ATE103293T1 - Menschliche peptidische hemmungsstoffe von leukozyten-elastase (hle). - Google Patents

Menschliche peptidische hemmungsstoffe von leukozyten-elastase (hle).

Info

Publication number
ATE103293T1
ATE103293T1 AT88304080T AT88304080T ATE103293T1 AT E103293 T1 ATE103293 T1 AT E103293T1 AT 88304080 T AT88304080 T AT 88304080T AT 88304080 T AT88304080 T AT 88304080T AT E103293 T1 ATE103293 T1 AT E103293T1
Authority
AT
Austria
Prior art keywords
formula
hle
human leukocyte
leukocyte elastase
peptidic inhibitors
Prior art date
Application number
AT88304080T
Other languages
English (en)
Inventor
Philip Duke Edwards
Joseph James Lewis
Charles William Perkins
Diane Amy Trainor
Richard Alan Wildonger
Original Assignee
Zeneca Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878711050A external-priority patent/GB8711050D0/en
Priority claimed from GB888803206A external-priority patent/GB8803206D0/en
Application filed by Zeneca Inc filed Critical Zeneca Inc
Application granted granted Critical
Publication of ATE103293T1 publication Critical patent/ATE103293T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
AT88304080T 1987-05-11 1988-05-05 Menschliche peptidische hemmungsstoffe von leukozyten-elastase (hle). ATE103293T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878711050A GB8711050D0 (en) 1987-05-11 1987-05-11 Selected heterocyclic ketones
GB888803206A GB8803206D0 (en) 1988-02-11 1988-02-11 Selected heterocyclic ketones
EP88304080A EP0291234B1 (de) 1987-05-11 1988-05-05 Menschliche peptidische Hemmungsstoffe von Leukozyten-Elastase (HLE)

Publications (1)

Publication Number Publication Date
ATE103293T1 true ATE103293T1 (de) 1994-04-15

Family

ID=26292230

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88304080T ATE103293T1 (de) 1987-05-11 1988-05-05 Menschliche peptidische hemmungsstoffe von leukozyten-elastase (hle).

Country Status (22)

Country Link
US (1) US5164371A (de)
EP (1) EP0291234B1 (de)
JP (1) JPS6445395A (de)
KR (1) KR880013926A (de)
CN (1) CN1037519A (de)
AT (1) ATE103293T1 (de)
AU (1) AU605284B2 (de)
CA (1) CA1326107C (de)
DE (1) DE3888568T2 (de)
DK (1) DK260588A (de)
ES (1) ES2063034T3 (de)
FI (1) FI91072C (de)
GB (1) GB8809316D0 (de)
HU (1) HU201963B (de)
IE (1) IE62524B1 (de)
IL (1) IL86236A (de)
NO (1) NO176519C (de)
NZ (1) NZ224452A (de)
PT (1) PT87454B (de)
SU (1) SU1678207A3 (de)
ZA (1) ZA883006B (de)
ZW (1) ZW4988A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8910550D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted amides
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
ES2129401T3 (es) * 1990-05-24 1999-06-16 Zeneca Ltd Uso de un compuesto terapeutico para el tratamiento de bronquitis.
DE69129083T2 (de) * 1990-05-24 1998-07-09 Zeneca Ltd Therapeutisches Mittel zur Vorbeugung und Behandlung des Atemnotsyndroms bei Erwachsenen
CA2049100A1 (en) * 1990-09-10 1992-03-11 Hirohiko Yamada Benzoic acid phenylester compounds and elastase inhibiting compositions containing the same
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US20020119985A1 (en) * 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
WO1998046628A1 (en) * 1997-04-14 1998-10-22 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
CA2285659A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6274602B1 (en) * 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6177572B1 (en) * 1997-08-20 2001-01-23 Sepracor, Inc. Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
US6184377B1 (en) 1997-12-15 2001-02-06 Sepracor Inc. Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
WO1999062538A1 (en) * 1998-06-03 1999-12-09 Cortech Inc. Alpha-keto oxadiazoles as serine protease inhibitors
JP2000256396A (ja) 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
WO2000056724A1 (en) * 1999-03-22 2000-09-28 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Oxazole and thiazole combinatorial libraries
AU5625900A (en) * 1999-06-17 2001-01-09 Cortech, Inc. Method and compounds for inhibiting activity of serine elastases
EP1383748A2 (de) 2000-12-22 2004-01-28 Axys Pharmaceuticals, Inc. Neue verbindungen und zusammensetzungen als cathepsin-inhibitoren
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2005504078A (ja) 2001-09-14 2005-02-10 アベンティス・ファーマスーティカルズ・インコーポレイテツド カテプシン阻害剤としての新規化合物および組成物
EP1446392A1 (de) 2001-11-14 2004-08-18 Aventis Pharmaceuticals, Inc. Oligopeptide und diese enthaltende zusammensetzungen als cathepsininhibitoren
US7091360B2 (en) * 2002-04-16 2006-08-15 Aventis Pharma S.A. Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses thereof
JP3744890B2 (ja) 2002-11-01 2006-02-15 ハッピー工業株式会社 ミシン
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
BRPI0712021A2 (pt) 2006-05-23 2012-01-03 Irm Llc composto e composiÇÕes como inibidores da protease ativadora de canal
US8754107B2 (en) * 2006-11-17 2014-06-17 Abbvie Inc. Aminopyrrolidines as chemokine receptor antagonists
CN101600428A (zh) 2007-02-09 2009-12-09 Irm责任有限公司 作为通道活化蛋白酶抑制剂的化合物和组合物
FR2914920B1 (fr) 2007-04-11 2011-09-09 Clariant Specialty Fine Chem F Procede de deacetalisation d'alpha-aminoacetals.
FR2916441B1 (fr) 2007-05-22 2009-08-28 Clariant Specialty Fine Chem Procede de racemisation d'alpha-aminoacetals optiquement actifs.
US20100273835A1 (en) * 2007-07-10 2010-10-28 Probiodrug Ag Novel compounds
US20090156509A1 (en) * 2007-12-12 2009-06-18 Accuthera, Inc. Tri-peptide Inhibitors of Serine Elastases
FR2927900B1 (fr) 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124317B1 (de) * 1983-04-27 1990-04-11 Ici Americas Inc. Prolin-Derivate
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
JPH03505210A (ja) * 1988-09-09 1991-11-14 ユニバーシティー オブ ケンタッキー リサーチ ファウンデーション エラスターゼ阻害ポリマーおよび方法
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones

Also Published As

Publication number Publication date
PT87454B (pt) 1992-08-31
FI91072C (fi) 1994-05-10
CA1326107C (en) 1994-01-11
NO882036D0 (no) 1988-05-10
EP0291234A2 (de) 1988-11-17
DK260588A (da) 1988-11-12
JPS6445395A (en) 1989-02-17
ES2063034T3 (es) 1995-01-01
DK260588D0 (da) 1988-05-11
AU605284B2 (en) 1991-01-10
NO882036L (no) 1988-11-14
ZA883006B (de) 1988-11-11
NO176519C (no) 1995-04-19
HU201963B (en) 1991-01-28
DE3888568T2 (de) 1994-07-21
AU1539088A (en) 1988-11-17
NO176519B (no) 1995-01-09
US5164371A (en) 1992-11-17
HUT46708A (en) 1988-11-28
IL86236A (en) 1994-12-29
GB8809316D0 (en) 1988-05-25
FI882176A (fi) 1988-11-12
EP0291234B1 (de) 1994-03-23
FI91072B (fi) 1994-01-31
EP0291234A3 (en) 1990-08-22
IE881416L (en) 1988-11-11
IE62524B1 (en) 1995-02-08
CN1037519A (zh) 1989-11-29
DE3888568D1 (de) 1994-04-28
ZW4988A1 (en) 1989-12-06
SU1678207A3 (ru) 1991-09-15
KR880013926A (ko) 1988-12-22
FI882176A0 (fi) 1988-05-10
NZ224452A (en) 1991-06-25
PT87454A (pt) 1989-05-31
IL86236A0 (en) 1988-11-15

Similar Documents

Publication Publication Date Title
ATE103293T1 (de) Menschliche peptidische hemmungsstoffe von leukozyten-elastase (hle).
DE69232022D1 (de) Naphthyridinderivate als Angiotensin-II-Antagonist-Inhibitoren
DK0976748T3 (da) Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
DE69324120D1 (de) HIV-Proteaseinhibitoren und ihre Verwendung zur Behandlung von AIDS
DE69200160D1 (de) Angiotensin-II-Antagonisten.
NO934718L (no) Nye HIV protease inhibitorer
ATE66675T1 (de) Stickstoffhaltige heterozyklische verbindungen.
EP0276101A3 (de) Substituierte Peptid-Derivate
ATE116974T1 (de) 5- piperazinylalkyl-1,5-benzothiazepinone verwendbar als calciumantagonisten.
DK23089A (da) Thioformamidderivater og deres anvendelse
ES2086059T3 (es) Derivados fungicidas de la furanona.
DE68903188D1 (de) Acylsulfonamid-derivate von alpha-carbocyclyltoluylsaeuren und ihre verwendung als leukotrienantagonisten.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee