ATE175116T1 - Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften - Google Patents

Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften

Info

Publication number
ATE175116T1
ATE175116T1 AT92921892T AT92921892T ATE175116T1 AT E175116 T1 ATE175116 T1 AT E175116T1 AT 92921892 T AT92921892 T AT 92921892T AT 92921892 T AT92921892 T AT 92921892T AT E175116 T1 ATE175116 T1 AT E175116T1
Authority
AT
Austria
Prior art keywords
lungs
antioxidant properties
surface active
active composition
synthetic surface
Prior art date
Application number
AT92921892T
Other languages
German (de)
English (en)
Inventor
Larry R Mclean
Marguerite H Payne
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE175116T1 publication Critical patent/ATE175116T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92921892T 1991-11-04 1992-10-13 Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften ATE175116T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/789,918 US5272252A (en) 1991-11-04 1991-11-04 Synthetic lung surfactant having antioxidant properties

Publications (1)

Publication Number Publication Date
ATE175116T1 true ATE175116T1 (de) 1999-01-15

Family

ID=25149105

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92921892T ATE175116T1 (de) 1991-11-04 1992-10-13 Synthetische, oberflächen aktive zusammensetzung für die lunge mit antioxidativen eigenschaften

Country Status (15)

Country Link
US (2) US5272252A (https=)
EP (1) EP0666754B1 (https=)
JP (1) JPH07502500A (https=)
KR (1) KR100250847B1 (https=)
AT (1) ATE175116T1 (https=)
AU (1) AU667200B2 (https=)
CA (1) CA2121147C (https=)
DE (1) DE69228077T2 (https=)
DK (1) DK0666754T3 (https=)
ES (1) ES2127764T3 (https=)
FI (1) FI942032L (https=)
GR (1) GR3029279T3 (https=)
HU (1) HUT66424A (https=)
NO (1) NO941616D0 (https=)
WO (1) WO1993008824A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
WO1994003484A1 (en) * 1992-07-31 1994-02-17 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants
DK0886652T3 (da) * 1995-11-20 2002-08-12 Ortho Mcneil Pharm Inc Fremgangsmåde til solubilisering af pulmonale overfladeaktive peptider
US5927273A (en) * 1996-03-08 1999-07-27 Life Resuscitation Technologies, Inc. Combined liquid ventilation and cardiopulmonary resuscitation method
AU2001278864A1 (en) * 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) * 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
US6998384B2 (en) * 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
WO2003090682A2 (en) * 2002-04-25 2003-11-06 The Scripps Research Institute Treatment and prevention of pulmonary conditions
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
EP1809272A4 (en) * 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
SI1841458T1 (sl) 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
JPWO2007001094A1 (ja) * 2005-06-29 2009-01-22 相男 李 人工肺サーファクタント組成物
JP2010503731A (ja) * 2006-09-19 2010-02-04 ディスカバリー ラボラトリーズ，インコーポレイテッド 肺サーファクタント製剤および粘液クリアランスの促進方法
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US4705684A (en) * 1985-05-31 1987-11-10 The University Of Tennessee Research Corporation Synthetic M proteins - streptococci type 6
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
EP0273916A4 (en) * 1986-05-06 1989-11-30 Childrens Hosp Medical Center LUNG HYDROPHOBES, PROTEIN ASSOCIATED TO A SURFACE ACTIVE MEDIUM OF 6000 DALTON MOLECULAR WEIGHT AND MULTIMEREOUS ITEMS.
EP0290516A4 (en) * 1986-10-24 1989-11-14 Jeffrey A Whitsett PROTEINS RELATED TO SURFACE-EFFECTIVE HYDROPHOBIC LUNG ACTIVE SUBSTANCES.
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1989000167A1 (en) * 1987-07-01 1989-01-12 Kabigen Ab Proteins and protein compositions and their use
EP0383837B1 (en) * 1987-11-04 1998-02-04 Byk Gulden Lomberg Chemische Fabrik GmbH Alveolar surfactant proteins
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
NZ229737A (en) * 1988-07-01 1991-05-28 Merrell Dow Pharma Polypeptides and derivatives of them with lung surfactant properties and their preparation
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5134129A (en) * 1989-03-15 1992-07-28 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
CA2049301A1 (en) * 1989-03-31 1990-10-01 Steven Shak Method for treating respiratory distress syndrome
EP0458167B1 (en) * 1990-05-21 1997-04-23 Abbott Laboratories Fatty acid-pulmonary surfactant conjugates
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties

Also Published As

Publication number Publication date
FI942032A7 (fi) 1994-05-03
HUT66424A (en) 1994-11-28
FI942032A0 (fi) 1994-05-03
EP0666754A4 (en) 1996-06-26
AU2778392A (en) 1993-06-07
KR100250847B1 (ko) 2000-09-01
US5272252A (en) 1993-12-21
CA2121147A1 (en) 1993-05-13
DE69228077D1 (de) 1999-02-11
EP0666754B1 (en) 1998-12-30
AU667200B2 (en) 1996-03-14
US5683982A (en) 1997-11-04
WO1993008824A1 (en) 1993-05-13
CA2121147C (en) 2002-12-10
EP0666754A1 (en) 1995-08-16
DK0666754T3 (da) 1999-08-30
HU9401293D0 (en) 1994-08-29
JPH07502500A (ja) 1995-03-16
GR3029279T3 (en) 1999-05-28
NO941616L (https=) 1994-06-24
FI942032L (fi) 1994-05-03
ES2127764T3 (es) 1999-05-01
DE69228077T2 (de) 1999-07-08
NO941616D0 (no) 1994-05-03

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee