ATE136907T1 - Neue insulinanaloge geeignet für die transdermale anwendung - Google Patents
Neue insulinanaloge geeignet für die transdermale anwendungInfo
- Publication number
- ATE136907T1 ATE136907T1 AT92903864T AT92903864T ATE136907T1 AT E136907 T1 ATE136907 T1 AT E136907T1 AT 92903864 T AT92903864 T AT 92903864T AT 92903864 T AT92903864 T AT 92903864T AT E136907 T1 ATE136907 T1 AT E136907T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin analogues
- new insulin
- transdermal use
- analogues suitable
- molecule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK010191A DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Hidtil ukendte peptider |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE136907T1 true ATE136907T1 (de) | 1996-05-15 |
Family
ID=8089747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92903864T ATE136907T1 (de) | 1991-01-22 | 1992-01-22 | Neue insulinanaloge geeignet für die transdermale anwendung |
Country Status (9)
Country | Link |
---|---|
US (1) | US5597796A (de) |
EP (1) | EP0568594B1 (de) |
JP (1) | JPH06506444A (de) |
AT (1) | ATE136907T1 (de) |
AU (1) | AU1190292A (de) |
CA (1) | CA2100565A1 (de) |
DE (1) | DE69210011T2 (de) |
DK (1) | DK10191D0 (de) |
WO (1) | WO1992012999A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2087087C (en) * | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
IT1285405B1 (it) | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
US5747453A (en) * | 1995-06-06 | 1998-05-05 | Alza Corporation | Method for increasing the electrotransport flux of polypeptides |
JP4307550B2 (ja) * | 1995-11-13 | 2009-08-05 | メドトロニック ミニメッド、 インコーポレイティド | 単量体状タンパク質の送達のための方法及び組成物 |
US6333189B1 (en) | 1996-06-06 | 2001-12-25 | Alza Corporation | Method of making an electrotransport device |
US5857994A (en) * | 1996-10-01 | 1999-01-12 | Becton, Dickinson And Company | Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof |
DE19726167B4 (de) * | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
EP1030688B1 (de) * | 1997-11-12 | 2004-09-29 | Alza Corporation | Verfahren zur dermalen verabreichung von polypeptiden |
US6562942B1 (en) * | 1999-02-23 | 2003-05-13 | Neurocrine Biosciences, Inc. | Methods for treatment of diabetes using peptide analogues of insulin |
US6406455B1 (en) * | 1998-12-18 | 2002-06-18 | Biovalve Technologies, Inc. | Injection devices |
WO2000048669A1 (en) | 1999-02-18 | 2000-08-24 | Biovalve Technologies, Inc. | Electroactive pore |
DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
EP1270012A1 (de) * | 2001-06-21 | 2003-01-02 | Pfizer Products Inc. | Verwendung pulmonär verabreichten Insulins zur Behandlung von Diabetes |
JP4033382B2 (ja) * | 2002-04-08 | 2008-01-16 | 久光製薬株式会社 | インスリン投与装置 |
DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
EP1991575A1 (de) * | 2006-02-21 | 2008-11-19 | Novo Nordisk A/S | Einkettige insulinanaloga und pharmazeutische formulierungen daraus |
US8796205B2 (en) | 2006-05-09 | 2014-08-05 | Novo Nordisk A/S | Insulin derivative |
WO2007128817A2 (en) | 2006-05-09 | 2007-11-15 | Novo Nordisk A/S | Insulin derivative |
WO2008015099A2 (en) | 2006-07-31 | 2008-02-07 | Novo Nordisk A/S | Pegylated, extended insulins |
CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
EP2152245B1 (de) | 2007-04-30 | 2015-12-02 | Novo Nordisk A/S | Verfahren zum Trocknen einer Proteinzusammensetzung, getrocknete Proteinzusammensetzung und pharmazeutische Zusammensetzungen mit dem getrockneten Protein |
JP2009067766A (ja) * | 2007-09-12 | 2009-04-02 | Kosumedei Seiyaku Kk | 経皮吸収促製剤及びそれを用いた経皮吸収システム |
KR20100111683A (ko) * | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
JP5694779B2 (ja) | 2008-01-09 | 2015-04-01 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体 |
JP5762001B2 (ja) | 2008-03-14 | 2015-08-12 | ノボ・ノルデイスク・エー/エス | プロテアーゼ安定化インスリンアナログ |
US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
US20120241356A1 (en) * | 2009-07-06 | 2012-09-27 | Sanofi-Aventis Deutschland Gmbh | Heat- and vibration-stable insulin preparations |
US10029011B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine |
PT2498801T (pt) | 2009-11-13 | 2018-05-02 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendin-4(1-39)-lys6-nh2 e metionina |
EP2552407A1 (de) | 2010-03-31 | 2013-02-06 | Wockhardt Limited | Zusammensetzung mit insulin und kräuteröl für transdermale oder transmukosale verabreichung |
SG187904A1 (en) | 2010-08-30 | 2013-04-30 | Sanofi Aventis Deutschland | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
KR101983982B1 (ko) | 2011-08-29 | 2019-05-30 | 사노피-아벤티스 도이칠란트 게엠베하 | 2형 당뇨병 환자의 혈당 조절에 사용하기 위한 약제학적 병용물 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
WO2013110069A1 (en) * | 2012-01-20 | 2013-07-25 | Case Western Reserve University | Glutamic acid-stabilized insulin analogues |
BR112014025132A2 (pt) | 2012-04-11 | 2017-07-11 | Novo Nordisk As | formulações de insulina |
KR20150138251A (ko) * | 2013-03-15 | 2015-12-09 | 케이스 웨스턴 리저브 유니버시티 | 부위 2 인슐린 유사체 |
BR112016007166A2 (pt) | 2013-10-07 | 2017-09-12 | Novo Nordisk As | derivado de um análogo de insulina |
GB201321489D0 (en) | 2013-12-05 | 2014-01-22 | Chemical & Biopharmaceutical Lab Of Patras S A | Biologically active insulin derivatives |
NZ733670A (en) | 2014-12-12 | 2021-12-24 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
CA3035850A1 (en) | 2016-09-06 | 2018-03-15 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | Proinsulin derivatives |
JP6690062B2 (ja) | 2016-12-16 | 2020-04-28 | ノヴォ ノルディスク アー/エス | インスリン含有医薬組成物 |
PE20211264A1 (es) | 2017-08-17 | 2021-07-15 | Novo Nordisk As | Analogos de insulina acilados novedosos y usos de estos |
EP3756679A1 (de) | 2019-06-28 | 2020-12-30 | Université de Genève | Zusammensetzungen zur verwendung in der behandlung von insulinmangelstörungen |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
DK257988D0 (da) * | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
KR900701842A (ko) * | 1988-07-20 | 1990-12-04 | 헨리 브뢰늄 | 인간 인슐린 동족체와 그를 포함하는 제제 |
JPH04502465A (ja) * | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
PT93057B (pt) * | 1989-02-09 | 1995-12-29 | Lilly Co Eli | Processo para a preparacao de analogos da insulina |
-
1991
- 1991-01-22 DK DK010191A patent/DK10191D0/da not_active Application Discontinuation
-
1992
- 1992-01-22 CA CA002100565A patent/CA2100565A1/en not_active Abandoned
- 1992-01-22 EP EP92903864A patent/EP0568594B1/de not_active Expired - Lifetime
- 1992-01-22 AU AU11902/92A patent/AU1190292A/en not_active Abandoned
- 1992-01-22 JP JP4503787A patent/JPH06506444A/ja active Pending
- 1992-01-22 DE DE69210011T patent/DE69210011T2/de not_active Expired - Fee Related
- 1992-01-22 WO PCT/DK1992/000019 patent/WO1992012999A1/en active IP Right Grant
- 1992-01-22 AT AT92903864T patent/ATE136907T1/de not_active IP Right Cessation
-
1994
- 1994-09-07 US US08/301,838 patent/US5597796A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5597796A (en) | 1997-01-28 |
EP0568594B1 (de) | 1996-04-17 |
AU1190292A (en) | 1992-08-27 |
DK10191D0 (da) | 1991-01-22 |
JPH06506444A (ja) | 1994-07-21 |
EP0568594A1 (de) | 1993-11-10 |
DE69210011D1 (de) | 1996-05-23 |
DE69210011T2 (de) | 1996-09-05 |
CA2100565A1 (en) | 1992-07-23 |
WO1992012999A1 (en) | 1992-08-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE136907T1 (de) | Neue insulinanaloge geeignet für die transdermale anwendung | |
MX172600B (es) | , "procedimiento para la produccion de una proteina biologicamente activa | |
FR2444064A1 (fr) | Melange de polymere du chlorure de vinyle et de polyetherurethane a groupe amine tertiaire et/ou ammonium, notamment pour objet conforme a usage medical | |
ATE67505T1 (de) | Tetrapyrrolverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. | |
BR9406363A (pt) | Composiçao farmacêutica processo para a preparaçao da mesma uso da mesma e processo para o tratamento de doenças relacionadas com o ácido gástrico | |
KR900013961A (ko) | 기억력 및 학습력 증강 또는 인식 또는 정신장해 치료용 d-시클로세린 및 d-알라닌 함유 조성물 | |
ATE66614T1 (de) | Insulinzubereitung fuer nicht-parenterale verabreichung. | |
DE59105808D1 (de) | Verwendung von pharmazeutischen und kosmetischen Präparaten mit Mischmicellen. | |
MX163955B (es) | Composicion farmaceutica de dihidrocodeina e ibuprofen | |
ATA260690A (de) | Therapeutische infusionszubereitung auf basis von aminosäurederivaten | |
HUP9904023A2 (hu) | Leptin antagonisták alkalmazása inzulin rezisztencia kezelésére II. típusú cukorbajban | |
DE59303365D1 (de) | Derivate in der vitamin d-reihe mit modifikationen in der 20 position, verfahren zu ihrer herstellung, zwischenprodukte für dieses verfahren, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln | |
AU4626389A (en) | Use of minoxidil for wound healing | |
PT101444A (pt) | Associacao sinergizante com efeito antagonista dos receptores nk1 e nk2, uso de produtos com actividade antagonista dos receptores nk1 e nk2 na sua preparacao e composicao farmaceutica contendo a referida associacao | |
UA26403A (uk) | Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція | |
ATE97001T1 (de) | Topisch anzuwendende defibrotid enthaltende arzneizubereitungen. | |
ITRM910730A0 (it) | Composizioni farmaceutiche, per uso topico, contenenti "scavengers" diradicali liberi dell'ossigeno e antibatterici, indicate nella terapia dei tessuti superficiali | |
DE68920896D1 (de) | N2-(1-Carboxy-3-phenylpropyl)-L-lysinderivate und Verfahren für die Herstellung von Lysinopril mit Hilfe dieser Verbindung. | |
AU4140585A (en) | 1,4-dihydropyridine-3-carboxylates and salts thereof | |
IL101675A0 (en) | Method and pharmaceutical compositions for detecting and localizing tissues having neurokinine 1 receptors | |
BR8601575A (pt) | Controle da velocidade de agentes de"cura"diamina em cimentos de poliuretana | |
ATE128862T1 (de) | Zusammensetzung zur lokalen anwendung. | |
EP0353474A3 (de) | Glyzerin-Derivat und dessen pharmazeutische Verwendung | |
DK277387A (da) | Terapeutisk topikal sammensaetning mod en hyperprolifererende epithelsygdom | |
ES2066605T3 (es) | Nuevas ureas y tioureas, su preparacion y su aplicacion en terapeutica. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |