ATE304601T1 - Verfahren zur herstellung von häm-enthaltende proteine durch pflanzenzellen, hergestellte proteine und diese enthaltende produkten - Google Patents

Verfahren zur herstellung von häm-enthaltende proteine durch pflanzenzellen, hergestellte proteine und diese enthaltende produkten

Info

Publication number
ATE304601T1
ATE304601T1 AT96925810T AT96925810T ATE304601T1 AT E304601 T1 ATE304601 T1 AT E304601T1 AT 96925810 T AT96925810 T AT 96925810T AT 96925810 T AT96925810 T AT 96925810T AT E304601 T1 ATE304601 T1 AT E304601T1
Authority
AT
Austria
Prior art keywords
protein
proteins
haemin
nucleic acid
plant cells
Prior art date
Application number
AT96925810T
Other languages
English (en)
Inventor
Bertrand Merot
Wilfrid Dieryck
Philippe Lenee
Michael Marden
Veronique Gruber
Renee-Josee Pagnier
Sylvie Baudino
Claude Poyart
Original Assignee
Meristem Therapeutics
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meristem Therapeutics, Inst Nat Sante Rech Med filed Critical Meristem Therapeutics
Application granted granted Critical
Publication of ATE304601T1 publication Critical patent/ATE304601T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96925810T 1995-07-17 1996-07-17 Verfahren zur herstellung von häm-enthaltende proteine durch pflanzenzellen, hergestellte proteine und diese enthaltende produkten ATE304601T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9508615A FR2736930B1 (fr) 1995-07-17 1995-07-17 Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
PCT/FR1996/001123 WO1997004115A2 (fr) 1995-07-17 1996-07-17 Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines

Publications (1)

Publication Number Publication Date
ATE304601T1 true ATE304601T1 (de) 2005-09-15

Family

ID=9481043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96925810T ATE304601T1 (de) 1995-07-17 1996-07-17 Verfahren zur herstellung von häm-enthaltende proteine durch pflanzenzellen, hergestellte proteine und diese enthaltende produkten

Country Status (7)

Country Link
US (2) US6344600B1 (de)
EP (1) EP0839204B1 (de)
AT (1) ATE304601T1 (de)
AU (1) AU6619096A (de)
DE (1) DE69635186T2 (de)
FR (1) FR2736930B1 (de)
WO (1) WO1997004115A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
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FR2736930B1 (fr) * 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
FR2762850B1 (fr) * 1997-05-02 2000-02-11 Biocem Lactoferrines recombinantes, leurs procedes de production par les plantes ainsi que leurs utilisations
CA2344269A1 (en) * 1998-10-07 2000-04-13 Syngenta Participations Ag Therapeutically active proteins in plants
AU771908C (en) 1998-12-09 2005-03-10 Phyton Holdings, Llc A method for manufacturing glycoproteins having human-type glycosylation
IL149271A0 (en) * 1999-10-26 2002-11-10 Plant Res Int Bv Mammalian-type glycosylation in plants
US7304208B2 (en) * 2000-05-02 2007-12-04 Ventria Bioscience Expression of human serum albumin (HSA) in monocot seeds
ES2275736T3 (es) * 2000-09-12 2007-06-16 Filligent Limited Filtro para humo de tabaco.
GB0025225D0 (en) * 2000-10-14 2000-11-29 Cambridge Advanced Tech Plant cell death system
ZA200306406B (en) 2001-01-19 2004-09-06 Dow Chemical Co Method for secretory production of glycoprotein having human-type sugar chain using plant cell.
CN1541059A (zh) * 2001-03-06 2004-10-27 �Ϻ���ͨ��ѧ 具有动物型糖链加成功能的植物细胞
KR20040029122A (ko) * 2001-08-27 2004-04-03 신젠타 파티서페이션즈 아게 자가-프로세싱 식물 및 식물 부분
NZ534881A (en) 2002-03-19 2006-09-29 Plant Res Internat B Mammalian GnTIII expression in plants
KR101196023B1 (ko) 2002-03-19 2012-10-30 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서 글리칸 프로세싱의 최적화
CL2003002461A1 (es) * 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
EP1651760A4 (de) * 2003-04-11 2006-10-18 Ventria Bioscience In monokotyledonensamen exprimierte proteine aus menschlichem blut
SI2277996T1 (sl) 2003-05-21 2014-12-31 Genzyme Corporation Postopki za izdelavo pripravkov rekombinantnih AAV virionov v bistvu brez praznih kapsid
WO2005056578A2 (en) * 2003-12-09 2005-06-23 Ventria Bioscience High-level expression of fusion polypeptides in plant seeds utilizing seed-storage proteins as fusion carriers
AU2003297781A1 (en) * 2003-12-23 2005-08-03 Ventria Bioscience Methods of expressing heterologous protein in plant seeds using monocot non seed-storage protein promoters
AU2008237632B2 (en) 2007-04-17 2014-01-16 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
US9567382B2 (en) 2008-04-15 2017-02-14 Genzyme Corporation Methods to produce rod-derived cone viability factor (RdCVF)
DK3044320T3 (da) * 2013-09-11 2020-03-16 Impossible Foods Inc Sekretion af hæmholdige polypeptider
PT3294762T (pt) 2015-05-11 2022-03-21 Impossible Foods Inc Constructos de expressão e métodos de modificar geneticamente levedura metilotrófica
WO2018102721A1 (en) * 2016-12-02 2018-06-07 City Of Hope Transgenic plants with upregulated heme biosynthesis
EP3684389A4 (de) 2017-09-21 2021-06-16 Dana Farber Cancer Institute, Inc. Isolierung, konservierung, zusammensetzungen und verwendungen von extrakten aus justicia-pflanzen
BR112021021154A2 (pt) 2019-04-25 2021-12-14 Impossible Foods Inc Cepas e métodos para produção de proteínas que contêm heme
US20230380373A1 (en) * 2020-10-28 2023-11-30 Pioneer Hi-Bred International, Inc. Leghemoglobin in soybean
EP4323530A1 (de) * 2021-04-13 2024-02-21 Kyomei Ltd. Transgene pflanzen mit myoglobin und verfahren zur herstellung von myoglobin in transgenen pflanzen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8605621D0 (sv) * 1986-12-30 1986-12-30 Biokonsult Ab Heteromultimeric proteins and their manufacture
US5316931A (en) * 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US5202422A (en) * 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
ATE119917T1 (de) * 1990-11-29 1995-04-15 Upjohn Co Mit imidoester quer-vernetzte hämoglobinzusammensetzungen.
DK0596979T3 (da) * 1991-08-01 2002-05-13 Large Scale Biology Corp Rekombinante nucleinsyrer fra plantevirus
WO1993008831A1 (en) * 1991-10-30 1993-05-13 Strohtech, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
WO1993025697A1 (en) * 1992-06-15 1993-12-23 California Institute Of Technology Enhancement of cell growth by expression of cloned oxygen-binding proteins
EP0693924B2 (de) * 1993-02-22 2008-04-09 Abraxis BioScience, Inc. Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen
US5521852A (en) * 1993-10-29 1996-05-28 Holophane Lighting, Inc. Method and system for designing lighting installations
FR2736930B1 (fr) * 1995-07-17 1997-09-19 Biocem Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines
US5959187A (en) * 1996-09-26 1999-09-28 Bailey; James E. Expression of oxygen-binding proteins in plants

Also Published As

Publication number Publication date
EP0839204A2 (de) 1998-05-06
US20020194643A1 (en) 2002-12-19
WO1997004115A2 (fr) 1997-02-06
AU6619096A (en) 1997-02-18
WO1997004115A3 (fr) 1997-02-27
FR2736930B1 (fr) 1997-09-19
US6344600B1 (en) 2002-02-05
US6916787B2 (en) 2005-07-12
DE69635186T2 (de) 2006-06-29
FR2736930A1 (fr) 1997-01-24
EP0839204B1 (de) 2005-09-14
DE69635186D1 (de) 2005-10-20

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