MX9707669A - Uso del factor neurotrofico glial (gdnf) para el tratamiento de padecimientos del oido. - Google Patents
Uso del factor neurotrofico glial (gdnf) para el tratamiento de padecimientos del oido.Info
- Publication number
- MX9707669A MX9707669A MX9707669A MX9707669A MX9707669A MX 9707669 A MX9707669 A MX 9707669A MX 9707669 A MX9707669 A MX 9707669A MX 9707669 A MX9707669 A MX 9707669A MX 9707669 A MX9707669 A MX 9707669A
- Authority
- MX
- Mexico
- Prior art keywords
- gdnf
- neurotrophic factor
- treatment
- hearing disorders
- glial neurotrophic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invencion se relaciona de manera general con los métodos para prevenir y/o tratar el daño o degeneracion de las células ciliadas cocleares (y vestibulares) y las neuronas del ganglio espiral administrando factor neurotrofico derivado del linaje celular glial (GDNF). La invencion se relaciona de manera más específica con los métodos para tratar la pérdida del oído sensorineural.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/606,176 US5837681A (en) | 1996-02-23 | 1996-02-23 | Method for treating sensorineural hearing loss using glial cell line-derived neurotrophic factor (GDNF) protein product |
US08/710,219 US5929041A (en) | 1996-02-23 | 1996-09-13 | Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product |
PCT/US1997/002677 WO1997030722A1 (en) | 1996-02-23 | 1997-02-14 | Use of glial neurotrophic factor (gdnf) for treatment of hearing disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9707669A true MX9707669A (es) | 1997-11-29 |
Family
ID=27085161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9707669A MX9707669A (es) | 1996-02-23 | 1997-02-14 | Uso del factor neurotrofico glial (gdnf) para el tratamiento de padecimientos del oido. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5929041A (es) |
EP (1) | EP0822829B1 (es) |
JP (1) | JP4028598B2 (es) |
KR (1) | KR100271247B1 (es) |
CN (1) | CN1130221C (es) |
AT (1) | ATE211392T1 (es) |
AU (1) | AU691443B2 (es) |
CA (1) | CA2217565C (es) |
CZ (1) | CZ322797A3 (es) |
DE (1) | DE69709458T2 (es) |
DK (1) | DK0822829T3 (es) |
EA (1) | EA199700225A1 (es) |
ES (1) | ES2170938T3 (es) |
HU (1) | HU223999B1 (es) |
IL (1) | IL121790A (es) |
MX (1) | MX9707669A (es) |
NO (1) | NO974767L (es) |
NZ (1) | NZ328918A (es) |
PT (1) | PT822829E (es) |
SK (1) | SK138697A3 (es) |
WO (1) | WO1997030722A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184200B1 (en) * | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
US6677135B1 (en) | 1996-05-08 | 2004-01-13 | Biogen, Inc. | Ret ligand (RetL) for stimulating neutral and renal growth |
WO1998020889A1 (en) * | 1996-11-15 | 1998-05-22 | Creative Biomolecules Inc | Morphogen peptide-induced regeneration of sense perceptory tissues |
EP1304119A3 (en) * | 1997-07-30 | 2004-01-21 | Amgen Inc. | Method for preventing and treating hearing loss using a neurturin protein product |
US6043221A (en) * | 1997-07-30 | 2000-03-28 | Amgen Inc. | Method for preventing and treating hearing loss using a neuturin protein product |
US6177434B1 (en) * | 1997-12-16 | 2001-01-23 | The United States Of America As Represented By The Secretary Of The Navy | Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms |
US7236888B2 (en) * | 1998-03-06 | 2007-06-26 | The Regents Of The University Of California | Method to measure the activation state of signaling pathways in cells |
US6304787B1 (en) | 1998-08-26 | 2001-10-16 | Advanced Bionics Corporation | Cochlear electrode array having current-focusing and tissue-treating features |
US6309410B1 (en) | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
ES2288042T3 (es) | 1998-09-25 | 2007-12-16 | Cephalon, Inc. | Uso de pirrolocarbazoles condensados para prevenir/tratar daños de las celulas ciliadas sensoriales y neuronas cocleares. |
US7053200B1 (en) | 1999-06-01 | 2006-05-30 | Baylor College Of Medicine | Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation |
ATE490777T1 (de) * | 1999-06-01 | 2010-12-15 | Baylor College Medicine | Zusammensetzungen und verfahren zur therapeutischen anwendung einer mit dem gen atonal assoziierten sequenz |
DK1223966T3 (da) * | 1999-10-29 | 2003-08-18 | Bioph Biotech Entw Pharm Gmbh | Anvendelse af GDNF til behandling af hornhindedefekter |
US6551575B1 (en) | 1999-12-02 | 2003-04-22 | Neurosciences Research Foundation, Inc. | Methods for identifying compounds for motion sickness, vertigo and other disorders related to balance and the perception of gravity |
DE10025152A1 (de) * | 2000-05-23 | 2001-12-06 | Marlies Knipper | Neurotrophin stimulierende Substanzen, insbesondere Thyroidhormon (T3) oder Schilddrüsenhormon stimulierende Substanzen, für die therapeutische Behandlung von lärm-und altersbedingter Schwerhörigkeit |
AUPR148400A0 (en) * | 2000-11-14 | 2000-12-07 | Cochlear Limited | Apparatus for delivery of pharmaceuticals to the cochlea |
US9089450B2 (en) * | 2000-11-14 | 2015-07-28 | Cochlear Limited | Implantatable component having an accessible lumen and a drug release capsule for introduction into same |
WO2004096256A1 (en) * | 2001-01-23 | 2004-11-11 | The United States Of America, As Represented By The Secretary Of The Navy | Methods for preventing and treating loss of balance function due to oxidative stress |
US20030050273A1 (en) * | 2001-08-29 | 2003-03-13 | Keiya Ozawa | Compositions and methods for treating neurodegenerative diseases |
AUPR879201A0 (en) * | 2001-11-09 | 2001-12-06 | Cochlear Limited | Subthreshold stimulation of a cochlea |
AUPS081502A0 (en) * | 2002-02-28 | 2002-03-21 | Cochlear Limited | Connector for drug delivery system |
EP1547618B1 (en) * | 2002-10-02 | 2010-05-26 | AnGes MG, Inc. | Drug for auditory dysfunction |
AT507045B1 (de) * | 2002-11-29 | 2010-04-15 | Cochlear Ltd | Implantierbare, gewebe-stimulierende vorrichtung |
US20040166091A1 (en) * | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
US8309057B2 (en) * | 2005-06-10 | 2012-11-13 | The Invention Science Fund I, Llc | Methods for elevating neurotrophic agents |
US8133215B2 (en) * | 2007-08-13 | 2012-03-13 | Cochlear Limited | Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical device |
WO2009029866A2 (en) * | 2007-08-29 | 2009-03-05 | Advanced Bionics, Llc | Minimizing trauma during and after insertion of a cochlear lead |
US8271101B2 (en) * | 2007-08-29 | 2012-09-18 | Advanced Bionics | Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead |
KR20190026056A (ko) | 2008-04-21 | 2019-03-12 | 오토노미, 인코포레이티드 | 귀 질환 및 병태를 치료하기 위한 귀 조제물 |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
US8617097B2 (en) | 2010-05-24 | 2013-12-31 | Cochlear Limited | Drug-delivery accessory for an implantable medical device |
US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
WO2014152511A1 (en) | 2013-03-15 | 2014-09-25 | The Jackson Laboratory | Methods for promoting wound healing and hair growth |
US10265380B2 (en) | 2014-03-05 | 2019-04-23 | Amarantus Bioscience Holdings, Inc. | Method of administering MANF for the protection of sensory cells |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
CN109414501A (zh) * | 2016-05-03 | 2019-03-01 | 斯克利普斯研究院 | 用于治疗神经退行性疾病的TrkB激动剂抗体 |
JP2019535267A (ja) | 2016-11-10 | 2019-12-12 | ケロス セラピューティクス インコーポレイテッドKeros Therapeutics,Inc. | Gdnf融合ポリペプチド及びその使用方法 |
EP3406259A1 (en) * | 2017-05-24 | 2018-11-28 | Dompé farmaceutici S.p.A. | Neurotrophins for use in the treatment of hearing loss |
AU2019207704B2 (en) * | 2018-01-09 | 2024-05-02 | Dompé Farmaceutici S.P.A. | Growth factor otic formulations |
CN112920998B (zh) * | 2021-02-05 | 2022-06-14 | 复旦大学附属眼耳鼻喉科医院 | 一种成年鼠耳蜗体培养体系的建立方法及其应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
ATE135370T1 (de) * | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
CA2119463C (en) * | 1991-09-20 | 2003-09-16 | Leu-Fen H. Lin | Glial cell line-derived neutrophic factor |
DK0802800T3 (da) * | 1993-08-12 | 2002-10-07 | Neurotech Sa | Biokompatible immunoisolatoriske kapsler indeholdende genetisk ændrede celler for levering af biologisk aktive molekyler |
FR2717824B1 (fr) * | 1994-03-25 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
US5658785A (en) * | 1994-06-06 | 1997-08-19 | Children's Hospital, Inc. | Adeno-associated virus materials and methods |
-
1996
- 1996-09-13 US US08/710,219 patent/US5929041A/en not_active Expired - Lifetime
-
1997
- 1997-02-14 KR KR1019970707148A patent/KR100271247B1/ko not_active IP Right Cessation
- 1997-02-14 IL IL12179097A patent/IL121790A/en not_active IP Right Cessation
- 1997-02-14 MX MX9707669A patent/MX9707669A/es unknown
- 1997-02-14 HU HU9901758A patent/HU223999B1/hu not_active IP Right Cessation
- 1997-02-14 CN CN97190100A patent/CN1130221C/zh not_active Expired - Fee Related
- 1997-02-14 JP JP53032397A patent/JP4028598B2/ja not_active Expired - Lifetime
- 1997-02-14 CA CA002217565A patent/CA2217565C/en not_active Expired - Fee Related
- 1997-02-14 CZ CZ973227A patent/CZ322797A3/cs unknown
- 1997-02-14 EP EP97906022A patent/EP0822829B1/en not_active Expired - Lifetime
- 1997-02-14 DK DK97906022T patent/DK0822829T3/da active
- 1997-02-14 NZ NZ328918A patent/NZ328918A/en not_active IP Right Cessation
- 1997-02-14 EA EA199700225A patent/EA199700225A1/ru unknown
- 1997-02-14 AT AT97906022T patent/ATE211392T1/de active
- 1997-02-14 SK SK1386-97A patent/SK138697A3/sk unknown
- 1997-02-14 AU AU22779/97A patent/AU691443B2/en not_active Ceased
- 1997-02-14 WO PCT/US1997/002677 patent/WO1997030722A1/en active IP Right Grant
- 1997-02-14 ES ES97906022T patent/ES2170938T3/es not_active Expired - Lifetime
- 1997-02-14 DE DE69709458T patent/DE69709458T2/de not_active Expired - Lifetime
- 1997-02-14 PT PT97906022T patent/PT822829E/pt unknown
- 1997-10-15 NO NO974767A patent/NO974767L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2217565A1 (en) | 1997-08-28 |
DK0822829T3 (da) | 2002-04-02 |
CZ322797A3 (cs) | 1998-01-14 |
NO974767D0 (no) | 1997-10-15 |
EA199700225A1 (ru) | 1998-04-30 |
ATE211392T1 (de) | 2002-01-15 |
DE69709458D1 (de) | 2002-02-07 |
DE69709458T2 (de) | 2002-08-29 |
HUP9901758A3 (en) | 2001-10-29 |
ES2170938T3 (es) | 2002-08-16 |
KR19980703748A (ko) | 1998-12-05 |
WO1997030722A1 (en) | 1997-08-28 |
EP0822829B1 (en) | 2002-01-02 |
SK138697A3 (en) | 1998-02-04 |
JP4028598B2 (ja) | 2007-12-26 |
PT822829E (pt) | 2002-06-28 |
NO974767L (no) | 1997-12-22 |
AU2277997A (en) | 1997-09-10 |
KR100271247B1 (ko) | 2000-11-01 |
CN1181704A (zh) | 1998-05-13 |
EP0822829A1 (en) | 1998-02-11 |
HU223999B1 (hu) | 2005-04-28 |
AU691443B2 (en) | 1998-05-14 |
JPH11504351A (ja) | 1999-04-20 |
CN1130221C (zh) | 2003-12-10 |
IL121790A0 (en) | 1998-02-22 |
CA2217565C (en) | 2002-04-16 |
HUP9901758A2 (hu) | 1999-08-30 |
NZ328918A (en) | 1999-08-30 |
US5929041A (en) | 1999-07-27 |
IL121790A (en) | 2002-08-14 |
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