IT1265440B1 - Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse - Google Patents

Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse

Info

Publication number
IT1265440B1
IT1265440B1 IT93MI002728A ITMI932728A IT1265440B1 IT 1265440 B1 IT1265440 B1 IT 1265440B1 IT 93MI002728 A IT93MI002728 A IT 93MI002728A IT MI932728 A ITMI932728 A IT MI932728A IT 1265440 B1 IT1265440 B1 IT 1265440B1
Authority
IT
Italy
Prior art keywords
paramagnetic
protons
chelate
those
images
Prior art date
Application number
IT93MI002728A
Other languages
English (en)
Inventor
Silvio Aime
Mario Botta
Luisella Calabi
Lino Paleari
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Priority to IT93MI002728A priority Critical patent/IT1265440B1/it
Publication of ITMI932728A0 publication Critical patent/ITMI932728A0/it
Priority to DE69430758T priority patent/DE69430758T2/de
Priority to EP95903299A priority patent/EP0735900B1/en
Priority to JP7517742A priority patent/JPH09502734A/ja
Priority to PCT/EP1994/003944 priority patent/WO1995017910A2/en
Publication of ITMI932728A1 publication Critical patent/ITMI932728A1/it
Application granted granted Critical
Publication of IT1265440B1 publication Critical patent/IT1265440B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Si descrive un metodo per ottenere immagini di un organo, un tessuto, un distretto biologico del corpo umano o animale mediante la risonanza magnetica nucleare (RMN), comprendente,a) la somministrazione di una formulazione farmaceutica fisiologicamente accettabile, contenente almeno un chelato/complesso paramagnetico, o un suo sale, in cui:1) la parte paramagnetica è costituita da uno ione di un metallo paramagnetico selezionato fra quelli a numero atomico compreso fra 21 e 29, 42, 44 e fra 58 e 83 ad eccezione di 64 e 71,2) la parte legante, o chelante, o complessante è costituita da una molecola organica, lineare o ciclica, i cui nuclei elettrodonatori sono 0, N, S, P,essendo tale chelato/complesso paramagnetico caratterizzato da uno o più segnali di risonanza protonica che cadono al di fuori dell'intervallo occupato dal segnale del protoni dell'acqua circostante e da quelli dei protoni dei costituenti dei sistemi biologici,b) l'ottenimento di detto immagini tramite tecniche di "Chemical Shift Imaging".
IT93MI002728A 1993-12-24 1993-12-24 Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse IT1265440B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT93MI002728A IT1265440B1 (it) 1993-12-24 1993-12-24 Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse
DE69430758T DE69430758T2 (de) 1993-12-24 1994-11-28 Paramagnetische diagnostische zusammensetzungen und verfahren zur verwendung
EP95903299A EP0735900B1 (en) 1993-12-24 1994-11-28 Paramagnetic diagnostic formulations and their method of use
JP7517742A JPH09502734A (ja) 1993-12-24 1994-11-28 常磁性診断用配合物及びその使用方法
PCT/EP1994/003944 WO1995017910A2 (en) 1993-12-24 1994-11-28 Paramagnetic diagnostic formulations and their method of use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI002728A IT1265440B1 (it) 1993-12-24 1993-12-24 Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse

Publications (3)

Publication Number Publication Date
ITMI932728A0 ITMI932728A0 (it) 1993-12-24
ITMI932728A1 ITMI932728A1 (it) 1995-06-25
IT1265440B1 true IT1265440B1 (it) 1996-11-22

Family

ID=11367404

Family Applications (1)

Application Number Title Priority Date Filing Date
IT93MI002728A IT1265440B1 (it) 1993-12-24 1993-12-24 Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse

Country Status (5)

Country Link
EP (1) EP0735900B1 (it)
JP (1) JPH09502734A (it)
DE (1) DE69430758T2 (it)
IT (1) IT1265440B1 (it)
WO (1) WO1995017910A2 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81095A (da) * 1995-07-11 1997-01-12 Henrik S Thomsen Peroralt MR-kontraststof til lever og øvre tarmkanal
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
ES2123449B1 (es) 1997-03-06 1999-09-16 Univ Madrid Nac Educacion Procedimiento para la obtencion de imagenes y espectros del ph extracelular por resonancia magnetica con indicadores extrinsecos conteniendo 1h o 19f.
EP1178837A2 (en) 1999-04-21 2002-02-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Method for enhancing contrast produced by mri
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
FR2848750B1 (fr) * 2002-12-13 2007-02-09 Centre Nat Rech Scient Procede d'acquisition de signaux electromagnetiques et produit de contraste pour une telle acquisition
FR2867473B1 (fr) * 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
JP5858515B2 (ja) * 2011-02-28 2016-02-10 杏林製薬株式会社 Ｎｍｒによる定量分析を用いた分配係数の測定方法
JP6032729B2 (ja) * 2012-05-08 2016-11-30 国立研究開発法人理化学研究所 イメージングマーカーおよびその利用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3219832A1 (de) * 1982-05-26 1983-12-01 Bruker Medizintechnik Gmbh, 7512 Rheinstetten Verfahren zur nicht-invasiven ermittlung von messwerten innerhalb eines lebenden koerpers
US4558279A (en) * 1983-03-07 1985-12-10 University Of Cincinnati Methods for detecting and imaging a temperature of an object by nuclear magnetic resonance
CA1242643A (en) * 1983-08-12 1988-10-04 Eric T. Fossel Nmr imaging utilizing chemical shift reagents
US4915933A (en) * 1986-06-26 1990-04-10 The University Of New Mexico Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden

Also Published As

Publication number Publication date
JPH09502734A (ja) 1997-03-18
WO1995017910A2 (en) 1995-07-06
EP0735900B1 (en) 2002-06-05
DE69430758T2 (de) 2002-09-19
EP0735900A1 (en) 1996-10-09
WO1995017910A3 (en) 1995-07-27
ITMI932728A0 (it) 1993-12-24
DE69430758D1 (de) 2002-07-11
ITMI932728A1 (it) 1995-06-25

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971223