ATE164851T1 - Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung - Google Patents

Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung

Info

Publication number
ATE164851T1
ATE164851T1 AT89912002T AT89912002T ATE164851T1 AT E164851 T1 ATE164851 T1 AT E164851T1 AT 89912002 T AT89912002 T AT 89912002T AT 89912002 T AT89912002 T AT 89912002T AT E164851 T1 ATE164851 T1 AT E164851T1
Authority
AT
Austria
Prior art keywords
peg
polyethylene glycol
separation
protein adducts
adducts
Prior art date
Application number
AT89912002T
Other languages
English (en)
Inventor
Cristina Delgado
Gillian Elizabeth Francis
Derek Fisher
Original Assignee
Polymasc Pharmaceuticals Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polymasc Pharmaceuticals Plc filed Critical Polymasc Pharmaceuticals Plc
Application granted granted Critical
Publication of ATE164851T1 publication Critical patent/ATE164851T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/42—Flow patterns using counter-current
AT89912002T 1988-10-20 1989-10-20 Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung ATE164851T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888824591A GB8824591D0 (en) 1988-10-20 1988-10-20 Fractionation process

Publications (1)

Publication Number Publication Date
ATE164851T1 true ATE164851T1 (de) 1998-04-15

Family

ID=10645511

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89912002T ATE164851T1 (de) 1988-10-20 1989-10-20 Polyethylenglycol (peg)-protein addukte und prozess zu ihrer auftrennung

Country Status (7)

Country Link
US (2) US6384195B1 (de)
EP (4) EP0727438A3 (de)
JP (2) JP3195336B2 (de)
AT (1) ATE164851T1 (de)
DE (1) DE68928638T2 (de)
GB (1) GB8824591D0 (de)
WO (1) WO1990004606A1 (de)

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Also Published As

Publication number Publication date
EP0727438A2 (de) 1996-08-21
EP0439508A1 (de) 1991-08-07
WO1990004606A1 (en) 1990-05-03
DE68928638D1 (de) 1998-05-14
US20020127244A1 (en) 2002-09-12
EP0439508B1 (de) 1998-04-08
EP1316562A3 (de) 2003-12-17
EP0727437A2 (de) 1996-08-21
EP0727437A3 (de) 1997-01-08
EP1316562A2 (de) 2003-06-04
DE68928638T2 (de) 1998-08-20
JP3195336B2 (ja) 2001-08-06
US6384195B1 (en) 2002-05-07
JPH11315098A (ja) 1999-11-16
JPH04501260A (ja) 1992-03-05
GB8824591D0 (en) 1988-11-23
EP0727438A3 (de) 1997-03-05

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