ATE277058T1 - Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel - Google Patents

Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel

Info

Publication number
ATE277058T1
ATE277058T1 AT97908699T AT97908699T ATE277058T1 AT E277058 T1 ATE277058 T1 AT E277058T1 AT 97908699 T AT97908699 T AT 97908699T AT 97908699 T AT97908699 T AT 97908699T AT E277058 T1 ATE277058 T1 AT E277058T1
Authority
AT
Austria
Prior art keywords
complexes
contrast agents
acid
polyazomacrocyclofluoromonoalkylphosphenic
polyazamacrocyclofluoromonoalkylphosphonic
Prior art date
Application number
AT97908699T
Other languages
English (en)
Inventor
Garry E Kiefer
A Dean Sherry
Original Assignee
Dow Global Technologies Inc
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc, Univ Texas filed Critical Dow Global Technologies Inc
Application granted granted Critical
Publication of ATE277058T1 publication Critical patent/ATE277058T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT97908699T 1996-02-23 1997-02-21 Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel ATE277058T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/606,162 US5834456A (en) 1996-02-23 1996-02-23 Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
PCT/US1997/002799 WO1997031005A1 (en) 1996-02-23 1997-02-21 Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents

Publications (1)

Publication Number Publication Date
ATE277058T1 true ATE277058T1 (de) 2004-10-15

Family

ID=24426818

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97908699T ATE277058T1 (de) 1996-02-23 1997-02-21 Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel

Country Status (6)

Country Link
US (1) US5834456A (de)
EP (1) EP0882055B1 (de)
AT (1) ATE277058T1 (de)
AU (1) AU2054097A (de)
DE (1) DE69730820T2 (de)
WO (1) WO1997031005A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
US6670456B2 (en) * 2001-02-28 2003-12-30 Dow Global Technologies Inc. Actinium-225 complexes and conjugates for targeted radiotherapy
US6911017B2 (en) * 2001-09-19 2005-06-28 Advanced Cardiovascular Systems, Inc. MRI visible catheter balloon
US20040115822A1 (en) * 2002-09-12 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
EP1791565B1 (de) 2004-09-23 2016-04-20 Genentech, Inc. Zystein-modifizierte Antikörper und Konjugate
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
AR060978A1 (es) 2006-05-30 2008-07-23 Genentech Inc Anticuerpos e inmunoconjugados y sus usos
SI2502938T1 (sl) 2006-10-27 2015-05-29 Genentech, Inc. Protitelesa in imunokonjugati in njihove uporabe
CA2676766A1 (en) 2007-02-09 2008-08-21 Genentech, Inc. Anti-robo4 antibodies and uses therefor
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
TW200918089A (en) 2007-07-16 2009-05-01 Genentech Inc Humanized anti-CD79b antibodies and immunoconjugates and methods of use
SI2657253T1 (sl) 2008-01-31 2017-10-30 Genentech, Inc. Protitelesa proti CD79b in imunokonjugati in postopki za uporabo
CN102159964B (zh) * 2008-09-22 2015-08-19 皇家飞利浦电子股份有限公司 用于微创图像引导吻合的mri可见缝线
AU2010236787A1 (en) 2009-04-01 2011-11-10 Genentech, Inc. Anti-FcRH5 antibodies and immunoconjugates and methods of use
EP3248619A3 (de) 2009-06-04 2018-03-07 Novartis AG Verfahren zur identifizierung von stellen zur igg-konjugation
EP2507381A4 (de) 2009-12-04 2016-07-20 Hoffmann La Roche Multispezifische antikörper, antikörperanaloge, zusammensetzungen und verfahren
US8362281B2 (en) 2010-03-31 2013-01-29 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8722020B2 (en) 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
US8765977B2 (en) 2010-03-31 2014-07-01 General Electric Company Hydroxylated contrast enhancement agents and imaging method
BR112012029866A2 (pt) 2010-06-03 2017-03-07 Genentech Inc método para a determinação da presença de uma proteína steap-1
CA3220104A1 (en) 2010-06-08 2011-12-15 Genentech, Inc. Cysteine engineered antibodies and conjugates
CA2872192A1 (en) 2012-07-04 2014-01-09 F. Hoffmann-La Roche Ag Anti-biotin antibodies and methods of use
MX353951B (es) 2012-07-04 2018-02-07 Hoffmann La Roche Anticuerpos de anti-teofilina y metodos de uso.
ES2604012T3 (es) 2012-07-04 2017-03-02 F. Hoffmann-La Roche Ag Conjugados de antígeno-anticuerpo unidos covalentemente
JP6521464B2 (ja) 2014-01-03 2019-05-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 共有結合で連結されたポリペプチド毒素−抗体コンジュゲート
EP3089996B1 (de) 2014-01-03 2021-07-28 F. Hoffmann-La Roche AG Bispezifische anti-hapten-/anti-blut-hirn-schranke-rezeptor-antikörper, komplexe davon und deren verwendung als blut-hirn-schranke-shuttles
BR112016012666A2 (pt) 2014-01-03 2017-09-26 Hoffmann La Roche conjugado, anticorpos, formulação farmacêutica e usos de conjugado
CA2957354A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Cysteine engineered antibodies and conjugates
MX2017007503A (es) 2014-12-17 2017-10-04 Hoffmann La Roche Metodos novedosos para conjugacion de polipeptido mediada por enzimas usando sortasa.
CN104945312A (zh) * 2015-06-24 2015-09-30 黄荣辉 一种2,6-二氯甲基吡啶盐酸盐的制备方法
EP3353291B1 (de) 2015-09-25 2021-06-09 F. Hoffmann-La Roche AG Neuartige lösliche sortase a
JP6895953B2 (ja) 2015-09-25 2021-06-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ソルターゼａを利用してチオエステルを作製するための方法
CN108026560A (zh) 2015-09-25 2018-05-11 豪夫迈·罗氏有限公司 在低共熔溶剂中使用分选酶的转酰胺反应
JP6861702B2 (ja) 2015-09-25 2021-04-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ソルターゼ・コンジュゲート化ループを含む組換え免疫グロブリン重鎖およびそのコンジュゲート
JP6727325B2 (ja) 2016-03-30 2020-07-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 改善されたソルターゼ
KR102495650B1 (ko) 2017-04-12 2023-02-02 에프. 호프만-라 로슈 아게 알데히드 함유 표적 분자의 라벨링 방법
KR20200027522A (ko) 2017-07-13 2020-03-12 에프. 호프만-라 로슈 아게 Pivka에 대한 신규 결합제 및 어세이
BR112020007321A2 (pt) 2017-10-20 2020-09-29 F. Hoffmann-La Roche Ag conjugado de anticorpo, uso, uso de um marcador isotópico estável e kit
EP3717517A1 (de) 2017-11-30 2020-10-07 H. Hoffnabb-La Roche Ag Anti-pd-l1-antikörper und verfahren zu deren verwendung zum nachweis von pd-l1
EP3765497A1 (de) 2018-03-14 2021-01-20 F. Hoffmann-La Roche AG Neuartige anti-troponin-t-antikörper
BR112020018235A2 (pt) 2018-03-14 2020-12-29 F. Hoffmann-La Roche Ag Métodos para gerar uma biblioteca de polinucleotídeos, bibliotecas de polinucleotídeos, uso de uma biblioteca, método para gerar uma biblioteca de anticorpos e método de seleção de um anticorpo
CN111936522A (zh) 2018-04-18 2020-11-13 豪夫迈·罗氏有限公司 新型抗胸苷激酶抗体
WO2020043868A1 (en) 2018-08-31 2020-03-05 F. Hoffmann-La Roche Ag Thymidine kinase (tk-1) in prognostic indices for dlbcl
CN113166255A (zh) 2018-09-28 2021-07-23 伊麦吉纳博公司 Cd8成像构建体及其使用方法
JP2023550278A (ja) 2020-10-30 2023-12-01 エフ． ホフマン－ラ ロシュ アーゲー 胆管癌のマーカーとしてのｔｉｍｐ１
WO2023111168A1 (en) 2021-12-17 2023-06-22 F. Hoffmann-La Roche Ag A novel antibody for detection of amyloid beta 42 (aβ42)

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5188816A (en) * 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
US4639364A (en) * 1984-11-14 1987-01-27 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4778926A (en) * 1985-08-21 1988-10-18 Merrell Dow Pharmaceuticals Inc. Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
US4719313A (en) * 1985-08-21 1988-01-12 Merrell Dow Pharmaceuticals Inc. Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
US4914240A (en) * 1985-08-21 1990-04-03 Merrell Dow Pharmaceuticals Inc. Gem-dihalo-1, 8-diamino-4-aza-octanes
US4695654A (en) * 1985-08-21 1987-09-22 Merrell Dow Pharmaceuticals Inc. Gem-dihalo-1,8-diamino-4-aza-octanes
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8723438D0 (en) * 1987-10-06 1987-11-11 Amersham Int Plc Cationic complexes of technetium-99m
US5582980A (en) * 1989-07-17 1996-12-10 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5284647A (en) * 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
DE69028001T2 (de) * 1989-11-27 1996-12-19 Concat Ltd Qualitätssteigerung von mr-bildern von knochen und ähnlichem gewebe mittels paramagnetischer kationenkomplexe und polyphosphonatliganden
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
IT1246380B (it) * 1990-04-12 1994-11-18 Bracco Spa Sali insolubili di lantanidi per la visualizzazione in risonanza magnetica nucleare del tratto gastro-intestinale
CA2057868A1 (en) * 1990-04-18 1991-10-19 David Parker Tetra-aza macrocycles processes for their preparation and their use in magnetic resonance imaging
IL98534A0 (en) * 1990-06-18 1992-07-15 Dow Chemical Co The use of macrocyclic aminophosphonic acid complexes as imaging agents
US5248498A (en) * 1991-08-19 1993-09-28 Mallinckrodt Medical, Inc. Fullerene compositions for magnetic resonance spectroscopy and imaging
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
IL104060A (en) * 1991-12-10 1998-12-06 Dow Chemical Co Bicyclopolyazamacyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
WO1993018795A1 (en) * 1992-03-19 1993-09-30 Daikin Industries, Ltd. Mri contrast medium and diagnostic method
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
GB9216843D0 (en) * 1992-08-07 1992-09-23 Cancer Res Inst Contrast agents for medical imaging
JPH06181890A (ja) * 1992-10-06 1994-07-05 Terumo Corp Ｍｒｉ造影剤
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
EP0703790B1 (de) * 1993-06-02 2000-08-16 BRACCO S.p.A. Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel
JPH0797340A (ja) * 1993-06-03 1995-04-11 Terumo Corp Ｍｒｉ造影剤組成物
DE69432105T2 (de) * 1993-11-26 2003-10-09 Dow Global Technologies Inc Verfahren zur herstellung von polyazamacrocylen
IT1265440B1 (it) * 1993-12-24 1996-11-22 Bracco Spa Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse

Also Published As

Publication number Publication date
EP0882055A1 (de) 1998-12-09
WO1997031005A1 (en) 1997-08-28
EP0882055B1 (de) 2004-09-22
DE69730820T2 (de) 2005-09-29
DE69730820D1 (de) 2004-10-28
AU2054097A (en) 1997-09-10
US5834456A (en) 1998-11-10

Similar Documents

Publication Publication Date Title
ATE277058T1 (de) Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel
ATE227297T1 (de) 2-pyridylmethylen-polyazamacrocyclophosphonsäur n,ihre komplexe und derivate zur verwendung als kontrastmittel
ATE316377T1 (de) Tricyclopolyazamacrocyclophosphonsäuren, ihre komplexe und derivate, für eine verwendung als kontrastmittel
IL124593A0 (en) Substituted aryl or heteroarylamides having retinoid-like biological activity
DE69106135D1 (de) Quasi-azeotrope Mischungen zur Verwendung als Kältemittel.
BG105784A (en) Triazole compounds with dopamine-d3-receptor affinity
MX9700557A (es) Dihidrobenzofuranos.
ATE238307T1 (de) Substituierte porphyrinen
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
AU9744298A (en) Substituted tetrahydronaphthaline and analogous compounds
DE69927688D1 (de) Antivirales Mittel in Kombination mit Strahlentherapie zur Verwendung in der Behandlung von Krebs
DE69938192D1 (en) Imidazonaphthyridine
CU23088A3 (es) Compuestos de tetra-hidropiridina.
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
PE20399A1 (es) Muteina ob
AU2455600A (en) Apoptosis-inducing factor
MX9706138A (es) Benzoxazolilisoindoleninas.
BG103087A (en) Method for the preparation of naphthiridons and intermediate compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties