ATE181920T1 - Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen - Google Patents

Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen

Info

Publication number
ATE181920T1
ATE181920T1 AT91303135T AT91303135T ATE181920T1 AT E181920 T1 ATE181920 T1 AT E181920T1 AT 91303135 T AT91303135 T AT 91303135T AT 91303135 T AT91303135 T AT 91303135T AT E181920 T1 ATE181920 T1 AT E181920T1
Authority
AT
Austria
Prior art keywords
alkyl
alkoxy
bridged
amino
compounds
Prior art date
Application number
AT91303135T
Other languages
English (en)
Inventor
Abraham Fisher
Yoffi Segall
Ezra Shirin
Yishai Karton
Haim Meshulam
Original Assignee
Israel Inst Biolog Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/507,228 external-priority patent/US5053412A/en
Application filed by Israel Inst Biolog Res filed Critical Israel Inst Biolog Res
Application granted granted Critical
Publication of ATE181920T1 publication Critical patent/ATE181920T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT91303135T 1990-04-10 1991-04-09 Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen ATE181920T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50770890A 1990-04-10 1990-04-10
US07/507,228 US5053412A (en) 1990-04-10 1990-04-10 Spiro nitrogen-bridged heterocyclic compounds
AU81241/91A AU636047B2 (en) 1990-04-10 1991-07-23 Spiro bridged and unbridged heterocyclic compounds

Publications (1)

Publication Number Publication Date
ATE181920T1 true ATE181920T1 (de) 1999-07-15

Family

ID=27156423

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91303135T ATE181920T1 (de) 1990-04-10 1991-04-09 Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen

Country Status (8)

Country Link
EP (1) EP0452101B1 (de)
JP (1) JP3266624B2 (de)
AT (1) ATE181920T1 (de)
AU (1) AU636047B2 (de)
CA (1) CA2039826C (de)
DE (1) DE69131409T2 (de)
ES (1) ES2137926T3 (de)
IL (1) IL97726A (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
DE69516524T2 (de) * 1994-08-24 2001-01-18 Astrazeneca Ab, Soedertaelje Therapeutisch verwendbare spiro-azabicyclische verbindungen
US7863291B2 (en) * 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US8309577B2 (en) 2008-04-23 2012-11-13 Bristol-Myers Squibb Company Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
KR101675174B1 (ko) * 2009-01-26 2016-11-10 이스라엘 인스티튜트 포 바이올로지컬 리서치 이환형 헤테로사이클릭 스피로 화합물
CN102686595A (zh) 2009-10-28 2012-09-19 百时美施贵宝公司 作为α-7 烟碱乙酰胆碱受体配体的氮杂二环化合物
US8278320B2 (en) 2009-10-28 2012-10-02 Bristol-Myers Squibb Company Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
EP2493892B1 (de) * 2009-10-29 2015-07-01 Bristol-Myers Squibb Company Chinuklidine-derivate als alpha-7 nikotin acetylcholin rezeptor liganden
CN101798311A (zh) * 2010-04-07 2010-08-11 天津炜杰凯华科技有限公司 顺式西维美林的制备方法
CN103025744A (zh) 2010-04-30 2013-04-03 百时美施贵宝公司 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物
WO2013177024A1 (en) * 2012-05-24 2013-11-28 Bristol-Myers Squibb Company QUINUCLIDINE, 1-AZABICYCLO[2.2.1]HEPTANE, 1-AZABICYCLO [3.2.1]OCTANE, and 1-AZABICYCLO[3.2.2]NONANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
JP5714745B2 (ja) * 2014-04-28 2015-05-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物
US20230348493A1 (en) * 2020-05-12 2023-11-02 Beijing Greatway Pharmaceutical Technology Co., Ltd. Compound for adjusting activity of nmda receptor, and pharmaceutical composition and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3629276A (en) * 1969-07-16 1971-12-21 Abbott Lab 2-amino-5-spiro-substituted-oxazo compounds
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
EP0452101B1 (de) 1999-07-07
AU8124191A (en) 1993-01-28
DE69131409T2 (de) 2000-02-03
AU636047B2 (en) 1993-04-08
ES2137926T3 (es) 2000-01-01
CA2039826A1 (en) 1991-10-11
IL97726A (en) 1994-12-29
EP0452101A3 (en) 1993-02-24
CA2039826C (en) 2002-01-15
DE69131409D1 (de) 1999-08-12
EP0452101A2 (de) 1991-10-16
JPH06293761A (ja) 1994-10-21
JP3266624B2 (ja) 2002-03-18

Similar Documents

Publication Publication Date Title
ATE181920T1 (de) Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen
ES2059069T3 (es) Nuevos derivados de 1-alcoxi-(2-acilamino-etil)-naftalenos y su procedimiento de preparacion.
ATE283268T1 (de) 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission
ES2094204T3 (es) Derivados de piperazina.
ATE143943T1 (de) Arylglycinamidderivate, verfahren zur deren herstellung und deren verwendung zur therapie der dysurie
ATE108448T1 (de) Piperdinyloxy- und chinindidinyloxy- isoxazol- derivate, ihre herstellung und ihre therapeutische verwendung.
DE69018726D1 (de) Cumarinderivate, ihre Herstellung und ihre Verwendung zur Behandlung von zerebrovaskulären Störungen.
NO174712C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive heterocykliske forbindelser
ES2088903T3 (es) Nuevos inhibidores de la s-adenosilmetionina descarboxilasa.
ATE23328T1 (de) 2-amino-1,2,3,4-tetrahydronaphthalen-derivate, ihre herstellung und ihre therapeutische verwendung.
DE69514532D1 (de) Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung
NO150436C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-fenylamino-imidazolin-derivater
ATE47851T1 (de) 1,5-benzoxathiepin-derivate, deren herstellung und verwendung.
ATE122037T1 (de) Cyclohexanacetamid-derivate.
ATE28639T1 (de) Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung.
SE8901060D0 (sv) New compounds
ATE10370T1 (de) Benzothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung.
DE69110219D1 (de) 3-(1H-Indazol-3-yl)-4-pyridiname, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
DE69119642D1 (de) Verwendung von Pyrido-Indol-Derivaten bei der Behandlung ischämischer Störungen
HUT49878A (en) Herbicide and plant growth regulator comprising heterocyclic substituted n-sultamsulfonamide derivatives as active ingredient and process for producing the active ingredients
NO830399L (no) Fremgangsmaate ved fremstilling av nye carbacycliner
DK0784973T3 (da) Quinoxalinderivater til behandling af tinnitus
ATE19881T1 (de) Tropyl- und pseudotropylalkylbenzoate und ihre verwendung in der behandlung von migraene.
FR2566407B1 (fr) Nouveaux derives de l'isoxazoloquinoleine, procede de preparation, application a titre de medicaments, et compositions les renfermant
TH11174EX (th) อนุพันธ์ของพิเพอดิลอกซิ-ไอซอกซาโซล,การเตรียมสารเหล่านั้นและการใช้ในการรักษา

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee