ATE181920T1 - Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen - Google Patents
Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungenInfo
- Publication number
- ATE181920T1 ATE181920T1 AT91303135T AT91303135T ATE181920T1 AT E181920 T1 ATE181920 T1 AT E181920T1 AT 91303135 T AT91303135 T AT 91303135T AT 91303135 T AT91303135 T AT 91303135T AT E181920 T1 ATE181920 T1 AT E181920T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- alkoxy
- bridged
- amino
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50770890A | 1990-04-10 | 1990-04-10 | |
US07/507,228 US5053412A (en) | 1990-04-10 | 1990-04-10 | Spiro nitrogen-bridged heterocyclic compounds |
AU81241/91A AU636047B2 (en) | 1990-04-10 | 1991-07-23 | Spiro bridged and unbridged heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE181920T1 true ATE181920T1 (de) | 1999-07-15 |
Family
ID=27156423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91303135T ATE181920T1 (de) | 1990-04-10 | 1991-04-09 | Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0452101B1 (de) |
JP (1) | JP3266624B2 (de) |
AT (1) | ATE181920T1 (de) |
AU (1) | AU636047B2 (de) |
CA (1) | CA2039826C (de) |
DE (1) | DE69131409T2 (de) |
ES (1) | ES2137926T3 (de) |
IL (1) | IL97726A (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
DE69516524T2 (de) * | 1994-08-24 | 2001-01-18 | Astrazeneca Ab, Soedertaelje | Therapeutisch verwendbare spiro-azabicyclische verbindungen |
US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
US8309577B2 (en) | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
US9034891B2 (en) | 2009-01-26 | 2015-05-19 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
KR101675174B1 (ko) * | 2009-01-26 | 2016-11-10 | 이스라엘 인스티튜트 포 바이올로지컬 리서치 | 이환형 헤테로사이클릭 스피로 화합물 |
CN102686595A (zh) | 2009-10-28 | 2012-09-19 | 百时美施贵宝公司 | 作为α-7 烟碱乙酰胆碱受体配体的氮杂二环化合物 |
US8278320B2 (en) | 2009-10-28 | 2012-10-02 | Bristol-Myers Squibb Company | Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands |
EP2493892B1 (de) * | 2009-10-29 | 2015-07-01 | Bristol-Myers Squibb Company | Chinuklidine-derivate als alpha-7 nikotin acetylcholin rezeptor liganden |
CN101798311A (zh) * | 2010-04-07 | 2010-08-11 | 天津炜杰凯华科技有限公司 | 顺式西维美林的制备方法 |
CN103025744A (zh) | 2010-04-30 | 2013-04-03 | 百时美施贵宝公司 | 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物 |
WO2013177024A1 (en) * | 2012-05-24 | 2013-11-28 | Bristol-Myers Squibb Company | QUINUCLIDINE, 1-AZABICYCLO[2.2.1]HEPTANE, 1-AZABICYCLO [3.2.1]OCTANE, and 1-AZABICYCLO[3.2.2]NONANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS |
JP5714745B2 (ja) * | 2014-04-28 | 2015-05-07 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | α7ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 |
US20230348493A1 (en) * | 2020-05-12 | 2023-11-02 | Beijing Greatway Pharmaceutical Technology Co., Ltd. | Compound for adjusting activity of nmda receptor, and pharmaceutical composition and use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3629276A (en) * | 1969-07-16 | 1971-12-21 | Abbott Lab | 2-amino-5-spiro-substituted-oxazo compounds |
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
GB8816299D0 (en) * | 1988-07-08 | 1988-08-10 | Merck Sharp & Dohme | Therapeutic agents |
-
1991
- 1991-03-28 IL IL9772691A patent/IL97726A/en not_active IP Right Cessation
- 1991-04-04 CA CA002039826A patent/CA2039826C/en not_active Expired - Fee Related
- 1991-04-09 DE DE69131409T patent/DE69131409T2/de not_active Expired - Fee Related
- 1991-04-09 EP EP91303135A patent/EP0452101B1/de not_active Expired - Lifetime
- 1991-04-09 ES ES91303135T patent/ES2137926T3/es not_active Expired - Lifetime
- 1991-04-09 AT AT91303135T patent/ATE181920T1/de not_active IP Right Cessation
- 1991-04-10 JP JP10689591A patent/JP3266624B2/ja not_active Expired - Fee Related
- 1991-07-23 AU AU81241/91A patent/AU636047B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0452101B1 (de) | 1999-07-07 |
AU8124191A (en) | 1993-01-28 |
DE69131409T2 (de) | 2000-02-03 |
AU636047B2 (en) | 1993-04-08 |
ES2137926T3 (es) | 2000-01-01 |
CA2039826A1 (en) | 1991-10-11 |
IL97726A (en) | 1994-12-29 |
EP0452101A3 (en) | 1993-02-24 |
CA2039826C (en) | 2002-01-15 |
DE69131409D1 (de) | 1999-08-12 |
EP0452101A2 (de) | 1991-10-16 |
JPH06293761A (ja) | 1994-10-21 |
JP3266624B2 (ja) | 2002-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE181920T1 (de) | Ueberbrückte und nicht-überbrückte heterocyclische spiroverbindungen | |
ES2059069T3 (es) | Nuevos derivados de 1-alcoxi-(2-acilamino-etil)-naftalenos y su procedimiento de preparacion. | |
ATE283268T1 (de) | 2-adamantylethylamine und deren verwendung bei der behandlung von abnormalitäten in der glutamat transmission | |
ES2094204T3 (es) | Derivados de piperazina. | |
ATE143943T1 (de) | Arylglycinamidderivate, verfahren zur deren herstellung und deren verwendung zur therapie der dysurie | |
ATE108448T1 (de) | Piperdinyloxy- und chinindidinyloxy- isoxazol- derivate, ihre herstellung und ihre therapeutische verwendung. | |
DE69018726D1 (de) | Cumarinderivate, ihre Herstellung und ihre Verwendung zur Behandlung von zerebrovaskulären Störungen. | |
NO174712C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive heterocykliske forbindelser | |
ES2088903T3 (es) | Nuevos inhibidores de la s-adenosilmetionina descarboxilasa. | |
ATE23328T1 (de) | 2-amino-1,2,3,4-tetrahydronaphthalen-derivate, ihre herstellung und ihre therapeutische verwendung. | |
DE69514532D1 (de) | Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung | |
NO150436C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-fenylamino-imidazolin-derivater | |
ATE47851T1 (de) | 1,5-benzoxathiepin-derivate, deren herstellung und verwendung. | |
ATE122037T1 (de) | Cyclohexanacetamid-derivate. | |
ATE28639T1 (de) | Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung. | |
SE8901060D0 (sv) | New compounds | |
ATE10370T1 (de) | Benzothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung. | |
DE69110219D1 (de) | 3-(1H-Indazol-3-yl)-4-pyridiname, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Arzneimittel. | |
DE69119642D1 (de) | Verwendung von Pyrido-Indol-Derivaten bei der Behandlung ischämischer Störungen | |
HUT49878A (en) | Herbicide and plant growth regulator comprising heterocyclic substituted n-sultamsulfonamide derivatives as active ingredient and process for producing the active ingredients | |
NO830399L (no) | Fremgangsmaate ved fremstilling av nye carbacycliner | |
DK0784973T3 (da) | Quinoxalinderivater til behandling af tinnitus | |
ATE19881T1 (de) | Tropyl- und pseudotropylalkylbenzoate und ihre verwendung in der behandlung von migraene. | |
FR2566407B1 (fr) | Nouveaux derives de l'isoxazoloquinoleine, procede de preparation, application a titre de medicaments, et compositions les renfermant | |
TH11174EX (th) | อนุพันธ์ของพิเพอดิลอกซิ-ไอซอกซาโซล,การเตรียมสารเหล่านั้นและการใช้ในการรักษา |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |