
US6093570A
(en)
*
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
JP4002605B2
(ja)
*
|
1995-06-07 |
2007-11-07 |
ユニバーシティ オブ ノース カロライナ アット チャペル ヒル |
筋組織のaav形質導入
|
|
KR100470180B1
(ko)
|
1995-06-15 |
2005-02-04 |
크루셀 홀란드 비.브이. |
유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템
|
|
US6783980B2
(en)
|
1995-06-15 |
2004-08-31 |
Crucell Holland B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
|
US6265212B1
(en)
*
|
1995-06-15 |
2001-07-24 |
Introgene B.V. |
Packaging systems for human recombinant adenovirus to be used in gene therapy
|
|
FR2737222B1
(fr)
*
|
1995-07-24 |
1997-10-17 |
Transgene Sa |
Nouveaux vecteurs viraux et lignee pour la therapie genique
|
|
EP1983057A3
(de)
*
|
1995-09-08 |
2009-01-07 |
Genzyme Corporation |
Verbesserte AAV-Vektoren für die Gentherapie
|
|
US6004797A
(en)
*
|
1995-11-09 |
1999-12-21 |
Avigen, Inc. |
Adenovirus helper-free recombinant AAV Virion production
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
US5846528A
(en)
|
1996-01-18 |
1998-12-08 |
Avigen, Inc. |
Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence
|
|
US5858351A
(en)
*
|
1996-01-18 |
1999-01-12 |
Avigen, Inc. |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
|
|
DE19620687A1
(de)
*
|
1996-05-22 |
1997-11-27 |
Centeon Pharma Gmbh |
Neuer adenoviraler Vektor für den Transfer humaner Gene in vivo
|
|
ES2208942T3
(es)
*
|
1996-07-05 |
2004-06-16 |
Philip E. Branton |
Proteinas e4 de adenovirus para inducir la muerte celular.
|
|
US6730662B1
(en)
|
1996-07-05 |
2004-05-04 |
Mcgill University |
Adenovirus E4 proteins for inducing cell death
|
|
EP2243827B2
(de)
*
|
1996-08-30 |
2017-11-22 |
Life Technologies Corporation |
Serumfreies kulturmedium für säugerzellen und seine verwendung
|
|
JP2001500015A
(ja)
*
|
1996-09-06 |
2001-01-09 |
トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
T7ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法
|
|
EP0937150A2
(de)
*
|
1996-09-25 |
1999-08-25 |
Novartis AG |
Verpackungszellinien in der verwendung zur erleichterung der entwicklung hocheffizienter adenoviraler vektoren
|
|
US7232899B2
(en)
|
1996-09-25 |
2007-06-19 |
The Scripps Research Institute |
Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
|
|
DE19644500C2
(de)
*
|
1996-10-25 |
1998-11-05 |
Deutsches Krebsforsch |
AAV-DNA mit Helfervirus-Sequenzen
|
|
WO1998032860A1
(en)
*
|
1997-01-28 |
1998-07-30 |
Baxter International Inc. |
Methods for highly efficient generation of adenoviral vectors
|
|
US6403370B1
(en)
|
1997-02-10 |
2002-06-11 |
Genstar Therapeutics Corporation |
Oncolytic/immunogenic complementary-adenoviral vector system
|
|
US6100086A
(en)
*
|
1997-04-14 |
2000-08-08 |
Genzyme Corporation |
Transgene expression systems
|
|
US20030125278A1
(en)
*
|
1997-08-13 |
2003-07-03 |
Tang De-Chu C. |
Immunization of animals by topical applications of a salmonella-based vector
|
|
US20030045492A1
(en)
*
|
1997-08-13 |
2003-03-06 |
Tang De-Chu C. |
Vaccination by topical application of recombinant vectors
|
|
US6706693B1
(en)
|
1997-08-13 |
2004-03-16 |
The Uab Research Foundation |
Vaccination by topical application of genetic vectors
|
|
US6716823B1
(en)
|
1997-08-13 |
2004-04-06 |
The Uab Research Foundation |
Noninvasive genetic immunization, expression products therefrom, and uses thereof
|
|
US6348450B1
(en)
*
|
1997-08-13 |
2002-02-19 |
The Uab Research Foundation |
Noninvasive genetic immunization, expression products therefrom and uses thereof
|
|
US6066626A
(en)
*
|
1997-10-29 |
2000-05-23 |
Genzyme Corporation |
Compositions and method for treating lysosomal storage disease
|
|
US20080050367A1
(en)
|
1998-04-07 |
2008-02-28 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
US7790856B2
(en)
|
1998-04-07 |
2010-09-07 |
Janssen Alzheimer Immunotherapy |
Humanized antibodies that recognize beta amyloid peptide
|
|
US7964192B1
(en)
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
|
JP2001526900A
(ja)
|
1997-12-23 |
2001-12-25 |
イントロヘーネ ベスローテン フェンノートシャップ |
標的細胞の染色体dnaへの外来遺伝子情報の組み込みに有用な、アデノ随伴ウイルスおよびアデノウイルスのキメラ組換えウイルス
|
|
CA2324225A1
(en)
*
|
1998-03-20 |
1999-09-23 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6953690B1
(en)
|
1998-03-20 |
2005-10-11 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
WO1999057296A1
(en)
*
|
1998-05-01 |
1999-11-11 |
Genzyme Corporation |
Partially deleted adenoviral vectors
|
|
US6113913A
(en)
*
|
1998-06-26 |
2000-09-05 |
Genvec, Inc. |
Recombinant adenovirus
|
|
US6221349B1
(en)
|
1998-10-20 |
2001-04-24 |
Avigen, Inc. |
Adeno-associated vectors for expression of factor VIII by target cells
|
|
US6200560B1
(en)
*
|
1998-10-20 |
2001-03-13 |
Avigen, Inc. |
Adeno-associated virus vectors for expression of factor VIII by target cells
|
|
US6759237B1
(en)
*
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
ATE454445T1
(de)
*
|
1998-11-10 |
2010-01-15 |
Univ North Carolina |
Virusvektoren und verfahren für ihre herstellung und verabreichung.
|
|
JP4693244B2
(ja)
|
1999-03-18 |
2011-06-01 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスのヘルパー無しの生産のための組成物および方法
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6864235B1
(en)
|
1999-04-01 |
2005-03-08 |
Eva A. Turley |
Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
|
|
US6911429B2
(en)
*
|
1999-04-01 |
2005-06-28 |
Transition Therapeutics Inc. |
Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
|
|
US20040009936A1
(en)
*
|
1999-05-03 |
2004-01-15 |
Tang De-Chu C. |
Vaccine and drug delivery by topical application of vectors and vector extracts
|
|
US6495360B1
(en)
*
|
1999-05-28 |
2002-12-17 |
Photogen, Inc. |
Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
|
|
WO2001034825A1
(en)
*
|
1999-11-10 |
2001-05-17 |
Genzyme Corporation |
Ptp/dna polymerase cell line as packaging cell line for minimal adenoviral vectors
|
|
AU2001257611A1
(en)
|
2000-04-28 |
2001-11-12 |
Avigen, Inc. |
Polynucleotides for use in recombinant adeno-associated virus virion production
|
|
EP1950297A2
(de)
|
2000-05-31 |
2008-07-30 |
Novartis Vaccines and Diagnostics, Inc. |
Zusammensetzungen und Verfahren zur Behandlung neoplastischer Erkrankungen mithilfe von Chemotherapie und Strahlungssensibilisatoren
|
|
AU2001294562B2
(en)
*
|
2000-09-15 |
2007-05-24 |
Merck & Co., Inc. |
Enhanced First Generation Adenovirus Vaccines Expressing Codon Optimized HIV1-Gag, Pol, Nef and Modifications
|
|
US6916635B2
(en)
*
|
2000-10-02 |
2005-07-12 |
The Research Foundation Of State University Of New York |
Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
|
|
AU2002329176A1
(en)
*
|
2001-05-25 |
2002-12-23 |
The Trustees Of The University Of Pennsylvania |
Targeted particles and methods of using the same
|
|
US6682929B2
(en)
|
2001-07-23 |
2004-01-27 |
Genvec, Inc. |
Adenovector complementing cells
|
|
KR100432953B1
(ko)
*
|
2001-09-01 |
2004-05-28 |
김주항 |
개선된 종양 살상 효과를 나타내는 재조합 아데노바이러스
|
|
WO2003022311A1
(en)
*
|
2001-09-13 |
2003-03-20 |
Genvec, Inc. |
Adenoviral vector and related system and methods of making and use
|
|
US20030158112A1
(en)
|
2002-02-15 |
2003-08-21 |
Johns Hopkins University School Of Medicine |
Selective induction of apoptosis to treat ocular disease
|
|
MY139983A
(en)
|
2002-03-12 |
2009-11-30 |
Janssen Alzheimer Immunotherap |
Humanized antibodies that recognize beta amyloid peptide
|
|
US20030198620A1
(en)
*
|
2002-04-16 |
2003-10-23 |
Keiya Ozawa |
Method of treating amino acid metabolic disorders using recombinant adeno-associated virus virions
|
|
AU2003223775A1
(en)
|
2002-04-30 |
2003-11-17 |
Duke University |
Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use
|
|
US7090836B2
(en)
*
|
2002-06-21 |
2006-08-15 |
Institut Pasteur |
Vector for expressing α-L-iduronidase and method of treating MPS I by stereotactic injection into the brain of a mammal
|
|
US7977049B2
(en)
|
2002-08-09 |
2011-07-12 |
President And Fellows Of Harvard College |
Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
|
|
CA2421269A1
(en)
|
2002-08-09 |
2004-02-09 |
President And Fellows Of Harvard College |
Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
|
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
|
US7186699B2
(en)
*
|
2003-06-03 |
2007-03-06 |
Cell Genesys, Inc. |
Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
|
|
US7485291B2
(en)
*
|
2003-06-03 |
2009-02-03 |
Cell Genesys, Inc. |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
|
|
CA2526120A1
(en)
*
|
2003-06-03 |
2005-02-24 |
Cell Genesys, Inc. |
Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
|
|
WO2005056762A2
(en)
*
|
2003-12-05 |
2005-06-23 |
University Of Iowa Research Foundation |
Truncated cmv promoters and vectors containing same
|
|
US20060057127A1
(en)
*
|
2004-09-10 |
2006-03-16 |
Pocheng Liu |
Cytokine-expressing cellular vaccines for treatment of prostate cancer
|
|
AU2005316476A1
(en)
*
|
2004-12-15 |
2006-06-22 |
University Of Florida Research Foundation, Inc. |
Chimeric vectors
|
|
PE20061329A1
(es)
|
2004-12-15 |
2006-12-08 |
Neuralab Ltd |
Anticuerpos ab humanizados para mejorar la cognicion
|
|
US7524510B2
(en)
*
|
2005-02-23 |
2009-04-28 |
The Uab Research Foundation |
Alkyl-glycoside enhanced vaccination
|
|
US20060234347A1
(en)
*
|
2005-04-13 |
2006-10-19 |
Harding Thomas C |
Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors
|
|
EP2468881A3
(de)
|
2005-07-21 |
2012-08-15 |
Abbott Laboratories |
Mehrfache Genexpression mit sORF-Konstrukten und Verfahren mit Polyproteinen, Pro-Proteinen und Proteolyse
|
|
US20070231298A1
(en)
*
|
2006-03-31 |
2007-10-04 |
Cell Genesys, Inc. |
Cytokine-expressing cancer immunotherapy combinations
|
|
US8784810B2
(en)
|
2006-04-18 |
2014-07-22 |
Janssen Alzheimer Immunotherapy |
Treatment of amyloidogenic diseases
|
|
US8003097B2
(en)
|
2007-04-18 |
2011-08-23 |
Janssen Alzheimer Immunotherapy |
Treatment of cerebral amyloid angiopathy
|
|
SI2182983T1
(sl)
|
2007-07-27 |
2014-09-30 |
Janssen Alzheimer Immunotherapy |
Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta
|
|
US8425897B2
(en)
*
|
2007-08-30 |
2013-04-23 |
Immutep S.A. |
Compositions containing LAG-3 and cells that secrete GM-CSF and methods of use
|
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
|
EP2315833B8
(de)
|
2008-05-20 |
2015-05-27 |
Eos Neuroscience, Inc. |
Vektoren zur freisetzung lichtempfindlicher proteine und anwendungsverfahren dafür
|
|
US8840881B2
(en)
|
2008-08-28 |
2014-09-23 |
Aduro Gvax Inc. |
Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer
|
|
US9067981B1
(en)
|
2008-10-30 |
2015-06-30 |
Janssen Sciences Ireland Uc |
Hybrid amyloid-beta antibodies
|
|
US8889641B2
(en)
|
2009-02-11 |
2014-11-18 |
The University Of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
WO2011053699A1
(en)
|
2009-10-30 |
2011-05-05 |
Abbott Laboratories |
Sorf constructs and multiple gene expression
|
|
AU2010328335B2
(en)
*
|
2009-12-08 |
2013-09-26 |
Memorial Sloan-Kettering Cancer Center |
Method and composition to increase radiation-induced tumor therapeutic effects
|
|
RU2737765C2
(ru)
|
2012-05-04 |
2020-12-02 |
Пфайзер Инк. |
Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
|
|
ES2752190T3
(es)
|
2012-09-14 |
2020-04-03 |
Us Health |
Proteína Brachyury, vectores adenovirales que codifican proteína Brachyury y su uso
|
|
DE102013004595A1
(de)
|
2013-03-15 |
2014-09-18 |
Emergent Product Development Germany Gmbh |
RSV-Impfstoffe
|
|
GB201322626D0
(en)
|
2013-12-19 |
2014-02-05 |
Immutep S A |
Combined preparations for the treatment of cancer
|
|
EP3117002B1
(de)
|
2014-03-11 |
2025-12-03 |
Wayne State University |
Modifiziertermglur6-promoter und verfahren zur verwendung
|
|
GB201500374D0
(en)
|
2015-01-09 |
2015-02-25 |
Immutep S A |
Combined preparations for the treatment of cancer
|
|
EP4137150A1
(de)
|
2015-08-03 |
2023-02-22 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Brachyury-deletionsmutanten, nichthefevektoren zur codierung von brachyury-deletionsmutanten und verwendung davon
|
|
ES2907486T3
(es)
|
2015-09-24 |
2022-04-25 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para reducir metástasis
|
|
WO2023150553A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Gpr17 promoter-based targeting and transduction of glial progenitor cells
|
|
LT3436593T
(lt)
|
2016-03-28 |
2023-03-10 |
Ultragenyx Pharmaceutical Inc. |
Adenoviruso šiluminio inaktyvavimo būdai
|
|
ES3012649T3
(en)
*
|
2016-10-14 |
2025-04-09 |
Ultragenyx Pharmaceutical Inc |
Use of tonicifying agents to enhance recombinant adeno-associated virus yield
|
|
WO2018175775A1
(en)
|
2017-03-22 |
2018-09-27 |
Dimension Therapeutics |
Cell culture methods involving hdac inhibitors or rep proteins
|
|
JP7218303B2
(ja)
|
2017-05-09 |
2023-02-06 |
ウルトラジェニックス ファーマシューティカル インコーポレイテッド |
トランスフェクション試薬を生成するための拡大可能な方法
|
|
WO2021028837A1
(en)
|
2019-08-13 |
2021-02-18 |
Waters Technologies Corporation |
Affinity resins and sample preparation devices based on cartilaginous fish ignar derived binding domains
|
|
TWI819268B
(zh)
*
|
2020-01-16 |
2023-10-21 |
詹姆斯 W 希爾 |
藉由基因轉導改變眼睛顏色
|
|
GB202013940D0
(en)
|
2020-09-04 |
2020-10-21 |
Synpromics Ltd |
Regulatory nucleic acid sequences
|
|
WO2022076556A2
(en)
|
2020-10-07 |
2022-04-14 |
Asklepios Biopharmaceutical, Inc. |
Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy disorders including limb girdle 2i (lgmd2i)
|
|
US12305188B2
(en)
|
2021-05-27 |
2025-05-20 |
Neuracle Genetics Inc. |
Dual helper plasmid
|
|
AU2022282057B2
(en)
*
|
2021-05-27 |
2025-01-23 |
Elisigen Inc. |
Novel dual helper plasmid
|
|
WO2023069881A1
(en)
|
2021-10-20 |
2023-04-27 |
University Of Rochester |
Treatment with genetically modified cells, and genetically modified cells per se, with increased competitive advantage and/or decreased competitive disadvantage
|
|
US20230190961A1
(en)
|
2021-10-20 |
2023-06-22 |
University Of Rochester |
Compositions and methods for treating myelin deficiency by rejuvenating glial progenitor cells
|
|
EP4472648A1
(de)
|
2022-02-01 |
2024-12-11 |
University of Rochester |
Verfahren zur erzeugung einer population von neuronen aus menschlichen glialvorläuferzellen und genetische konstrukte zur durchführung solcher verfahren
|
|
TW202506733A
(zh)
|
2023-06-12 |
2025-02-16 |
美商安進公司 |
淋巴毒素β受體促效劑結合蛋白
|
|
WO2026035486A2
(en)
|
2024-08-05 |
2026-02-12 |
University Of Rochester |
G protein-coupled receptor (gpcr) agonists and use thereof
|