ATE292180T1 - Fibrinolytisch wirksames polypeptid - Google Patents

Fibrinolytisch wirksames polypeptid

Info

Publication number
ATE292180T1
ATE292180T1 AT00965554T AT00965554T ATE292180T1 AT E292180 T1 ATE292180 T1 AT E292180T1 AT 00965554 T AT00965554 T AT 00965554T AT 00965554 T AT00965554 T AT 00965554T AT E292180 T1 ATE292180 T1 AT E292180T1
Authority
AT
Austria
Prior art keywords
polypeptide
fibrinolytic
vivo
useful
called
Prior art date
Application number
AT00965554T
Other languages
German (de)
English (en)
Inventor
Thomas Charles Boone
Huimin Li
Michael Benjamin Mann
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE292180T1 publication Critical patent/ATE292180T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT00965554T 1999-10-01 2000-09-29 Fibrinolytisch wirksames polypeptid ATE292180T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/411,329 US6261820B1 (en) 1999-10-01 1999-10-01 Fibronolytically active polypeptide
PCT/US2000/027029 WO2001025445A1 (en) 1999-10-01 2000-09-29 Fibrinolytically active polypeptide

Publications (1)

Publication Number Publication Date
ATE292180T1 true ATE292180T1 (de) 2005-04-15

Family

ID=23628486

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00965554T ATE292180T1 (de) 1999-10-01 2000-09-29 Fibrinolytisch wirksames polypeptid

Country Status (29)

Country Link
US (4) US6261820B1 (ru)
EP (2) EP1224298B1 (ru)
JP (1) JP2003511034A (ru)
KR (2) KR100700753B1 (ru)
CN (2) CN101230340A (ru)
AT (1) ATE292180T1 (ru)
AU (1) AU767827B2 (ru)
BG (1) BG106577A (ru)
BR (1) BR0014414A (ru)
CA (1) CA2386185A1 (ru)
CZ (1) CZ298502B6 (ru)
DE (1) DE60019147T2 (ru)
DK (1) DK1224298T3 (ru)
EA (2) EA005944B1 (ru)
ES (1) ES2240167T3 (ru)
HK (1) HK1049351B (ru)
HU (1) HUP0202650A3 (ru)
IL (1) IL148787A0 (ru)
MX (1) MXPA02003126A (ru)
NO (1) NO20021501L (ru)
NZ (1) NZ517951A (ru)
PL (1) PL355017A1 (ru)
PT (1) PT1224298E (ru)
RS (1) RS20060033A (ru)
SG (1) SG127720A1 (ru)
SK (1) SK4232002A3 (ru)
WO (1) WO2001025445A1 (ru)
YU (2) YU59604A (ru)
ZA (1) ZA200202206B (ru)

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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6523647B2 (en) * 2001-05-21 2003-02-25 Hydro Mobile Inc. Elevating platform assembly
JP4373792B2 (ja) * 2002-02-11 2009-11-25 ゴールド−ティー テック インコーポレイテッド 血栓形成を予防する方法
US7016409B2 (en) * 2003-11-12 2006-03-21 Sony Corporation Apparatus and method for use in providing dynamic bit rate encoding
ES2239532B1 (es) * 2004-02-06 2006-11-01 Proyecto De Biomedicina Cima S.L. Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr.
US20070141625A1 (en) * 2005-02-03 2007-06-21 Santos Jose H Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies
WO2007092820A2 (en) 2006-02-03 2007-08-16 Lazarus Effect, Inc. Methods and devices for restoring blood flow within blocked vasculature
EP2403583B1 (en) 2009-03-06 2016-10-19 Lazarus Effect, Inc. Retrieval systems
WO2011056872A2 (en) 2009-11-03 2011-05-12 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP3191605B1 (en) 2014-09-09 2022-07-27 The Broad Institute, Inc. A droplet-based method and apparatus for composite single-cell nucleic acid analysis
CN107405470A (zh) 2015-02-11 2017-11-28 柯惠有限合伙公司 带可扩张尖端的医疗装置和方法
US11873483B2 (en) 2015-03-11 2024-01-16 The Broad Institute, Inc. Proteomic analysis with nucleic acid identifiers
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
WO2017075265A1 (en) 2015-10-28 2017-05-04 The Broad Institute, Inc. Multiplex analysis of single cell constituents
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers

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DE3330699A1 (de) * 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
US4610879A (en) 1984-01-06 1986-09-09 University Of Southern California Fibrinolytic enzyme from snake vernom
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ZA889415B (en) 1987-12-18 1989-09-27 Chiron Corp Compositions and method for recombinant production of crotalidus venum fibrolase
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ES2180528T3 (es) * 1990-01-16 2003-02-16 Ct Ingenieria Genetica Biotech Metodo de expresion de genes heterologos en la levadura pichia pastoris, vectores de expresion y microorganismos transformados.
US5709676A (en) 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
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US5626564A (en) 1995-03-31 1997-05-06 Creighton University Adjustable sideholes catheter
US6020181A (en) 1995-05-17 2000-02-01 New York Blood, Inc. Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase
US5830468A (en) 1995-05-17 1998-11-03 The New York Blood Center, Inc. Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
US5741779A (en) 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
NZ505584A (en) 1996-05-24 2002-04-26 Univ British Columbia Delivery of a therapeutic agent to the smooth muscle cells of a body passageway via an adventia
US5951981A (en) 1996-12-02 1999-09-14 Diatide, Inc. Thrombolytic agents with antithrombotic activity
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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
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Also Published As

Publication number Publication date
EA005944B1 (ru) 2005-08-25
DE60019147D1 (en) 2005-05-04
HK1049351A1 (en) 2003-05-09
CZ298502B6 (cs) 2007-10-24
RS20060033A (sr) 2006-12-15
EP1224298B1 (en) 2005-03-30
AU767827B2 (en) 2003-11-27
CN101230340A (zh) 2008-07-30
MXPA02003126A (es) 2002-09-30
KR20060114034A (ko) 2006-11-03
NO20021501D0 (no) 2002-03-26
KR100700753B1 (ko) 2007-03-28
DE60019147T2 (de) 2006-05-11
CN1402788A (zh) 2003-03-12
HK1049351B (zh) 2005-07-29
PT1224298E (pt) 2005-06-30
EA200200410A1 (ru) 2002-10-31
AU7625400A (en) 2001-05-10
DK1224298T3 (da) 2005-05-30
US6261820B1 (en) 2001-07-17
BR0014414A (pt) 2002-06-11
YU22502A (sh) 2005-07-19
CA2386185A1 (en) 2001-04-12
NO20021501L (no) 2002-05-31
HUP0202650A2 (hu) 2002-12-28
YU59604A (sh) 2005-11-28
SG127720A1 (en) 2006-12-29
ZA200202206B (en) 2002-12-24
EA200400290A1 (ru) 2005-02-24
IL148787A0 (en) 2002-09-12
JP2003511034A (ja) 2003-03-25
KR100711312B1 (ko) 2007-04-27
HUP0202650A3 (en) 2005-01-28
US7195903B2 (en) 2007-03-27
US20030186422A1 (en) 2003-10-02
NZ517951A (en) 2004-02-27
US6617145B2 (en) 2003-09-09
US20080058256A1 (en) 2008-03-06
EP1224298A1 (en) 2002-07-24
KR20020047208A (ko) 2002-06-21
EP1605049A3 (en) 2006-12-13
ES2240167T3 (es) 2005-10-16
BG106577A (bg) 2003-04-30
CZ20021034A3 (cs) 2003-06-18
EP1605049A2 (en) 2005-12-14
EA006487B1 (ru) 2005-12-29
CN100357430C (zh) 2007-12-26
SK4232002A3 (en) 2003-09-11
US20020058322A1 (en) 2002-05-16
PL355017A1 (en) 2004-03-22
WO2001025445A1 (en) 2001-04-12

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