ATE273395T1 - Gen für die fettsäure-desaturase, besagtes gen enthaltender vektor, eine pflanze, in die besagtes gen eingebracht ist, und ein verfahren zur schaffung besagter pflanze - Google Patents
Gen für die fettsäure-desaturase, besagtes gen enthaltender vektor, eine pflanze, in die besagtes gen eingebracht ist, und ein verfahren zur schaffung besagter pflanzeInfo
- Publication number
- ATE273395T1 ATE273395T1 AT95904020T AT95904020T ATE273395T1 AT E273395 T1 ATE273395 T1 AT E273395T1 AT 95904020 T AT95904020 T AT 95904020T AT 95904020 T AT95904020 T AT 95904020T AT E273395 T1 ATE273395 T1 AT E273395T1
- Authority
- AT
- Austria
- Prior art keywords
- gene
- plant
- fatty acid
- creating
- vector containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19002—Acyl-[acyl-carrier-protein] desaturase (1.14.19.2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP35285893 | 1993-12-28 | ||
PCT/JP1994/002288 WO1995018222A1 (fr) | 1993-12-28 | 1994-12-28 | Gene pour acide gras-desaturase, vecteur contenant ledit gene, vegetal contenant ledit gene lui ayant ete transfere, et procede pour creer ledit vegetal |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE273395T1 true ATE273395T1 (de) | 2004-08-15 |
Family
ID=18426926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95904020T ATE273395T1 (de) | 1993-12-28 | 1994-12-28 | Gen für die fettsäure-desaturase, besagtes gen enthaltender vektor, eine pflanze, in die besagtes gen eingebracht ist, und ein verfahren zur schaffung besagter pflanze |
Country Status (15)
Country | Link |
---|---|
US (1) | US6043411A (de) |
EP (1) | EP0736598B1 (de) |
JP (1) | JP3313724B2 (de) |
KR (1) | KR100224120B1 (de) |
CN (2) | CN1108382C (de) |
AT (1) | ATE273395T1 (de) |
AU (1) | AU688834B2 (de) |
BR (1) | BR9408435A (de) |
CA (1) | CA2180154C (de) |
DE (1) | DE69433941T2 (de) |
ES (1) | ES2222462T3 (de) |
FI (1) | FI962664A (de) |
NO (1) | NO962727L (de) |
NZ (1) | NZ277562A (de) |
WO (1) | WO1995018222A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2332908B (en) * | 1996-10-31 | 2001-03-28 | Ca Nat Research Council | Flax promoter for manipulating gene expression |
CA2278923C (en) | 1997-01-24 | 2007-10-16 | Kirin Beer Kabushiki Kaisha | .beta.-ketoacyl-acp synthetase ii enzymes and genes coding for same |
US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
US6051754A (en) * | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
US6225528B1 (en) * | 1997-09-04 | 2001-05-01 | Rutgers, The State University Of New Jersey | Method of making pathogen-resistant plants by transformation with a fatty acid desaturase gene |
AU3367899A (en) * | 1998-03-30 | 1999-10-18 | Dow Agrosciences Llc | Modification of fatty acid composition in plants by expression of an (aspergillus nidulans) delta-9 coa desaturase |
DK1086236T3 (da) | 1998-06-12 | 2007-12-03 | Calgene Llc | Polyumættede fedtsyrer i planter |
DK1181373T3 (da) | 1999-06-07 | 2006-11-27 | Basf Plant Science Gmbh | Delta-6-acetylenase og delta-6-desaturase ud fra Ceratodon purpureus |
DE10030976A1 (de) | 2000-06-30 | 2002-01-10 | Basf Ag | DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren |
ES2331228T3 (es) | 2000-02-09 | 2009-12-28 | Basf Se | Nuevo gen de elongasa y proceso para la preparacion de acidos grasos poliinsaturados. |
DE10102337A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
DE10134660A1 (de) * | 2001-07-20 | 2003-02-06 | Basf Plant Science Gmbh | Fettsäure-Desaturase-Gene aus Granatapfel und Verfahren zur Herstellung von ungesättigten Fettsäuren |
DE50312241D1 (de) | 2002-01-30 | 2010-01-28 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter f |
GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
DE10219203A1 (de) | 2002-04-29 | 2003-11-13 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen |
EP2216405A1 (de) | 2002-05-03 | 2010-08-11 | Monsanto Technology LLC | Saatspezifische USP-Promotoren zur Expression von Genen in Pflanzen |
US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
WO2004057001A2 (en) * | 2002-12-19 | 2004-07-08 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
GB0229578D0 (en) * | 2002-12-19 | 2003-01-22 | Univ Bristol | Novel method for the production of polyunsaturated fatty acids |
WO2004076617A2 (de) | 2003-02-27 | 2004-09-10 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren |
EP1613730A4 (de) | 2003-03-28 | 2007-12-05 | Monsanto Technology Llc | Neue pflanzenpromotoren zur verwendung in der frühen samenentwicklungsphase |
CA2868312A1 (en) | 2003-03-31 | 2004-10-14 | University Of Bristol | Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
US7629503B2 (en) | 2003-04-08 | 2009-12-08 | Basf Plant Science Gmbh | Δ-4 desaturases from Euglena gracilis, expressing plants, and oils containing PUFA |
US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
BRPI0413073A (pt) | 2003-08-01 | 2006-10-03 | Basf Plant Science Gmbh | processo para a produção de compostos, óleo, lipìdeo ou ácido graxo, ou uma fração dos mesmos, composição de óleo, lipìdeo ou ácido graxo, processo para a produção de óleos, lipìdeos ou composições de ácido graxo, uso de óleo, lipìdeo ou ácidos graxos ou de composições de óleo, lipìdeo ou ácido graxo ou de óleos, lipìdeos ou composições de ácido graxo, seqüência de ácido nucleico isolado, seqüência de aminoácidos, construção de gene, vetor, e, organismo não humano transgênico |
ATE430802T1 (de) | 2003-08-21 | 2009-05-15 | Monsanto Technology Llc | Fettsäuredesaturasen aus primula |
CA2450000A1 (en) * | 2003-12-18 | 2005-06-18 | Alberta Research Council Inc. | Method of creating plants with reduced level of saturated fatty acid in seed oil |
MY140210A (en) * | 2003-12-22 | 2009-11-30 | Suntory Holdings Ltd | Marchantiales-derived unsaturated fatty acid synthetase genes and use of the same |
JP4567047B2 (ja) | 2004-02-27 | 2010-10-20 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | トランスジェニック植物における多価不飽和脂肪酸の製造方法 |
ATE528403T1 (de) * | 2004-02-27 | 2011-10-15 | Basf Plant Science Gmbh | Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen |
US8378186B2 (en) | 2004-04-16 | 2013-02-19 | Monsanto Technology Llc | Expression of fatty acid desaturases in corn |
US7364883B2 (en) | 2004-05-07 | 2008-04-29 | Yeastern Biotech Co., Ltd. | Process for producing poly-unsaturated fatty acids by oleaginous yeasts |
CA2583380C (en) | 2004-10-08 | 2016-08-02 | Dow Agrosciences Llc | Certain plants with no saturate or reduced saturate levels of fatty acids in seeds, and oil derived from the seeds |
US20090040249A1 (en) * | 2004-12-17 | 2009-02-12 | Agfa Graphics Nv | Ink Circulation System For Inkjet Printing |
DE102004063326A1 (de) * | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
BRPI0607378A2 (pt) | 2005-02-26 | 2010-03-23 | Basf Plant Science Gmbh | cassetes de expressço, seqÜÊncia nucleotÍdica isolada, vetor, cÉlula hospedeira transgÊnica ou organismo nço humano, cÉlula de planta ou planta transgÊnica, mÉtodos para identificar e/ou isolar uma seqÜÊncia nucleotÍdica reguladora da transcriÇço, para prover ou produzir um cassete de expressço transgÊnica, e para prover uma seqÜÊncia nucleotÍdica reguladora de transcriÇço sintÉtica, e, seqÜÊncia reguladora de transcriÇço sintÉtica |
EP2194140A2 (de) | 2005-03-02 | 2010-06-09 | Metanomics GmbH | Verfaheren zur Herstellung von Feinchemikalien |
DE102005013779A1 (de) | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen |
CN101198701B (zh) | 2005-04-19 | 2013-04-24 | 巴斯福植物科学有限公司 | 单子叶植物中的淀粉胚乳特异性和/或萌芽胚特异性表达 |
EP1874937A2 (de) | 2005-04-20 | 2008-01-09 | BASF Plant Science GmbH | Expressionskassetten zur saatbevorzugten expression in pflanzen |
WO2006120197A2 (en) | 2005-05-10 | 2006-11-16 | Basf Plant Science Gmbh | Expression cassettes for seed-preferential expression in plants |
CN1302110C (zh) * | 2005-06-23 | 2007-02-28 | 复旦大学 | 水稻Osfad8编码序列及其应用 |
DE102005038036A1 (de) * | 2005-08-09 | 2007-02-15 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen |
GB2431158A (en) | 2005-10-13 | 2007-04-18 | Rothamsted Res Ltd | Process for the production of arachidonic and/or eicosapentaenoic acid |
DE102005052551A1 (de) | 2005-11-02 | 2007-05-16 | Rothamsted Res Harpenden | Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae |
GB0603160D0 (en) | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
US8629195B2 (en) | 2006-04-08 | 2014-01-14 | Bayer Materialscience Ag | Production of polyurethane foams |
EP2041275B1 (de) | 2006-07-19 | 2011-05-04 | Monsanto Technology, LLC | Fettsäuredesaturasen aus tetraselmis suecica |
WO2008022963A2 (en) | 2006-08-24 | 2008-02-28 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
EP2054509A2 (de) | 2006-10-06 | 2009-05-06 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
US20110035840A1 (en) | 2007-02-16 | 2011-02-10 | Basf Plant Science Gmbh | Nucleic acid sequences for regulation of embryo-specific expression in monocotyledoneous plants |
EP2176416B1 (de) | 2007-07-31 | 2016-03-16 | BASF Plant Science GmbH | Elongasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
DE112008003237T5 (de) | 2007-12-14 | 2011-03-17 | Basf Plant Science Gmbh | Promotoren von Brassica napus für samenspezifische Genexpression |
EP2281051B1 (de) | 2008-04-30 | 2015-03-11 | Rothamsted Research Limited | Desaturase und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
CA2989798C (en) | 2008-07-01 | 2019-11-05 | Basf Plant Science Gmbh | Promoters from brassica napus for seed specific gene expression |
JP5757870B2 (ja) | 2008-08-26 | 2015-08-05 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | デサチュラーゼをコードする核酸および改変植物油 |
ES2435572T3 (es) | 2008-12-12 | 2013-12-20 | Basf Plant Science Gmbh | Desaturasas y proceso para la producción de ácidos grasos poliinsaturados en organismos transgénicos |
RU2561463C2 (ru) | 2009-04-22 | 2015-08-27 | Басф Плант Сайенс Компани Гмбх | Промотор целого семени |
US9212371B2 (en) | 2009-05-13 | 2015-12-15 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
EP2451958A1 (de) | 2009-07-10 | 2012-05-16 | BASF Plant Science Company GmbH | Expressionskassetten für nährgewebespezifische expression in pflanzen |
US20120240287A1 (en) | 2009-12-03 | 2012-09-20 | Basf Plant Science Company Gmbh | Expression Cassettes for Embryo-Specific Expression in Plants |
CA2804925A1 (en) | 2010-06-25 | 2011-12-29 | Basf Plant Science Company Gmbh | Acyltransferases from thraustochytrium species and uses thereof in fatty acid production |
CN104195169A (zh) * | 2014-08-29 | 2014-12-10 | 兰州理工大学 | 一种基于脂肪酸去饱和酶基因的抗寒转基因烟草的构建方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2077896C (en) * | 1990-03-16 | 2008-02-19 | Gregory A. Thompson | Plant desaturases - compositions and uses |
NL9002130A (nl) * | 1990-09-28 | 1992-04-16 | Stichting Tech Wetenschapp | Dna-sequentie die ten minste een deel van een gen coderend voor stearoyl-acp-desaturase omvat, alsmede toepassing van de dna-sequentie in een werkwijze voor het wijzigen van de vetzuurbiosynthese van een plant. |
CA2084348A1 (en) * | 1991-12-31 | 1993-07-01 | David F. Hildebrand | Fatty acid alteration by a d9 desaturase in transgenic plant tissue |
DK0561569T3 (da) * | 1992-03-13 | 2003-10-06 | Agrigenetics Inc | Modifikation af vegetabilske olier ved anvendelse af desaturase |
US5639645A (en) * | 1993-09-22 | 1997-06-17 | Mitsubishi Corporation | Recombinant Δ9 desaturase and a gene encoding the same |
-
1994
- 1994-12-28 BR BR9408435A patent/BR9408435A/pt not_active IP Right Cessation
- 1994-12-28 EP EP95904020A patent/EP0736598B1/de not_active Expired - Lifetime
- 1994-12-28 CN CN94195032A patent/CN1108382C/zh not_active Expired - Fee Related
- 1994-12-28 ES ES95904020T patent/ES2222462T3/es not_active Expired - Lifetime
- 1994-12-28 KR KR1019960703438A patent/KR100224120B1/ko not_active IP Right Cessation
- 1994-12-28 DE DE69433941T patent/DE69433941T2/de not_active Expired - Lifetime
- 1994-12-28 AU AU12837/95A patent/AU688834B2/en not_active Ceased
- 1994-12-28 CA CA002180154A patent/CA2180154C/en not_active Expired - Fee Related
- 1994-12-28 WO PCT/JP1994/002288 patent/WO1995018222A1/ja active IP Right Grant
- 1994-12-28 AT AT95904020T patent/ATE273395T1/de not_active IP Right Cessation
- 1994-12-28 US US08/663,082 patent/US6043411A/en not_active Expired - Fee Related
- 1994-12-28 JP JP51792895A patent/JP3313724B2/ja not_active Expired - Fee Related
- 1994-12-28 NZ NZ277562A patent/NZ277562A/en unknown
-
1996
- 1996-06-27 NO NO962727A patent/NO962727L/no not_active Application Discontinuation
- 1996-06-27 FI FI962664A patent/FI962664A/fi not_active Application Discontinuation
-
2001
- 2001-07-24 CN CN01123093.2A patent/CN1334340A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN1142853A (zh) | 1997-02-12 |
CA2180154C (en) | 2000-02-15 |
EP0736598B1 (de) | 2004-08-11 |
NO962727D0 (no) | 1996-06-27 |
EP0736598A4 (de) | 1998-05-06 |
FI962664A (fi) | 1996-08-26 |
NZ277562A (en) | 1997-12-19 |
NO962727L (no) | 1996-08-27 |
BR9408435A (pt) | 1997-08-05 |
DE69433941T2 (de) | 2005-07-28 |
AU688834B2 (en) | 1998-03-19 |
EP0736598A1 (de) | 1996-10-09 |
CN1334340A (zh) | 2002-02-06 |
KR100224120B1 (ko) | 1999-10-15 |
US6043411A (en) | 2000-03-28 |
CN1108382C (zh) | 2003-05-14 |
CA2180154A1 (en) | 1995-07-06 |
AU1283795A (en) | 1995-07-17 |
JP3313724B2 (ja) | 2002-08-12 |
WO1995018222A1 (fr) | 1995-07-06 |
DE69433941D1 (de) | 2004-09-16 |
FI962664A0 (fi) | 1996-06-27 |
ES2222462T3 (es) | 2005-02-01 |
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