JPH11504351A - 神経膠細胞系由来神経栄養因子(gdnf)タンパク質産物を使用する感覚神経性聴力損失及び前庭障害の予防及び治療方法 - Google Patents
神経膠細胞系由来神経栄養因子(gdnf)タンパク質産物を使用する感覚神経性聴力損失及び前庭障害の予防及び治療方法Info
- Publication number
- JPH11504351A JPH11504351A JP9530323A JP53032397A JPH11504351A JP H11504351 A JPH11504351 A JP H11504351A JP 9530323 A JP9530323 A JP 9530323A JP 53032397 A JP53032397 A JP 53032397A JP H11504351 A JPH11504351 A JP H11504351A
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- Prior art keywords
- gdnf
- protein product
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- gdnf protein
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- Granted
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.感覚神経性聴力損失の治療用医薬組成物の製造のための、神経膠細胞系由来 神経栄養因子(GDNF)タンパク質産物の使用。 2.聴力損失が内耳病変に関連する請求項1に記載の使用。 3.聴力損失が内耳における神経上皮毛細胞の損傷又は変性に関連する請求項1 に記載の使用。 4.聴力損失が螺旋神経節ニューロンの損傷又は変性に関連する請求項1に記載 の使用。 5.GDNFタンパク質産物が配列番号1に示すアミノ酸配列又はその変異体も しくは誘導体である請求項1に記載の使用。 6.GDNFタンパク質産物が配列番号1に示すアミノ酸配列をもつ請求項5に 記載の使用。 7.GDNFタンパク質産物が[Met-1]GDNFである請求項5に記載の使 用。 8.GDNFタンパク質産物を約1μg/kg/日〜約100mg/kg/日の 用量で投与する請求項1に記載の使用。 9.GDNFタンパク質産物を産生及び分泌するように細胞を 改変しておく細胞治療又は遺伝子治療手段によりGDNFタンパク質産物を投与 する請求項1に記載の使用。 10.細胞をエクスビボ改変しておく請求項9に記載の使用。 11.細胞をインビボ改変しておく請求項9に記載の使用。 12.前庭器の病変又は障害の治療用医薬組成物の製造のための、神経膠細胞系 由来神経栄養因子(GDNF)タンパク質産物の使用。 13.病変又は障害がめまい感、めまい又は平衡損失をもたらす請求項12に記 載の使用。 14.GDNFタンパク質産物が配列番号1に示すアミノ酸配列又はその変異体 もしくは誘導体である請求項12に記載の使用。 15.GDNFタンパク質産物が配列番号1に示すアミノ酸配列をもつ請求項1 4に記載の使用。 16.GDNFタンパク質産物が[Met-1]GDNFである請求項14に記載 の使用。 17.GDNFタンパク質産物を約1μg/kg/日〜約100mg/kg/日 の用量で投与する請求項12に記載の使用。 18.GDNFタンパク質産物を産生及び分泌するように細胞 を改変しておく細胞治療又は遺伝子治療手段によりGDNFタンパク質産物を投 与する請求項12に記載の使用。 19.細胞をエクスビボ改変しておく請求項18に記載の使用。 20.細胞をインビボ改変しておく請求項18に記載の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US08/606,176 US5837681A (en) | 1996-02-23 | 1996-02-23 | Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product |
US08/606,176 | 1996-02-23 | ||
US08/710,219 US5929041A (en) | 1996-02-23 | 1996-09-13 | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product |
US08/710,219 | 1996-09-13 | ||
PCT/US1997/002677 WO1997030722A1 (en) | 1996-02-23 | 1997-02-14 | Use of glial neurotrophic factor (gdnf) for treatment of hearing disorders |
Publications (2)
Publication Number | Publication Date |
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JPH11504351A true JPH11504351A (ja) | 1999-04-20 |
JP4028598B2 JP4028598B2 (ja) | 2007-12-26 |
Family
ID=27085161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP53032397A Expired - Lifetime JP4028598B2 (ja) | 1996-02-23 | 1997-02-14 | 神経膠細胞系由来神経栄養因子(gdnf)タンパク質産物を使用する感覚神経性聴力損失及び前庭障害の予防及び治療方法 |
Country Status (21)
Country | Link |
---|---|
US (1) | US5929041A (ja) |
EP (1) | EP0822829B1 (ja) |
JP (1) | JP4028598B2 (ja) |
KR (1) | KR100271247B1 (ja) |
CN (1) | CN1130221C (ja) |
AT (1) | ATE211392T1 (ja) |
AU (1) | AU691443B2 (ja) |
CA (1) | CA2217565C (ja) |
CZ (1) | CZ322797A3 (ja) |
DE (1) | DE69709458T2 (ja) |
DK (1) | DK0822829T3 (ja) |
EA (1) | EA199700225A1 (ja) |
ES (1) | ES2170938T3 (ja) |
HU (1) | HU223999B1 (ja) |
IL (1) | IL121790A (ja) |
MX (1) | MX9707669A (ja) |
NO (1) | NO974767L (ja) |
NZ (1) | NZ328918A (ja) |
PT (1) | PT822829E (ja) |
SK (1) | SK138697A3 (ja) |
WO (1) | WO1997030722A1 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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JPWO2004030702A1 (ja) * | 2002-10-02 | 2006-01-26 | アンジェスMg株式会社 | 聴覚機能障害用医薬 |
JP2017508793A (ja) * | 2014-03-05 | 2017-03-30 | シュワルツ、ローレンス エム.SCHWARTZ, Lawrence M. | 感覚細胞を保護するための方法及び組成物 |
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SI1005358T1 (en) * | 1997-07-30 | 2003-06-30 | Amgen Inc. | Use of a neurturin protein product for preventing and treating hearing loss |
US6043221A (en) * | 1997-07-30 | 2000-03-28 | Amgen Inc. | Method for preventing and treating hearing loss using a neuturin protein product |
US6177434B1 (en) * | 1997-12-16 | 2001-01-23 | The United States Of America As Represented By The Secretary Of The Navy | Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms |
US7236888B2 (en) * | 1998-03-06 | 2007-06-26 | The Regents Of The University Of California | Method to measure the activation state of signaling pathways in cells |
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DE10025152A1 (de) * | 2000-05-23 | 2001-12-06 | Marlies Knipper | Neurotrophin stimulierende Substanzen, insbesondere Thyroidhormon (T3) oder Schilddrüsenhormon stimulierende Substanzen, für die therapeutische Behandlung von lärm-und altersbedingter Schwerhörigkeit |
AUPR148400A0 (en) * | 2000-11-14 | 2000-12-07 | Cochlear Limited | Apparatus for delivery of pharmaceuticals to the cochlea |
US9089450B2 (en) * | 2000-11-14 | 2015-07-28 | Cochlear Limited | Implantatable component having an accessible lumen and a drug release capsule for introduction into same |
US20030191064A1 (en) * | 2001-01-23 | 2003-10-09 | Kopke Richard D. | Methods for preventing and treating loss of balance function due to oxidative stress |
US20030050273A1 (en) * | 2001-08-29 | 2003-03-13 | Keiya Ozawa | Compositions and methods for treating neurodegenerative diseases |
AUPR879201A0 (en) * | 2001-11-09 | 2001-12-06 | Cochlear Limited | Subthreshold stimulation of a cochlea |
AUPS081502A0 (en) * | 2002-02-28 | 2002-03-21 | Cochlear Limited | Connector for drug delivery system |
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EP3406259A1 (en) * | 2017-05-24 | 2018-11-28 | Dompé farmaceutici S.p.A. | Neurotrophins for use in the treatment of hearing loss |
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CN112920998B (zh) * | 2021-02-05 | 2022-06-14 | 复旦大学附属眼耳鼻喉科医院 | 一种成年鼠耳蜗体培养体系的建立方法及其应用 |
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CA2006596C (en) * | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
KR100242093B1 (ko) * | 1991-09-20 | 2000-02-01 | 그레고리 아보트 | 신경교 유도 신경 영양성 인자 |
EP0802800B1 (en) * | 1993-08-12 | 2002-06-12 | Neurotech S.A. | Biocompatible immunoisolatory capsules containing genetically altered cells for the delivery of biologically active molecules |
FR2717824B1 (fr) * | 1994-03-25 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
US5658785A (en) * | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPWO2004030702A1 (ja) * | 2002-10-02 | 2006-01-26 | アンジェスMg株式会社 | 聴覚機能障害用医薬 |
JP2017508793A (ja) * | 2014-03-05 | 2017-03-30 | シュワルツ、ローレンス エム.SCHWARTZ, Lawrence M. | 感覚細胞を保護するための方法及び組成物 |
US10265380B2 (en) | 2014-03-05 | 2019-04-23 | Amarantus Bioscience Holdings, Inc. | Method of administering MANF for the protection of sensory cells |
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IL121790A (en) | 2002-08-14 |
MX9707669A (es) | 1997-11-29 |
NO974767L (no) | 1997-12-22 |
AU2277997A (en) | 1997-09-10 |
CA2217565C (en) | 2002-04-16 |
SK138697A3 (en) | 1998-02-04 |
AU691443B2 (en) | 1998-05-14 |
DE69709458D1 (de) | 2002-02-07 |
CA2217565A1 (en) | 1997-08-28 |
DK0822829T3 (da) | 2002-04-02 |
KR19980703748A (ko) | 1998-12-05 |
EA199700225A1 (ru) | 1998-04-30 |
DE69709458T2 (de) | 2002-08-29 |
IL121790A0 (en) | 1998-02-22 |
NO974767D0 (no) | 1997-10-15 |
ES2170938T3 (es) | 2002-08-16 |
ATE211392T1 (de) | 2002-01-15 |
CN1181704A (zh) | 1998-05-13 |
KR100271247B1 (ko) | 2000-11-01 |
WO1997030722A1 (en) | 1997-08-28 |
NZ328918A (en) | 1999-08-30 |
HUP9901758A2 (hu) | 1999-08-30 |
CZ322797A3 (cs) | 1998-01-14 |
EP0822829A1 (en) | 1998-02-11 |
US5929041A (en) | 1999-07-27 |
PT822829E (pt) | 2002-06-28 |
HUP9901758A3 (en) | 2001-10-29 |
EP0822829B1 (en) | 2002-01-02 |
JP4028598B2 (ja) | 2007-12-26 |
HU223999B1 (hu) | 2005-04-28 |
CN1130221C (zh) | 2003-12-10 |
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