ATE129697T1 - 9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin. - Google Patents

9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin.

Info

Publication number
ATE129697T1
ATE129697T1 AT92114054T AT92114054T ATE129697T1 AT E129697 T1 ATE129697 T1 AT E129697T1 AT 92114054 T AT92114054 T AT 92114054T AT 92114054 T AT92114054 T AT 92114054T AT E129697 T1 ATE129697 T1 AT E129697T1
Authority
AT
Austria
Prior art keywords
amino
substituted
deoxytetracycline
desmethyl
disclosed
Prior art date
Application number
AT92114054T
Other languages
German (de)
English (en)
Inventor
Joseph J Hlavka
Phaik-Eng Sum
Yakov Gluzman
Ving J Lee
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE129697T1 publication Critical patent/ATE129697T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Moulding By Coating Moulds (AREA)
  • Tires In General (AREA)
AT92114054T 1991-10-04 1992-08-18 9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin. ATE129697T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (1)

Publication Number Publication Date
ATE129697T1 true ATE129697T1 (de) 1995-11-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92114054T ATE129697T1 (de) 1991-10-04 1992-08-18 9-amino-7-substituierte-6-desmethyl-6- desoxytetracyclin.

Country Status (24)

Country Link
US (3) US5281628A (cg-RX-API-DMAC7.html)
EP (1) EP0535346B1 (cg-RX-API-DMAC7.html)
JP (1) JP3183729B2 (cg-RX-API-DMAC7.html)
KR (1) KR100261528B1 (cg-RX-API-DMAC7.html)
CN (1) CN1053182C (cg-RX-API-DMAC7.html)
AT (1) ATE129697T1 (cg-RX-API-DMAC7.html)
AU (1) AU651734B2 (cg-RX-API-DMAC7.html)
CA (1) CA2079703C (cg-RX-API-DMAC7.html)
CZ (1) CZ285015B6 (cg-RX-API-DMAC7.html)
DE (1) DE69205792T2 (cg-RX-API-DMAC7.html)
DK (1) DK0535346T3 (cg-RX-API-DMAC7.html)
ES (1) ES2081005T3 (cg-RX-API-DMAC7.html)
FI (1) FI111716B (cg-RX-API-DMAC7.html)
GR (1) GR3017978T3 (cg-RX-API-DMAC7.html)
HU (2) HU211214B (cg-RX-API-DMAC7.html)
IL (1) IL103319A (cg-RX-API-DMAC7.html)
MX (1) MX9205573A (cg-RX-API-DMAC7.html)
NO (1) NO300129B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ244556A (cg-RX-API-DMAC7.html)
PH (1) PH30343A (cg-RX-API-DMAC7.html)
PL (2) PL170939B1 (cg-RX-API-DMAC7.html)
SK (1) SK281113B6 (cg-RX-API-DMAC7.html)
TW (1) TW222616B (cg-RX-API-DMAC7.html)
ZA (1) ZA927608B (cg-RX-API-DMAC7.html)

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CZ301835B6 (cs) * 1999-09-14 2010-07-07 Trustees Of Tufts College Zpusob prípravy 7-, 9- nebo 13- substituované tetracyklinové slouceniny, reaktivní tetracyklinový chemický komplex a tetracyklinová sloucenina substituovaná v poloze 7 nebo 9
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CN1690047B (zh) * 2000-07-07 2010-10-06 塔夫茨大学信托人 9-取代的二甲胺四环素化合物
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EP2311799A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EA201000491A1 (ru) * 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
AU2003218243B2 (en) 2002-03-21 2010-04-01 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EA012136B1 (ru) 2002-07-12 2009-08-28 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
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KR101228706B1 (ko) * 2003-07-09 2013-02-01 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
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AU2006331685A1 (en) * 2005-12-22 2007-07-05 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
KR20080080205A (ko) * 2005-12-22 2008-09-02 와이어쓰 티게사이클린을 포함하는 경구 제형
CN101489987A (zh) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 四环素衍生物的分离
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
DE202007019460U1 (de) * 2006-04-24 2012-10-24 Teva Pharmaceutical Industries Ltd. Kristalline Tigecyclin-Formen
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Also Published As

Publication number Publication date
US5326759A (en) 1994-07-05
GR3017978T3 (en) 1996-02-29
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
PL170939B1 (pl) 1997-02-28
DE69205792T2 (de) 1996-06-20
HUT64298A (en) 1993-12-28
FI924453L (fi) 1993-04-05
AU2618292A (en) 1993-04-08
SK297292A3 (en) 1994-12-07
US5281628A (en) 1994-01-25
IL103319A0 (en) 1993-03-15
KR100261528B1 (ko) 2000-07-15
TW222616B (cg-RX-API-DMAC7.html) 1994-04-21
CZ285015B6 (cs) 1999-05-12
CA2079703C (en) 2004-07-20
CZ297292A3 (en) 1993-04-14
EP0535346B1 (en) 1995-11-02
JPH05239006A (ja) 1993-09-17
HU211214B (en) 1995-11-28
CN1071415A (zh) 1993-04-28
NO300129B1 (no) 1997-04-14
JP3183729B2 (ja) 2001-07-09
HU9203143D0 (en) 1992-12-28
SK281113B6 (sk) 2000-12-11
PL170933B1 (pl) 1997-02-28
MX9205573A (es) 1993-05-01
ES2081005T3 (es) 1996-02-16
EP0535346A1 (en) 1993-04-07
FI111716B (fi) 2003-09-15
PH30343A (en) 1997-04-02
NO923856D0 (no) 1992-10-02
US5401863A (en) 1995-03-28
CN1053182C (zh) 2000-06-07
HU211922A9 (en) 1996-01-29
FI924453A0 (fi) 1992-10-02
DE69205792D1 (de) 1995-12-07
DK0535346T3 (da) 1995-12-04
KR930007895A (ko) 1993-05-20
IL103319A (en) 1996-07-23
ZA927608B (en) 1993-04-13
PL296140A1 (en) 1993-11-02
HK1000319A1 (en) 1998-02-27
NZ244556A (en) 1994-06-27
NO923856L (no) 1993-04-05

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee