ATE117212T1 - Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung. - Google Patents

Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung.

Info

Publication number
ATE117212T1
ATE117212T1 AT89307922T AT89307922T ATE117212T1 AT E117212 T1 ATE117212 T1 AT E117212T1 AT 89307922 T AT89307922 T AT 89307922T AT 89307922 T AT89307922 T AT 89307922T AT E117212 T1 ATE117212 T1 AT E117212T1
Authority
AT
Austria
Prior art keywords
hirudin
biocompatible
bicompatible
analogues
fragments
Prior art date
Application number
AT89307922T
Other languages
English (en)
Inventor
Ralph K Ito
Frank W Logerfo
Original Assignee
New England Deaconess Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Deaconess Hospital filed Critical New England Deaconess Hospital
Application granted granted Critical
Publication of ATE117212T1 publication Critical patent/ATE117212T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A61L33/128—Other specific proteins or polypeptides not covered by A61L33/122 - A61L33/126
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
AT89307922T 1988-08-03 1989-08-03 Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung. ATE117212T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/227,700 US5167960A (en) 1988-08-03 1988-08-03 Hirudin-coated biocompatible substance

Publications (1)

Publication Number Publication Date
ATE117212T1 true ATE117212T1 (de) 1995-02-15

Family

ID=22854125

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89307922T ATE117212T1 (de) 1988-08-03 1989-08-03 Ein mit hirudin, deren analoge oder deren fragmente beschichtetes bioverträgliches und thromboresistentes material und seine herstellung.

Country Status (17)

Country Link
US (1) US5167960A (de)
EP (1) EP0357242B1 (de)
JP (1) JPH02147067A (de)
KR (1) KR900002752A (de)
AT (1) ATE117212T1 (de)
AU (1) AU624170B2 (de)
CA (1) CA1338756C (de)
DD (1) DD283933A5 (de)
DE (1) DE68920671T2 (de)
DK (1) DK379189A (de)
ES (1) ES2068897T3 (de)
FI (1) FI893660A (de)
IE (1) IE892501L (de)
IL (1) IL91188A (de)
NZ (1) NZ230180A (de)
PT (1) PT91345A (de)
ZA (1) ZA895862B (de)

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US5342693A (en) * 1988-06-08 1994-08-30 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coating and methods of manufacture
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5112615A (en) * 1988-08-03 1992-05-12 New England Deaconess Hospital Corporation Soluble hirudin conjugates
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US5053453A (en) * 1988-11-01 1991-10-01 Baxter International Inc. Thromboresistant materials and methods for making same
US6146358A (en) * 1989-03-14 2000-11-14 Cordis Corporation Method and apparatus for delivery of therapeutic agent
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
CA2074362A1 (en) * 1990-11-22 1992-05-23 Hajimu Kurumatani Implantation materials
DE69229312T2 (de) * 1991-03-29 1999-11-04 Vascular Graft Research Center Künstliches blutgefäss aus komposit-material
US5837808A (en) * 1991-08-20 1998-11-17 Baxter International Inc. Analogs of hirudin
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
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US6663881B2 (en) 1993-01-28 2003-12-16 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
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US5718694A (en) * 1993-11-09 1998-02-17 The Board Of Regents Of The University Of Nebraska Inhibition of adherence of microorganisms to biomaterial surfaces by treatment with carbohydrates
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AT404357B (de) * 1995-06-13 1998-11-25 Immuno Ag Prothrombin-derivate
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US5900433A (en) * 1995-06-23 1999-05-04 Cormedics Corp. Vascular treatment method and apparatus
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US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
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US6702851B1 (en) 1996-09-06 2004-03-09 Joseph A. Chinn Prosthetic heart valve with surface modification
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US5891196A (en) * 1997-04-16 1999-04-06 Baxter International Inc. Method for actively binding heparin to crosslinked biological tissues
US5879697A (en) * 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US7132413B1 (en) * 1997-07-31 2006-11-07 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Anticoagulant/sterilizing compositions and methods
US8304390B2 (en) * 1997-07-31 2012-11-06 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treatment for preventing or reducing tumor growth in the liver of patient
US20050124608A1 (en) * 2001-04-03 2005-06-09 Redmond H. P. Treatment of cancers
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6530946B1 (en) 1998-04-21 2003-03-11 Alsius Corporation Indwelling heat exchange heat pipe catheter and method of using same
US6419643B1 (en) 1998-04-21 2002-07-16 Alsius Corporation Central venous catheter with heat exchange properties
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US6126684A (en) * 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
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BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US6582398B1 (en) * 1999-02-19 2003-06-24 Alsius Corporation Method of managing patient temperature with a heat exchange catheter
US7892530B2 (en) * 1999-06-04 2011-02-22 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of tumor metastases and cancer
US7345039B2 (en) * 1999-06-04 2008-03-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
US8030301B2 (en) * 1999-06-04 2011-10-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of cancers with methylol-containing compounds and at least one electrolyte
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CA2971349C (en) * 2005-11-28 2020-09-08 The Trustees Of The University Of Pennsylvania Potent compstatin analogs
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JP7423070B2 (ja) 2018-04-06 2024-01-29 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 増加した溶解度および改善された薬物動態特性を有するコンプスタチンアナログ

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Also Published As

Publication number Publication date
KR900002752A (ko) 1990-03-23
ZA895862B (en) 1990-05-30
DE68920671T2 (de) 1995-07-06
CA1338756C (en) 1996-12-03
DE68920671D1 (de) 1995-03-02
NZ230180A (en) 1991-02-26
PT91345A (pt) 1990-03-08
US5167960A (en) 1992-12-01
AU3918889A (en) 1990-02-08
DK379189A (da) 1990-02-04
FI893660A0 (fi) 1989-08-02
IE892501L (en) 1990-02-03
DK379189D0 (da) 1989-08-02
FI893660A (fi) 1990-02-04
JPH02147067A (ja) 1990-06-06
EP0357242A1 (de) 1990-03-07
EP0357242B1 (de) 1995-01-18
IL91188A (en) 1994-02-27
ES2068897T3 (es) 1995-05-01
IL91188A0 (en) 1990-03-19
AU624170B2 (en) 1992-06-04
DD283933A5 (de) 1990-10-31

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