ATE230607T1 - Verwendung von neurturin protein zur vorbeugung und behandlung von gehörverlust - Google Patents

Verwendung von neurturin protein zur vorbeugung und behandlung von gehörverlust

Info

Publication number
ATE230607T1
ATE230607T1 AT98937956T AT98937956T ATE230607T1 AT E230607 T1 ATE230607 T1 AT E230607T1 AT 98937956 T AT98937956 T AT 98937956T AT 98937956 T AT98937956 T AT 98937956T AT E230607 T1 ATE230607 T1 AT E230607T1
Authority
AT
Austria
Prior art keywords
hearing loss
prevent
neurturin protein
treat hearing
methods
Prior art date
Application number
AT98937956T
Other languages
English (en)
Inventor
Ella Magal
John M Delaney
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE230607T1 publication Critical patent/ATE230607T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
AT98937956T 1997-07-30 1998-07-17 Verwendung von neurturin protein zur vorbeugung und behandlung von gehörverlust ATE230607T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5418497P 1997-07-30 1997-07-30
US09/106,486 US6043221A (en) 1997-07-30 1998-06-29 Method for preventing and treating hearing loss using a neuturin protein product
PCT/US1998/014600 WO1999006064A1 (en) 1997-07-30 1998-07-17 Method for preventing and treating hearing loss using a neurturin protein product

Publications (1)

Publication Number Publication Date
ATE230607T1 true ATE230607T1 (de) 2003-01-15

Family

ID=26732740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98937956T ATE230607T1 (de) 1997-07-30 1998-07-17 Verwendung von neurturin protein zur vorbeugung und behandlung von gehörverlust

Country Status (10)

Country Link
US (2) US6043221A (de)
EP (1) EP1005358B1 (de)
JP (1) JP2001525316A (de)
AT (1) ATE230607T1 (de)
AU (1) AU8658298A (de)
CA (1) CA2298414C (de)
DE (1) DE69810635T2 (de)
DK (1) DK1005358T3 (de)
ES (1) ES2190093T3 (de)
WO (1) WO1999006064A1 (de)

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US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
DE19807426A1 (de) 1998-02-23 1999-10-14 Otogene Biotechnologische Fors Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs
US6423321B2 (en) 1999-02-24 2002-07-23 Edward L. Tobinick Cytokine antagonists for the treatment of sensorineural hearing loss
DE60045350D1 (de) 1999-06-01 2011-01-20 Baylor College Medicine Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz
US7053200B1 (en) 1999-06-01 2006-05-30 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
DE10025152A1 (de) * 2000-05-23 2001-12-06 Marlies Knipper Neurotrophin stimulierende Substanzen, insbesondere Thyroidhormon (T3) oder Schilddrüsenhormon stimulierende Substanzen, für die therapeutische Behandlung von lärm-und altersbedingter Schwerhörigkeit
US20050222070A1 (en) 2002-05-29 2005-10-06 Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung Pancreas-specific proteins
WO2003099318A2 (en) 2002-05-29 2003-12-04 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Pancreas-specific proteins
US20100030130A1 (en) * 2001-11-09 2010-02-04 Cochlear Limited Pharmaceutical intervention for modulation of neural plasticity
US20050171579A1 (en) * 2001-11-09 2005-08-04 Claudia Tasche Stimulating device
AUPR879201A0 (en) * 2001-11-09 2001-12-06 Cochlear Limited Subthreshold stimulation of a cochlea
US20100030301A1 (en) * 2001-11-09 2010-02-04 Cochlear Limited Electrical stimulation for modulation of neural plasticity
WO2003063789A2 (en) * 2002-01-30 2003-08-07 House Ear Institute L-carnitine for treatment of hearing loss
WO2004003020A1 (ja) * 2002-06-27 2004-01-08 Nippon Medical School Foundation 外リンパ瘻の検出方法
WO2004016167A1 (en) * 2002-08-16 2004-02-26 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
CN1703248A (zh) 2002-10-02 2005-11-30 安琪士摩奇株式会社 用于听觉损害的药物制剂
WO2004066975A1 (en) 2002-12-18 2004-08-12 Hough Ear Institute Otologic nanotechnology
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
PL1694354T3 (pl) 2003-11-27 2009-12-31 Develogen Ag Sposób zapobiegania i leczenia cukrzycy za pomocą neurturyny
US20050222127A1 (en) * 2004-03-30 2005-10-06 Alcon, Inc. Use of Rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance
JP2008502788A (ja) * 2004-06-08 2008-01-31 アルザ コーポレイション ４成分縮合反応による高分子コンジュゲートの調製
JP5548336B2 (ja) 2004-06-15 2014-07-16 コクレア リミテッド 誘発神経応答閾値の自動決定
WO2006099325A2 (en) * 2005-03-10 2006-09-21 3M Innovative Properties Company Methods of treating ear infections
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
WO2007030743A2 (en) 2005-09-08 2007-03-15 Massachusetts Eye & Ear Infirmary Cochlear implants containing biological cells and uses thereof
EP1872790A1 (de) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft Neue Zusammensetzung zur Erhöhung der Bioverfügbarkeit von Neurturin
CA2742839A1 (en) * 2007-11-05 2009-05-14 Develogen Aktiengesellschaft Novel neurturin conjugates for pharmaceutical use
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
RU2499592C2 (ru) 2008-04-21 2013-11-27 Отономи, Инк. Фармацевтическая композиция для лечения ушных заболеваний
BR112012009801A8 (pt) * 2009-10-30 2016-08-30 Cns Therapeutics Inc Polipeptídeo neurturina e variante de neurturina
US20110195402A1 (en) * 2010-02-10 2011-08-11 Selinfreund Richard H Systems and methods for detecting drug use
CA2951905A1 (en) * 2014-06-12 2015-12-17 Orbis Biosciences, Inc. Extended-release drug delivery compositions
TWI710635B (zh) 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
WO2020045980A1 (en) * 2018-08-28 2020-03-05 Industry-Academic Cooperation Foundation, Yonsei University Pharmaceutical composition for treating or preventing sensorineural hearing loss
CN110124014A (zh) * 2019-05-16 2019-08-16 杭州师范大学 重组人神经突起生长因子Neuritin蛋白的应用及一种用于治疗听神经病的药物

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US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
WO1997019693A1 (en) * 1995-11-29 1997-06-05 Amgen Inc. Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product

Also Published As

Publication number Publication date
DK1005358T3 (da) 2003-02-24
JP2001525316A (ja) 2001-12-11
DE69810635D1 (de) 2003-02-13
WO1999006064A1 (en) 1999-02-11
EP1005358A1 (de) 2000-06-07
EP1005358B1 (de) 2003-01-08
AU8658298A (en) 1999-02-22
CA2298414C (en) 2004-09-28
US6274554B1 (en) 2001-08-14
CA2298414A1 (en) 1999-02-11
ES2190093T3 (es) 2003-07-16
US6043221A (en) 2000-03-28
DE69810635T2 (de) 2003-05-28

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