ATE106869T1 - Verfahren zur herstellung von (+)-1,2-dihydro-3h- pyrrolo(1,2-a>-pyrrol-1-carbonsäure und verwandten verbindungen. - Google Patents

Verfahren zur herstellung von (+)-1,2-dihydro-3h- pyrrolo(1,2-a>-pyrrol-1-carbonsäure und verwandten verbindungen.

Info

Publication number
ATE106869T1
ATE106869T1 AT88104768T AT88104768T ATE106869T1 AT E106869 T1 ATE106869 T1 AT E106869T1 AT 88104768 T AT88104768 T AT 88104768T AT 88104768 T AT88104768 T AT 88104768T AT E106869 T1 ATE106869 T1 AT E106869T1
Authority
AT
Austria
Prior art keywords
pyrrolo
dihydro
pyrrol
preparation
carbonic acid
Prior art date
Application number
AT88104768T
Other languages
English (en)
Inventor
Michael P Fleming
George C Schloemer
Hiralal N Khatri
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Application granted granted Critical
Publication of ATE106869T1 publication Critical patent/ATE106869T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT88104768T 1987-03-25 1988-03-24 Verfahren zur herstellung von (+)-1,2-dihydro-3h- pyrrolo(1,2-a>-pyrrol-1-carbonsäure und verwandten verbindungen. ATE106869T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/030,774 US4874871A (en) 1987-03-25 1987-03-25 Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds

Publications (1)

Publication Number Publication Date
ATE106869T1 true ATE106869T1 (de) 1994-06-15

Family

ID=21855950

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88104768T ATE106869T1 (de) 1987-03-25 1988-03-24 Verfahren zur herstellung von (+)-1,2-dihydro-3h- pyrrolo(1,2-a>-pyrrol-1-carbonsäure und verwandten verbindungen.

Country Status (5)

Country Link
US (1) US4874871A (de)
EP (1) EP0284076B1 (de)
AT (1) ATE106869T1 (de)
DE (1) DE3889957T2 (de)
ES (1) ES2056072T3 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464609A (en) * 1990-03-16 1995-11-07 The Procter & Gamble Company Use of ketorolac for treatment of oral diseases and conditions
US5082950A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor
EP0707465A4 (de) * 1993-07-08 1997-04-16 Cygnus Therapeutic Systems Monolithisches matrix transdermales abgabesystem
KR0140134B1 (ko) * 1994-11-16 1998-06-01 강재헌 피롤리진 유도체의 제조방법
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
US6197976B1 (en) 1998-12-14 2001-03-06 Syntex (U.S.A.) Llc Preparation of ketorolac

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE804567C (de) * 1949-07-16 1951-04-26 Basf Ag Verfahren zur Herstellung von Halogencarbonsaeurehalogeniden
SU126887A1 (ru) * 1959-07-04 1959-11-30 Э.И. Будовский Способ получени 1-оксиметилпирролизидина
AU429651B2 (en) * 1968-08-08 1972-11-01 Commonwealth Scientific And Industrial Research Organization Antiviral 6, 7 dihydro 5h pyrrolizines and related compounds
NZ178996A (en) * 1974-11-15 1978-06-02 Kornis G Pyrfazole amides and thioamides;herbicidal compositions
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4087539A (en) * 1976-07-14 1978-05-02 Syntex (U.S.A.) Inc. 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
JPS539789A (en) * 1976-07-14 1978-01-28 Syntex Inc Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4347186A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
DE3368416D1 (en) * 1982-02-25 1987-01-29 Beecham Group Plc Aroyl pyrrolizine compounds, process for their preparation and pharmaceutical compositions containing them
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4536512A (en) * 1982-10-08 1985-08-20 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents
US4533671A (en) * 1982-10-08 1985-08-06 Merck & Co., Inc. 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents
US4496741A (en) * 1983-01-24 1985-01-29 Merck & Co., Inc. Process for the preparation of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivative

Also Published As

Publication number Publication date
DE3889957D1 (de) 1994-07-14
US4874871A (en) 1989-10-17
DE3889957T2 (de) 1995-01-12
EP0284076B1 (de) 1994-06-08
EP0284076A1 (de) 1988-09-28
ES2056072T3 (es) 1994-10-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time