ATE153064T1 - Oberflächen mit wünschenswerten zellhaftungseffekten - Google Patents
Oberflächen mit wünschenswerten zellhaftungseffektenInfo
- Publication number
- ATE153064T1 ATE153064T1 AT90914567T AT90914567T ATE153064T1 AT E153064 T1 ATE153064 T1 AT E153064T1 AT 90914567 T AT90914567 T AT 90914567T AT 90914567 T AT90914567 T AT 90914567T AT E153064 T1 ATE153064 T1 AT E153064T1
- Authority
- AT
- Austria
- Prior art keywords
- treated
- present
- cell
- amino acid
- peptides
- Prior art date
Links
- 230000021164 cell adhesion Effects 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 2
- 230000004956 cell adhesive effect Effects 0.000 abstract 2
- 239000011521 glass Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- MWOGMBZGFFZBMK-LJZWMIMPSA-N (2s)-2-[[(2s)-2-[[2-[[(2s,3s)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 MWOGMBZGFFZBMK-LJZWMIMPSA-N 0.000 abstract 1
- CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical compound FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 abstract 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000000919 ceramic Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- -1 glycine amino acid Chemical group 0.000 abstract 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
- 238000007654 immersion Methods 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 abstract 1
- 238000002203 pretreatment Methods 0.000 abstract 1
- 230000017854 proteolysis Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 108010052768 tyrosyl-isoleucyl-glycyl-seryl-arginine Proteins 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
- A61L17/145—Coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/044—Proteins; Polypeptides; Degradation products thereof
- A61L29/048—Other specific proteins or polypeptides not covered by A61L29/045 - A61L29/047
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Surgery (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Materials Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Primary Cells (AREA)
- Peptides Or Proteins (AREA)
- Sealing Battery Cases Or Jackets (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/414,144 US5278063A (en) | 1989-09-28 | 1989-09-28 | Chemical modification of promote animal cell adhesion on surfaces |
US07/527,198 US5330911A (en) | 1989-09-28 | 1990-05-21 | Surfaces having desirable cell adhesive effects |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE153064T1 true ATE153064T1 (de) | 1997-05-15 |
Family
ID=27022433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90914567T ATE153064T1 (de) | 1989-09-28 | 1990-09-27 | Oberflächen mit wünschenswerten zellhaftungseffekten |
Country Status (10)
Country | Link |
---|---|
US (1) | US5330911A (de) |
EP (1) | EP0494216B1 (de) |
JP (1) | JPH05502998A (de) |
AT (1) | ATE153064T1 (de) |
AU (1) | AU646644B2 (de) |
CA (1) | CA2066213A1 (de) |
DE (1) | DE69030730T2 (de) |
DK (1) | DK0494216T3 (de) |
ES (1) | ES2102366T3 (de) |
WO (1) | WO1991005036A2 (de) |
Families Citing this family (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
DE69118826T2 (de) * | 1990-11-27 | 1996-11-14 | Fuji Photo Film Co Ltd | Propenamidderivate, deren Polymere, Copolymere und deren Verwendung |
US5197973A (en) * | 1990-12-14 | 1993-03-30 | Creative Biomolecules, Inc. | Synthetic bioadhesive |
JPH05252941A (ja) * | 1991-08-12 | 1993-10-05 | Sakai Enetsukusu Kk | 動物細胞培養用担体 |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
EP0567886A3 (de) * | 1992-04-21 | 1994-11-02 | Kurashiki Boseki Kk | Beschichtungszusammensetzung zur Züchtung von haftenden Tierzellen und Verfahren zur Züchtung der Zellen in serumfreien Verhältnissen. |
USRE36844E (en) * | 1993-04-05 | 2000-08-29 | Desmos Incorporated | Cellular attachment to trans-epithelial appliances |
US5585267A (en) * | 1993-04-05 | 1996-12-17 | Desmos, Inc. | Cellular attachment to trans-epithelial appliances |
AU6486494A (en) * | 1993-06-24 | 1995-01-05 | Siemens Aktiengesellschaft | Compound and method of applying anti-fouling coatings on medical devices |
JP2500472B2 (ja) * | 1993-10-06 | 1996-05-29 | 日本電気株式会社 | 細胞配列培養装置およびその方法 |
DE4339524C2 (de) * | 1993-11-19 | 1999-02-18 | Konrad Prof Dr Planz | Vorrichtung und System zum temporären Schienen im Harnleiter- und Harnröhrentrakt |
US5834029A (en) * | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
US5583114A (en) | 1994-07-27 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Adhesive sealant composition |
USRE38827E1 (en) | 1994-07-27 | 2005-10-11 | 3M Innovative Properties Company | Adhesive sealant composition |
US5677276A (en) * | 1994-12-23 | 1997-10-14 | La Jolla Cancer Research Foundation | Immobilization of peptides to hyaluronate |
DE19505070C2 (de) * | 1995-02-15 | 1997-03-27 | Axel Prof Dr Med Haverich | Künstliche Gefäßsysteme und Verfahren zu ihrer Herstellung |
US5733538A (en) * | 1995-06-07 | 1998-03-31 | Thoratec Laboratories, Inc. | Surface-modifying copolymers having cell adhesion properties |
JP2000505077A (ja) * | 1996-01-16 | 2000-04-25 | レンセレール ポリテクニック インスティチュート | 骨芽細胞の接着を改良するためのペプチド |
WO1997035000A1 (en) | 1996-03-18 | 1997-09-25 | The Trustees Of The University Of Pennsylvania | Bioactive material substrate for enhanced cellular attachment and function |
US5874165A (en) * | 1996-06-03 | 1999-02-23 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto polymeric subtrates |
US5916585A (en) * | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
US5914182A (en) * | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
US20030077317A1 (en) * | 1996-06-25 | 2003-04-24 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
AU3813597A (en) * | 1996-07-26 | 1998-02-20 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
EP0877580B1 (de) * | 1996-11-01 | 2005-05-18 | Medtronic MiniMed, Inc. | Pumpe zur medikamentösen infusion mit einer durch ein protein stabilisierten beschichtung |
US6443942B2 (en) | 1996-11-01 | 2002-09-03 | Minimed, Inc. | Medication device with protein stabilizing surface coating |
DE19706667A1 (de) * | 1997-02-20 | 1998-08-27 | Merck Patent Gmbh | Knochenersatzmaterial mit einer Oberflächenbelegung mit Peptiden mit RGD-Aminosäuresequenz |
CA2286590C (en) * | 1997-04-18 | 2005-08-02 | California Institute Of Technology | Multifunctional polymeric tissue coatings |
US6548263B1 (en) * | 1997-05-29 | 2003-04-15 | Cellomics, Inc. | Miniaturized cell array methods and apparatus for cell-based screening |
US6368877B1 (en) * | 1997-06-25 | 2002-04-09 | Massachusetts Institute Of Technology | Self-assembling peptide surfaces for cell patterning and interactions |
CA2311445C (en) * | 1997-11-24 | 2008-10-21 | Herbert Peter Jennissen | Method for immobilizing mediator molecule on inorganic and metal implant material |
US6140127A (en) * | 1998-02-18 | 2000-10-31 | Cordis Corporation | Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide |
US6267784B1 (en) | 1998-05-01 | 2001-07-31 | Benz Research And Development Corporation | Intraocular lens and haptics made of a copolymer |
US6096799A (en) | 1998-05-07 | 2000-08-01 | Benz Research & Development Corporation | Contact lens of high water content and high water balance |
US6428579B1 (en) | 1998-07-01 | 2002-08-06 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
JP2003513682A (ja) * | 1998-07-24 | 2003-04-15 | ファーマカル、バイオテクノロジーズ、インコーポレーテッド | 骨組織復元システムおよび方法 |
US6958212B1 (en) * | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
EP2311895B1 (de) | 1999-02-01 | 2017-04-12 | Eidgenössische Technische Hochschule Zürich | Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind |
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US6836559B2 (en) | 2000-03-09 | 2004-12-28 | The Regents Of The University Of California | Automated video-microscopic imaging and data acquisition system for colloid deposition measurements |
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EP1355965B1 (de) * | 2000-10-19 | 2012-09-19 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Verfahren zur herstellung von blockcopolymeren für multifunktionelle selbstorganisierende systeme |
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US7285412B2 (en) * | 2001-07-27 | 2007-10-23 | Surface Logix Inc. | Device for magnetic immobilization of cells |
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US7101693B2 (en) * | 2001-09-07 | 2006-09-05 | Brigham Young University | Plasticized hydrophilic glasses for improved stabilization of biological agents |
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US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
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CN104874031B (zh) * | 2015-04-20 | 2017-10-10 | 苏州大学 | 模拟人体纤溶系统和血管内皮系统的聚氨酯衍生物及制备方法及相关产物制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US4614517A (en) * | 1982-08-04 | 1986-09-30 | La Jolla Cancer Research Foundation | Tetrapeptide |
EP0277993A4 (de) * | 1986-08-15 | 1989-01-19 | Commw Scient Ind Res Org | Verbesserung der zelladhäsion und wachstum auf einem substrat. |
US5092885A (en) * | 1987-02-12 | 1992-03-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Peptides with laminin activity |
IL85372A (en) * | 1987-02-12 | 1992-12-01 | Us Health | Penta to nona-peptides with laminin - like activity having an amino acid sequence and anti- metastatic compositions containing them |
JPS63264069A (ja) * | 1987-04-22 | 1988-10-31 | 出光興産株式会社 | 細胞接着性材料 |
US7221982B2 (en) * | 2004-07-12 | 2007-05-22 | Cardiac Pacemakers, Inc. | Apparatus and method of coating implantable leads |
-
1990
- 1990-05-21 US US07/527,198 patent/US5330911A/en not_active Expired - Lifetime
- 1990-09-27 DK DK90914567.4T patent/DK0494216T3/da active
- 1990-09-27 CA CA002066213A patent/CA2066213A1/en not_active Abandoned
- 1990-09-27 DE DE69030730T patent/DE69030730T2/de not_active Expired - Fee Related
- 1990-09-27 JP JP2513835A patent/JPH05502998A/ja active Pending
- 1990-09-27 AU AU64472/90A patent/AU646644B2/en not_active Ceased
- 1990-09-27 ES ES90914567T patent/ES2102366T3/es not_active Expired - Lifetime
- 1990-09-27 AT AT90914567T patent/ATE153064T1/de not_active IP Right Cessation
- 1990-09-27 EP EP90914567A patent/EP0494216B1/de not_active Expired - Lifetime
- 1990-09-27 WO PCT/US1990/005525 patent/WO1991005036A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0494216B1 (de) | 1997-05-14 |
AU6447290A (en) | 1991-04-28 |
US5330911A (en) | 1994-07-19 |
WO1991005036A3 (en) | 1991-05-16 |
DE69030730T2 (de) | 1998-01-02 |
CA2066213A1 (en) | 1991-03-29 |
AU646644B2 (en) | 1994-03-03 |
JPH05502998A (ja) | 1993-05-27 |
ES2102366T3 (es) | 1997-08-01 |
DE69030730D1 (de) | 1997-06-19 |
DK0494216T3 (da) | 1997-11-24 |
WO1991005036A2 (en) | 1991-04-18 |
EP0494216A1 (de) | 1992-07-15 |
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