ATE22562T1 - 6-substituierte s-triazolo(3,4-a)phthalazinderivate. - Google Patents

6-substituierte s-triazolo(3,4-a)phthalazinderivate.

Info

Publication number
ATE22562T1
ATE22562T1 AT83100232T AT83100232T ATE22562T1 AT E22562 T1 ATE22562 T1 AT E22562T1 AT 83100232 T AT83100232 T AT 83100232T AT 83100232 T AT83100232 T AT 83100232T AT E22562 T1 ATE22562 T1 AT E22562T1
Authority
AT
Austria
Prior art keywords
triazolo
substitute
phthalazine derivatives
phthalazine
derivatives
Prior art date
Application number
AT83100232T
Other languages
German (de)
English (en)
Inventor
Emilio Occelli
Domenico Barone
Giorgio Tarzia
Adele Giunta
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Application granted granted Critical
Publication of ATE22562T1 publication Critical patent/ATE22562T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT83100232T 1982-01-18 1983-01-13 6-substituierte s-triazolo(3,4-a)phthalazinderivate. ATE22562T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8201273 1982-01-18
EP83100232A EP0085840B1 (en) 1982-01-18 1983-01-13 New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives

Publications (1)

Publication Number Publication Date
ATE22562T1 true ATE22562T1 (de) 1986-10-15

Family

ID=10527683

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83100232T ATE22562T1 (de) 1982-01-18 1983-01-13 6-substituierte s-triazolo(3,4-a)phthalazinderivate.

Country Status (20)

Country Link
US (1) US4788186A (instruction)
EP (1) EP0085840B1 (instruction)
JP (1) JPS58124786A (instruction)
KR (1) KR890000184B1 (instruction)
AT (1) ATE22562T1 (instruction)
AU (1) AU564026B2 (instruction)
CA (1) CA1214168A (instruction)
DE (1) DE3366494D1 (instruction)
DK (1) DK163145C (instruction)
ES (1) ES8601995A1 (instruction)
FI (1) FI81350C (instruction)
GR (1) GR78442B (instruction)
HU (1) HU193033B (instruction)
IE (1) IE55032B1 (instruction)
IL (1) IL67697A (instruction)
NO (1) NO161674C (instruction)
NZ (1) NZ203021A (instruction)
PH (1) PH21834A (instruction)
PT (1) PT76107A (instruction)
ZA (1) ZA83224B (instruction)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
EP0915877A1 (en) 1996-07-25 1999-05-19 MERCK SHARP & DOHME LTD. SUBSTITUTED TRIAZOLO PYRIDAZINE DERIVATIVES AS INVERSE AGONISTS OF THE GABA A?$g(a)5 RECEPTOR SUBTYPE
ES2194205T3 (es) 1996-07-25 2003-11-16 Merck Sharp & Dohme Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.
ES2179490T3 (es) * 1997-05-08 2003-01-16 Merck Sharp & Dohme Derivados de 1,2,4-triazolo(3,4-a)ftalazina sustituidos como ligandos de gaba alfa 5.
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
WO1999025353A1 (en) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Therapeutic uses of triazolo-pyridazine derivatives
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en) 1998-01-14 2002-05-02 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801210D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
IL136442A0 (en) 1998-01-21 2001-06-14 Merck Sharp & Dohme Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) * 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
CN1291194A (zh) * 1998-02-25 2001-04-11 默克·夏普-道姆公司 取代的1,2,4－三唑并[3,4－a]哒嗪
CZ291302B6 (cs) 1998-02-25 2003-01-15 Merck Sharp & Dohme Limited Substituovaný 1,2,4-triazolo[3,4-a]ftalazinový derivát
WO2000027849A2 (en) 1998-11-12 2000-05-18 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
GB9929569D0 (en) * 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
AU2002307163B2 (en) * 2001-04-10 2006-06-29 Merck & Co., Inc. A method of treating cancer
US6958334B2 (en) * 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
AU2003226301A1 (en) * 2002-04-08 2003-10-20 Merck And Co., Inc. Method of treating cancer
US20050054647A1 (en) * 2002-12-27 2005-03-10 Detlev Schuppan New pharmaceutical combination
CA2578368C (en) * 2004-09-02 2013-07-02 Altana Pharma Ag Triazolophthalazines
CA2591991C (en) * 2005-01-05 2013-11-19 Altana Pharma Ag Triazolophthalazines
EA012505B1 (ru) 2005-01-05 2009-10-30 Никомед Гмбх Триазолофталазины в качестве ингибиторов pde-2
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) * 2014-01-09 2016-03-30 郑州大学 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) * 2014-03-13 2016-02-03 郑州大学 3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (en) * 2022-05-19 2023-11-22 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Azolo compounds for treatment of fibrotic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
JPS5132598A (en) * 1974-09-13 1976-03-19 Eisai Co Ltd Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (instruction) * 1979-10-29 1982-09-08 Dow Chemical Co

Also Published As

Publication number Publication date
AU1055083A (en) 1983-07-28
CA1214168A (en) 1986-11-18
IL67697A (en) 1990-02-09
DK163145B (da) 1992-01-27
IE55032B1 (en) 1990-05-09
DK163145C (da) 1992-06-22
AU564026B2 (en) 1987-07-30
DK17983D0 (da) 1983-01-18
DK17983A (da) 1983-07-19
DE3366494D1 (de) 1986-11-06
FI830100A0 (fi) 1983-01-12
ZA83224B (en) 1983-10-26
FI81350B (fi) 1990-06-29
NO161674C (no) 1989-09-13
PH21834A (en) 1988-03-17
IL67697A0 (en) 1983-05-15
KR890000184B1 (ko) 1989-03-09
GR78442B (instruction) 1984-09-27
ES531458A0 (es) 1985-11-01
FI81350C (fi) 1990-10-10
HU193033B (en) 1987-08-28
NO830110L (no) 1983-07-19
ES8601995A1 (es) 1985-11-01
KR840003254A (ko) 1984-08-20
NO161674B (no) 1989-06-05
US4788186A (en) 1988-11-29
EP0085840A1 (en) 1983-08-17
JPH048428B2 (instruction) 1992-02-17
IE830082L (en) 1983-07-18
PT76107A (en) 1983-02-01
NZ203021A (en) 1986-05-09
EP0085840B1 (en) 1986-10-01
FI830100L (fi) 1983-07-19
JPS58124786A (ja) 1983-07-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee