ATE224953T1 - Paraoxonase aus serum - Google Patents

Paraoxonase aus serum

Info

Publication number
ATE224953T1
ATE224953T1 AT95925340T AT95925340T ATE224953T1 AT E224953 T1 ATE224953 T1 AT E224953T1 AT 95925340 T AT95925340 T AT 95925340T AT 95925340 T AT95925340 T AT 95925340T AT E224953 T1 ATE224953 T1 AT E224953T1
Authority
AT
Austria
Prior art keywords
polypeptide
disclosed
present
serum paraoxonase
polypeptides
Prior art date
Application number
AT95925340T
Other languages
English (en)
Inventor
Peter L Hudson
Wei Wu He
Steven M Ruben
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Application granted granted Critical
Publication of ATE224953T1 publication Critical patent/ATE224953T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT95925340T 1994-07-05 1995-06-28 Paraoxonase aus serum ATE224953T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/270,583 US5629193A (en) 1994-07-05 1994-07-05 Paraoxonase
PCT/US1995/008111 WO1996001322A1 (en) 1994-07-05 1995-06-28 Serum paraoxonase

Publications (1)

Publication Number Publication Date
ATE224953T1 true ATE224953T1 (de) 2002-10-15

Family

ID=23031914

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95925340T ATE224953T1 (de) 1994-07-05 1995-06-28 Paraoxonase aus serum

Country Status (13)

Country Link
US (4) US5629193A (de)
EP (2) EP0804591B1 (de)
JP (2) JPH10502255A (de)
KR (1) KR970704887A (de)
CN (1) CN1151760A (de)
AT (1) ATE224953T1 (de)
CA (1) CA2194390A1 (de)
DE (1) DE69528379T2 (de)
DK (1) DK0804591T3 (de)
ES (1) ES2180648T3 (de)
NZ (1) NZ289607A (de)
PT (1) PT804591E (de)
WO (1) WO1996001322A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629193A (en) 1994-07-05 1997-05-13 Human Genome Sciences, Inc. Paraoxonase
GB9511412D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improvements in emission control
US7541519B2 (en) * 1995-12-14 2009-06-02 Cargill, Incorporated Fatty acid desaturases and mutant sequences thereof
DE69822164T2 (de) * 1997-06-30 2005-04-14 Glaxo Group Ltd., Greenford Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität
US6414223B1 (en) * 1998-08-03 2002-07-02 Cargill, Incorporated Plants, seeds and oils having an elevated total monounsaturated fatty acid content
US6391298B1 (en) 1998-11-25 2002-05-21 Bayer Corporation Method of using PON-1 to decrease atheroma formation
JP2000333674A (ja) * 1999-05-24 2000-12-05 Bml Inc パラオキソナーゼに対するモノクローナル抗体及びこれを用いる動脈硬化の判定方法
US6573370B1 (en) 2000-05-19 2003-06-03 Regents Of The University Of Michigan PON3 and uses thereof
US20020151068A1 (en) * 2001-01-03 2002-10-17 Board Of Regents, The University Of Texas System Compositions and methods for the diagnosis and treatment of organophosphate toxicity
CN1854300B (zh) * 2005-04-29 2013-04-17 中国人民解放军军事医学科学院毒物药物研究所 含pon基因的重组质粒及其应用
JP2011503517A (ja) * 2006-11-13 2011-01-27 アテリス テクノロジーズ，エルエルシー 農薬バイオマーカー
CA2719103A1 (en) * 2007-11-14 2009-05-22 Ateris Technologies, Llc Biomarker detection
WO2013040501A1 (en) 2011-09-16 2013-03-21 Pharmathene, Inc. Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
CN108196064A (zh) * 2017-12-26 2018-06-22 黑龙江八农垦大学 一种牛pon1蛋白的双抗夹心elisa检测试剂盒及检测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260203A (en) * 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5629193A (en) 1994-07-05 1997-05-13 Human Genome Sciences, Inc. Paraoxonase

Also Published As

Publication number Publication date
EP0804591B1 (de) 2002-09-25
US7026140B2 (en) 2006-04-11
EP1217007A2 (de) 2002-06-26
NZ289607A (en) 1998-11-25
EP0804591A1 (de) 1997-11-05
DE69528379T2 (de) 2003-06-12
US20050026226A1 (en) 2005-02-03
US6140093A (en) 2000-10-31
CA2194390A1 (en) 1996-01-18
US5792639A (en) 1998-08-11
PT804591E (pt) 2002-12-31
JPH10502255A (ja) 1998-03-03
DK0804591T3 (da) 2003-01-20
US5629193A (en) 1997-05-13
DE69528379D1 (de) 2002-10-31
ES2180648T3 (es) 2003-02-16
JP2003088364A (ja) 2003-03-25
KR970704887A (ko) 1997-09-06
WO1996001322A1 (en) 1996-01-18
CN1151760A (zh) 1997-06-11
AU704834B2 (en) 1999-05-06
AU2950795A (en) 1996-01-25
EP0804591A4 (de) 1998-07-29

Similar Documents

Publication Publication Date Title
ATE224953T1 (de) Paraoxonase aus serum
ATE310819T1 (de) Säugetieren apoptosis inhibitorprotein genfamilie,primers, probes und verfahren zur nachweis
Summaria et al. Isolation and characterization of the affinity chromatography forms of human Glu-and Lys-plasminogens and plasmins.
CY1107629T1 (el) Πρωτεïνη crsp (πλουσιες σε κυστεïνη εκκρινομενες πρωτεïνες) μορια νουκλεϊνικου οξεως που τις κωδικοποιουν και χρησεις τους
ATE318896T1 (de) Rekombinante rna-replikase von hepatitis-c-virus
NZ323795A (en) Isolated nucleic acid molecules encoding AUR-1 (aurora-1) and AUR-2 polypeptides
ATE368127T1 (de) Optische sonden und assays zur messung der proteinphosphorylierung
Rodriguez et al. Modification of the C-terminus of brain tubulin during development
DE69808743T2 (de) Netrinrezeptoren
ATE523593T1 (de) Membranproteine aus säugetierzellen und verwandte reagentien
WO2000020446A3 (en) Bax-mediated apoptosis modulating reagents and methods
DK0750626T3 (da) Stannius-korpuskel-protein, stanniocalcin
DE69735562D1 (de) Sonden zur Erkennung und Identifizierung von Helicobacter Pylori
WO1997035976A3 (en) Epidermal differentiation factor
MX9700149A (es) Seroparaoxonasa.
Boschetti et al. The membrane anchor of mammalian brain acetylcholinesterase consists of a single glycosylated protein of 22 kDa
EP0841399A3 (de) Menschliche Fin-1 Nukleinsäure (eine Caspase) und Proteinsequenzen und Verwendung davon
Miyanishi et al. Differences in chemical structure around the reactive lysine residues in the burst and the nonburst heads of skeletal muscle myosin
Finel Studies on the oligomeric state of isolated cytochrome oxidase using cross-linking reagents
WO2003044170A3 (en) Cyclic amp phosphodiesterase 4d7 isoforms and methods of use
Kageoka et al. Amino acid substitution and chemical characterization of a Japanese variant of carbonic anhydrase I: CA I Hiroshima-1 (86 Asp→ Gly)
Oppenheim et al. A modified procedure for the purification of clostridial collagenase
EP0837127A3 (de) Erbliches multiple Exostose Gen, Ext2
ATE430156T1 (de) Tumor-oberflächenprotein und sein entsprechender oberflächenrezeptor auf natürlichen killerzellen
Kurosawa et al. Classification of mouse submaxillary gland esteroproteases by their substrate specificities

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0804591

Country of ref document: EP

REN Ceased due to non-payment of the annual fee