CA2026717A1 - Absorbent for the removal of biomacromolecules such as ldl and endotoxins from whole blood in extracorporeal circuits - Google Patents

Absorbent for the removal of biomacromolecules such as ldl and endotoxins from whole blood in extracorporeal circuits

Info

Publication number
CA2026717A1
CA2026717A1 CA2026717A CA2026717A CA2026717A1 CA 2026717 A1 CA2026717 A1 CA 2026717A1 CA 2026717 A CA2026717 A CA 2026717A CA 2026717 A CA2026717 A CA 2026717A CA 2026717 A1 CA2026717 A1 CA 2026717A1
Authority
CA
Canada
Prior art keywords
biomacromolecules
absorbent
whole blood
ldl
endotoxins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2026717A
Other languages
French (fr)
Other versions
CA2026717C (en
Inventor
Veit Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius SE and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6390742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2026717(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fresenius SE and Co KGaA filed Critical Fresenius SE and Co KGaA
Publication of CA2026717A1 publication Critical patent/CA2026717A1/en
Application granted granted Critical
Publication of CA2026717C publication Critical patent/CA2026717C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/264—Synthetic macromolecular compounds derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B01J20/28019—Spherical, ellipsoidal or cylindrical
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3092—Packing of a container, e.g. packing a cartridge or column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/327—Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)

Abstract

A material for the elimination of biomacromolecules, in particular LDL and ignotoxins from a whole blood circuit, comprising an absorbent, comprising a porous carrier material of a homo-, co-, or terpolymerizate of acrylic acid and/or methacrylic acid with a particle range of between 50 and 250 mmol and an exclusion level of at least 5 x 10 5 daltons, as well as organic ligands which are covalently bound to the carrier material via a spacer, wherein the carrier material has a spherical shape and suitably, the spacer contains no double bonds.
CA002026717A 1989-10-03 1990-10-02 Absorbent for the removal of biomacromolecules such as ldl and endotoxins from whole blood in extracorporeal circuits Expired - Lifetime CA2026717C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3932971A DE3932971C2 (en) 1989-10-03 1989-10-03 Adsorbent suitable for the elimination of biomacromolecules, especially LDL and endotoxins, from whole blood in an extracorporeal circuit
DEP3932971.2 1989-10-03

Publications (2)

Publication Number Publication Date
CA2026717A1 true CA2026717A1 (en) 1991-04-04
CA2026717C CA2026717C (en) 2000-01-25

Family

ID=6390742

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002026717A Expired - Lifetime CA2026717C (en) 1989-10-03 1990-10-02 Absorbent for the removal of biomacromolecules such as ldl and endotoxins from whole blood in extracorporeal circuits

Country Status (6)

Country Link
EP (1) EP0424698B1 (en)
JP (1) JP3100974B2 (en)
AT (1) ATE146700T1 (en)
CA (1) CA2026717C (en)
DE (2) DE3932971C2 (en)
ES (1) ES2098237T3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763348B2 (en) 1997-01-07 2010-07-27 Kaneka Corporation Cellulosic particles, spherical object comprising cross-linked polymer particles, and adsorbent for body fluid purification

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4331358A1 (en) * 1992-10-12 1994-04-14 Braun Melsungen Ag Process for the quantitative selective removal or preparation of tumor necrosis factor (TNF) and / or lipopolysaccharides (LPS) from aqueous liquids
DE4300412A1 (en) * 1993-01-09 1994-07-14 Behringwerke Ag Hydrophobic adsorbents and their use for the absorption of lipoproteins
DE4435612A1 (en) * 1994-10-05 1996-04-11 Braun Melsungen Ag Process for the simultaneous removal of tumor necrosis factor alpha and bacterial lipopolysaccharides from an aqueous liquid
DE19507580A1 (en) * 1995-03-04 1995-08-31 Gerd Heim Autologous blood collection and re:infusion appts. with expanding bellow
DE19740770A1 (en) * 1997-09-17 1999-03-18 Biotechnolog Forschung Gmbh Microfiltration layer for removing endotoxins from liquids
DE19856387B4 (en) * 1998-12-07 2004-12-23 Fresenius Ag Process for producing an adsorber material, adsorber material produced thereafter and its use
DE10011481A1 (en) * 2000-03-09 2001-10-18 Fresenius Hemocare Gmbh Adsorbent for lowering the concentration of fibrinogen and / or fibrin, use of the adsorbent for the production of an adsorber and adsorber with the adsorbent
DE10011482B4 (en) * 2000-03-09 2004-06-09 Fresenius Hemocare Gmbh Process for producing an adsorbent for lowering the concentration of fibrinogen and / or fibrin, adsorbent and use of the adsorbent for producing an adsorber
DE10116042A1 (en) * 2001-03-30 2002-10-24 Fresenius Hemocare Gmbh Exotoxin ligand
SE0201257D0 (en) 2002-04-25 2002-04-25 Medical Invest In Sweden Ab Improved Separation
AU2008201015B2 (en) * 2002-04-25 2008-11-13 Alteco Medical Ab Improved separation
US6803183B2 (en) 2002-07-18 2004-10-12 Clarigen, Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
JP4226050B1 (en) * 2007-09-12 2009-02-18 株式会社Ｒｅｉメディカル Absorption column for body fluid purification treatment
AT507846B1 (en) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh SORPTION FOR ENDOTOXINES
DE102009034150A1 (en) 2009-07-20 2011-01-27 Fresenius Medical Care Deutschland Gmbh Adsorbent for the adsorption of hepcidin
JP5673894B2 (en) * 2012-07-20 2015-02-18 Dic株式会社 Sugar chain-immobilized hydrophilic resin compound, polymer substrate for virus removal, and biocompatible material
DE102012020497A1 (en) 2012-10-18 2014-04-24 Fresenius Medical Care Adsorber Tec GmbH Performing extracorporeal depletion of calcium ions in blood useful for treating blood, involves processing blood, preferably whole blood using cation exchanger
JP6621414B2 (en) * 2014-01-30 2019-12-18 フレゼニウス・ヘモケア・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータＦＲＥＳＥＮＩＵＳ ＨＥＭＯＣＡＲＥ ＩＴＡＬＩＡ Ｓ．ｒ．ｌ． Filtration device
DE102016208024A1 (en) 2016-05-10 2017-11-16 B. Braun Avitum Ag Adsorber material for the prevention or treatment of severe disease of infectious diseases
JP7741628B2 (en) * 2020-11-16 2025-09-18 ナガセケムテックス株式会社 Adsorbent for low density lipoprotein and/or very low density lipoprotein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5810055A (en) * 1981-07-09 1983-01-20 旭化成株式会社 Manufacturing method of immunoadsorber
JPS5810056A (en) * 1981-07-10 1983-01-20 株式会社クラレ Blood purifying apparatus
JPS5854959A (en) * 1981-09-25 1983-04-01 旭化成株式会社 Production of immune adsorbing apparatus
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
DE3480177D1 (en) * 1983-11-25 1989-11-23 Asahi Chemical Ind A porous adsorbent for adsorbing low density lipoproteins
JPH0655223B2 (en) * 1986-05-06 1994-07-27 宇部興産株式会社 Non-biological adsorbent
JP2568846B2 (en) * 1987-05-18 1997-01-08 旭メディカル株式会社 Myoglobin adsorbent
JPH02286173A (en) * 1989-04-26 1990-11-26 Terumo Corp Adsorbent and adsorbing device for bilirubin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763348B2 (en) 1997-01-07 2010-07-27 Kaneka Corporation Cellulosic particles, spherical object comprising cross-linked polymer particles, and adsorbent for body fluid purification

Also Published As

Publication number Publication date
EP0424698A1 (en) 1991-05-02
ATE146700T1 (en) 1997-01-15
DE59010619D1 (en) 1997-02-06
CA2026717C (en) 2000-01-25
ES2098237T3 (en) 1997-05-01
DE3932971A1 (en) 1991-04-11
EP0424698B1 (en) 1996-12-27
JPH03254756A (en) 1991-11-13
JP3100974B2 (en) 2000-10-23
DE3932971C2 (en) 2003-03-13

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