ATE239449T1 - (3'-desoxy-3-oxo-mebmt)1-(val)2-ciclosporin enthaltende arzneimittelemulsion - Google Patents
(3'-desoxy-3-oxo-mebmt)1-(val)2-ciclosporin enthaltende arzneimittelemulsionInfo
- Publication number
- ATE239449T1 ATE239449T1 AT97901563T AT97901563T ATE239449T1 AT E239449 T1 ATE239449 T1 AT E239449T1 AT 97901563 T AT97901563 T AT 97901563T AT 97901563 T AT97901563 T AT 97901563T AT E239449 T1 ATE239449 T1 AT E239449T1
- Authority
- AT
- Austria
- Prior art keywords
- ciclosporine
- mebmt
- desoxy
- val
- oxo
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 1
- 229930186217 Glycolipid Natural products 0.000 abstract 1
- ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 abstract 1
- ZDQSOHOQTUFQEM-XCXYXIJFSA-N ascomycin Natural products CC[C@H]1C=C(C)C[C@@H](C)C[C@@H](OC)[C@H]2O[C@@](O)([C@@H](C)C[C@H]2OC)C(=O)C(=O)N3CCCC[C@@H]3C(=O)O[C@H]([C@H](C)[C@@H](O)CC1=O)C(=C[C@@H]4CC[C@@H](O)[C@H](C4)OC)C ZDQSOHOQTUFQEM-XCXYXIJFSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000002960 lipid emulsion Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 229940068196 placebo Drugs 0.000 abstract 1
- 239000000902 placebo Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 150000003408 sphingolipids Chemical class 0.000 abstract 1
Classifications
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9601120.0A GB9601120D0 (en) | 1996-01-19 | 1996-01-19 | Organic compounds |
| PCT/EP1997/000252 WO1997025977A1 (en) | 1996-01-19 | 1997-01-20 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239449T1 true ATE239449T1 (de) | 2003-05-15 |
Family
ID=10787276
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02022257T ATE310504T1 (de) | 1996-01-19 | 1997-01-20 | Arzneizusammensetzungen enthaltend ascomycinderivate |
| AT02022256T ATE304842T1 (de) | 1996-01-19 | 1997-01-20 | Arzneizusammensetzungen enthaltend rapamycinderivate |
| AT05018663T ATE510532T1 (de) | 1996-01-19 | 1997-01-20 | Arzneizusammensetzungen enthaltend rapamycinderivate |
| AT97901563T ATE239449T1 (de) | 1996-01-19 | 1997-01-20 | (3'-desoxy-3-oxo-mebmt)1-(val)2-ciclosporin enthaltende arzneimittelemulsion |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02022257T ATE310504T1 (de) | 1996-01-19 | 1997-01-20 | Arzneizusammensetzungen enthaltend ascomycinderivate |
| AT02022256T ATE304842T1 (de) | 1996-01-19 | 1997-01-20 | Arzneizusammensetzungen enthaltend rapamycinderivate |
| AT05018663T ATE510532T1 (de) | 1996-01-19 | 1997-01-20 | Arzneizusammensetzungen enthaltend rapamycinderivate |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6239102B1 (de) |
| EP (4) | EP1273288B1 (de) |
| JP (2) | JP4077386B2 (de) |
| KR (1) | KR100485146B1 (de) |
| AT (4) | ATE310504T1 (de) |
| AU (1) | AU1543497A (de) |
| CA (2) | CA2678707A1 (de) |
| DE (3) | DE69734253T2 (de) |
| DK (4) | DK1273289T3 (de) |
| ES (4) | ES2365734T3 (de) |
| GB (1) | GB9601120D0 (de) |
| HK (2) | HK1054183B (de) |
| PT (2) | PT1679064E (de) |
| WO (1) | WO1997025977A1 (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5660858A (en) * | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
| SI1208847T1 (sl) | 1996-07-30 | 2007-06-30 | Novartis Ag | Farmacevtski sestavki za zdravljenje stanj zavračanja transplantatov in avtoimunskih ali vnetnih stanj |
| US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| EP1039893B1 (de) | 1997-12-10 | 2011-02-02 | Cyclosporine Therapeutics Limited | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
| DE19810655A1 (de) * | 1998-03-12 | 1999-09-16 | Univ Eberhard Karls | Arzneimittel mit einem Gehalt an Ciclosporin |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| TW537894B (en) | 1998-05-26 | 2003-06-21 | Novartis Ag | A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist |
| US6376517B1 (en) * | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
| US7265150B1 (en) * | 1998-08-14 | 2007-09-04 | Gpi Nil Holdings Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders |
| US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| CZ20013769A3 (cs) * | 1999-04-30 | 2002-03-13 | Sucampo Ag | Činidlo pro léčbu suchého oka |
| WO2000067773A2 (en) | 1999-05-10 | 2000-11-16 | Novartis Ag | Combinations of immunosupressive agents for the treatment or prevention of graft rejections |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| IL155297A0 (en) | 2000-10-31 | 2003-11-23 | Pharma Mar Sa | Kahalalide f formulation |
| LT3351246T (lt) | 2001-02-19 | 2019-07-10 | Novartis Pharma Ag | Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui |
| WO2003005836A2 (en) * | 2001-07-10 | 2003-01-23 | Trustees Of Boston University | Modified-fat nutritional products useful for preventing or treating obesity |
| US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
| US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
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1996
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- 1997-01-20 DK DK02022257T patent/DK1273289T3/da active
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- 1997-01-20 ES ES05018663T patent/ES2365734T3/es not_active Expired - Lifetime
- 1997-01-20 ES ES97901563T patent/ES2199338T3/es not_active Expired - Lifetime
- 1997-01-20 DE DE69734253T patent/DE69734253T2/de not_active Expired - Lifetime
- 1997-01-20 DK DK97901563T patent/DK0874621T3/da active
- 1997-01-20 WO PCT/EP1997/000252 patent/WO1997025977A1/en not_active Ceased
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- 1997-01-20 DK DK05018663.4T patent/DK1679064T3/da active
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