ATE26115T1 - Substituierte 8-phenylxanthine. - Google Patents
Substituierte 8-phenylxanthine.Info
- Publication number
- ATE26115T1 ATE26115T1 AT83302136T AT83302136T ATE26115T1 AT E26115 T1 ATE26115 T1 AT E26115T1 AT 83302136 T AT83302136 T AT 83302136T AT 83302136 T AT83302136 T AT 83302136T AT E26115 T1 ATE26115 T1 AT E26115T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- phenylxanthins
- phenylxanthines
- bronchodilators
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/370,649 US4452788A (en) | 1982-04-21 | 1982-04-21 | Substituted 8-phenylxanthines |
EP83302136A EP0092398B1 (de) | 1982-04-21 | 1983-04-15 | Substituierte 8-Phenylxanthine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE26115T1 true ATE26115T1 (de) | 1987-04-15 |
Family
ID=23460567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT83302136T ATE26115T1 (de) | 1982-04-21 | 1983-04-15 | Substituierte 8-phenylxanthine. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4452788A (de) |
EP (1) | EP0092398B1 (de) |
JP (1) | JPS58189181A (de) |
AT (1) | ATE26115T1 (de) |
DE (1) | DE3370482D1 (de) |
DK (1) | DK173883A (de) |
GR (1) | GR78575B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4593095A (en) * | 1983-02-18 | 1986-06-03 | The Johns Hopkins University | Xanthine derivatives |
US4769377A (en) * | 1983-02-18 | 1988-09-06 | The Johns Hopkins University | Adenosine receptor antagonists |
DE3324115A1 (de) * | 1983-07-05 | 1985-01-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3347290A1 (de) * | 1983-12-28 | 1985-07-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
US4696932A (en) * | 1984-10-26 | 1987-09-29 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically-active xanthine derivatives |
US4612315A (en) * | 1984-10-26 | 1986-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically-active 1,3-dipropyl-8-phenylxanthine derivatives |
GB8510758D0 (en) * | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
JPS62208295A (ja) * | 1986-03-07 | 1987-09-12 | Nippon Kayaku Co Ltd | ヒポキサンチン塩基を有する新規化合物およびその製造法 |
US4772607A (en) * | 1986-05-20 | 1988-09-20 | Warner-Lambert Company | Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
US4755517A (en) * | 1986-07-31 | 1988-07-05 | Warner-Lambert Company | Derivatives of xanthine, pharmaceutical compositions and methods of use therefor |
AT388500B (de) * | 1987-10-27 | 1989-06-26 | Wellcome Found | Antivirale 8-phenylxanthine |
US5298508A (en) * | 1988-07-19 | 1994-03-29 | The United States Of America As Represented By The Department Of Health And Human Services | Irreversible inhibitors of adenosine receptors |
FR2659656B1 (fr) * | 1990-03-15 | 1994-09-09 | Sanofi Sa | Derives de pyrimidinedione-2,4 et medicaments les contenant. |
US5208240A (en) * | 1991-03-12 | 1993-05-04 | Merrell Dow Pharmaceuticals Inc. | 8-substituted purines as selective adenosine receptor agents |
US5484920A (en) * | 1992-04-08 | 1996-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for Parkinson's disease |
TW252044B (de) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
CA2112031A1 (en) * | 1992-12-24 | 1994-06-25 | Fumio Suzuki | Xanthine derivatives |
US5661153A (en) * | 1994-07-19 | 1997-08-26 | Japan Energy Corporation | 1-arylpyrimidine derivatives and pharmaceutical use thereof |
US6545002B1 (en) | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
US7317017B2 (en) | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
NZ532816A (en) | 2001-11-09 | 2005-11-25 | Cv Therapeutics Inc | A2B adenosine receptor antagonists |
US6977300B2 (en) * | 2001-11-09 | 2005-12-20 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
ES2208063B1 (es) * | 2002-04-01 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de la 4-(pirrolopirimidin-6-il)bencenosulfonamida. |
PL1789053T3 (pl) * | 2004-09-01 | 2012-12-31 | Gilead Sciences Inc | Sposób gojenia się rany wykorzystujący antagonistów receptora adenozynowego A2B |
US20070059740A1 (en) * | 2005-08-26 | 2007-03-15 | Linden Joel M | Method of targeting a2b adenosine receptor antagonist therapy |
US8193200B2 (en) * | 2007-01-04 | 2012-06-05 | University Of Virginia Patent Foundation | Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2840559A (en) * | 1954-06-22 | 1958-06-24 | Krantz Jr | Nuclearly substituted 8-theophyllines and method of making the same |
GB982079A (en) * | 1962-05-01 | 1965-02-03 | Dresden Arzneimittel | Process for the production of xanthine derivatives |
FR5878M (de) * | 1966-07-27 | 1968-03-18 |
-
1982
- 1982-04-21 US US06/370,649 patent/US4452788A/en not_active Expired - Fee Related
-
1983
- 1983-04-15 DE DE8383302136T patent/DE3370482D1/de not_active Expired
- 1983-04-15 EP EP83302136A patent/EP0092398B1/de not_active Expired
- 1983-04-15 AT AT83302136T patent/ATE26115T1/de not_active IP Right Cessation
- 1983-04-19 GR GR71131A patent/GR78575B/el unknown
- 1983-04-20 DK DK173883A patent/DK173883A/da active IP Right Grant
- 1983-04-20 JP JP58068487A patent/JPS58189181A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS58189181A (ja) | 1983-11-04 |
EP0092398A1 (de) | 1983-10-26 |
DK173883D0 (da) | 1983-04-20 |
EP0092398B1 (de) | 1987-03-25 |
GR78575B (de) | 1984-09-27 |
DK173883A (da) | 1983-10-22 |
US4452788A (en) | 1984-06-05 |
DE3370482D1 (en) | 1987-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |