ATE13059T1 - Verfahren zur 5-aroylierung von 1,2-dihydro-3-hpyrrolo(1,2-a)pyrrol-1-carboxyl-estern und nitrilen. - Google Patents
Verfahren zur 5-aroylierung von 1,2-dihydro-3-hpyrrolo(1,2-a)pyrrol-1-carboxyl-estern und nitrilen.Info
- Publication number
- ATE13059T1 ATE13059T1 AT81305496T AT81305496T ATE13059T1 AT E13059 T1 ATE13059 T1 AT E13059T1 AT 81305496 T AT81305496 T AT 81305496T AT 81305496 T AT81305496 T AT 81305496T AT E13059 T1 ATE13059 T1 AT E13059T1
- Authority
- AT
- Austria
- Prior art keywords
- aroylation
- dihydro
- nitrilenes
- hpyrrolo
- pyrrol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/208,920 US4353829A (en) | 1980-11-21 | 1980-11-21 | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
EP81305496A EP0053021B1 (de) | 1980-11-21 | 1981-11-20 | Verfahren zur 5-Aroylierung von 1,2-Dihydro-3-H-pyrrolo(1,2-a)pyrrol-1-carboxyl-Estern und -Nitrilen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE13059T1 true ATE13059T1 (de) | 1985-05-15 |
Family
ID=22776597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT81305496T ATE13059T1 (de) | 1980-11-21 | 1981-11-20 | Verfahren zur 5-aroylierung von 1,2-dihydro-3-hpyrrolo(1,2-a)pyrrol-1-carboxyl-estern und nitrilen. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4353829A (de) |
EP (1) | EP0053021B1 (de) |
JP (3) | JPS57145878A (de) |
KR (1) | KR880001658B1 (de) |
AT (1) | ATE13059T1 (de) |
AU (1) | AU545034B2 (de) |
CA (1) | CA1168244A (de) |
DE (1) | DE3170342D1 (de) |
DK (2) | DK161966C (de) |
ES (1) | ES507305A0 (de) |
FI (1) | FI813710L (de) |
HK (1) | HK3488A (de) |
HU (2) | HU185982B (de) |
IE (1) | IE52217B1 (de) |
IL (1) | IL64329A (de) |
MY (1) | MY8700828A (de) |
NO (1) | NO159598C (de) |
NZ (1) | NZ199014A (de) |
SG (1) | SG94587G (de) |
ZA (1) | ZA818078B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0091181B1 (de) * | 1982-02-25 | 1986-12-17 | Beecham Group Plc | Aroylpyrrolizinverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
US4612325A (en) * | 1982-06-08 | 1986-09-16 | Syntex (U.S.A) Inc. | 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories |
US4560699A (en) * | 1983-01-17 | 1985-12-24 | Syntex (U.S.A.) Inc. | 5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories |
US4873340A (en) * | 1986-05-29 | 1989-10-10 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates |
US4988822A (en) * | 1986-05-29 | 1991-01-29 | Syntex (U.S.A.) Inc. | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates |
US4849526A (en) * | 1987-01-14 | 1989-07-18 | Syntex (U.S.A.) Inc. | Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates |
HU198927B (en) * | 1987-01-14 | 1989-12-28 | Richter Gedeon Vegyeszet | Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same |
US4835288A (en) * | 1987-01-14 | 1989-05-30 | Syntex Inc. | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates |
US4874872A (en) * | 1987-01-14 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates |
US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
JP2649168B2 (ja) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | 新規な5,6−ジフェニル−1,2−ジヒドロ−3H−ピロロ[1,2−a]ピロール−1−カルボン酸誘導体 |
IT1241124B (it) * | 1990-04-20 | 1993-12-29 | Industriale Chimica | Processo per la preparazione di derivati di acidi 1,2-diidro 3h pirrol (1,2-a) pirrol-l-carbossilici e relativi intermedi |
US5082951A (en) * | 1990-10-12 | 1992-01-21 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor |
US5082950A (en) * | 1990-10-12 | 1992-01-21 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor |
WO1995001767A1 (en) * | 1993-07-08 | 1995-01-19 | Cygnus Therapeutic Systems | Monolithic matrix transdermal delivery system |
US5621115A (en) * | 1996-02-21 | 1997-04-15 | Ohmeda Pharmaceutical Products Division Inc. | Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids |
US6191285B1 (en) | 1997-07-03 | 2001-02-20 | Abbott Laboratories | Process for the preparation of ketorolac tromethamine |
US6197976B1 (en) | 1998-12-14 | 2001-03-06 | Syntex (U.S.A.) Llc | Preparation of ketorolac |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
US4087539A (en) * | 1976-07-14 | 1978-05-02 | Syntex (U.S.A.) Inc. | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
JPS539789A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative |
JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
US4097579A (en) * | 1977-03-31 | 1978-06-27 | Syntex (U.S.A.) Inc. | 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof |
US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
US4232038A (en) * | 1979-08-31 | 1980-11-04 | Syntex (U.S.A.) Inc. | 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids |
-
1980
- 1980-11-21 US US06/208,920 patent/US4353829A/en not_active Expired - Lifetime
-
1981
- 1981-11-20 NO NO813949A patent/NO159598C/no not_active IP Right Cessation
- 1981-11-20 ES ES507305A patent/ES507305A0/es active Granted
- 1981-11-20 IE IE2731/81A patent/IE52217B1/en not_active IP Right Cessation
- 1981-11-20 AT AT81305496T patent/ATE13059T1/de not_active IP Right Cessation
- 1981-11-20 KR KR1019810004496A patent/KR880001658B1/ko active
- 1981-11-20 DE DE8181305496T patent/DE3170342D1/de not_active Expired
- 1981-11-20 FI FI813710A patent/FI813710L/fi not_active Application Discontinuation
- 1981-11-20 DK DK516081A patent/DK161966C/da not_active IP Right Cessation
- 1981-11-20 ZA ZA818078A patent/ZA818078B/xx unknown
- 1981-11-20 AU AU77707/81A patent/AU545034B2/en not_active Expired
- 1981-11-20 HU HU813476A patent/HU185982B/hu unknown
- 1981-11-20 JP JP56185571A patent/JPS57145878A/ja active Pending
- 1981-11-20 CA CA000390585A patent/CA1168244A/en not_active Expired
- 1981-11-20 IL IL64329A patent/IL64329A/xx not_active IP Right Cessation
- 1981-11-20 NZ NZ199014A patent/NZ199014A/en unknown
- 1981-11-20 EP EP81305496A patent/EP0053021B1/de not_active Expired
- 1981-11-20 HU HU832033A patent/HU191850B/hu unknown
-
1987
- 1987-10-29 SG SG945/87A patent/SG94587G/en unknown
- 1987-12-30 MY MY828/87A patent/MY8700828A/xx unknown
-
1988
- 1988-01-14 HK HK34/88A patent/HK3488A/xx not_active IP Right Cessation
-
1990
- 1990-03-15 JP JP2062823A patent/JPH0660182B2/ja not_active Expired - Lifetime
- 1990-09-06 DK DK213990A patent/DK161967C/da not_active IP Right Cessation
-
1992
- 1992-07-28 JP JP4220702A patent/JPH0742290B2/ja not_active Expired - Lifetime
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |