KR100250847B1 - 산화방지 특성을 지닌 합성 폐 표면활성제 - Google Patents

산화방지 특성을 지닌 합성 폐 표면활성제 Download PDF

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Publication number
KR100250847B1
KR100250847B1 KR1019940701486A KR19940701486A KR100250847B1 KR 100250847 B1 KR100250847 B1 KR 100250847B1 KR 1019940701486 A KR1019940701486 A KR 1019940701486A KR 19940701486 A KR19940701486 A KR 19940701486A KR 100250847 B1 KR100250847 B1 KR 100250847B1
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KR
South Korea
Prior art keywords
amino acid
leu
lys
group
independently
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Expired - Fee Related
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KR1019940701486A
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English (en)
Korean (ko)
Inventor
알. 맥린 래리
에이치. 페인 마거리트
Original Assignee
슈테펜 엘. 네스비트
메렐 다우 파마슈티칼스 인크.
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Publication of KR100250847B1 publication Critical patent/KR100250847B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
KR1019940701486A 1991-11-04 1992-10-13 산화방지 특성을 지닌 합성 폐 표면활성제 Expired - Fee Related KR100250847B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7/789.918 1991-11-04
US07/789,918 US5272252A (en) 1991-11-04 1991-11-04 Synthetic lung surfactant having antioxidant properties
PCT/US1992/008728 WO1993008824A1 (en) 1991-11-04 1992-10-13 Synthetic lung surfactant having antioxidant properties

Publications (1)

Publication Number Publication Date
KR100250847B1 true KR100250847B1 (ko) 2000-09-01

Family

ID=25149105

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940701486A Expired - Fee Related KR100250847B1 (ko) 1991-11-04 1992-10-13 산화방지 특성을 지닌 합성 폐 표면활성제

Country Status (15)

Country Link
US (2) US5272252A (https=)
EP (1) EP0666754B1 (https=)
JP (1) JPH07502500A (https=)
KR (1) KR100250847B1 (https=)
AT (1) ATE175116T1 (https=)
AU (1) AU667200B2 (https=)
CA (1) CA2121147C (https=)
DE (1) DE69228077T2 (https=)
DK (1) DK0666754T3 (https=)
ES (1) ES2127764T3 (https=)
FI (1) FI942032A7 (https=)
GR (1) GR3029279T3 (https=)
HU (1) HUT66424A (https=)
NO (1) NO941616D0 (https=)
WO (1) WO1993008824A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants
DE69620801T2 (de) * 1995-11-20 2002-10-10 Ortho Mcneil Pharm Inc Verfahren zur solubisierung des pulmonnären oberflächeraktiven peptides
EP0910423A4 (en) * 1996-03-08 1999-12-29 Life Resuscitation Tech LIQUID VENTILATION METHOD AND DEVICE
WO2002006301A2 (en) * 2000-06-30 2002-01-24 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
AU2002357168A1 (en) * 2001-12-12 2003-07-09 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
AU2003223718B2 (en) * 2002-04-25 2007-08-16 The Scripps Research Institute Treatment and prevention of pulmonary conditions
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
EP1809272A4 (en) * 2004-10-18 2008-01-02 Maroon Biotech Corp METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
SI1841458T1 (sl) 2005-01-06 2012-04-30 Discovery Lab Inc Zdravljenje s predpisanim odmerjanjem surfaktanta za zdravljenje ali preprečevanje bronhopulmonalne displazije
JPWO2007001094A1 (ja) * 2005-06-29 2009-01-22 相男 李 人工肺サーファクタント組成物
EP2063903A1 (en) * 2006-09-19 2009-06-03 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4705684A (en) * 1985-05-31 1987-11-10 The University Of Tennessee Research Corporation Synthetic M proteins - streptococci type 6
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1989000167A1 (en) * 1987-07-01 1989-01-12 Kabigen Ab Proteins and protein compositions and their use
ATE163013T1 (de) * 1987-11-04 1998-02-15 Byk Gulden Lomberg Chem Fab Alveolare oberflächenaktive proteine
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5134129A (en) * 1989-03-15 1992-07-28 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
JPH04504255A (ja) * 1989-03-31 1992-07-30 ジェネンテク，インコーポレイテッド 呼吸困難症候群の治療法
DE69125750D1 (de) * 1990-05-21 1997-05-28 Abbott Lab Fettsäure-Oberflächenaktives-Lungenprotein Konjate
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties

Also Published As

Publication number Publication date
WO1993008824A1 (en) 1993-05-13
CA2121147A1 (en) 1993-05-13
EP0666754A1 (en) 1995-08-16
HUT66424A (en) 1994-11-28
FI942032L (fi) 1994-05-03
US5272252A (en) 1993-12-21
DE69228077T2 (de) 1999-07-08
US5683982A (en) 1997-11-04
NO941616L (https=) 1994-06-24
DK0666754T3 (da) 1999-08-30
ES2127764T3 (es) 1999-05-01
ATE175116T1 (de) 1999-01-15
FI942032A0 (fi) 1994-05-03
HU9401293D0 (en) 1994-08-29
EP0666754B1 (en) 1998-12-30
CA2121147C (en) 2002-12-10
GR3029279T3 (en) 1999-05-28
DE69228077D1 (de) 1999-02-11
EP0666754A4 (en) 1996-06-26
AU2778392A (en) 1993-06-07
FI942032A7 (fi) 1994-05-03
AU667200B2 (en) 1996-03-14
NO941616D0 (no) 1994-05-03
JPH07502500A (ja) 1995-03-16

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