ATE260294T1 - Extrakorporales verfahren zur entfernung von endotoxin - Google Patents
Extrakorporales verfahren zur entfernung von endotoxinInfo
- Publication number
- ATE260294T1 ATE260294T1 AT00960909T AT00960909T ATE260294T1 AT E260294 T1 ATE260294 T1 AT E260294T1 AT 00960909 T AT00960909 T AT 00960909T AT 00960909 T AT00960909 T AT 00960909T AT E260294 T1 ATE260294 T1 AT E260294T1
- Authority
- AT
- Austria
- Prior art keywords
- endotoxin
- blood
- oligopeptides
- adsorption
- extracorporal
- Prior art date
Links
- 239000002158 endotoxin Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 3
- 108010038807 Oligopeptides Proteins 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 238000001179 sorption measurement Methods 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000002635 electroconvulsive therapy Methods 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000006068 polycondensation reaction Methods 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0081—After-treatment of organic or inorganic membranes
- B01D67/0093—Chemical modification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0017—Filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Water Supply & Treatment (AREA)
- Biophysics (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Manufacturing & Machinery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- External Artificial Organs (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15664999P | 1999-09-29 | 1999-09-29 | |
| US09/677,375 US6774102B1 (en) | 1999-09-29 | 2000-09-15 | Extracorporeal endotoxin removal method |
| PCT/IB2000/001364 WO2001023413A1 (en) | 1999-09-29 | 2000-09-26 | Extracorporeal endotoxin removal method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE260294T1 true ATE260294T1 (de) | 2004-03-15 |
Family
ID=26853386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00960909T ATE260294T1 (de) | 1999-09-29 | 2000-09-26 | Extrakorporales verfahren zur entfernung von endotoxin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6774102B1 (de) |
| EP (1) | EP1220868B1 (de) |
| JP (1) | JP4709452B2 (de) |
| AT (1) | ATE260294T1 (de) |
| CA (1) | CA2383955C (de) |
| DE (1) | DE60008565T2 (de) |
| ES (1) | ES2213604T3 (de) |
| WO (1) | WO2001023413A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8197430B1 (en) * | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
| US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
| JP4945876B2 (ja) * | 2000-04-05 | 2012-06-06 | 東レ株式会社 | ハイモビリティーグループタンパクの吸着材および体液浄化カラム |
| EP1575507A2 (de) * | 2002-04-02 | 2005-09-21 | Scantibodies Laboratory, Inc. | Verfahren und vorrichtungen zur behandlung von schweren peripheren bakteriellen infektionen |
| SE0201257D0 (sv) * | 2002-04-25 | 2002-04-25 | Medical Invest In Sweden Ab | Improved Separation |
| AU2008201015B2 (en) * | 2002-04-25 | 2008-11-13 | Alteco Medical Ab | Improved separation |
| SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
| US6803183B2 (en) | 2002-07-18 | 2004-10-12 | Clarigen, Inc. | Method for removing pyrogens from plasma and blood for treatment of septic shock |
| FR2848223B1 (fr) * | 2002-12-09 | 2005-02-25 | Centre Nat Rech Scient | Nouveau procede d'isolement des endotoxines. |
| EP1518870B1 (de) * | 2003-09-17 | 2018-11-28 | Gambro Lundia AB | Trennungsmaterial |
| WO2005026224A1 (en) * | 2003-09-17 | 2005-03-24 | Gambro Lundia Ab | Separating material |
| US20050103712A1 (en) * | 2003-11-13 | 2005-05-19 | Voyce Brian D. | Methods and devices for treating severe peripheral bacterial infections |
| SI1949915T1 (sl) * | 2004-04-30 | 2012-12-31 | Biopheresis Technologies, Inc. | Postopek in sistem za odstranitev topnih TNFR1, TNFR2 in IL2R pri pacientih |
| US20050287515A1 (en) * | 2004-06-24 | 2005-12-29 | Reinhold Deppisch | Removal of bacterial DNA from therapeutic fluid formulations |
| CL2007002615A1 (es) * | 2006-09-08 | 2008-04-18 | Wyeth Corp | Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto. |
| GB0621452D0 (en) * | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Therapy for liver disease |
| GB0621454D0 (en) | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Goal directed therapy for liver failure |
| PT2115010E (pt) * | 2007-02-28 | 2012-03-09 | Lipoxen Technologies Ltd | Redução de endotoxinas em ácidos polisiálicos |
| GB0800228D0 (en) * | 2008-01-07 | 2008-02-13 | Novartis Ag | Lipopolysaccharide decontamination |
| EP2707055B1 (de) | 2011-05-09 | 2019-10-23 | The University of Miami | Verminderung des löslichen urokinase-rezeptors im blutkreislauf |
| CN117138146A (zh) | 2017-09-18 | 2023-12-01 | 圣特萨斯股份公司 | 用于针对循环无细胞dna纯化血液的方法和装置 |
| GB202004775D0 (en) | 2020-03-31 | 2020-05-13 | Ucl Business Ltd | Apparatus |
| WO2022071849A1 (en) | 2020-10-01 | 2022-04-07 | Alteco Medical Ab | Matrices for selective binding of at least one component from a body fluid |
| AU2021386427A1 (en) | 2020-11-30 | 2023-07-20 | Alteco Medical Ab | Device for binding and separation of at least one component from a body fluid |
| EP4378578A1 (de) | 2021-07-29 | 2024-06-05 | Japan Hemotech Co., Ltd. | Vliesstoffsubstrat, fasermaterial zur flüssigkeitsklärung, herstellungsverfahren für dieses material und reiniger mit diesem material |
| GB202307837D0 (en) | 2023-05-25 | 2023-07-12 | Yaqrit Ltd | Dialysis method |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5670028A (en) | 1979-11-12 | 1981-06-11 | Teijin Ltd | Polymer bonding with albumin |
| CA1204667A (en) | 1982-10-04 | 1986-05-20 | Masashi Kodama | Blood treating material |
| JPH0738880B2 (ja) | 1983-06-24 | 1995-05-01 | 東レ株式会社 | エンドトキシン血症治療剤 |
| WO1987005904A1 (en) * | 1986-03-24 | 1987-10-08 | The University Of Sydney | Antigenic analogues of platelet activating factor (paf) |
| SE468881B (sv) | 1991-01-09 | 1993-04-05 | Kabi Pharmacia Ab | Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar |
| DE4110730A1 (de) | 1991-04-03 | 1992-10-15 | Fresenius Ag | Vorrichtung zur auftrennung von zumindest zwei biologischen stoffen in loesung durch adsorption |
| GB9215780D0 (en) * | 1992-07-24 | 1992-09-09 | Univ London Pharmacy | Peptide compounds |
| WO1994002225A1 (en) * | 1992-07-27 | 1994-02-03 | Terrapin Technologies, Inc. | Sorbent families |
| US5780594A (en) * | 1993-03-01 | 1998-07-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Biologically active protein fragments containing specific binding regions of serum albumin or related proteins |
| WO1995000540A1 (en) * | 1993-06-18 | 1995-01-05 | Robert Webber | Synthetic carrier and immunogen |
| WO1995005393A2 (en) | 1993-08-18 | 1995-02-23 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Lipopolysaccharide-binding and neutralizing peptides |
| EP0800862B1 (de) | 1994-12-26 | 2002-02-27 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adsorbent für endotoxine, tumor nekrose faktor-alpha oder interleukine, methode zur entfernung mittels adsorption sowie adsorber |
| US6376655B1 (en) | 1995-06-02 | 2002-04-23 | Riso National Laboratory | Physically functional materials |
| WO1996041185A1 (en) | 1995-06-07 | 1996-12-19 | Perseptive Biosystems, Inc. | Methods and compositions for binding endotoxins |
| ES2234183T3 (es) | 1996-02-06 | 2005-06-16 | Bellco S.P.A. | Separacion por absorcion de citoquinas de un paciente afectado por el fallo agudo de un organo. |
| DE19609479A1 (de) * | 1996-03-11 | 1997-09-18 | Biotechnolog Forschung Gmbh | Endotoxin-spezifische Membranen |
| EP0884327B1 (de) * | 1997-06-11 | 2001-03-14 | The School Of Pharmacy, University Of London | Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung |
| DE19740770A1 (de) * | 1997-09-17 | 1999-03-18 | Biotechnolog Forschung Gmbh | Mikrofiltrationsfilterschicht sowie deren Verwendung |
| JP4625180B2 (ja) * | 1998-03-11 | 2011-02-02 | センサーズ・フォー・メディシン・アンド・サイエンス・インコーポレイテッド | 被分析物の蛍光ランタニドキレートによる検出 |
-
2000
- 2000-09-15 US US09/677,375 patent/US6774102B1/en not_active Expired - Lifetime
- 2000-09-26 ES ES00960909T patent/ES2213604T3/es not_active Expired - Lifetime
- 2000-09-26 DE DE60008565T patent/DE60008565T2/de not_active Expired - Lifetime
- 2000-09-26 CA CA2383955A patent/CA2383955C/en not_active Expired - Fee Related
- 2000-09-26 WO PCT/IB2000/001364 patent/WO2001023413A1/en active IP Right Grant
- 2000-09-26 JP JP2001526563A patent/JP4709452B2/ja not_active Expired - Lifetime
- 2000-09-26 AT AT00960909T patent/ATE260294T1/de not_active IP Right Cessation
- 2000-09-26 EP EP00960909A patent/EP1220868B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1220868B1 (de) | 2004-02-25 |
| ES2213604T3 (es) | 2004-09-01 |
| CA2383955C (en) | 2010-10-12 |
| EP1220868A1 (de) | 2002-07-10 |
| DE60008565T2 (de) | 2004-12-16 |
| JP2003511354A (ja) | 2003-03-25 |
| WO2001023413A1 (en) | 2001-04-05 |
| DE60008565D1 (de) | 2004-04-01 |
| US6774102B1 (en) | 2004-08-10 |
| CA2383955A1 (en) | 2001-04-05 |
| JP4709452B2 (ja) | 2011-06-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE260294T1 (de) | Extrakorporales verfahren zur entfernung von endotoxin | |
| DE69533855D1 (de) | UNTERBRECHUNG DER BINDUNG DER PROTEINE MDM2 UND p53 UND ENTSPRECHENDE THERAPEUTISCHE ANWENDUNG | |
| EA200100050A1 (ru) | Метод удаления бета-2 микроглобулина из крови | |
| DE69718150D1 (de) | Peptid-immunogene zur schutzimpfung gegen und behandlung von allergien | |
| WO2003044053A3 (en) | Peptides effective in the treatment of tumors and other conditions requiring the removal or destruction of cells | |
| WO2003035695A3 (en) | Agents that activate or inhibit toll-like receptor 9 | |
| ATE231549T1 (de) | Verfahren zur konservierung von infektiösen rekombinierenden viren, virale wässrige suspension und ihre medizinische verwendung | |
| ATE195891T1 (de) | Sorbentmittel und dessen herstellungsverfahren | |
| EA200400205A1 (ru) | Пептиды, эффективные в лечении опухолей и других заболеваний, требующих удаления или разрушения клеток | |
| ATE283071T1 (de) | Adsorbentien und geräte zur verminderung von kleinen organischen verbindungen aus blutprodukten | |
| WO2002097030A3 (en) | Peptides derived from neural thread proteins and their medical use | |
| DE60038851D1 (de) | Verfahren zur Herstellung von vernetzten organischen Partikeln und Suspensionen | |
| CA2026717A1 (en) | Absorbent for the removal of biomacromolecules such as ldl and endotoxins from whole blood in extracorporeal circuits | |
| DE69534325D1 (de) | Peptide zur behandlung von krebs | |
| ES2269238T3 (es) | Procedimiento para la produccion de un adsorbente para disminuir la concentracion de fibrinogeno y/o de fibrina, adsorbente y su uso en la produccion de un adsorbedor. | |
| ATE299371T1 (de) | Antikonvulsiva zur behandlung von autismus | |
| JPH0436300A (ja) | 変性ｌｄｌの吸着体およびそれを用いる変性ｌｄｌの除去装置 | |
| DE69934057D1 (de) | Verfahren zur Behandlung von Alkylamino (Meth)Acrylaten | |
| DE29716635U1 (de) | Distraktionsvorrichtung zur Behandlung von Knochendefekten | |
| DE69737202D1 (de) | Thrombolytische substanzen mit antithrombotische aktivität | |
| ATE255594T1 (de) | Hepatitis b inhibitoren | |
| WO2022004707A1 (ja) | ＳＡＲＳ－ＣｏＶ－２吸着担体およびそれを含むカラム | |
| ATE196424T1 (de) | Methode und zusammensetzung zur behandlung von herpes ähnlichen krankheiten | |
| JPH0640899B2 (ja) | 吸着体の製造法 | |
| JPH06218051A (ja) | Ｃｄ４陽性細胞捕集材 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |