ATE283702T1 - Leptin als inhibitor der tumorzellenproliferation - Google Patents

Leptin als inhibitor der tumorzellenproliferation

Info

Publication number
ATE283702T1
ATE283702T1 AT98917580T AT98917580T ATE283702T1 AT E283702 T1 ATE283702 T1 AT E283702T1 AT 98917580 T AT98917580 T AT 98917580T AT 98917580 T AT98917580 T AT 98917580T AT E283702 T1 ATE283702 T1 AT E283702T1
Authority
AT
Austria
Prior art keywords
leptin
inhibitor
cell proliferation
tumor cell
tumor
Prior art date
Application number
AT98917580T
Other languages
English (en)
Inventor
Dalit Barkan
Batya Cohen
Menachem Rubinstein
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE283702T1 publication Critical patent/ATE283702T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98917580T 1997-04-29 1998-04-26 Leptin als inhibitor der tumorzellenproliferation ATE283702T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12073397A IL120733A0 (en) 1997-04-29 1997-04-29 Leptin as an inhibitor of cell proliferation
PCT/IL1998/000196 WO1998048831A1 (en) 1997-04-29 1998-04-26 Leptin as an inhibitor of tumor cell proliferation

Publications (1)

Publication Number Publication Date
ATE283702T1 true ATE283702T1 (de) 2004-12-15

Family

ID=11070075

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917580T ATE283702T1 (de) 1997-04-29 1998-04-26 Leptin als inhibitor der tumorzellenproliferation

Country Status (26)

Country Link
US (1) US7109159B1 (de)
EP (1) EP0981365B1 (de)
JP (1) JP4330662B2 (de)
KR (1) KR100507731B1 (de)
CN (1) CN1168497C (de)
AR (1) AR012626A1 (de)
AT (1) ATE283702T1 (de)
AU (1) AU742927B2 (de)
BG (1) BG63490B1 (de)
CA (1) CA2288238A1 (de)
CZ (1) CZ299872B6 (de)
DE (1) DE69827942T2 (de)
EA (1) EA002353B1 (de)
EE (1) EE04801B1 (de)
ES (1) ES2232944T3 (de)
HK (1) HK1028350A1 (de)
HU (1) HUP0002427A3 (de)
IL (2) IL120733A0 (de)
NO (1) NO322304B1 (de)
NZ (1) NZ500589A (de)
PL (1) PL195275B1 (de)
PT (1) PT981365E (de)
SK (1) SK284848B6 (de)
UA (1) UA66793C2 (de)
WO (1) WO1998048831A1 (de)
ZA (1) ZA983608B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208572B2 (en) 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) * 1999-09-05 2001-03-19 Yeda Res & Dev Use of leptin in inhibition of endothelial cell proliferation
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
WO2005077072A2 (en) 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
US7863240B2 (en) * 2004-10-08 2011-01-04 Enzo Therapeutics, Inc. Methods and uses of leptin in hepatocellular carcinoma
US8969291B2 (en) 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
AU2006213607A1 (en) 2005-02-11 2006-08-17 Amylin Pharmaceuticals, Llc GIP analog and hybrid polypeptides with selectable properties
WO2007022123A2 (en) 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
US8227408B2 (en) * 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
CA2712606A1 (en) * 2008-02-08 2009-08-13 Ambrx, Inc. Modified leptin polypeptides and their uses
KR20110028457A (ko) * 2008-05-21 2011-03-18 뉴로테즈 인코포레이티드 신경섬유 매듭과 연관된 신경변성 장애를 치료하는 방법
JP2012508242A (ja) * 2008-11-04 2012-04-05 ニコラオス テザプシディス 神経原線維のもつれ及びアミロイドβの蓄積に起因する進行性認知機能障害を治療するためのレプチン組成物及び方法
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
TWI824372B (zh) 2015-10-12 2023-12-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
MX2019005397A (es) 2016-11-08 2019-10-09 Regeneron Pharma Proteinas de union a antigeno que antagonizan el receptor de leptina.
BR112020012011A2 (pt) 2017-12-18 2020-11-24 Regeneron Pharmaceuticals, Inc. moléculas de ligação a antígeno biespecífica isolada e de ligação a antígeno biespecífica ou cadeia de imunoglobulina, composição farmacêutica, recipiente ou dispositivo de injeção, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, métodos para tratar uma doença ou condição, para tratar uma condição de lipodistrofia em um sujeito, para produzir uma molécula de ligação a antígeno biespecífica, e, para administrar uma molécula de ligação a antígeno biespecífica isolada ou composição farmacêutica.
CN112040980A (zh) 2018-04-06 2020-12-04 瑞泽恩制药公司 用于治疗代谢功能障碍或低瘦蛋白血症的瘦蛋白受体激动剂抗体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0836479A2 (de) * 1995-06-30 1998-04-22 Eli Lilly And Company Verfahren zur behandlung von diabetes
WO1997011192A1 (en) * 1995-09-19 1997-03-27 Eli Lilly And Company Dna encoding medicinal proteins
DK0892849T3 (da) * 1996-01-23 2006-07-24 Indevus Pharmaceuticals Inc Fremgangsmåde til anvendelse af obese-genet og dets genprodukt til stimulering af hæmatopoietisk udvikling

Also Published As

Publication number Publication date
US7109159B1 (en) 2006-09-19
EP0981365A1 (de) 2000-03-01
EE9900510A (et) 2000-06-15
SK284848B6 (sk) 2006-01-05
JP2001524968A (ja) 2001-12-04
HUP0002427A2 (hu) 2000-12-28
HUP0002427A3 (en) 2003-02-28
PT981365E (pt) 2005-03-31
NO322304B1 (no) 2006-09-11
EE04801B1 (et) 2007-04-16
PL336582A1 (en) 2000-07-03
BG63490B1 (bg) 2002-03-29
AU742927B2 (en) 2002-01-17
CN1168497C (zh) 2004-09-29
EA199900981A1 (ru) 2000-04-24
BG103832A (en) 2000-10-31
HK1028350A1 (en) 2001-02-16
AR012626A1 (es) 2000-11-08
JP4330662B2 (ja) 2009-09-16
IL120733A0 (en) 1997-08-14
KR100507731B1 (ko) 2005-08-10
AU7076298A (en) 1998-11-24
SK147199A3 (en) 2000-06-12
WO1998048831A1 (en) 1998-11-05
ZA983608B (en) 1998-11-02
IL132633A (en) 2007-07-04
DE69827942D1 (de) 2005-01-05
CZ299872B6 (cs) 2008-12-17
NO995267L (no) 1999-12-28
DE69827942T2 (de) 2005-12-08
CZ384899A3 (cs) 2000-06-14
NO995267D0 (no) 1999-10-28
CA2288238A1 (en) 1998-11-05
CN1261802A (zh) 2000-08-02
KR20010012080A (ko) 2001-02-15
UA66793C2 (uk) 2004-06-15
EA002353B1 (ru) 2002-04-25
NZ500589A (en) 2001-03-30
EP0981365B1 (de) 2004-12-01
PL195275B1 (pl) 2007-08-31
ES2232944T3 (es) 2005-06-01

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