ATE277611T1 - Zusammensetzung, l-carnitin oder alkanoyl l- carnitin und langkettige alkanole enthaltend - Google Patents
Zusammensetzung, l-carnitin oder alkanoyl l- carnitin und langkettige alkanole enthaltendInfo
- Publication number
- ATE277611T1 ATE277611T1 AT98932504T AT98932504T ATE277611T1 AT E277611 T1 ATE277611 T1 AT E277611T1 AT 98932504 T AT98932504 T AT 98932504T AT 98932504 T AT98932504 T AT 98932504T AT E277611 T1 ATE277611 T1 AT E277611T1
- Authority
- AT
- Austria
- Prior art keywords
- carnitine
- alkanoyl
- chain alkanols
- composition containing
- long chain
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- -1 alkanoyl L-carnitines Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97RM000487A IT1294227B1 (it) | 1997-08-01 | 1997-08-01 | Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione |
| PCT/IT1998/000190 WO1999006039A1 (en) | 1997-08-01 | 1998-07-09 | Composition comprising l-carnitine or an alkanoyl l-carnitine and long-chain alkanols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277611T1 true ATE277611T1 (de) | 2004-10-15 |
Family
ID=11405212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98932504T ATE277611T1 (de) | 1997-08-01 | 1998-07-09 | Zusammensetzung, l-carnitin oder alkanoyl l- carnitin und langkettige alkanole enthaltend |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6328998B1 (de) |
| EP (1) | EP0999832B1 (de) |
| JP (1) | JP4295429B2 (de) |
| KR (1) | KR100530878B1 (de) |
| AT (1) | ATE277611T1 (de) |
| AU (1) | AU741363B2 (de) |
| CA (1) | CA2295746C (de) |
| DE (1) | DE69826674T2 (de) |
| DK (1) | DK0999832T3 (de) |
| ES (1) | ES2229514T3 (de) |
| IT (1) | IT1294227B1 (de) |
| NZ (1) | NZ501967A (de) |
| PT (1) | PT999832E (de) |
| SI (1) | SI0999832T1 (de) |
| WO (1) | WO1999006039A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1306178B1 (it) | 1999-07-27 | 2001-05-30 | Sigma Tau Ind Farmaceuti | Uso della l-carnitina e dei suoi alcanoil derivati per la preparazionedi un medicamento utile nel trattamento del paziente affetto da |
| IT1306722B1 (it) * | 1999-10-08 | 2001-10-02 | Sigma Tau Healthscience Spa | Composizione per la prevenzione e/o il trattamento di disfunzionicircolatorie, comprendente derivati della l-carnitina ed estratti di |
| US7214394B2 (en) * | 2002-05-31 | 2007-05-08 | Archer-Daniels-Midland Company | Policosanol compositions, extraction from novel sources, and uses thereof |
| US20060166951A1 (en) * | 2002-05-31 | 2006-07-27 | Archer-Daniels-Midland Company | Compositions and methods for sterol isolation and purification |
| AU2003241477A1 (en) | 2002-06-10 | 2003-12-22 | Elan Pharma International, Ltd. | Nanoparticulate polycosanol formulations and novel polycosanol combinations |
| AU2003240187A1 (en) * | 2002-06-17 | 2003-12-31 | Medestea Research And Production S.R.L. | A process for preparing long chain saturated or unsaturated oxygenated compounds |
| US20090196914A1 (en) * | 2002-11-14 | 2009-08-06 | Optime Therapeutics, Inc. | Liposomal l-carnitine |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| ITRM20040327A1 (it) * | 2004-07-01 | 2004-10-01 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici. |
| US7615641B2 (en) * | 2004-07-20 | 2009-11-10 | Sino Pharmaceuticals Corporation | Long chain aliphatic alcohol derivatives and methods of making and using same |
| US20070087975A1 (en) * | 2005-10-17 | 2007-04-19 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Compound useful for the prevention and treatment of left ventricular hypertrophy in dialysed patients |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| BR112020002419A2 (pt) | 2017-08-14 | 2020-07-28 | Axcella Health Inc. | aminoácido para o tratamento de doença do fígado |
| WO2019246225A1 (en) | 2018-06-20 | 2019-12-26 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2903558C2 (de) * | 1978-02-03 | 1994-09-01 | Sigma Tau Ind Farmaceuti | Verwendung von L-Carnitin |
| JPS6299323A (ja) * | 1985-10-25 | 1987-05-08 | Yoshihide Hagiwara | 高脂血症剤 |
| IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
| US5135956A (en) * | 1988-10-18 | 1992-08-04 | The Regents Of The University Of California | Method of using cytoprotective alcohols to treat neural disease and neural injury |
| US5243094A (en) * | 1989-10-13 | 1993-09-07 | Medafor | Derivatives of long chain fatty alcohols, their uses, particularly as cytotrophic and cytoprotective molecules, and pharmaceutical compositions containing them |
| JPH05103629A (ja) * | 1991-10-11 | 1993-04-27 | Yukio Yanagimoto | 体力増強剤 |
| JPH05103596A (ja) * | 1991-10-11 | 1993-04-27 | Yukio Yanagimoto | 陸上動物用体力増強剤及び陸上動物用飼料 |
| CU22229A1 (es) * | 1992-09-29 | 1996-01-31 | Dalmer Lab Sa | Policosanol, una mezcla de alcoholes alifaticos primarios superiores para hipergregabilidad plaquetaria, los accidentes isquemicos, trombosis e incluso efectividad contra ulceras gastricas quimicamente inducidas y su proceso de obtencion de la caña de azucar. el tratamiento de complicaciones ateroscleroticas tales como la |
| JPH05310563A (ja) * | 1992-05-15 | 1993-11-22 | Nippon Oil & Fats Co Ltd | カルシトニン産生増強剤 |
| JPH0825891B2 (ja) * | 1993-06-25 | 1996-03-13 | 株式会社薬理学中央研究所 | 脱脂米胚芽由来のリパーゼインヒビター |
| US5560928A (en) * | 1995-06-23 | 1996-10-01 | Defelice; Stephen L. | Nutritional and/or dietary composition and method of using the same |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| IT1283967B1 (it) * | 1996-03-29 | 1998-05-07 | Sigma Tau Ind Farmaceuti | Uso di l-carnitina o derivati della l-carnitina ed antiossidanti nella prevenzione e trattamento di patologie derivanti da danni ossidativi |
-
1997
- 1997-08-01 IT IT97RM000487A patent/IT1294227B1/it active IP Right Grant
-
1998
- 1998-07-09 EP EP98932504A patent/EP0999832B1/de not_active Expired - Lifetime
- 1998-07-09 AT AT98932504T patent/ATE277611T1/de active
- 1998-07-09 PT PT98932504T patent/PT999832E/pt unknown
- 1998-07-09 DK DK98932504T patent/DK0999832T3/da active
- 1998-07-09 KR KR10-2000-7001034A patent/KR100530878B1/ko not_active Expired - Fee Related
- 1998-07-09 NZ NZ501967A patent/NZ501967A/en not_active IP Right Cessation
- 1998-07-09 US US09/462,169 patent/US6328998B1/en not_active Expired - Lifetime
- 1998-07-09 JP JP2000504853A patent/JP4295429B2/ja not_active Expired - Fee Related
- 1998-07-09 ES ES98932504T patent/ES2229514T3/es not_active Expired - Lifetime
- 1998-07-09 WO PCT/IT1998/000190 patent/WO1999006039A1/en not_active Ceased
- 1998-07-09 DE DE69826674T patent/DE69826674T2/de not_active Expired - Lifetime
- 1998-07-09 AU AU82407/98A patent/AU741363B2/en not_active Ceased
- 1998-07-09 CA CA002295746A patent/CA2295746C/en not_active Expired - Fee Related
- 1998-07-09 SI SI9830694T patent/SI0999832T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6328998B1 (en) | 2001-12-11 |
| DK0999832T3 (da) | 2005-01-17 |
| CA2295746A1 (en) | 1999-02-11 |
| JP4295429B2 (ja) | 2009-07-15 |
| WO1999006039A1 (en) | 1999-02-11 |
| NZ501967A (en) | 2001-09-28 |
| KR20010022449A (ko) | 2001-03-15 |
| KR100530878B1 (ko) | 2005-11-23 |
| IT1294227B1 (it) | 1999-03-24 |
| HK1028547A1 (en) | 2001-02-23 |
| DE69826674D1 (de) | 2004-11-04 |
| AU741363B2 (en) | 2001-11-29 |
| ES2229514T3 (es) | 2005-04-16 |
| ITRM970487A1 (it) | 1999-02-01 |
| CA2295746C (en) | 2007-11-20 |
| SI0999832T1 (en) | 2004-12-31 |
| EP0999832B1 (de) | 2004-09-29 |
| JP2001511447A (ja) | 2001-08-14 |
| DE69826674T2 (de) | 2005-02-24 |
| PT999832E (pt) | 2004-12-31 |
| EP0999832A1 (de) | 2000-05-17 |
| AU8240798A (en) | 1999-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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