KR880013926A - 복소환식 케톤 - Google Patents

복소환식 케톤 Download PDF

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Publication number
KR880013926A
KR880013926A KR1019880005474A KR880005474A KR880013926A KR 880013926 A KR880013926 A KR 880013926A KR 1019880005474 A KR1019880005474 A KR 1019880005474A KR 880005474 A KR880005474 A KR 880005474A KR 880013926 A KR880013926 A KR 880013926A
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KR
South Korea
Prior art keywords
group
alkyl
trifluoromethyl
alkoxy
halogeno
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KR1019880005474A
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English (en)
Inventor
필립 듀크 에드워드
조세프 제임스 루이스
찰스 윌리암 퍼킨스
다이안 아미 트레이너
리차드 알랜 윌돈저
Original Assignee
원본미기재
아이씨아이 아메리카스 아이엔씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GB878711050A external-priority patent/GB8711050D0/en
Priority claimed from GB888803206A external-priority patent/GB8803206D0/en
Application filed by 원본미기재, 아이씨아이 아메리카스 아이엔씨 filed Critical 원본미기재
Publication of KR880013926A publication Critical patent/KR880013926A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

복소환식 케톤
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 식 1의 화합물 및 그것의 제약학적으로 허용가능한 염기-부가 염.
    식중, -Q-는 (ⅰ) 할로게노, 니트로, -NRgRh의 아미노 그룹, -NHCORm의 아실아미노 그룹, 하이드록시, -OCORn의 아실옥시 그룹, (1-4c)알콕시, (1-4c)알킬, 트리플루오로메틸, 카복시, 시아노, 〔(1-4c)알콕시〕카보닐, -CONRpRq(Rp=Rq일대 -CONRp 2포함)의 아미노카보닐 그룹, 설포, SO2NRiRj의 설폰아미도 및 (1-3c)하이드록시알킬로 구성되는 그룹에서 독립적으로 선택된 하나 또는 두 개의 치환제를 임으로 가지는 오르토-페닐렌 ; 및 (ⅱ) -C(Ra)=C(Rb)의 시스-비닐렌 그룹으로 구성되는 그룹에서 선택 ; Ra및 Rb는 수소, 니트로, -NRgRh의 아미노 그룹, -OCORn의 아실옥시 그룹, (1-4c)알콕시, (r6c)알킬, 트리플루오로메틸, 카복시, 시아노, 〔(1-4c)알콕시〕카보닐, -CONRpRq(Rp=Rq일대 -CONRp 2포함)의 아미노카보닐 그룹, 하이드록시메틸 그룹 및 할로게노, 니트로, (1-4c)알콕시, (1-4c)알킬 및 트리플루오로메틸로 구성되는 그룹에서 선태된 하나 또는 두 개의 치환제를 임의로 가지는 페닐로 구성되는 구릅에서 각각 독립적으로 선택; Rg, Rh, Ri, Rj, Rm, Rp및 Rq는 각각 수소 및(1-4c)알킬로 구성되는 그룹에서 독립적으로 선택; Rn은 (1-4c)알킬, X는 산소 및 황으로 구성되는 그룹에서 선택; A는 -CO-, -NH.CO- 및 -O.CO-로 구성되는 그룹에서 선택; L은 알켄디일의이중결합에 또는 페닐렌알킬 그룹의 임의 이중결합내에 포함된 탄소가 그룹A의 질소 또는 산소 원자에 직접적으로 결합되지 않는 조건으로, 알킬 부분내에 하나의 이중 결합을 임으로 포함하는, 페닐렌, (1-6c)알칸디일, (2-6c)알켄디일 및 페닐렌(1-3c)알킬로 구성되는 그룹에서 선택; R4는 R5, S(O2).NH.CO-의 아실설폰아미드, R5.CO.NH.S(O2)-의 아실설폰아미드, R5.NH.CO.NH.S(O2)-의 설포닐우레아, R5.S(O2).NH.CO.NR6-의 설포닐우레아 및 CF3.S(O2).NH-의 트리플루오로메틸설폰아미드로 구성되는 그룹에서 선택; R5는 (1-10c)알킬; 트리플루오로메틸; (3-10c)사이클로알킬; 할로게노, 니트로, 아미노, 디메틸아미노, 하이드록시, 메틸, 트리플루오로메틸, 카복시, 페닐 및 〔(1-5c) 알킬카보닐〕아미노로 구성되는 그룹의 1-3개로 임의 치환된 (6 또는 10c)아릴; 및 방향족계의 탄소 3개까지가 할로게노 및 트리플루오로메틸로 구성되는 그룹에서 독립적으로 선택된 치환체를 가질 수 있는 방향족 복소환식 그룹으로 구성되는 그룹에서 선택; R6은 수소 또는 메틸.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880005474A 1987-05-11 1988-05-11 복소환식 케톤 KR880013926A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8711050 1987-05-11
GB878711050A GB8711050D0 (en) 1987-05-11 1987-05-11 Selected heterocyclic ketones
GB8803206 1988-02-11
GB888803206A GB8803206D0 (en) 1988-02-11 1988-02-11 Selected heterocyclic ketones

Publications (1)

Publication Number Publication Date
KR880013926A true KR880013926A (ko) 1988-12-22

Family

ID=26292230

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880005474A KR880013926A (ko) 1987-05-11 1988-05-11 복소환식 케톤

Country Status (22)

Country Link
US (1) US5164371A (ko)
EP (1) EP0291234B1 (ko)
JP (1) JPS6445395A (ko)
KR (1) KR880013926A (ko)
CN (1) CN1037519A (ko)
AT (1) ATE103293T1 (ko)
AU (1) AU605284B2 (ko)
CA (1) CA1326107C (ko)
DE (1) DE3888568T2 (ko)
DK (1) DK260588A (ko)
ES (1) ES2063034T3 (ko)
FI (1) FI91072C (ko)
GB (1) GB8809316D0 (ko)
HU (1) HU201963B (ko)
IE (1) IE62524B1 (ko)
IL (1) IL86236A (ko)
NO (1) NO176519C (ko)
NZ (1) NZ224452A (ko)
PT (1) PT87454B (ko)
SU (1) SU1678207A3 (ko)
ZA (1) ZA883006B (ko)
ZW (1) ZW4988A1 (ko)

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EP0368449A3 (en) * 1988-09-09 1991-08-14 George Alexander Digenis Elastase inhibiting polymers and methods to produce them
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones

Also Published As

Publication number Publication date
IE62524B1 (en) 1995-02-08
DE3888568D1 (de) 1994-04-28
AU1539088A (en) 1988-11-17
DK260588A (da) 1988-11-12
PT87454B (pt) 1992-08-31
NO882036L (no) 1988-11-14
FI882176A0 (fi) 1988-05-10
ZW4988A1 (en) 1989-12-06
DE3888568T2 (de) 1994-07-21
NZ224452A (en) 1991-06-25
FI91072C (fi) 1994-05-10
EP0291234A3 (en) 1990-08-22
CA1326107C (en) 1994-01-11
NO176519C (no) 1995-04-19
SU1678207A3 (ru) 1991-09-15
CN1037519A (zh) 1989-11-29
JPS6445395A (en) 1989-02-17
AU605284B2 (en) 1991-01-10
NO176519B (no) 1995-01-09
IL86236A (en) 1994-12-29
ES2063034T3 (es) 1995-01-01
GB8809316D0 (en) 1988-05-25
PT87454A (pt) 1989-05-31
HUT46708A (en) 1988-11-28
EP0291234B1 (en) 1994-03-23
HU201963B (en) 1991-01-28
DK260588D0 (da) 1988-05-11
NO882036D0 (no) 1988-05-10
EP0291234A2 (en) 1988-11-17
FI882176A (fi) 1988-11-12
ATE103293T1 (de) 1994-04-15
US5164371A (en) 1992-11-17
FI91072B (fi) 1994-01-31
ZA883006B (ko) 1988-11-11
IL86236A0 (en) 1988-11-15
IE881416L (en) 1988-11-11

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