ATE224395T1 - Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung - Google Patents

Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung

Info

Publication number
ATE224395T1
ATE224395T1 AT98936398T AT98936398T ATE224395T1 AT E224395 T1 ATE224395 T1 AT E224395T1 AT 98936398 T AT98936398 T AT 98936398T AT 98936398 T AT98936398 T AT 98936398T AT E224395 T1 ATE224395 T1 AT E224395T1
Authority
AT
Austria
Prior art keywords
metalation
tetrazole
ortho
substituted
producing
Prior art date
Application number
AT98936398T
Other languages
German (de)
English (en)
Inventor
Marco Villa
Pietro Allegrini
Katiuscia Arrighi
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of ATE224395T1 publication Critical patent/ATE224395T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98936398T 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung ATE224395T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
PCT/EP1998/003969 WO1999001459A1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Publications (1)

Publication Number Publication Date
ATE224395T1 true ATE224395T1 (de) 2002-10-15

Family

ID=11377464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98936398T ATE224395T1 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung

Country Status (12)

Country Link
US (1) US6271375B1 (OSRAM)
EP (1) EP0994881B1 (OSRAM)
JP (1) JP4128633B2 (OSRAM)
AT (1) ATE224395T1 (OSRAM)
CA (1) CA2294609C (OSRAM)
CZ (1) CZ293277B6 (OSRAM)
DE (1) DE69808093T2 (OSRAM)
ES (1) ES2182349T3 (OSRAM)
HU (1) HU226471B1 (OSRAM)
IL (1) IL133249A (OSRAM)
IT (1) IT1292437B1 (OSRAM)
WO (1) WO1999001459A1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2233362T3 (es) * 1999-04-28 2005-06-16 Takeda Pharmaceutical Company Limited Agentes para prevenir/tratar/inhibir el avance de retinopatia simple o retinopatia preproliferativa.
BR0312968A (pt) 2002-07-26 2005-06-14 Pharmacia Groningen Bv Método e dispositivo para manipulação de uma lente intraocular
CN1759113A (zh) * 2003-01-16 2006-04-12 特瓦制药工业有限公司 伊贝沙坦的新合成方法
CA2519490A1 (en) * 2003-03-17 2004-09-30 Teva Pharmaceutical Industries Ltd Polymorphis of valsartan
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
US7199144B2 (en) * 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
WO2004094391A2 (en) * 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valsartan and intermediates thereof
TW200505879A (en) 2003-04-21 2005-02-16 Teva Pharma Process for the preparation of valsartan
US7385062B2 (en) * 2003-08-08 2008-06-10 Dipharma S.P.A. Process for the preparation of phenyltetrazole derivatives
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
AU2005249794A1 (en) 2004-06-04 2005-12-15 Teva Pharmaceutical Industries, Ltd. Pharmaceutical composition containing irbesartan
US20090124577A1 (en) * 2004-12-22 2009-05-14 Enantia Si Intermediate Compounds for the Preparation of an Angiotensin II Receptor Antagonist
ES2308591T3 (es) * 2004-12-22 2008-12-01 Algry Quimica, S.L Intermedios para la preparacion de antagonistas de los receptores de la angiotensina ii.
EP1812411A2 (en) * 2005-07-05 2007-08-01 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
WO2008035364A2 (en) * 2006-06-23 2008-03-27 Usv Limited Process for the preparation of micronized valsartan
US7943794B2 (en) * 2008-02-13 2011-05-17 Ranbaxy Laboratories Limited Processes for the preparation of intermediates of valsartan
EP2260018A2 (en) * 2008-04-07 2010-12-15 Hetero Research Foundation Process for preparation of valsartan intermediate
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
WO2021111464A1 (en) 2019-12-02 2021-06-10 Harman Finochem Limited A process for the preparation of highly pure valsartan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
TW226375B (OSRAM) * 1991-10-24 1994-07-11 American Home Prod
US5256654A (en) 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5149699A (en) 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
EP0550313A1 (fr) 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2696746B1 (fr) 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
US5760220A (en) 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
HUP9900871A3 (en) * 1995-06-07 2000-07-28 Wyeth Corp Process for preparation of biphenyl derivatives

Also Published As

Publication number Publication date
ES2182349T3 (es) 2003-03-01
HUP0004227A3 (en) 2003-03-28
IL133249A0 (en) 2001-04-30
CA2294609A1 (en) 1999-01-14
JP4128633B2 (ja) 2008-07-30
ITMI971544A0 (OSRAM) 1997-06-30
IT1292437B1 (it) 1999-02-08
ITMI971544A1 (it) 1998-12-30
HUP0004227A2 (hu) 2001-06-28
CZ477499A3 (cs) 2000-07-12
CZ293277B6 (cs) 2004-03-17
JP2002510314A (ja) 2002-04-02
DE69808093D1 (de) 2002-10-24
DE69808093T2 (de) 2003-06-05
WO1999001459A1 (en) 1999-01-14
EP0994881A1 (en) 2000-04-26
CA2294609C (en) 2008-08-19
EP0994881B1 (en) 2002-09-18
US6271375B1 (en) 2001-08-07
IL133249A (en) 2003-12-10
HU226471B1 (en) 2008-12-29

Similar Documents

Publication Publication Date Title
ATE224395T1 (de) Verfahren zur herstellung von 2-substituierten 1- (tetrazol-5-yl)benzenverbindungen durch ortho- metallierung
ATE232868T1 (de) Verfahren zur herstellung von ecteinascidin- verbindungen
ECSP11006282A (es) Proceso para la preparación de derivados de tetrazol a partir de azidas de organo-boro y de organo-aluminio
EA200300970A1 (ru) Энантиоселективный синтез промежуточных соединений для получения азетидинонов
ES2095907T3 (es) Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos.
ATE266030T1 (de) 1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen
DE69233734D1 (de) 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
ATE178058T1 (de) Verfahren zur herstellung von gewissen biphenyltetrazolderivaten
ATE407127T1 (de) Verfahren zur herstellung von beraprost und dessen salzen
ATE270275T1 (de) Verfahren zur herstellung von 2-aryl-3-aryl-5- halogen-pyridinen, verwendbar als cox-2 inhibitoren
AT397654B (de) Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
ATE267799T1 (de) Ein verfahren zur herstellung von (2s,2'r,3'r)-2- (2,3-dicarboxycyclopropyl)-glycin
DE69635057D1 (de) Verfahren zur herstellung von campothecinderivate
DE60015563D1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
ATE272061T1 (de) Friedel-craft verfahren zur herstellung von thioxanthonen
ATE250042T1 (de) Verfahren zur herstellung von cyclen
ATE279422T1 (de) Verfahren zur herstellung von 1-hydroxy-1, 1- diphosphonsäureverbindungen
DE50207388D1 (de) Verfahren zur herstellung von biperiden ii
ATE370950T1 (de) Verfahren zur herstellung von (1s,4r)-cis-4-(2- amino-6-chlor-9h-purin-9-yl)-2-cyclopenten-1- methanol
ATE380183T1 (de) Verfahren zur herstellung von phenyltetrazolderivaten
DE69810653D1 (de) Verfahren zur wiederverwertung eines nebenproduktes aus der diltiazem-synthese
ATE236132T1 (de) Verfahren zur herstellung von 1,3-diaza- spiro(4.4)non-1-en-4-on derivaten und 1-cyano-1- acylaminocyclopentan zwischenprodukte
ATE330612T1 (de) Verfahren zur herstellung von benazeprilhydrochloride
DE60003711D1 (de) Verfahren zur herstellung von peptidzwischenprodukten
DE69620244D1 (de) Verfahren zur herstellung von prostaglandin e1

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0994881

Country of ref document: EP