ATE214699T1 - Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-struktur - Google Patents

Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-struktur

Info

Publication number
ATE214699T1
ATE214699T1 AT96941539T AT96941539T ATE214699T1 AT E214699 T1 ATE214699 T1 AT E214699T1 AT 96941539 T AT96941539 T AT 96941539T AT 96941539 T AT96941539 T AT 96941539T AT E214699 T1 ATE214699 T1 AT E214699T1
Authority
AT
Austria
Prior art keywords
synthesis
compositions
beta structure
dioxolane nucleosides
nucleosides
Prior art date
Application number
AT96941539T
Other languages
German (de)
English (en)
Inventor
Tarek Mansour
Alex Cimpoia
Krzystof Bednarski
Original Assignee
Shire Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc
Application granted granted Critical
Publication of ATE214699T1 publication Critical patent/ATE214699T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96941539T 1995-12-14 1996-12-13 Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-struktur ATE214699T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
PCT/CA1996/000845 WO1997021706A1 (en) 1995-12-14 1996-12-13 METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION

Publications (1)

Publication Number Publication Date
ATE214699T1 true ATE214699T1 (de) 2002-04-15

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96941539T ATE214699T1 (de) 1995-12-14 1996-12-13 Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-struktur

Country Status (27)

Country Link
US (4) US5922867A (d)
EP (1) EP0970074B1 (d)
JP (1) JP3229990B2 (d)
KR (1) KR100406159B1 (d)
CN (1) CN1080263C (d)
AP (1) AP879A (d)
AT (1) ATE214699T1 (d)
AU (1) AU706328B2 (d)
BR (1) BR9612351A (d)
CA (1) CA2237730C (d)
DE (1) DE69620042T2 (d)
DK (1) DK0970074T3 (d)
EA (1) EA000844B1 (d)
ES (1) ES2172697T3 (d)
GB (1) GB9525606D0 (d)
HU (1) HU224076B1 (d)
IL (3) IL124663A (d)
IN (1) IN187349B (d)
MX (1) MX9804701A (d)
NO (1) NO309901B1 (d)
NZ (1) NZ323855A (d)
OA (1) OA11094A (d)
PL (1) PL188447B1 (d)
PT (1) PT970074E (d)
TW (1) TW341574B (d)
WO (1) WO1997021706A1 (d)
ZA (1) ZA9610544B (d)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0986375A2 (en) 1997-04-07 2000-03-22 Triangle Pharmaceuticals Inc. Use of mkc-442 in combination with other antiviral agents
PT1104415E (pt) 1998-08-12 2005-03-31 Univ Emory Metodo de preparacao de nucleosidos de 1,3-oxatiolano
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
DK1140937T3 (da) 1998-12-23 2004-03-22 Shire Biochem Inc Antivirale nucleosid-analoger
EP1151133A1 (en) * 1999-02-11 2001-11-07 McGILL UNIVERSITY Stereoselective synthesis of nucleoside analogues
CA2385349A1 (en) * 1999-09-24 2001-04-05 Francis J. Giles Method for the treatment or prevention of viral infection using nucleoside analogues
EP1225899A2 (en) * 1999-11-04 2002-07-31 Virochem Pharma Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
CA2366513A1 (en) * 2000-02-10 2001-08-16 Mitsui Chemicals, Inc. Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing a nucleoside
DE60127946D1 (de) 2000-02-11 2007-05-31 Shire Biochem Inc Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
KR20040002871A (ko) * 2001-03-01 2004-01-07 트라이앵글 파마슈티칼스 인코포레이티드 시스-ｆｔｃ의 다형 및 기타 결정형
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
JP2005512984A (ja) * 2001-11-02 2005-05-12 シャイアー バイオケム インコーポレイテッド ジオキソランヌクレオシド類似体を含む白血病の治療のための医薬組成物
JP2005519916A (ja) * 2001-12-14 2005-07-07 フアーマセツト・リミテツド ウィルス感染治療用ｎ４−アシルシトシンヌクレオシド類
EP1467990B1 (en) * 2002-01-25 2012-03-07 Shire BioChem Inc. Process for producing dioxolane nucleoside analogue precursors
ES2360096T3 (es) 2002-08-06 2011-05-31 Pharmasset, Inc. Procedimientos de preparación de nucleosidos de 1,3-dioxolano.
ES2394304T3 (es) 2002-10-15 2013-01-30 Exxonmobil Chemical Patents, Inc. Sistema de múltiples catalizadores para la polimerización de olefinas y polímeros producidos a partir de éstos
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
EP1720840B1 (en) * 2004-02-03 2016-02-03 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process

Also Published As

Publication number Publication date
IL124663A (en) 2001-10-31
EA000844B1 (ru) 2000-06-26
GB9525606D0 (en) 1996-02-14
IL124663A0 (en) 1998-12-06
PL188447B1 (pl) 2005-02-28
DK0970074T3 (da) 2002-07-15
HU224076B1 (hu) 2005-05-30
PL327443A1 (en) 1998-12-07
NZ323855A (en) 1999-11-29
CA2237730A1 (en) 1997-06-19
IL144155A (en) 2003-07-06
KR100406159B1 (ko) 2004-11-16
DE69620042D1 (de) 2002-04-25
US20030060476A1 (en) 2003-03-27
EP0970074B1 (en) 2002-03-20
EP0970074A1 (en) 2000-01-12
ES2172697T3 (es) 2002-10-01
JP2000501714A (ja) 2000-02-15
TW341574B (en) 1998-10-01
DE69620042T2 (de) 2002-10-17
OA11094A (en) 2003-03-13
CA2237730C (en) 2001-12-04
HUP9901050A2 (hu) 2001-04-28
AP9801252A0 (en) 1998-06-30
IL144155A0 (en) 2002-05-23
AP879A (en) 2000-10-02
HUP9901050A3 (en) 2001-05-28
ZA9610544B (en) 1997-07-29
NO982716L (no) 1998-06-12
CN1208414A (zh) 1999-02-17
CN1080263C (zh) 2002-03-06
JP3229990B2 (ja) 2001-11-19
PT970074E (pt) 2002-09-30
US20020058670A1 (en) 2002-05-16
MX9804701A (es) 1998-10-31
BR9612351A (pt) 1999-07-13
AU706328B2 (en) 1999-06-17
NO982716D0 (no) 1998-06-12
EA199800555A1 (ru) 1999-02-25
IN187349B (d) 2002-03-30
HK1017886A1 (en) 1999-12-03
WO1997021706A1 (en) 1997-06-19
US5922867A (en) 1999-07-13
US6069250A (en) 2000-05-30
NO309901B1 (no) 2001-04-17
KR19990072141A (ko) 1999-09-27
AU1089397A (en) 1997-07-03

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