ATE211392T1 - Verwendung des glialen, neurotrophen faktors (gdnf) zur behandlung von gehörstörungen - Google Patents

Verwendung des glialen, neurotrophen faktors (gdnf) zur behandlung von gehörstörungen

Info

Publication number
ATE211392T1
ATE211392T1 AT97906022T AT97906022T ATE211392T1 AT E211392 T1 ATE211392 T1 AT E211392T1 AT 97906022 T AT97906022 T AT 97906022T AT 97906022 T AT97906022 T AT 97906022T AT E211392 T1 ATE211392 T1 AT E211392T1
Authority
AT
Austria
Prior art keywords
gdnf
neurotrophic factor
vestibular
neurons
hearing disorders
Prior art date
Application number
AT97906022T
Other languages
English (en)
Inventor
Ella Magal
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/606,176 external-priority patent/US5837681A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE211392T1 publication Critical patent/ATE211392T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
AT97906022T 1996-02-23 1997-02-14 Verwendung des glialen, neurotrophen faktors (gdnf) zur behandlung von gehörstörungen ATE211392T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/606,176 US5837681A (en) 1996-02-23 1996-02-23 Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product
US08/710,219 US5929041A (en) 1996-02-23 1996-09-13 Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
PCT/US1997/002677 WO1997030722A1 (en) 1996-02-23 1997-02-14 Use of glial neurotrophic factor (gdnf) for treatment of hearing disorders

Publications (1)

Publication Number Publication Date
ATE211392T1 true ATE211392T1 (de) 2002-01-15

Family

ID=27085161

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97906022T ATE211392T1 (de) 1996-02-23 1997-02-14 Verwendung des glialen, neurotrophen faktors (gdnf) zur behandlung von gehörstörungen

Country Status (21)

Country Link
US (1) US5929041A (de)
EP (1) EP0822829B1 (de)
JP (1) JP4028598B2 (de)
KR (1) KR100271247B1 (de)
CN (1) CN1130221C (de)
AT (1) ATE211392T1 (de)
AU (1) AU691443B2 (de)
CA (1) CA2217565C (de)
CZ (1) CZ322797A3 (de)
DE (1) DE69709458T2 (de)
DK (1) DK0822829T3 (de)
EA (1) EA199700225A1 (de)
ES (1) ES2170938T3 (de)
HU (1) HU223999B1 (de)
IL (1) IL121790A (de)
MX (1) MX9707669A (de)
NO (1) NO974767L (de)
NZ (1) NZ328918A (de)
PT (1) PT822829E (de)
SK (1) SK138697A3 (de)
WO (1) WO1997030722A1 (de)

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US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
WO1998020889A1 (en) * 1996-11-15 1998-05-22 Creative Biomolecules Inc Morphogen peptide-induced regeneration of sense perceptory tissues
SI1005358T1 (en) * 1997-07-30 2003-06-30 Amgen Inc. Use of a neurturin protein product for preventing and treating hearing loss
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
US7236888B2 (en) * 1998-03-06 2007-06-26 The Regents Of The University Of California Method to measure the activation state of signaling pathways in cells
US6304787B1 (en) 1998-08-26 2001-10-16 Advanced Bionics Corporation Cochlear electrode array having current-focusing and tissue-treating features
US6309410B1 (en) 1998-08-26 2001-10-30 Advanced Bionics Corporation Cochlear electrode with drug delivery channel and method of making same
EP1126855B1 (de) 1998-09-25 2007-05-09 Cephalon, Inc. Methoden zur prophylaxe und behandlung von schäden der wahrnehmungshärchenzellen und der cochlearen neuronen
US7053200B1 (en) 1999-06-01 2006-05-30 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
DE60045350D1 (de) * 1999-06-01 2011-01-20 Baylor College Medicine Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz
ES2198367T3 (es) * 1999-10-29 2004-02-01 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Uso de gdnf para tratar defectos de la cornea.
US6551575B1 (en) 1999-12-02 2003-04-22 Neurosciences Research Foundation, Inc. Methods for identifying compounds for motion sickness, vertigo and other disorders related to balance and the perception of gravity
DE10025152A1 (de) * 2000-05-23 2001-12-06 Marlies Knipper Neurotrophin stimulierende Substanzen, insbesondere Thyroidhormon (T3) oder Schilddrüsenhormon stimulierende Substanzen, für die therapeutische Behandlung von lärm-und altersbedingter Schwerhörigkeit
AUPR148400A0 (en) * 2000-11-14 2000-12-07 Cochlear Limited Apparatus for delivery of pharmaceuticals to the cochlea
US9089450B2 (en) * 2000-11-14 2015-07-28 Cochlear Limited Implantatable component having an accessible lumen and a drug release capsule for introduction into same
US20030191064A1 (en) * 2001-01-23 2003-10-09 Kopke Richard D. Methods for preventing and treating loss of balance function due to oxidative stress
US20030050273A1 (en) * 2001-08-29 2003-03-13 Keiya Ozawa Compositions and methods for treating neurodegenerative diseases
AUPR879201A0 (en) * 2001-11-09 2001-12-06 Cochlear Limited Subthreshold stimulation of a cochlea
AUPS081502A0 (en) * 2002-02-28 2002-03-21 Cochlear Limited Connector for drug delivery system
CN1703248A (zh) * 2002-10-02 2005-11-30 安琪士摩奇株式会社 用于听觉损害的药物制剂
AT507045B1 (de) * 2002-11-29 2010-04-15 Cochlear Ltd Implantierbare, gewebe-stimulierende vorrichtung
US20040166091A1 (en) * 2003-02-24 2004-08-26 Genvec, Inc. Materials and methods for treating disorders of the ear
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
US8133215B2 (en) * 2007-08-13 2012-03-13 Cochlear Limited Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical device
US8271101B2 (en) * 2007-08-29 2012-09-18 Advanced Bionics Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead
WO2009029866A2 (en) * 2007-08-29 2009-03-05 Advanced Bionics, Llc Minimizing trauma during and after insertion of a cochlear lead
RU2499592C2 (ru) 2008-04-21 2013-11-27 Отономи, Инк. Фармацевтическая композиция для лечения ушных заболеваний
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8617097B2 (en) 2010-05-24 2013-12-31 Cochlear Limited Drug-delivery accessory for an implantable medical device
US8920855B1 (en) 2012-10-30 2014-12-30 Setem Hemth, Inc Methods of topically treating tinnitus and related disorders
US10376562B2 (en) 2013-03-15 2019-08-13 The Jackson Laboratory Methods for promoting wound healing and hair growth comprising GDNF administration
EP3113788A4 (de) * 2014-03-05 2017-10-18 Lawrence M. Schwartz Verfahren und zusammensetzungen zum schutz von sinneszellen
TWI710635B (zh) 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
US10975152B2 (en) * 2016-05-03 2021-04-13 The Scripps Research Institute TrkB agonist antibodies and methods for treating an ocular degenerative disorder characterized by degeneration of retinal ganglion cells (RGCs)
CN110461880A (zh) 2016-11-10 2019-11-15 科乐斯疗法公司 Gdnf融合多肽及其使用方法
EP3406259A1 (de) * 2017-05-24 2018-11-28 Dompé farmaceutici S.p.A. Neurotrophine zur verwendung bei der behandlung von hörverlust
EP3737233A4 (de) * 2018-01-09 2021-10-13 Otonomy, Inc. Wachstumsfaktorformulierungen für das ohr
CN112920998B (zh) * 2021-02-05 2022-06-14 复旦大学附属眼耳鼻喉科医院 一种成年鼠耳蜗体培养体系的建立方法及其应用

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US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
EP0401384B1 (de) * 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemisch modifizierte granulocytenkolonie erregender faktor
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
HU220795B1 (hu) * 1991-09-20 2002-05-28 Amgen Inc. Gliasejtvonal-eredetű neurotróf faktorfehérjék, továbbá berendezések és gyógyászati készítmények idegsejtkárosodás megelőzésére és kezelésére
AU7568094A (en) * 1993-08-12 1995-03-14 Cytotherapeutics, Inc. Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
FR2717824B1 (fr) * 1994-03-25 1996-04-26 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
US5658785A (en) * 1994-06-06 1997-08-19 Children's Hospital, Inc. Adeno-associated virus materials and methods

Also Published As

Publication number Publication date
DE69709458D1 (de) 2002-02-07
ES2170938T3 (es) 2002-08-16
IL121790A0 (en) 1998-02-22
HUP9901758A2 (hu) 1999-08-30
HUP9901758A3 (en) 2001-10-29
KR100271247B1 (ko) 2000-11-01
SK138697A3 (en) 1998-02-04
PT822829E (pt) 2002-06-28
KR19980703748A (ko) 1998-12-05
EP0822829B1 (de) 2002-01-02
IL121790A (en) 2002-08-14
WO1997030722A1 (en) 1997-08-28
CZ322797A3 (cs) 1998-01-14
NO974767D0 (no) 1997-10-15
AU2277997A (en) 1997-09-10
EA199700225A1 (ru) 1998-04-30
CA2217565C (en) 2002-04-16
MX9707669A (es) 1997-11-29
JPH11504351A (ja) 1999-04-20
DE69709458T2 (de) 2002-08-29
EP0822829A1 (de) 1998-02-11
JP4028598B2 (ja) 2007-12-26
HU223999B1 (hu) 2005-04-28
NO974767L (no) 1997-12-22
CN1181704A (zh) 1998-05-13
DK0822829T3 (da) 2002-04-02
AU691443B2 (en) 1998-05-14
CA2217565A1 (en) 1997-08-28
US5929041A (en) 1999-07-27
CN1130221C (zh) 2003-12-10
NZ328918A (en) 1999-08-30

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