ES2137926T3 - Compuestos espiro heterociclicos puenteados y no puenteados. - Google Patents
Compuestos espiro heterociclicos puenteados y no puenteados.Info
- Publication number
- ES2137926T3 ES2137926T3 ES91303135T ES91303135T ES2137926T3 ES 2137926 T3 ES2137926 T3 ES 2137926T3 ES 91303135 T ES91303135 T ES 91303135T ES 91303135 T ES91303135 T ES 91303135T ES 2137926 T3 ES2137926 T3 ES 2137926T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- alkoxy
- amino
- unbridged
- bridged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LOS COMPUESTOS (I) Y (II), INCLUYENDO ENANTIOMEROS, RACEMATOS Y ADICION DE SALES Y SALES CUATERNARIAS, SON PARA TRATAR ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL Y PERIFERICO DONDE EN LA FORMULA (I) Q ES (CH SUB 2) SUB M O C(CH SUB 3) SUB 2 UNIDA A LAS POSICIONES 1'', 4'' O 1'', 5'' DEL ANILLO DE SEIS MIEMBROS (M = 1,2 O 3) Y EN LA FORMULA Q ES DOS ATOMOS DE HIDROGENO, (CH SUB 2) SUB M O C(CH SUB 2) SUB 2 (M = 1, 2 O 3) Y N Y P SON CADA UNA INDEPENDIENTEMENTE 0, 1, 2 O 3, DADO QUE N+P=1-3; R ELEVADO 0 ES HIDROGENO, METILO O OH; R Y R'' SON INDEPENDIENTEMENTE H, NH SUB 2, NH-C SUB 1-6-ALQUILO, N (C SUB 1-6-ALQUILO) SUB 2, ALQUILO -C SUB 1-6, ALQUENILO C SUB 2-6, ALQUINILO C SUB 2-6, CICLOALQUILO-C SUB 3-7, ALQUILO C SUB 1-6 SUBSTITUIDO MEDIANTE 1-6 ATOMOS HALOGENOS, HO-ALQUILO-C SUB 1-6, ALCOXI-C SUB 1-6, ALQUITIO C SUB 1-6, ALCOXI-C SUB 1-6-ALQUILO-C SUB 1-6, CARBOXI-ALQUILO-C SUB 1-6, (ALCOXI-C SUB 1-6=) CARBONILO-ALQUILO-C SUB 1-6, AMIENO-ALQUILO-C SUB 1-6, MONO-(ALQUILO-C SUB 1-6)AMINO-ALQUILO-C SUB 1-6, DI(ALQUILO-C SUB 1-6) AMINO-ALQUILO-C SUB 1-6, 2-OXO-PIRROLIDINA-1-YL-METILO, AR, DI(AR)METILOL, O (AR) SUB 1-2 ALQUILO-C SUB 1-6, O R ELEVADO 1 PUEDE SER ALCONOILO-C SUB 1-6 O ARCARBONILO; Y AR SIGNIFICA PH OPCIONALMENTE SUBSTITUIDO POR 1-3 DE HALOGENO, ALQUILO-C SUB 1-6, ALCOXI-C SUB 1-6 Y CF SUB 3, SUJETO A CIERTAS SALVEDADES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50770890A | 1990-04-10 | 1990-04-10 | |
US07/507,228 US5053412A (en) | 1990-04-10 | 1990-04-10 | Spiro nitrogen-bridged heterocyclic compounds |
AU81241/91A AU636047B2 (en) | 1990-04-10 | 1991-07-23 | Spiro bridged and unbridged heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2137926T3 true ES2137926T3 (es) | 2000-01-01 |
Family
ID=27156423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91303135T Expired - Lifetime ES2137926T3 (es) | 1990-04-10 | 1991-04-09 | Compuestos espiro heterociclicos puenteados y no puenteados. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0452101B1 (es) |
JP (1) | JP3266624B2 (es) |
AT (1) | ATE181920T1 (es) |
AU (1) | AU636047B2 (es) |
CA (1) | CA2039826C (es) |
DE (1) | DE69131409T2 (es) |
ES (1) | ES2137926T3 (es) |
IL (1) | IL97726A (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
DE69516524T2 (de) * | 1994-08-24 | 2001-01-18 | Astrazeneca Ab, Soedertaelje | Therapeutisch verwendbare spiro-azabicyclische verbindungen |
US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
US8309577B2 (en) | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
US9034891B2 (en) | 2009-01-26 | 2015-05-19 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
KR101675174B1 (ko) * | 2009-01-26 | 2016-11-10 | 이스라엘 인스티튜트 포 바이올로지컬 리서치 | 이환형 헤테로사이클릭 스피로 화합물 |
CN102686595A (zh) | 2009-10-28 | 2012-09-19 | 百时美施贵宝公司 | 作为α-7 烟碱乙酰胆碱受体配体的氮杂二环化合物 |
US8278320B2 (en) | 2009-10-28 | 2012-10-02 | Bristol-Myers Squibb Company | Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands |
EP2493892B1 (en) * | 2009-10-29 | 2015-07-01 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
CN101798311A (zh) * | 2010-04-07 | 2010-08-11 | 天津炜杰凯华科技有限公司 | 顺式西维美林的制备方法 |
CN103025744A (zh) | 2010-04-30 | 2013-04-03 | 百时美施贵宝公司 | 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物 |
WO2013177024A1 (en) * | 2012-05-24 | 2013-11-28 | Bristol-Myers Squibb Company | QUINUCLIDINE, 1-AZABICYCLO[2.2.1]HEPTANE, 1-AZABICYCLO [3.2.1]OCTANE, and 1-AZABICYCLO[3.2.2]NONANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS |
JP5714745B2 (ja) * | 2014-04-28 | 2015-05-07 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | α7ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 |
US20230348493A1 (en) * | 2020-05-12 | 2023-11-02 | Beijing Greatway Pharmaceutical Technology Co., Ltd. | Compound for adjusting activity of nmda receptor, and pharmaceutical composition and use thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3629276A (en) * | 1969-07-16 | 1971-12-21 | Abbott Lab | 2-amino-5-spiro-substituted-oxazo compounds |
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
GB8816299D0 (en) * | 1988-07-08 | 1988-08-10 | Merck Sharp & Dohme | Therapeutic agents |
-
1991
- 1991-03-28 IL IL9772691A patent/IL97726A/en not_active IP Right Cessation
- 1991-04-04 CA CA002039826A patent/CA2039826C/en not_active Expired - Fee Related
- 1991-04-09 DE DE69131409T patent/DE69131409T2/de not_active Expired - Fee Related
- 1991-04-09 EP EP91303135A patent/EP0452101B1/en not_active Expired - Lifetime
- 1991-04-09 ES ES91303135T patent/ES2137926T3/es not_active Expired - Lifetime
- 1991-04-09 AT AT91303135T patent/ATE181920T1/de not_active IP Right Cessation
- 1991-04-10 JP JP10689591A patent/JP3266624B2/ja not_active Expired - Fee Related
- 1991-07-23 AU AU81241/91A patent/AU636047B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0452101B1 (en) | 1999-07-07 |
AU8124191A (en) | 1993-01-28 |
DE69131409T2 (de) | 2000-02-03 |
AU636047B2 (en) | 1993-04-08 |
CA2039826A1 (en) | 1991-10-11 |
ATE181920T1 (de) | 1999-07-15 |
IL97726A (en) | 1994-12-29 |
EP0452101A3 (en) | 1993-02-24 |
CA2039826C (en) | 2002-01-15 |
DE69131409D1 (de) | 1999-08-12 |
EP0452101A2 (en) | 1991-10-16 |
JPH06293761A (ja) | 1994-10-21 |
JP3266624B2 (ja) | 2002-03-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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