ATE287291T1 - Prozessoptimierungsreaktor mit parallelem durchfluss - Google Patents

Prozessoptimierungsreaktor mit parallelem durchfluss

Info

Publication number
ATE287291T1
ATE287291T1 AT01914751T AT01914751T ATE287291T1 AT E287291 T1 ATE287291 T1 AT E287291T1 AT 01914751 T AT01914751 T AT 01914751T AT 01914751 T AT01914751 T AT 01914751T AT E287291 T1 ATE287291 T1 AT E287291T1
Authority
AT
Austria
Prior art keywords
feed
parallel flow
process optimization
flow
systems
Prior art date
Application number
AT01914751T
Other languages
English (en)
Inventor
H Sam Bergh
James R Engstrom
Shenheng Guan
Daniel Meron Pinkas
Kyle W Self
Original Assignee
Symyx Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26883153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE287291(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Symyx Technologies Inc filed Critical Symyx Technologies Inc
Application granted granted Critical
Publication of ATE287291T1 publication Critical patent/ATE287291T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00038—Processes in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00319—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks the blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00745—Inorganic compounds
    • B01J2219/00747—Catalysts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/08—Methods of screening libraries by measuring catalytic activity
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/18—Libraries containing only inorganic compounds or inorganic materials
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625—Dilution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer
AT01914751T 2000-03-07 2001-03-07 Prozessoptimierungsreaktor mit parallelem durchfluss ATE287291T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18756600P 2000-03-07 2000-03-07
US22998400P 2000-09-02 2000-09-02
PCT/US2001/007372 WO2001066245A2 (en) 2000-03-07 2001-03-07 Parallel flow process optimization reactor

Publications (1)

Publication Number Publication Date
ATE287291T1 true ATE287291T1 (de) 2005-02-15

Family

ID=26883153

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914751T ATE287291T1 (de) 2000-03-07 2001-03-07 Prozessoptimierungsreaktor mit parallelem durchfluss

Country Status (6)

Country Link
US (1) US7122156B2 (de)
EP (1) EP1265700B1 (de)
AT (1) ATE287291T1 (de)
AU (1) AU2001240104A1 (de)
DE (1) DE60108482T2 (de)
WO (1) WO2001066245A2 (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7150994B2 (en) * 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US6975924B2 (en) * 1999-12-03 2005-12-13 Baxter International Inc. Method and apparatus for controlling the strategy of compounding pharmaceutical admixtures
US7435392B2 (en) * 2000-02-03 2008-10-14 Acclavis, Llc Scalable continuous production system
ATE287291T1 (de) 2000-03-07 2005-02-15 Symyx Technologies Inc Prozessoptimierungsreaktor mit parallelem durchfluss
EP1299182A2 (de) * 2000-07-07 2003-04-09 Symyx Technologies, Inc. Untersuchungsverfahren für heterogenkatalysatoren in einem multivariabelen screening-reaktor
US7413714B1 (en) 2000-07-16 2008-08-19 Ymc Co. Ltd. Sequential reaction system
DE10036602A1 (de) 2000-07-27 2002-02-14 Cpc Cellular Process Chemistry Mikroreaktor für Reaktionen zwischen Gasen und Flüssigkeiten
US6436720B1 (en) * 2000-09-15 2002-08-20 Cellular Process Chemistry, Inc. Residence time providing module/apparatus
US7118917B2 (en) 2001-03-07 2006-10-10 Symyx Technologies, Inc. Parallel flow reactor having improved thermal control
DE10115474A1 (de) * 2001-03-29 2002-10-10 Infineon Technologies Ag Mikrofluidkanalstruktur und Verfahren zur Herstellung einer derartigen Mikrofluidkanalstruktur
WO2003008981A1 (fr) * 2001-07-10 2003-01-30 Kanagawa Academy Of Science And Technology Structure integree a microcanaux d'ecoulement multicouche et procede de fonctionnement d'un ecoulement multicouche a l'aide de cette derniere
US20030012700A1 (en) * 2001-07-11 2003-01-16 Carnahan James Claude Systems and methods for parallel testing of catalyst performance
GB2380528B (en) * 2001-10-05 2003-09-10 Minebea Co Ltd A bearing assembly and method of manufacturing a bearing assembly
US6901334B2 (en) 2001-12-17 2005-05-31 Rohm And Haas Company Methods and systems for high throughput analysis
ES2209588B1 (es) * 2002-01-14 2005-04-01 Universidad Politecnica De Valencia Sistema de control de flujos para pruebas multiples de materiales solidos y dispositivo para ensayos cataliticos multiples que comprende el sistema.
JP3740528B2 (ja) * 2002-02-05 2006-02-01 独立行政法人産業技術総合研究所 微細粒子製造方法
GB0217993D0 (en) * 2002-08-02 2002-09-11 Imp College Innovations Ltd Powder mixing microchip system and method
JP2004069498A (ja) * 2002-08-06 2004-03-04 Canon Inc 液体搬送装置及び液体搬送方法
US7250151B2 (en) * 2002-08-15 2007-07-31 Velocys Methods of conducting simultaneous endothermic and exothermic reactions
AU2002324369A1 (en) * 2002-09-20 2004-04-08 Avantium International B.V. Method and apparatus for performing chemical experiments
US7139595B2 (en) * 2002-10-24 2006-11-21 The Rail Network, Inc. Transit vehicle wireless transmission broadcast system
EP1419818B1 (de) * 2002-11-14 2013-10-30 Boehringer Ingelheim microParts GmbH Vorrichtung zum schrittweisen Transport von Flüssigkeit unter Ausnutzung von Kapillarkräften
AU2003297427A1 (en) 2002-12-20 2004-07-22 Honda Giken Kogyo Kabushiki Kaisha Methods for the preparation of catalysts for hydrogen generation
US7267987B2 (en) * 2003-01-06 2007-09-11 Uop Llc Process and assembly for simultaneously evaluating a plurality of catalysts
TW571101B (en) * 2003-01-21 2004-01-11 Ind Tech Res Inst Fluid analysis apparatus
US7311882B1 (en) * 2003-01-24 2007-12-25 Sandia National Laboratories Capillary interconnect device
WO2004092908A2 (en) 2003-04-14 2004-10-28 Cellular Process Chemistry, Inc. System and method for determining optimal reaction parameters using continuously running process
US20070077179A1 (en) * 2003-05-09 2007-04-05 Dirk Schmalz Component used in microprocess control
US7134459B2 (en) * 2003-06-12 2006-11-14 Symyx Technologies, Inc. Methods and apparatus for mixing powdered samples
JP4578867B2 (ja) * 2003-09-30 2010-11-10 株式会社日立製作所 水素貯蔵・供給装置とそのシステム及びそれを用いた分散電源並びに自動車
DE10361003B3 (de) 2003-12-23 2005-07-28 Hte Ag The High Throughput Experimentation Company Vorrichtung und Verfahren zur Druck- und Flusskontrolle in Parallelreaktoren
SE527130C2 (sv) * 2004-01-13 2005-12-27 Delaval Holding Ab Anordning och förfarande för utfodring av djur
US7507380B2 (en) * 2004-03-19 2009-03-24 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microchemical nanofactories
ES2378233T3 (es) * 2004-09-21 2012-04-10 G & I Irtech S.L. Proceso y máquina para la aglomeración y/o secado de materiales en polvo usando radiación infrarroja
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
GB0422378D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd A method
US20060171852A1 (en) * 2005-02-02 2006-08-03 Sandia National Laboratories Microfluidics prototyping platform and components
US8518346B1 (en) * 2005-02-02 2013-08-27 Sandia Corporation Multidimensional bioseparation with modular microfluidics
EP1888224B1 (de) * 2005-04-04 2015-12-09 Avantium International B.V. System und verfahren zur durchführung eines chemischen experiments
DE602006015012D1 (de) * 2005-04-18 2010-08-05 Asahi Kasei Bioprocess Inc Automatisierte Syntheseeinrichtung und Verfahren
GB0509742D0 (en) * 2005-05-13 2005-06-22 Ashe Morris Ltd Variable heat flux heat exchangers
US7846489B2 (en) 2005-07-22 2010-12-07 State of Oregon acting by and though the State Board of Higher Education on behalf of Oregon State University Method and apparatus for chemical deposition
SE529516C2 (sv) * 2005-10-24 2007-09-04 Alfa Laval Corp Ab Universell flödesmodul
DE102006001327A1 (de) * 2005-11-14 2007-05-16 Saltigo Gmbh Vorrichtung zur Dosierung von Reaktivgasen
US8679587B2 (en) * 2005-11-29 2014-03-25 State of Oregon acting by and through the State Board of Higher Education action on Behalf of Oregon State University Solution deposition of inorganic materials and electronic devices made comprising the inorganic materials
US7278308B2 (en) * 2005-12-08 2007-10-09 Honeywell International Inc. Thermal isolation between heating and sensing for flow sensors
US20080092969A1 (en) * 2006-08-07 2008-04-24 Diperna Paul Mario Variable flow reshapable flow restrictor apparatus and related methods
US20070246106A1 (en) 2006-04-25 2007-10-25 Velocys Inc. Flow Distribution Channels To Control Flow in Process Channels
US20080029173A1 (en) * 2006-08-07 2008-02-07 Diperna Paul Mario Variable flow reshapable flow restrictor apparatus and related methods
US20080108122A1 (en) * 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
FR2907228B1 (fr) * 2006-10-13 2009-07-24 Rhodia Recherches & Tech Dispositif d'ecoulement fluidique,ensemble de determination d'au moins une caracteristique d'un systeme physico-chimique comprenant un tel dispositif,procede de determination et procede de criblage correspondants
US8592220B2 (en) * 2006-10-26 2013-11-26 Intermolecular, Inc. High pressure parallel fixed bed reactor and method
SE530902C2 (sv) * 2006-12-19 2008-10-14 Alfa Laval Corp Ab Sektionerad flödesanordning och förfarande för att reglera temperaturen i denna
US20080175765A1 (en) * 2006-12-27 2008-07-24 Guang Cao High throughput, microwave energy heated continuous hydrothermal synthesis apparatus
CN101274254A (zh) * 2006-12-29 2008-10-01 亚申科技研发中心（上海）有限公司 一种加氢处理洁净原料的研究方法
US20100324157A1 (en) * 2006-12-29 2010-12-23 Bauman Richard F High throughput fischer-tropsch catalytic process development method
WO2008080365A1 (en) * 2006-12-29 2008-07-10 Accelergy Shanghai R & D Center Co., Ltd. High throughput development method for catalytic hydroprocessing of dirty feedstocks
US9308530B2 (en) * 2007-03-02 2016-04-12 Shimadzu Corporation Reaction container plate and reaction treatment apparatus
DE102007031680A1 (de) * 2007-07-06 2009-01-08 Thermo Fisher Scientific (Bremen) Gmbh Einrichtung zur Bereitstellung von Gasen, insbesondere für die Isotopenverhältnisanalyse
US20090046535A1 (en) 2007-07-25 2009-02-19 Carlson Eric D Systems and methods for mixing materials
TW200909338A (en) * 2007-08-23 2009-03-01 Ind Tech Res Inst Autonomous microfluidic apparatus
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US20090211977A1 (en) * 2008-02-27 2009-08-27 Oregon State University Through-plate microchannel transfer devices
NL2002365C2 (en) * 2008-05-26 2011-04-05 Avantium Holding B V Flow splitter and reaction assembly.
DE102008032097A1 (de) * 2008-07-08 2010-01-14 Hte Ag The High Throughput Experimentation Company Teststand mit Gruppen von Restriktoren
US8056582B2 (en) * 2008-08-08 2011-11-15 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
JP4722977B2 (ja) * 2008-08-27 2011-07-13 シャープ株式会社 検出器具、分析装置、検出方法および検出器具の制御方法
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
KR100971914B1 (ko) * 2008-10-14 2010-07-22 한국원자력연구원 초고온 가스로의 동심축 이중관형 고온가스관의 설계방법
US8236599B2 (en) 2009-04-09 2012-08-07 State of Oregon acting by and through the State Board of Higher Education Solution-based process for making inorganic materials
EP2445615B1 (de) * 2009-06-24 2017-05-17 Oregon State University Mikrofluidische vorrichtungen für dialyse
US8801922B2 (en) 2009-06-24 2014-08-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialysis system
EP3284494A1 (de) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Tragbares infusionspumpensystem
DE102010050599B4 (de) 2009-11-07 2014-11-13 Hte Gmbh The High Throughput Experimentation Company Vorrichtung und Verfahren zur Testung von Katalysatoren mit verbesserter Prozessdruckeinstellung
US20110189048A1 (en) * 2009-12-05 2011-08-04 Curtis James R Modular dialysis system
US8753515B2 (en) 2009-12-05 2014-06-17 Home Dialysis Plus, Ltd. Dialysis system with ultrafiltration control
US8580161B2 (en) 2010-05-04 2013-11-12 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluidic devices comprising photocontrollable units
US8501009B2 (en) 2010-06-07 2013-08-06 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Fluid purification system
EP2458358B1 (de) * 2010-11-29 2017-09-27 Corning Incorporated Kontaktlose Inline-Drucksensoren und Verfahren zur Druckmessung
GB201117064D0 (en) 2011-10-04 2011-11-16 Univ Brunel A modular flow reactor
JP2014533133A (ja) 2011-10-07 2014-12-11 ホーム・ダイアリシス・プラス・リミテッドＨｏｍｅ ＤｉａｌｙｓｉｓＰｌｕｓ， Ｌｔｄ． 透析システムのための熱交換流体の精製
US20130196053A1 (en) * 2012-01-10 2013-08-01 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Stat Flow cell design for uniform residence time fluid flow
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
DE102012014504A1 (de) 2012-07-20 2014-01-23 Dräger Safety AG & Co. KGaA Gasmesssystem
NL2009659C2 (en) * 2012-10-18 2014-04-22 Avantium Technologies B V System and method for operating parallel reactors.
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
DE102013006544B4 (de) * 2013-04-16 2017-04-27 Dräger Safety AG & Co. KGaA Messvorrichtung, Reaktionsträger und Messverfahren
US10086537B2 (en) * 2013-05-08 2018-10-02 Minipumps, Llc Flexible manufacture of polymeric tubing
US20140335626A1 (en) * 2013-05-10 2014-11-13 Cdti Test Bench Gas Flow Control System and Method
NL2011856C2 (en) * 2013-11-28 2014-09-25 Avantium Technologies B V Reactor system for high throughput applications.
US20150224502A1 (en) * 2014-02-12 2015-08-13 Monterey Bay Aquarium Research Institute Flow-through cartridge-based system for collecting and processing samples from water
ES2864727T3 (es) 2014-04-29 2021-10-14 Outset Medical Inc Sistema y métodos de diálisis
CN104190340B (zh) * 2014-08-29 2016-04-06 高剑峰 一种微管式反应装置及利用该装置制备氢化丁腈橡胶的工艺
US20160102283A1 (en) * 2014-10-09 2016-04-14 The United States Of America As Represented By The Secretary Department Of Health And Human Services Microfluidic device and system for precisely controlling and analyzing shear forces in blast-induced traumatic brain injuries
GB2533386B (en) * 2014-12-18 2019-09-11 Smiths Detection Watford Ltd A detection apparatus with pneumatic interface
TW201634738A (zh) * 2015-01-22 2016-10-01 應用材料股份有限公司 用於在空間上分離之原子層沉積腔室的經改良注射器
US10399079B2 (en) * 2015-01-30 2019-09-03 Hewlett-Packard Development Company, L.P. Diagnostic device
US10957561B2 (en) * 2015-07-30 2021-03-23 Lam Research Corporation Gas delivery system
US10825659B2 (en) 2016-01-07 2020-11-03 Lam Research Corporation Substrate processing chamber including multiple gas injection points and dual injector
EP3192583A1 (de) * 2016-01-12 2017-07-19 ETH Zurich Vorrichtung und verfahren zur automatisierten chemischen synthese von verbindungen
US10699878B2 (en) 2016-02-12 2020-06-30 Lam Research Corporation Chamber member of a plasma source and pedestal with radially outward positioned lift pins for translation of a substrate c-ring
US10651015B2 (en) 2016-02-12 2020-05-12 Lam Research Corporation Variable depth edge ring for etch uniformity control
US10438833B2 (en) 2016-02-16 2019-10-08 Lam Research Corporation Wafer lift ring system for wafer transfer
RU2729204C2 (ru) * 2016-04-06 2020-08-05 Флюидик Аналитикс Лимитед Улучшения в балансировке потока или по отношению к нему
CN105738638B (zh) * 2016-05-12 2019-06-04 利多(香港)有限公司 用于分析仪的保温壳
US11534537B2 (en) 2016-08-19 2022-12-27 Outset Medical, Inc. Peritoneal dialysis system and methods
US10410832B2 (en) 2016-08-19 2019-09-10 Lam Research Corporation Control of on-wafer CD uniformity with movable edge ring and gas injection adjustment
GB201704763D0 (de) 2017-01-05 2017-05-10 Illumina Inc
US11154855B2 (en) 2017-05-08 2021-10-26 Custom Sensors And Technology Automated liquid handling and testing systems and methods
WO2019006391A1 (en) 2017-06-30 2019-01-03 Sri International REACTION SCREENING AND OPTIMIZATION APPARATUSES, AND ASSOCIATED METHODS
CN107335395B (zh) * 2017-09-05 2023-11-03 山东豪迈化工技术有限公司 微反应器
WO2019118896A1 (en) * 2017-12-15 2019-06-20 Richard Nordman Automated liquid handling and testing systems and methods
DE102020109887B4 (de) 2020-04-08 2023-07-20 Opus Inspection, Inc. Gasmessgerät mit einer kompakten Bauform
CN111530515A (zh) * 2020-05-08 2020-08-14 北京森美希克玛生物科技有限公司 一种微流控芯片
WO2022251951A1 (en) * 2021-06-02 2022-12-08 Interface Fluidics Ltd. Manifolds for microfluidic chips, microfluidic chips, and related methods and assemblies

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1164381B (de) * 1961-03-18 1964-03-05 Bayer Ag Reaktorsystem
US3536452A (en) 1965-04-21 1970-10-27 Marathon Oil Co Multiple reactor apparatus
US3431077A (en) 1966-07-18 1969-03-04 Joseph D Danforth Analytical apparatus
US4099923A (en) 1977-01-17 1978-07-11 The Standard Oil Company Automatic catalytic screening unit
DE2714939C3 (de) 1977-04-02 1980-08-14 Hoechst Ag, 6000 Frankfurt Verfahren und Vorrichtung zur Untersuchung der Wirksamkeit von festen Katalysatoren
DD234941A1 (de) 1985-02-28 1986-04-16 Leuna Werke Veb Verfahren und anordnung zur katalysatoraktivitaetsbestimmung
JPH0619311B2 (ja) 1985-10-19 1994-03-16 株式会社堀場製作所 多成分同時測定用ガス分析装置
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
EP0396650B2 (de) 1988-09-02 1995-04-12 GebràœDer Sulzer Aktiengesellschaft Vorrichtung zur durchführung katalysierter reaktionen
US4869282A (en) 1988-12-09 1989-09-26 Rosemount Inc. Micromachined valve with polyimide film diaphragm
DE3902402C1 (de) 1989-01-27 1990-06-13 Draegerwerk Ag, 2400 Luebeck, De
US4996387A (en) 1989-07-20 1991-02-26 Phillips Petroleum Company Dehydrogenation process
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
US5204270A (en) * 1991-04-29 1993-04-20 Lacount Robert B Multiple sample characterization of coals and other substances by controlled-atmosphere programmed temperature oxidation
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5324483B1 (en) 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
DE69413012T2 (de) 1993-03-19 1999-03-25 Du Pont Integrierte vorrichtung für chemische verfahrensschritte und herstellungsverfahren dafür
US5534328A (en) 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5595712A (en) 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US5611214A (en) 1994-07-29 1997-03-18 Battelle Memorial Institute Microcomponent sheet architecture
US5811062A (en) 1994-07-29 1998-09-22 Battelle Memorial Institute Microcomponent chemical process sheet architecture
US6004617A (en) 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6030917A (en) 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
DE4438785C2 (de) 1994-10-24 1996-11-07 Wita Gmbh Wittmann Inst Of Tec Mikrochemische Reaktions- und Analyseeinheit
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
WO1996015576A1 (en) * 1994-11-10 1996-05-23 David Sarnoff Research Center, Inc. Liquid distribution system
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5658537A (en) 1995-07-18 1997-08-19 Basf Corporation Plate-type chemical reactor
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5750906A (en) 1995-11-02 1998-05-12 Chiron Diagnostics Corporation Multifunction valve
US6063633A (en) 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
CA2198433A1 (en) 1996-03-22 1997-09-23 Sheila Helen Hobbs Dewitt Information management system for automated multiple simultaneous synthesis
US6033544A (en) * 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
JPH11514012A (ja) 1996-07-23 1999-11-30 サイミックス・テクノロジーズ 有機金属化合物及び触媒の組み合わせ合成並びに分析
DE19632779A1 (de) 1996-08-15 1998-02-19 Hoechst Ag Verfahren und Vorrichtung zum Untersuchen von chemischen Reaktionen in parallel geschalteten, miniaturisierten Reaktoren
US5865417A (en) 1996-09-27 1999-02-02 Redwood Microsystems, Inc. Integrated electrically operable normally closed valve
US5866342A (en) 1996-09-27 1999-02-02 Glaxo Group Limited Systems and methods for the synthesis of organic compounds
CA2267897C (en) 1996-10-09 2005-12-06 Symyx Technologies Infrared spectroscopy and imaging of libraries
DE19642261A1 (de) 1996-10-11 1998-04-16 Hoechst Ag Verfahren und Vorrichtung zum Erkennen der katalytischen Aktivität von Feststoffen
US5927325A (en) 1996-10-25 1999-07-27 Inpod, Inc. Microelectromechanical machined array valve
US6447727B1 (en) 1996-11-19 2002-09-10 Caliper Technologies Corp. Microfluidic systems
US5780748A (en) 1997-01-29 1998-07-14 Hewlett-Packard Company Flow device having parallel flow surfaces which move toward and away from one another to adjust the flow channel in proportion to applied force
US5865147A (en) 1997-03-25 1999-02-02 Rubin; Ellice L. Animal exercise toy containing animal meal
WO1998053236A1 (en) 1997-05-21 1998-11-26 Redwood Microsystems, Inc. Low-power thermopneumatic microvalve
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5869004A (en) 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DE19805719A1 (de) 1998-02-12 1999-08-19 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
DE19806848A1 (de) 1998-02-18 1999-08-19 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
DE19855894A1 (de) 1998-12-03 2000-06-08 Basf Ag Verfahren zur kombinatorischen Herstellung und Testung von Heterogenkatalysatoren
JP2002502697A (ja) 1998-02-12 2002-01-29 ビーエーエスエフ アクチェンゲゼルシャフト 不均一系触媒のコンビナトリアル製造法および評価法
DE19809477C2 (de) 1998-03-06 2002-04-11 Hte Ag High Throughput Experim Anordnung zum Testen der katalytischen Aktivität von einem Reaktionsgas ausgesetzten Feststoffen
US6087181A (en) 1998-03-16 2000-07-11 Symyx Technologies Sampling and detection of trace gas species by optical spectroscopy
US6054047A (en) * 1998-03-27 2000-04-25 Synsorb Biotech, Inc. Apparatus for screening compound libraries
US6175409B1 (en) 1999-04-02 2001-01-16 Symyx Technologies, Inc. Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers
US6149882A (en) * 1998-06-09 2000-11-21 Symyx Technologies, Inc. Parallel fixed bed reactor and fluid contacting apparatus
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
US6410332B1 (en) 1998-09-08 2002-06-25 Symyx Technologies, Inc. Sampling and analysis of reactions by trapping reaction components on a sorbent
DE69917914T2 (de) 1998-09-18 2004-11-04 Symyx Technologies, Inc., Santa Clara Herstellung von kombinatorischen arrays von materialen durch methoden der synthese in lösung
US20020042140A1 (en) 1999-03-03 2002-04-11 Alfred Hagemeyer Methods for analysis of heterogeneous catalysts in a multi-variable screening reactor
DE60017702T2 (de) 1999-03-03 2006-04-06 Symyx Technologies, Inc., Santa Clara Chemische verfahrensmikrosysteme zur evaluierung heterogener katalysatoren und ihre verwendung
US7150994B2 (en) 1999-03-03 2006-12-19 Symyx Technologies, Inc. Parallel flow process optimization reactor
WO2001000315A2 (en) 1999-06-25 2001-01-04 Avantium International B.V. Reactor vessel array
ATE287291T1 (de) 2000-03-07 2005-02-15 Symyx Technologies Inc Prozessoptimierungsreaktor mit parallelem durchfluss
US6701774B2 (en) 2000-08-02 2004-03-09 Symyx Technologies, Inc. Parallel gas chromatograph with microdetector array

Also Published As

Publication number Publication date
DE60108482T2 (de) 2006-02-16
US7122156B2 (en) 2006-10-17
AU2001240104A1 (en) 2001-09-17
US20020045265A1 (en) 2002-04-18
DE60108482D1 (de) 2005-02-24
EP1265700B1 (de) 2005-01-19
WO2001066245A3 (en) 2002-04-25
EP1265700A2 (de) 2002-12-18
WO2001066245A2 (en) 2001-09-13

Similar Documents

Publication Publication Date Title
ATE287291T1 (de) Prozessoptimierungsreaktor mit parallelem durchfluss
AU3498900A (en) Sequencing by incorporation
BR9803848A (pt) Sistema para inferência em linha de propriedades fìsicas e quìmicas, sistema para inferência em linha de variáveis de processo, e, sistema de controle em linha
ATE273454T1 (de) Pneumatisches verteilersystem
WO2001059675A8 (en) Method and system for distributing and collecting spreadsheet information
ATE457796T1 (de) Einrichtung in einer verfahrenstechnischen kolonne
UA42056C2 (uk) Пристрій для оксихлорування
TW357285B (en) Membrane mask and method for fabricating and employing the same
AUPQ605900A0 (en) Thermal expansion compensation for printhead assemblies
ES8300842A1 (es) "metodo de efectuar la conversion de un material de carga hidrocarbonado".
Bond et al. Void swelling of annealed 304 stainless steel at∼ 370-385° C and PWR-relevant displacement rates
AU2002314538A1 (en) Mooring damper
NZ500180A (en) Cyanamide hydratase (cah) as a plant selection marker providing cyanamide tolerance
BR0203531A (pt) Método para produzir uma substáncia alvo pelo uso de um microorganismo, e, microorganismo no qual um gene da metanol desidrogenase é introduzido
BRPI0413279A (pt) processo de polimerização, e, aparelho para a obtenção de um material polimérico
ATE473043T1 (de) Reaktor mit gleichmässiger verteilung von betriebsmitteln
AU2003291229A1 (en) Missile control system and method
Niino et al. BINDING OF METHYL ORANGE BY WATER-SOLUBLE SYNTHETIC POLYORGANOSILOXANES.
BR0005682A (pt) Processo contìnuo em massa para a produção de polìmeros vinilaromáticos
ES2100758T3 (es) Proceso para la preparacion de alquil- o arildiclorosilanos.
AU2001226968A1 (en) Compact reactor with heat exchanger
BR0301557A (pt) Gerador de sinal de difusão simultânea de pico reduzido para um sinal radiodifundido digital e um sinal radiodifundido análogo, método para gerar o dito sinal, sinal radiodifundido de difusão simultânea, e, produto de programa de computador
角孝夫 RC active network synthesis
Peck et al. Louisiana Log Fern (Dryopteris ludoviciana) New to Arkansas
Waldie PHYSICAL AND CHEMICAL PROCESSING WITH THERMAL PLASMAS.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties