WO1997038726A3 - Hydrophobic carbomer complex compositions - Google Patents

Hydrophobic carbomer complex compositions Download PDF

Info

Publication number
WO1997038726A3
WO1997038726A3 PCT/EP1997/001847 EP9701847W WO9738726A3 WO 1997038726 A3 WO1997038726 A3 WO 1997038726A3 EP 9701847 W EP9701847 W EP 9701847W WO 9738726 A3 WO9738726 A3 WO 9738726A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrophobic
carbomer
complex compositions
carbomer complex
polymers
Prior art date
Application number
PCT/EP1997/001847
Other languages
French (fr)
Other versions
WO1997038726A2 (en
Inventor
Jean-Pierre Sachetto
Thomas Buser
Original Assignee
Tillotts Pharma Ag
Sachetto Jean Pierre
Thomas Buser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma Ag, Sachetto Jean Pierre, Thomas Buser filed Critical Tillotts Pharma Ag
Priority to AU26965/97A priority Critical patent/AU2696597A/en
Priority to EP97920670A priority patent/EP0914160A2/en
Priority to JP53674097A priority patent/JP2001509781A/en
Publication of WO1997038726A2 publication Critical patent/WO1997038726A2/en
Publication of WO1997038726A3 publication Critical patent/WO1997038726A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Hydrophilic carbomer complexes, such as bismuth or nicotine carbomer, are rendered hydrophobic at neutral to acid pH by milling to pass a 150 νm sieve screen and then impregnating with a water-insoluble anionic polymer. Preferred anionic polymers are partly methyl esterified methacrylic acid polymers.
PCT/EP1997/001847 1996-04-17 1997-04-14 Hydrophobic carbomer complex compositions WO1997038726A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU26965/97A AU2696597A (en) 1996-04-17 1997-04-14 Hydrophobic carbomer complex compositions
EP97920670A EP0914160A2 (en) 1996-04-17 1997-04-14 Hydrophobic carbomer complex compositions
JP53674097A JP2001509781A (en) 1996-04-17 1997-04-14 Hydrophobic carbomer complex composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9607955.3 1996-04-17
GBGB9607955.3A GB9607955D0 (en) 1996-04-17 1996-04-17 Hydrophobic carbomer salt compositions

Publications (2)

Publication Number Publication Date
WO1997038726A2 WO1997038726A2 (en) 1997-10-23
WO1997038726A3 true WO1997038726A3 (en) 1997-12-31

Family

ID=10792216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/001847 WO1997038726A2 (en) 1996-04-17 1997-04-14 Hydrophobic carbomer complex compositions

Country Status (6)

Country Link
EP (1) EP0914160A2 (en)
JP (1) JP2001509781A (en)
AU (1) AU2696597A (en)
CA (1) CA2251849A1 (en)
GB (1) GB9607955D0 (en)
WO (1) WO1997038726A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889028A (en) * 1996-02-09 1999-03-30 Mayo Foundation For Medical Education And Research Colonic delivery of nicotine to treat inflammatory bowel disease
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
MXPA05006802A (en) * 2002-12-19 2005-09-08 Pharmacia Corp Non-hygroscopic formulation comprising a hydroscopic drug.
PL1670433T3 (en) 2003-10-10 2013-03-29 Ferring Bv Transdermal pharmaceutical formulation for minimizing skin residues
CN116657439B (en) * 2023-06-29 2024-09-17 浙江科技学院 Preparation method of high-uniformity carbon paper base paper of pH response type dispersion system

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2246037A1 (en) * 1972-09-20 1974-04-11 Taeschner & Co Chemisch Pharma Delayed release medicaments - comprising film-coated resin adsorbate particles
EP0293885A2 (en) * 1987-06-05 1988-12-07 Abbott Laboratories Antibiotic-polymer compositions
EP0367746A2 (en) * 1988-11-02 1990-05-09 Richardson-Vicks, Inc. Sustained release drug-resin complexes
WO1992001457A1 (en) * 1990-07-20 1992-02-06 Slagel, David Products and processes for the treatment of the alimentary canal
EP0514008A1 (en) * 1991-04-19 1992-11-19 Takeda Chemical Industries, Ltd. Pharmaceutical preparations based on gastrointestinal mucosa-adherent matrixes or coatings
EP0526862A1 (en) * 1991-08-06 1993-02-10 VECTORPHARMA INTERNATIONAL S.p.A. Solid pharmaceutical compositions for oral administration with prolonged gastric residence
EP0587106A2 (en) * 1992-09-09 1994-03-16 VECTORPHARMA INTERNATIONAL S.p.A. Lipophilic salts containing neutron activable isotopes and compositions containing them
WO1994027576A1 (en) * 1993-05-20 1994-12-08 Danbiosyst Uk Limited Nasal drug delivery composition containing nicotine

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2246037A1 (en) * 1972-09-20 1974-04-11 Taeschner & Co Chemisch Pharma Delayed release medicaments - comprising film-coated resin adsorbate particles
EP0293885A2 (en) * 1987-06-05 1988-12-07 Abbott Laboratories Antibiotic-polymer compositions
EP0367746A2 (en) * 1988-11-02 1990-05-09 Richardson-Vicks, Inc. Sustained release drug-resin complexes
WO1992001457A1 (en) * 1990-07-20 1992-02-06 Slagel, David Products and processes for the treatment of the alimentary canal
EP0514008A1 (en) * 1991-04-19 1992-11-19 Takeda Chemical Industries, Ltd. Pharmaceutical preparations based on gastrointestinal mucosa-adherent matrixes or coatings
EP0526862A1 (en) * 1991-08-06 1993-02-10 VECTORPHARMA INTERNATIONAL S.p.A. Solid pharmaceutical compositions for oral administration with prolonged gastric residence
EP0587106A2 (en) * 1992-09-09 1994-03-16 VECTORPHARMA INTERNATIONAL S.p.A. Lipophilic salts containing neutron activable isotopes and compositions containing them
WO1994027576A1 (en) * 1993-05-20 1994-12-08 Danbiosyst Uk Limited Nasal drug delivery composition containing nicotine

Also Published As

Publication number Publication date
WO1997038726A2 (en) 1997-10-23
JP2001509781A (en) 2001-07-24
EP0914160A2 (en) 1999-05-12
GB9607955D0 (en) 1996-06-19
CA2251849A1 (en) 1997-10-23
AU2696597A (en) 1997-11-07

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