ATE275975T1 - Mikroverkapselte ngf zusammensetzungen mit geregelter freigabe - Google Patents
Mikroverkapselte ngf zusammensetzungen mit geregelter freigabeInfo
- Publication number
- ATE275975T1 ATE275975T1 AT98928902T AT98928902T ATE275975T1 AT E275975 T1 ATE275975 T1 AT E275975T1 AT 98928902 T AT98928902 T AT 98928902T AT 98928902 T AT98928902 T AT 98928902T AT E275975 T1 ATE275975 T1 AT E275975T1
- Authority
- AT
- Austria
- Prior art keywords
- encapsuled
- micro
- regulated release
- ngf compositions
- ngf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/874,647 US6113947A (en) | 1997-06-13 | 1997-06-13 | Controlled release microencapsulated NGF formulation |
PCT/US1998/011600 WO1998056426A1 (en) | 1997-06-13 | 1998-06-11 | Controlled release microencapsulated ngf formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE275975T1 true ATE275975T1 (de) | 2004-10-15 |
Family
ID=25364245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98928902T ATE275975T1 (de) | 1997-06-13 | 1998-06-11 | Mikroverkapselte ngf zusammensetzungen mit geregelter freigabe |
Country Status (12)
Country | Link |
---|---|
US (1) | US6113947A (de) |
EP (1) | EP1001814B1 (de) |
JP (1) | JP4316682B2 (de) |
AR (1) | AR012978A1 (de) |
AT (1) | ATE275975T1 (de) |
AU (1) | AU730612B2 (de) |
CA (1) | CA2293575C (de) |
DE (1) | DE69826289T2 (de) |
ES (1) | ES2227844T3 (de) |
IL (1) | IL133112A (de) |
WO (1) | WO1998056426A1 (de) |
ZA (1) | ZA985138B (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
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US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
US6391336B1 (en) * | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
US6406719B1 (en) * | 1998-05-13 | 2002-06-18 | Microbiological Research Authority | Encapsulation of bioactive agents |
GB9906882D0 (en) * | 1999-03-25 | 1999-05-19 | Novartis Ag | Organic compounds |
SE9903236D0 (sv) * | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
US7651703B2 (en) * | 1999-10-15 | 2010-01-26 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
US7582311B1 (en) * | 1999-10-15 | 2009-09-01 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
WO2001034178A2 (en) * | 1999-11-05 | 2001-05-17 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of traumatic brain injury |
US6998137B2 (en) * | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
WO2001078789A2 (en) | 2000-04-14 | 2001-10-25 | The Uab Research Foundation | Poliovirus replicons encoding therapeutic agents and uses thereof |
ES2253375T3 (es) | 2000-04-19 | 2006-06-01 | Genentech, Inc. | Formulaciones de liberacion sostenida. |
US6565888B1 (en) * | 2000-08-23 | 2003-05-20 | Alkermes Controlled Therapeutics, Inc. | Methods and compositions for the targeted delivery of biologically active agents |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
EP1356809A4 (de) | 2000-12-28 | 2008-05-14 | Takeda Pharmaceutical | Retardzubereitungen |
JP5160005B2 (ja) * | 2000-12-28 | 2013-03-13 | 武田薬品工業株式会社 | 徐放性製剤 |
JP3836684B2 (ja) | 2001-02-19 | 2006-10-25 | 明治乳業株式会社 | 排尿障害治療剤 |
JP4861560B2 (ja) * | 2001-02-19 | 2012-01-25 | 株式会社明治 | 糖尿病合併症治療剤 |
CA2439120C (en) * | 2001-02-23 | 2011-07-05 | Genentech, Inc. | Erodible polymers for injection |
US20030157161A1 (en) * | 2001-05-01 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents |
DK1397155T3 (en) * | 2001-06-21 | 2015-12-07 | Genentech Inc | Prolonged release formulation |
US20030093147A1 (en) * | 2001-11-13 | 2003-05-15 | Ogle Matthew F. | Medical devices that stimulate growth factor production |
EP1476178A4 (de) * | 2002-02-14 | 2009-08-26 | Bayer Pharmaceuticals Corp | Formulierungsstrategien zur stabilisierung von peptiden in organischen lösungsmitteln und in getrockneten zuständen |
CA2500065A1 (en) * | 2002-09-30 | 2004-04-15 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
AU2003277446A1 (en) | 2002-10-17 | 2004-05-04 | Alkermes Controlled Therapeutics, Inc. Ii | Microencapsulation and sustained release of biologically active polypeptides |
PT1610822E (pt) * | 2003-04-02 | 2011-01-05 | Ares Trading Sa | Formulações farmacêuticas líquidas ou liofilizadas de fsh e/ou lh em conjunto com o surfactante não iónico poloxâmero 188 e um agente bacteriostático |
DE10315640A1 (de) * | 2003-04-04 | 2004-10-14 | Ignatov, Konstantin | Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung |
CA2915574C (en) | 2003-07-18 | 2017-02-07 | Oakwood Laboratories, L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
AR045258A1 (es) * | 2003-08-21 | 2005-10-19 | Altana Pharma Ag | Un producto farmaceutico para inyeccion |
US7205387B2 (en) * | 2003-08-28 | 2007-04-17 | Agency For Science, Technology And Research | Recombinant polypeptide useful for neurotrophin receptor mediated gene delivery and as neurotrophin agonist |
JP2007533634A (ja) * | 2003-09-30 | 2007-11-22 | アキュスフィア, インコーポレイテッド | 注射、経口、または局所用の徐放性医薬製剤 |
US7090433B2 (en) * | 2003-10-07 | 2006-08-15 | Steve Searby | Underground cable laying apparatus |
US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
ATE531374T1 (de) * | 2004-04-15 | 2011-11-15 | Alkermes Inc | Vorrichtung auf polymerbasis mit verzögerter freisetzung |
US7456254B2 (en) * | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
US20060110423A1 (en) * | 2004-04-15 | 2006-05-25 | Wright Steven G | Polymer-based sustained release device |
WO2005122734A2 (en) * | 2004-06-14 | 2005-12-29 | The Research Foundation Of State University Of New York | Nanosphere/microsphere delivery system for the treatment of spinal cord injury |
US8128952B2 (en) * | 2005-01-12 | 2012-03-06 | Clemson University Research Foundation | Ligand-mediated controlled drug delivery |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
US7452867B2 (en) * | 2005-03-23 | 2008-11-18 | Ramot At Tel-Aviv University, Ltd. | Use of ADNF polypeptides for treating peripheral neurotoxicity |
US8067369B2 (en) * | 2006-02-24 | 2011-11-29 | Ramot At Tel-Aviv University | Protection of the retina against laser injury by NAP and related peptides |
US7682356B2 (en) | 2006-08-09 | 2010-03-23 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
JP5351884B2 (ja) | 2007-04-23 | 2013-11-27 | インターシア セラピューティクス,インコーポレイティド | インスリン分泌促進性ペプチドの懸濁製剤及び使用 |
US20080317865A1 (en) * | 2007-06-20 | 2008-12-25 | Alkermes, Inc. | Quench liquids and washing systems for production of microparticles |
CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
JP5713897B2 (ja) * | 2008-07-16 | 2015-05-07 | エボニック コーポレイションEvonik Corporation | 生理活性ペプチドを含有する微粒子を調製するためのプロセス |
EP2470876B1 (de) | 2009-08-24 | 2017-04-05 | Particle Measuring Systems, Inc. | Partikelsensor mit flussüberwachung |
HUE035862T2 (en) | 2009-09-28 | 2018-05-28 | Intarcia Therapeutics Inc | Rapid development and / or completion of substantially steady-state drug delivery |
US10669522B2 (en) | 2011-02-07 | 2020-06-02 | Life Technologies Corporation | Compositions and methods for stabilizing susceptible compounds |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
CN102488619B (zh) * | 2011-12-05 | 2014-08-06 | 上海交通大学 | 连续生产艾塞那肽微球的装置及控制微球释放速度的方法 |
US10983040B2 (en) | 2013-03-15 | 2021-04-20 | Particles Plus, Inc. | Particle counter with integrated bootloader |
US9677990B2 (en) | 2014-04-30 | 2017-06-13 | Particles Plus, Inc. | Particle counter with advanced features |
US11579072B2 (en) | 2013-03-15 | 2023-02-14 | Particles Plus, Inc. | Personal air quality monitoring system |
US10352844B2 (en) | 2013-03-15 | 2019-07-16 | Particles Plus, Inc. | Multiple particle sensors in a particle counter |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
ES2968262T3 (es) | 2015-06-03 | 2024-05-08 | I2O Therapeutics Inc | Sistemas de colocación de implantes |
EP3334460A4 (de) * | 2015-08-13 | 2019-04-03 | Northeastern University | Biomaterialien für kombinierte strahlentherapie und immuntherapie von krebs |
WO2017200943A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
KR102228571B1 (ko) * | 2017-02-09 | 2021-03-16 | 주식회사 메디폴리머 | 정신질환 또는 중추신경계 질환 치료용 약물전달 제형 |
EP3406259A1 (de) * | 2017-05-24 | 2018-11-28 | Dompé farmaceutici S.p.A. | Neurotrophine zur verwendung bei der behandlung von hörverlust |
CN110090293B (zh) * | 2019-05-10 | 2023-04-07 | 南京工业大学 | 一种抑制plga微球中多肽类药物酰化副反应的方法 |
US11988591B2 (en) | 2020-07-01 | 2024-05-21 | Particles Plus, Inc. | Modular optical particle counter sensor and apparatus |
Family Cites Families (20)
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US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4263428A (en) * | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
EP0052322B1 (de) * | 1980-11-10 | 1985-03-27 | Gersonde, Klaus, Prof. Dr. | Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
EP0088046B1 (de) * | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
DE3218121A1 (de) * | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
EP0102324A3 (de) * | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
DE3486459D1 (de) * | 1983-09-26 | 1997-12-11 | Udo Dr Med Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
EP0143949B1 (de) * | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmazeutische Zusammensetzung mit Gehalt an Urokinase |
CA1256638A (en) * | 1984-07-06 | 1989-06-27 | Motoaki Tanaka | Polymer and its production |
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JP2504289B2 (ja) * | 1990-05-21 | 1996-06-05 | 宇部興産株式会社 | 押出プレス用後面設備サブストレッチャのテ―ルストック |
US5488099A (en) * | 1992-03-06 | 1996-01-30 | Persson, Deceased; Hakan B. | Multifunctional chimeric neurotrophic factors |
DK0686045T3 (da) * | 1993-02-23 | 2001-03-05 | Genentech Inc | Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof |
US5728803A (en) * | 1994-06-03 | 1998-03-17 | Genentech, Inc. | Pantropic neurotrophic factors |
AU708756B2 (en) * | 1995-06-07 | 1999-08-12 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of human growth hormone |
WO1997017087A1 (en) * | 1995-11-07 | 1997-05-15 | Genentech, Inc. | Stabilizing formulation for ngf |
-
1997
- 1997-06-13 US US08/874,647 patent/US6113947A/en not_active Expired - Fee Related
-
1998
- 1998-06-11 IL IL13311298A patent/IL133112A/en not_active IP Right Cessation
- 1998-06-11 DE DE69826289T patent/DE69826289T2/de not_active Expired - Lifetime
- 1998-06-11 CA CA002293575A patent/CA2293575C/en not_active Expired - Fee Related
- 1998-06-11 ES ES98928902T patent/ES2227844T3/es not_active Expired - Lifetime
- 1998-06-11 AT AT98928902T patent/ATE275975T1/de active
- 1998-06-11 EP EP98928902A patent/EP1001814B1/de not_active Expired - Lifetime
- 1998-06-11 JP JP50289899A patent/JP4316682B2/ja not_active Expired - Fee Related
- 1998-06-11 AU AU80592/98A patent/AU730612B2/en not_active Ceased
- 1998-06-11 WO PCT/US1998/011600 patent/WO1998056426A1/en active IP Right Grant
- 1998-06-12 AR ARP980102806A patent/AR012978A1/es active IP Right Grant
- 1998-06-12 ZA ZA9805138A patent/ZA985138B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1001814B1 (de) | 2004-09-15 |
AR012978A1 (es) | 2000-11-22 |
ZA985138B (en) | 1999-12-13 |
IL133112A (en) | 2004-09-27 |
JP4316682B2 (ja) | 2009-08-19 |
EP1001814A1 (de) | 2000-05-24 |
CA2293575A1 (en) | 1998-12-17 |
IL133112A0 (en) | 2001-03-19 |
CA2293575C (en) | 2009-01-06 |
AU730612B2 (en) | 2001-03-08 |
WO1998056426A1 (en) | 1998-12-17 |
DE69826289D1 (de) | 2004-10-21 |
ES2227844T3 (es) | 2005-04-01 |
DE69826289T2 (de) | 2005-09-22 |
JP2002505671A (ja) | 2002-02-19 |
AU8059298A (en) | 1998-12-30 |
US6113947A (en) | 2000-09-05 |
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