ATE181361T1 - Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie - Google Patents
Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämieInfo
- Publication number
- ATE181361T1 ATE181361T1 AT95932544T AT95932544T ATE181361T1 AT E181361 T1 ATE181361 T1 AT E181361T1 AT 95932544 T AT95932544 T AT 95932544T AT 95932544 T AT95932544 T AT 95932544T AT E181361 T1 ATE181361 T1 AT E181361T1
- Authority
- AT
- Austria
- Prior art keywords
- sickle cell
- globin
- composition
- cell anemia
- treating sickle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30879594A | 1994-09-19 | 1994-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE181361T1 true ATE181361T1 (de) | 1999-07-15 |
Family
ID=23195426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95932544T ATE181361T1 (de) | 1994-09-19 | 1995-09-19 | Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie |
Country Status (8)
Country | Link |
---|---|
US (2) | US5861488A (de) |
EP (1) | EP0783575B1 (de) |
JP (1) | JPH10509027A (de) |
AT (1) | ATE181361T1 (de) |
CA (1) | CA2199832C (de) |
DE (1) | DE69510356D1 (de) |
GR (1) | GR3031229T3 (de) |
WO (1) | WO1996009385A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5853975A (en) | 1994-08-23 | 1998-12-29 | Millennium Pharmaceuticals, Inc. | Methods for identifying compositions for the treatment of body weight disorders, including obesity |
WO1996009385A1 (en) * | 1994-09-19 | 1996-03-28 | Massachusetts Institute Of Technology | Anti-sickling beta-globin protein, compositions and methods for treating sickle cell disease |
ATE474460T1 (de) | 2002-12-13 | 2010-08-15 | Genetix Pharmaceuticals Inc | Therapeutische retrovirus-vektoren für gentherapie |
WO2010012002A1 (en) * | 2008-07-25 | 2010-01-28 | Saryna Medical Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
US9783822B2 (en) | 2011-09-23 | 2017-10-10 | Bluebird Bio, Inc. | Gene therapy methods |
UA114796C2 (uk) | 2011-09-30 | 2017-08-10 | Блубьод Байо, Інк. | Спосіб підвищення ефективності трансдукції |
GB201322798D0 (en) | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
US10543257B2 (en) | 2014-09-11 | 2020-01-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lentiviral vector for treating hemoglobin disorders |
EP3356520B1 (de) | 2015-10-02 | 2022-03-23 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Lentivirales protein übertragungssystem zum rna-vermittelten genomeditieren |
RU2021103425A (ru) | 2016-02-12 | 2021-02-25 | Блубёрд Био, Инк. | Композиции, повышающие число копий вектора (чкв), и способы их применения |
CN108883136A (zh) | 2016-02-12 | 2018-11-23 | 蓝鸟生物公司 | Vcn增强子组合物及其使用方法 |
US20230002777A1 (en) | 2019-11-12 | 2023-01-05 | Oxford Biomedica (Uk) Limited | Production System |
WO2023003844A1 (en) | 2021-07-19 | 2023-01-26 | 2Seventy Bio, Inc. | Vector manufacturing processes |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2779192B2 (ja) * | 1987-09-17 | 1998-07-23 | マサチユセツツ・インスチチユート・オブ・テクノロジー | ヒト赤血球特異的転写エンハンサー |
US5239061A (en) * | 1990-06-20 | 1993-08-24 | Research Corporation Technologies, Inc. | Modified human hemoglobin, blood substitutes containing the same, and vectors for expressing the modified hemoglobin |
US5631162A (en) * | 1993-06-11 | 1997-05-20 | Massachusetts Institute Of Technology | Retroviral vectors for transducing β-globin gene and β-locus control region derivatives |
CA2165679A1 (en) * | 1993-06-21 | 1995-01-05 | Tim M. Townes | Anti-sickling hemoglobin |
WO1996009385A1 (en) * | 1994-09-19 | 1996-03-28 | Massachusetts Institute Of Technology | Anti-sickling beta-globin protein, compositions and methods for treating sickle cell disease |
-
1995
- 1995-09-19 WO PCT/US1995/011873 patent/WO1996009385A1/en active IP Right Grant
- 1995-09-19 AT AT95932544T patent/ATE181361T1/de not_active IP Right Cessation
- 1995-09-19 DE DE69510356T patent/DE69510356D1/de not_active Expired - Lifetime
- 1995-09-19 EP EP95932544A patent/EP0783575B1/de not_active Expired - Lifetime
- 1995-09-19 JP JP8511019A patent/JPH10509027A/ja active Pending
- 1995-09-19 CA CA002199832A patent/CA2199832C/en not_active Expired - Lifetime
-
1997
- 1997-09-23 US US08/935,648 patent/US5861488A/en not_active Expired - Lifetime
-
1999
- 1999-01-19 US US09/234,009 patent/US6051402A/en not_active Expired - Lifetime
- 1999-09-16 GR GR990402320T patent/GR3031229T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69510356D1 (de) | 1999-07-22 |
EP0783575B1 (de) | 1999-06-16 |
US6051402A (en) | 2000-04-18 |
WO1996009385A1 (en) | 1996-03-28 |
CA2199832A1 (en) | 1996-03-28 |
GR3031229T3 (en) | 1999-12-31 |
JPH10509027A (ja) | 1998-09-08 |
EP0783575A1 (de) | 1997-07-16 |
CA2199832C (en) | 2000-08-01 |
US5861488A (en) | 1999-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE181361T1 (de) | Anti-sickling beta-globin,zusammensetzung und verfahren zur behandlung von sichelzellanämie | |
DE59611371D1 (de) | Verfahren zur Herstellung von Erythropoietin frei von tierischen Proteinen | |
ATE266723T1 (de) | Lösung die chaotropische mittel enthält und verwendung dieser lösung in verfahren zur isolierung von dna, rna und proteinen | |
DE69430990T2 (de) | Zusammensetzung und methode zur anreicherung von weissen blutzellen aus menschlichem vollblut | |
EA200100502A1 (ru) | СПОСОБЫ И КОМПОЗИЦИЯ ДЛЯ ВОССТАНОВЛЕНИЯ КОНФОРМАЦИОННОЙ СТАБИЛЬНОСТИ БЕЛКА СЕМЕЙСТВА p53 | |
NO963742L (no) | Fremgangsmåte til å stimulere hematopoese med hemaglobin | |
DE3280479T2 (de) | Rekombinante DNS-Mittel und Verfahren | |
ATE257392T1 (de) | Verfahren zur modulierung der neovaskularisierung und/oder des wachstums von kollateraler arterien und / oder anderer arterien aus bestehenden arteriolären verbindungen | |
DE69927507D1 (de) | Zusammensetzungen und verfahren zur behandlung von abnormaler zellvermehrung | |
ATE342278T1 (de) | Verfahren zur behandlung von diabetes mittels kgf | |
ATE59962T1 (de) | Thrombin bindender stoff und verfahren zu seiner herstellung. | |
PT84089A (en) | Dna sequences coding for proteins having the biological activity of husi-type i inhibitors biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins | |
ATE414417T1 (de) | Translations-kontrollelemente für proteinexpression mit hoher ausbeute in den plastiden von höheren pflanzen und verfahren zu deren verwendung | |
ES2113878T3 (es) | Proteina c hibrida. | |
ATE232399T1 (de) | Verfahren zur modulierung des wachstums kollateraler arterien und / oder anderer arterien aus bestehenden arteriolen verbindungen | |
ATE251886T1 (de) | Verwendunf von apoe zum binden von tau und map2c proteinen und zur behandlung von alzheimer's krankheit | |
DE60102147D1 (de) | Anti-gefrier proteine, deren herstellung und verwendung | |
DE69835813D1 (de) | Verfahren zur kultivierung von zellen und zur vermehrung von viren | |
DE19781038T1 (de) | Keratinozytenwachstumsfaktor-2-Produkte | |
ATE233321T1 (de) | Verbesserungen in der herstellung von proteinen in wirtszellen | |
ATE419348T1 (de) | Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten | |
DE3485773T2 (de) | Aus kultivierten mesenchymzellen extrahierte makromolekuele zur behandlung von degenerationskrankheiten. | |
UA10281C2 (uk) | Спосіб отримання речовини для лікування захворювань підшлункової залози |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |